sevoflurane / Generic mfg. 
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  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Journal:  A 32-Year-Old Man Diagnosed with Type II Brugada Syndrome on Preoperative Electrocardiogram 1 Week Before Elective Tympanoplasty. (Pubmed Central) -  May 15, 2021   
    Type 2 and type 3 Brugada syndrome ECGs are difficult to recognize, and patients with them are considered to be less risky than a patient with a type I ECG. However, as Brugada syndrome ECG is dynamic and changeable, a type 2 or 3 Brugada syndrome ECG can change to a type I ECG under some conditions, and thus should not be overlooked, and the patient's past history or symptoms, such as syncope, should be carefully investigated.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  MicroRNA-1297 suppressed the Akt/GSK3β signaling pathway and stimulated neural apoptosis in an in vivo sevoflurane exposure model. (Pubmed Central) -  May 15, 2021   
    However, as Brugada syndrome ECG is dynamic and changeable, a type 2 or 3 Brugada syndrome ECG can change to a type I ECG under some conditions, and thus should not be overlooked, and the patient's past history or symptoms, such as syncope, should be carefully investigated. Collectively, the results indicated that miR-1297 stimulates sevoflurane-induced neurotoxicity via the Akt/GSK3β signaling pathway by regulating PTEN expression.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Anesthesia and airway management in a patient with acromegaly and tracheal compression caused by a giant retrosternal goiter: a case report. (Pubmed Central) -  May 15, 2021   
    We created a comprehensive emergency plan for a difficult airway, including regional and topical anesthesia for awake endotracheal intubation, sevoflurane inhalation, small doses of midazolam and sufentanil to increase tolerance, self-made extended-length tracheostomy, video laryngoscope-assisted fiber-optic bronchoscopy, extracorporeal membrane oxygenation, and surgical tracheostomy...The giant goiter was successfully removed through the cervical approach. A carefully designed airway management strategy and close communication among a multidisciplinary operation team are the basis of perioperative anesthetic management for these patients.
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Journal:  The Impact of Monitoring Depth of Anesthesia and Nociception on Postoperative Cognitive Function in Adult Multiple Trauma Patients. (Pubmed Central) -  May 15, 2021   
    The study showed a statistically significant inverse correlation between fentanyl and the NEECHAM Confusion Scale at 24 h (r = -0.32, p = 0.0005) and 48 h (r = -0.46, p = 0.0002), sevoflurane and the NEECHAM Confusion Scale at 24 h (r = -0.38, p = 0.0014) and 48 h (r = -0.52, p = 0.0002), and noradrenaline and POCD events in the first 48 h (r = -0.46, p = 0.0013 for the first 24 h, respectively, and r = -0.46, p = 0.0002 for the next 24 h). Entropy and SPI monitoring during anesthesia may play an important role in diminishing the risk of developing immediate POCD after emergency surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Comparison of blood pressure and pain rating index used for depth regulation of sevoflurane anaesthesia. (Pubmed Central) -  May 15, 2021   
    Entropy and SPI monitoring during anesthesia may play an important role in diminishing the risk of developing immediate POCD after emergency surgery. PRi was feasible to regulate depth of sevoflurane anaesthesia, which could shorten anaesthesia recovery time and extubation time, reduce sevoflurane consumption during general anaesthesia in patients undergoing cervical vertebra surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    [VIRTUAL] Methaemoglobinemia and G6PD in a patient for major surgery: Diagnostic dilemma & therapeutic enigma () -  May 12, 2021 - Abstract #BSH2021BSH_459;    
    Maintenance of anaesthe- sia was achieved using oxygen, air, sevoflurane with a target satura- tion of 93%...Even though the combined deficiency is rare, care should be taken to evaluate for G6PD deficiency in methaemoglobinemia, before ini- tiating methylene blue as it may lead to life-threatening haemolysis. A multidisciplinary evaluation and management are necessary to avoid adverse outcome and thereby improve patient satisfaction
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Preclinical, Journal:  Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats. (Pubmed Central) -  May 12, 2021   
    Similar levels of anaesthesia caused comparable programmed cell death in several developing brain regions. Depth of anaesthesia may be an important factor when comparing the neurotoxic effects of different anaesthetic regimens.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane inhibits cell proliferation and migration of glioma by targeting the miR‑27b/VEGF axis. (Pubmed Central) -  May 11, 2021   
