sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Ribbon Synapses and Hearing Impairment in Mice After in utero Sevoflurane Exposure. (Pubmed Central) -  Jun 5, 2021   
    Sevoflurane treatment also increased mitochondrial reactive-oxygen species stress and decreased autophagy in the cochlear explants. These results suggest that oxidative stress and reduced autophagy may underly ribbon-synapse involvement in sevoflurane-induced hearing loss.
  • ||||||||||  SCH-23390 / Boehringer Ingelheim
    Preclinical, Journal:  D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats. (Pubmed Central) -  Jun 5, 2021   
    Dexmedetomidine is an α-adrenoreceptor agonist that is commonly used for procedural sedation, whereas ketamine is an anesthetic that acts primarily by inhibiting NMDA-type glutamate receptors...Dexmedetomidine reversal by d-amphetamine is inhibited by SCH-23390, suggesting that the arousal effect is mediated by D and/or D receptors. These findings suggest that d-amphetamine may be clinically useful as a reversal agent for dexmedetomidine.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  Different Low-flow Sevoflurane Anesthesia Techniques (clinicaltrials.gov) -  Jun 3, 2021   
    P=N/A,  N=60, Completed, 
    It was calculated that Sevoflurane can significantly improve hemodynamics and inflammatory response in elderly patients with lung cancer lobectomy, but the incidence of complications is high. Not yet recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Systemic sclerosis in an anaesthetist. (Pubmed Central) -  Jun 3, 2021   
    The case reported is the second that we are aware of in recent years. Reporting scleroderma cases in workers may be the first step in assessing the causal link between occupational exposure to anaesthetic gases and the disease.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Confirmatory Study of HFVI Guided Analgesic Administration in Surgical Subjects (clinicaltrials.gov) -  Jun 2, 2021   
    P=N/A,  N=104, Enrolling by invitation, 
    Reporting scleroderma cases in workers may be the first step in assessing the causal link between occupational exposure to anaesthetic gases and the disease. Trial completion date: Apr 2021 --> Dec 2021 | Trial primary completion date: Apr 2021 --> Oct 2021
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion date:  Inhalational Anesthesia and Precipitation of Dementia: is There a Link? (clinicaltrials.gov) -  Jun 2, 2021   
    P=N/A,  N=500, Active, not recruiting, 
    Trial completion date: Apr 2021 --> Dec 2021 | Trial primary completion date: Apr 2021 --> Oct 2021 Trial completion date: Dec 2019 --> Dec 2021
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Potential rules of anesthetic gases on glioma. (Pubmed Central) -  Jun 1, 2021   
    Therefore, anesthetic gas may play a special therapeutic role in gliomas. In this review, we aim to collect existing research and summarize the rules of using anesthetic gases on glioma, providing potential strategies for further clinical treatment.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Chikusetsu saponin IVa alleviated sevoflurane-induced neuroinflammation and cognitive impairment by blocking NLRP3/caspase-1 pathway. (Pubmed Central) -  May 29, 2021   
    In children undergoing cardiac surgery in our department, the use of sevoflurane-balanced anesthesia during cardiopulmonary bypass showed no superiority of inhalational agents over total intravenous anesthesia with opioids and benzodiazepines preventing phases of superficial anesthesia, but a marked advantage for the postoperative ventilation time compared with total intravenous anesthesia. Our finding confirmed that ChIV provides a neuroprotective effect against sevoflurane-induced neuroinflammation and cognitive impairment by blocking the NLRP3/caspase-1 pathway, which may be an effective strategy for the clinical treatment of elderly patients with POCD induced by anesthesia.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA. (Pubmed Central) -  May 29, 2021   
    SEV inhibited tumor growth by controlling circ-PI4KA in vivo. Circ-PI4KA attenuated SEV-treated colon cancer cell malignancy by upregulating LASP1 through binding to miR-331-3p, which provided a new mechanism for studying surgery-mediated therapy of colon cancer.
