sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg., indomethacin / Generic mfg., dexmedetomidine / Generic mfg.
    Preclinical, Journal:  Effects of anesthetic agents on contractions of the pregnant rat myometrium in vivo and in vitro. (Pubmed Central) -  Apr 24, 2021   
    Arachidonic acid may play an important role in the enhancement of myometrial contraction induced by dexmedetomidine by increasing myofilament calcium sensitivity. Dexmedetomidine may be used as a sedative agent to promote uterine muscle contraction and suppress bleeding after fetal delivery.
  • ||||||||||  sevoflurane / Generic mfg.
    PK/PD data, Preclinical, Journal:  Pharmacokinetics of intraperitoneal and subcutaneous levobupivacaine in anesthetized rats. (Pubmed Central) -  Apr 24, 2021   
    Levobupivacaine is rapidly absorbed following IP administration, but its maximum plasma concentration within 2 h following IP administration is no statistical difference as that following SC administration. On the other hand, when levobupivacaine is given subcutaneously, T can exceed 1 h, so we need to be aware of local anesthetic toxicity during this period.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg., dantrolene / Generic mfg.
    Clinical, Journal:  Malignant hyperthermia in a 16-day-old infant with congenital diaphragmatic hernia: a case report. (Pubmed Central) -  Apr 24, 2021   
    Malignant hyperthermia (MH) is a severe hypermetabolic disorder associated with dysregulation of calcium homeostasis and is triggered by inhalational anesthetics (isoflurane, sevoflurane, desflurane) and a depolarizing muscle relaxant (succinylcholine)...After the diagnosis of MH, dantrolene was administered with sufficient hydration...Subsequently, two variants of the ryanodine receptor 1 (RYR1) gene were identified in the patient as the mutation point at c.1589G > A p.Arg530His and c.1841G > T p.Arg614Leu, which are known to be associated with MH. This was a rare case of MH in a 16-day-old infant that might be related to two RYR1 mutations inherited from the parents.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Effect of inhaled waste anaesthetic gas on blood and liver parameters among hospital staff. (Pubmed Central) -  Apr 23, 2021   
    The collected results showed increased plasma inorganic fluoride, HFIP and liver toxicity markers, as well as disturbances in haematological parameters. In conclusion, exposure to halogenated inhalational anaesthetics, in general, and Sevoflurane, in particular, induces alterations in hepatic markers and haematological indices.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation. (Pubmed Central) -  Apr 23, 2021   
    Therefore, volatile anesthetic (VA) agents might be the preferred anesthetics used during the transplantation procedure. This review highlights the molecular and cellular protective points of engagement of VA shown in in vitro studies and in vivo animal experiments, and the potential translation of these results to the clinical setting of kidney transplantation.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  Effects of Different Types of General Anesthesia on Postoperative Pupillary Reactivity (clinicaltrials.gov) -  Apr 23, 2021   
    P=N/A,  N=108, Recruiting, 
    This review highlights the molecular and cellular protective points of engagement of VA shown in in vitro studies and in vivo animal experiments, and the potential translation of these results to the clinical setting of kidney transplantation. Trial primary completion date: Mar 2021 --> Mar 2022
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., rocuronium / Generic mfg.
    Clinical, Journal:  Evaluation of a Safety Protocol for the Management of Thirst in the Postoperative Period. (Pubmed Central) -  Apr 21, 2021   
    Level of consciousness was the main criterion of disapproval. The protocol identified crucial clinical conditions that made it impossible for the patient to receive thirst relief strategies and demonstrated that thirst can be satiated precociously with safety.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Enrollment change, Immune cell:  Assessment of the Anesthetic Effect on the Activity of Immune Cell in Patient With Colon Cancer (clinicaltrials.gov) -  Apr 20, 2021   
    P=N/A,  N=153, Completed, 
    The protocol identified crucial clinical conditions that made it impossible for the patient to receive thirst relief strategies and demonstrated that thirst can be satiated precociously with safety. Recruiting --> Completed | N=300 --> 153
  • ||||||||||  ketamine / Generic mfg.