    Compared with the control group, sevoflurane inhibited the proliferation and migration of U251 and U87 cells, as well as the expression of matrix metalloproteinase (MMP)‑2 and MMP‑9, which were subsequently abolished by pre‑treatment with an miR‑27b inhibitor. The present results indicated the potential use of sevoflurane by anesthesiologists for the surgical resection of glioma, which may improve patient outcomes in the clinical setting.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Preclinical, Journal, IO biomarker:  Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats (Pubmed Central) -  May 11, 2021   
    Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and β-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and β-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3β/GSK-3β in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3β/GSK-3β were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3β/GSK-3β in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005). Conclusion Dex can mediate Wnt/GSK-3β/β-catenin signaling pathway to inhibit sevoflurane-induced cognitive impairment in neonatal rats.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  The effect of type of anesthesia on quality of postoperative recovery after orthopedic forearm surgery. (Pubmed Central) -  May 8, 2021   
    However, there was no significant difference at each timepoint between two groups. The present study suggests that brachial plexus block with intravenous dexmedetomidine infusion does not improve the quality of postoperative recovery compared to sevoflurane inhalation anesthesia with remifentanil infusion in patients undergoing orthopedic forearm surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Surgery:  APLICS: Anesthetics to Prevent Lung Injury in Cardiac Surgery (clinicaltrials.gov) -  May 5, 2021   
    P1/2,  N=51, Completed, 
    Registered at ChiCTR1900026956. Active, not recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  The Role of Anesthetic Management in Surgical Site Infections After Pediatric Intestinal Surgery. (Pubmed Central) -  May 5, 2021   
    Higher doses of sevoflurane are associated with increased odds of SSIs after pediatric elective intestinal surgery. A randomized controlled study of volatile anesthetic-based versus intravenous anesthetic-based anesthesia will be needed to further determine the role of anesthetic drugs in SSI risk.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Phase classification, Surgery:  Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium (clinicaltrials.gov) -  May 3, 2021   
    P=N/A,  N=1200, Completed, 
    Our data suggest that Sevo may be a valuable alternative anaesthetic agent in liver transplantation and major liver surgeries. Phase classification: P4 --> P=N/A
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  The effect of anesthetics on toll like receptor 9. (Pubmed Central) -  May 1, 2021   
    This is the first illustration that anesthetics can affect the binding of nucleic acids to their receptor. This study sets the foundation for the effect of anesthetics on TLR9 and will pave the way for future studies to determine the significance of such interactions in the clinical setting.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Preclinical, Journal:  The differential effects of isoflurane and sevoflurane on neonatal mice. (Pubmed Central) -  May 1, 2021   
    Our analysis observed significant levels of neuroinflammation and changes in the expression levels of proteins associated with both synaptic transmission and memory in mice from the isoflurane group but not the sevoflurane group. Our results therefore indicate that isoflurane and sevoflurane induce differential effects in the brains of neonatal mice.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Phase classification, Surgery:  Impact of Anesthesia Maintenance Methods on Long-term Survival (clinicaltrials.gov) -  Apr 28, 2021   
    P=N/A,  N=1200, Completed, 
    Trial completion date: Dec 2023 --> Sep 2022 | Trial primary completion date: Dec 2021 --> Sep 2022 Phase classification: P4 --> P=N/A
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  ECHOCARDIOGRAPHIC PARAMETERS IN AFRICAN WHITE-BELLIED PANGOLINS (PHATAGINUS TRICUSPIS) WITHOUT CARDIAC DISEASE. (Pubmed Central) -  Apr 28, 2021   
    All examinations were determined to be normal, with no evidence of valvular structural abnormalities, cardiac dysfunction, chamber enlargement, or cardiac hypertrophy. This report broadens understanding of normal echocardiogram parameters in pangolin species and contributes techniques and baseline data for veterinarians caring for these vulnerable populations.