sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal, IO biomarker:  Research on mechanism of sevoflurane in alleviating cerebral ischemia-reperfusion injury in rats through JNK signaling pathway. (Pubmed Central) -  Mar 30, 2021   
    Our results indicated that maternal treadmill exercise during pregnancy can ameliorate cognitive dysfunction induced by prenatal sevoflurane exposure; p300 HAT-mediated BDNF signaling activation might contribute to the neuroprotective effects of maternal exercise. Sevoflurane can regulate the protein and gene expressions of Bax and Bcl-2 and reduce apoptosis in CIRI by regulating the JNK signaling pathway, thereby exerting a protective effect on brain tissues and improving the symptoms of neurological deficit.
  • ||||||||||  progesterone / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Towards scheduled pre-parturient caesarean sections in bitches. (Pubmed Central) -  Mar 25, 2021   
    The first day of cytological dioestrus more precisely predicts the day of onset of spontaneous parturition than the first day of the LH surge or the dates during oestrus on which progesterone (P4) first exceeds 6 nM or 16 nM...A protocol associating medetomidine hydrochloride as premedicant with propofol as induction agent and sevoflurane as maintenance is safe for scheduled CS and yields good maternal and puppy survival rates at delivery, 2 hr and 7 days after CSs...Pre-parturient CSs can be scheduled and performed 57 days after onset of cytological dioestrus with puppy survival rates of 99%. Collectively, these studies provide a protocol to safely perform elective CSs in a large proportion of the obstetric population at a convenient time of the day but more research is required with larger numbers to establish whether this practice is routinely safe and safe in all breeds.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Propofol vs Sevoflurane in Cyanotic Congenital Heart Disease (clinicaltrials.gov) -  Mar 24, 2021   
    P4,  N=40, Recruiting, 
    Propofol should be considered a better choice during the operation to promote the patient's postoperative sleep quality, relieve postoperative pain and improve the incidence of postoperative dizziness and nausea and vomiting. Not yet recruiting --> Recruiting | Trial completion date: Mar 2020 --> Nov 2021 | Trial primary completion date: Feb 2020 --> Sep 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Anesthesia plus surgery in neonatal period impairs preference for social novelty in mice at the juvenile age. (Pubmed Central) -  Mar 17, 2021   
    Anesthetic sevoflurane could induce neurotoxicity in developing brain and cause adverse neurobehavioral outcomes in mice, including inattention, social interaction deficit, and learning and memory impairment...Collectively, these results suggested that anesthesia plus surgery could impair social novelty preference, but not sociability in mice, and that social memory might be more vulnerable than social affiliation in biological property. Furthermore, reduction in the levels of cortex OXTR and hippocampus NMDAR1 could be associated with social recognition memory in mice.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  The Influence of Type of Anesthesia on Postoperative Pain (clinicaltrials.gov) -  Mar 16, 2021   
    P=N/A,  N=468, Recruiting, 
    Trial completion date: Mar 2021 --> Dec 2021 | Trial primary completion date: Feb 2021 --> Sep 2021 Trial completion date: Feb 2021 --> Feb 2022 | Trial primary completion date: Feb 2021 --> Feb 2022
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling. (Pubmed Central) -  Mar 16, 2021   
    The present review article aims to provide a general overview of regulation of anti-cancer relevant signaling and explore potential underlying molecular mechanisms of volatile anesthetics. It may promote promising insights of guiding clinical anesthesia procedure and instructing enhance recovery after surgery (ERAS) with latent benefits.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Surgery:  SIRS in Cyanotic and Acyanotic Children in Cardiac Surgery (clinicaltrials.gov) -  Mar 15, 2021   
    P=N/A,  N=197, Completed, 
    When doing so, the use of propofol should be avoided if possible, as in our cohort it was associated with a lower anal sphincter resting pressure and at times prevented adequate assessment of the RAIR. N=150 --> 197
  • ||||||||||  ketamine / Generic mfg.
    [VIRTUAL] A Case of Status Asthmaticus Refractory to Conventional Treatment Strategies () -  Mar 14, 2021 - Abstract #ATS2021ATS_555;    
    There are currently no specific guidelines regarding the use of inhalational anesthetics in severe status asthamticus. It's use should be considered as a rescue therapy in severe status asthmaticus refractory to conventional treatment due to its effect of decreasing airway resistance, intrinsic PEEP and rapid bronchodilataion.
  • ||||||||||  sevoflurane / Generic mfg., rocuronium / Generic mfg.
    Clinical, Journal:  Relationship Between Daily Testosterone Production and Bi-spectral Index (BIS) Values in Patients Who Underwent Septoplasty Operation. (Pubmed Central) -  Mar 14, 2021   
    It's use should be considered as a rescue therapy in severe status asthmaticus refractory to conventional treatment due to its effect of decreasing airway resistance, intrinsic PEEP and rapid bronchodilataion. Sedation anaesthesia applied in patients who underwent septoplasty operation was associated with testosterone level and it was more difficult for patients to switch to sedation with increased testosterone level.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  DANA1: Neuroplasticity Induced by General Anaesthesia (clinicaltrials.gov) -  Mar 12, 2021   
    P=N/A,  N=30, Recruiting, 
    Sedation anaesthesia applied in patients who underwent septoplasty operation was associated with testosterone level and it was more difficult for patients to switch to sedation with increased testosterone level. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Aug 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane preconditioning inhibits cardiomyocyte injury induced by oxygen‑glucose deprivation by modulating TXNIP. (Pubmed Central) -  Mar 9, 2021   
    Furthermore, TXNIP modulated p27 expression via PKB (protein kinase B/AKT) phosphorylation following preconditioning with 3.5% sevoflurane, and oxygen and glucose deprivation. On the whole these findings indicated that sevoflurane preconditioning protected the H9c2 cells against injury induced by oxygen and glucose deprivation by modulating TXNIP, AKT activation and p27 signaling.
  • ||||||||||  sevoflurane / Generic mfg.
    Retrospective data, Review, Journal:  Anesthesia and Long-Term Oncological Outcomes: A Systematic Review and Meta-analysis. (Pubmed Central) -  Mar 9, 2021   
    Propofol-based TIVA is generally associated with better overall survival than volatile anesthesia during cancer surgery. Further large-scaled, high-quality randomized control trials are warranted to confirm our findings.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Intubation:  Neuromuscular-Blocking Agents and Hypoxemia During Intubation in Infants (ROC-HYPOX) (clinicaltrials.gov) -  Mar 8, 2021   
    P4,  N=412, Recruiting, 
    One month postrepair RVOT gradients were significantly reduced as compared to the intraoperative values. Trial completion date: Dec 2020 --> Dec 2022 | Trial primary completion date: Dec 2020 --> Dec 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, Surgery:  SIRS in Cyanotic and Acyanotic Children in Cardiac Surgery (clinicaltrials.gov) -  Mar 4, 2021   
    P=N/A,  N=150, Completed, 
    Our data showed that sevoflurane inhibited the proliferation, migration, invasion, and enhanced the apoptosis in glioma cells through regulating miR-218-5p/DEK/β-catenin axis. Recruiting --> Completed | Trial completion date: Nov 2020 --> Feb 2021 | Trial primary completion date: Aug 2020 --> Jan 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Confirmatory Study of HFVI Guided Analgesic Administration in Surgical Subjects (clinicaltrials.gov) -  Mar 1, 2021   
    P=N/A,  N=104, Enrolling by invitation, 
    Not yet recruiting --> Recruiting Trial completion date: Jan 2021 --> Apr 2021 | Trial primary completion date: Jan 2021 --> Apr 2021