    Review, Journal:  Anesthesia Medications and Interaction with Chemotherapeutic Agents. (Pubmed Central) -  Apr 17, 2021   
    Correctly paired anesthetic procedures and medications will reduce perioperative inflammatory and immune changes that could potentially contribute to improved results for future cancer patients. Further research into best practice strategies is required which will help to enhance the acute and long-term effects of cancer care in clinical practice.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Randomized double-blind trial comparing effects of low-flow vs high-flow anesthesia on postoperative lung functions using respirometer. (Pubmed Central) -  Apr 13, 2021   
    This was a prospective randomized double blind study wherein One hundred and ten patients undergoing peripheral surgeries under general anesthesia were allocated into two groups Group I- Low-flow anesthesia with O2 + N2O + Sevoflurane (0.5L + 0.5L + 3.5%) and Group II- High-flow anesthesia with O2 + N2O + Sevoflurane (2L + 2L + 2%)...The difference in single breath count (SBC), breath holding time (BHT), and respiratory rates (RR) were also similar in both the groups (P - 0.101, 0.698, and 0.467) respectively. The pulmonary effects of low-flow anesthesia are comparable with the high-flow ones in patients undergoing elective surgeries under general anesthesia.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Effect of Long-time Postnatal Exposure to Sevoflurane on Causing Attention-deficit/Hyperactivity Disorder in Rats (Pubmed Central) -  Apr 10, 2021   
    The time the SEVO 4 h group spent in the target quadrant was significantly shorter than that of the control group ( P=0.039) and percentage of distance traveled in the target quadrant was significantly reduced compared to that the control group ( P=0.048). The findings suggest that four hours of inhaled sevoflurane exposure in neonate rats may cause memory impairment, but does no increase risks for ADHD-related abnormal activities.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Reflection Versus Rebreathing for Administration of Sevoflurane During Minor Gynecological Surgery. (Pubmed Central) -  Apr 7, 2021   
    For pediatric sevoflurane induction, half the MV-based FGF provided similar anesthetic conditions for LMA insertion with minimum sevoflurane consumption. In this clinical setting with short procedures, low anesthetic requirements, and low tidal volumes, AnaConDa-S decreased anesthetic consumption, washin, and washout times compared to a circle system.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Carbon Dioxide Absorption During Inhalation Anesthesia: A Modern Practice. (Pubmed Central) -  Apr 7, 2021   
    When Sevoflurane and Desflurane were introduced, the potential for toxicity (compound A and CO, respectively) due to the interaction of these agents with absorbents became apparent...While CO2 absorbents may seem like a commodity item, differences in CO2 absorbent formulations can translate into significant performance differences, and the choice of absorbent should not be based on unit price alone. A modern practice of inhalation anesthesia utilizing a circle system to greatest effect requires reducing fresh gas flow to approach closed-circuit conditions, thoughtful selection of CO2 absorbent, and changing absorbents based on inspired CO2.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Comparison of isoflurane, sevoflurane, and desflurane as inhalant anesthetics in prairie rattlesnakes (Crotalus viridis). (Pubmed Central) -  Apr 7, 2021   
    A modern practice of inhalation anesthesia utilizing a circle system to greatest effect requires reducing fresh gas flow to approach closed-circuit conditions, thoughtful selection of CO2 absorbent, and changing absorbents based on inspired CO2. Isoflurane and sevoflurane, but not desflurane, inhalation anesthesia resulted in consistent and predictable loss of righting reflex and induction of anesthesia deep enough to allow intubation in snakes.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Journal:  Reduced Recovery Times with Total Intravenous Anesthesia in Patients with Obstructive Sleep Apnea. (Pubmed Central) -  Apr 7, 2021   
    Isoflurane and sevoflurane, but not desflurane, inhalation anesthesia resulted in consistent and predictable loss of righting reflex and induction of anesthesia deep enough to allow intubation in snakes. Patients having upper airway surgery with comorbid OSA that received TIVA (propofol and remifentanil) spent significantly less time in Phase I and the recovery room overall compared to those receiving volatile gas anesthesia in the form of sevoflurane, and this correlated with the severity of OSA.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Role of Sox2 in Learning, Memory, and Postoperative Cognitive Dysfunction in Mice. (Pubmed Central) -  Apr 7, 2021   
    Eighteen-month-old male mice were subjected to right-common-carotid-artery exposure under sevoflurane anesthesia...These results suggest a role of Sox2 in learning, memory, and POCD. EE and CE attenuated POCD via maintaining Sox2-positive cells in the hippocampus.
  • ||||||||||  ketamine / Generic mfg.
    Review, Journal:  Effect of anesthesia on electrocorticography for localization of epileptic focus: Literature review and future directions. (Pubmed Central) -  Apr 7, 2021   
    There is evidence to avoid halothane, nitrous oxide, etomidate, ketamine, thiopental, methohexital, midazolam, fentanyl, and alfentanil due to undesired effects...The proper use of anesthetic agents and careful dose titration, and effective communication between the neurophysiologist and anesthesiologist based on ECoG activity are essential in optimizing recordings. Anesthesia is a crucial variate to consider in the design of studies investigating ECoG and related biomarkers.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Enrollment change, Surgery:  The Effect of Propofol or Sevoflurane on Renal Function (clinicaltrials.gov) -  Apr 2, 2021   
    P4,  N=37, Completed, 
    Anesthesia is a crucial variate to consider in the design of studies investigating ECoG and related biomarkers. Recruiting --> Completed | N=60 --> 37
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  Neurotoxicity of Anesthesia in Middle Aged Patients (clinicaltrials.gov) -  Apr 1, 2021   
    P=N/A,  N=600, Active, not recruiting, 
    Recruiting --> Completed | N=60 --> 37 Enrolling by invitation --> Active, not recruiting | Trial completion date: Feb 2021 --> Aug 2021 | Trial primary completion date: Jan 2021 --> Jul 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Inhibits Glioma Cells Proliferation and Metastasis through miRNA-124-3p/ROCK1 Axis. (Pubmed Central) -  Apr 1, 2021   
    Its mechanism may be related to the upregulation of miR-124-3p, which suppresses ROCK1 signaling pathway. The results of the study will help to understand the pharmacological effects of inhaled general anesthetics more comprehensively and help to provide an experimental basis for selecting more reasonable anesthetics for cancer patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Sevoflurane inhibits neuronal apoptosis and expressions of HIF-1 and HSP70 in brain tissues of rats with cerebral ischemia/reperfusion injury. (Pubmed Central) -  Apr 1, 2021   
    The results of the study will help to understand the pharmacological effects of inhaled general anesthetics more comprehensively and help to provide an experimental basis for selecting more reasonable anesthetics for cancer patients. Sevoflurane can reduce the content of inflammatory factors, inhibit apoptosis, and reduce the expressions of HIF-1 and HSP70 in the case of cerebral I/R injury, thus exerting protective effects on rats with cerebral I/R injury.