  • ||||||||||  metamizole / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  The preemptive effect of tramadol and metamizole on the intensity of postoperative pain. (Pubmed Central) -  May 26, 2021   
    There was no significant difference in the intensity of pain when using these two analgesics (p=0.733). Conclusion The effect of preemptively administered tramadol prior to the introduction of general anaesthesia in postoperative pain is significantly more favourable than the effect of metamizole.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Anaesthesia-dependent oscillatory EEG features in the super-elderly. (Pubmed Central) -  May 26, 2021   
    Conclusion The effect of preemptively administered tramadol prior to the introduction of general anaesthesia in postoperative pain is significantly more favourable than the effect of metamizole. Quantification of δ-θ bicoherence is a candidate for anaesthesia monitoring in the super-elderly.
  • ||||||||||  Dynastat (parecoxib) / Pfizer
    Retrospective data, Journal:  Earlier Is Better? Timing of Adductor Canal Block for Arthroscopic Knee Surgery under General Anesthesia: A Retrospective Cohort Study. (Pubmed Central) -  May 25, 2021   
    Groups B and C had lower visual analogue scale (VAS) scores upon PACU discharge than Group A. Dynamic, but not at-rest VAS scores, were significantly higher in Group A. Opioid consumption was similar in the ward, but Group A requested more intravenous parecoxib for pain relief...Preoperative or postoperative ACB improved postoperative pain control. Consequently, preoperative ACB is optimal for intraoperative stress suppression and postoperative pain control.
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Involvement of Mitochondrial Dynamics and Mitophagy in Sevoflurane-Induced Cell Toxicity. (Pubmed Central) -  May 21, 2021   
    Accumulating evidence proves that sevoflurane exposure in young age could lead to cell toxicity by triggering the mitochondrial pathway of apoptosis, inducing the abnormalities of mitochondrial dynamics and mitophagy. In the present review, we focus on the current understanding of mitochondrial apoptosis, dynamics and mitophagy in cell function, the implications for cell toxicity in response to sevoflurane, and their underlying potential mechanisms.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Immunomodulatory effects of anaesthetic sevoflurane in septic mouse model. (Pubmed Central) -  May 21, 2021   
    Mice exposed to sevoflurane after CLP significantly improved outcomes of polymicrobial abdominal sepsis and reduced mortality by improving overall 7-day survival (83.3%) compared to mice without sevoflurane (no treatment group 16.6%) additionally decreasing the surrogate marker levels in the experimental sepsis animal model conducted. Our study suggests that the selection of certain anaesthetic drugs could be critical in the management of septic patients because their immunomodulatory effects could be large enough to affect sepsis pathophysiology.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Trial initiation date:  Desflurane and Sevoflurane in Pediatrics With Elevated Liver Enzymes (clinicaltrials.gov) -  May 20, 2021   
    P=N/A,  N=60, Enrolling by invitation, 
    Our study suggests that the selection of certain anaesthetic drugs could be critical in the management of septic patients because their immunomodulatory effects could be large enough to affect sepsis pathophysiology. Not yet recruiting --> Enrolling by invitation | Initiation date: Mar 2021 --> Jun 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Review, Journal:  The Impact of Anesthetic Regimen on Outcomes in Adult Cardiac Surgery: A Narrative Review. (Pubmed Central) -  May 20, 2021   
    Although the surgeon's skills and volume and patient- and procedure-related risk factors play a major role in the success of cardiac surgery, there is growing evidence that also optimizing perioperative care may improve outcomes significantly. The present review focuses on the aspects of perioperative care that are strictly related to the anesthesia regimen, with special reference to volatile anesthetics and neuraxial anesthesia, whose effect on outcome in adult cardiac surgery has been investigated extensively.
  • ||||||||||  sevoflurane / Generic mfg., sirolimus / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Dexmedetomidine alleviates sevoflurane-induced neurotoxicity via mitophagy signaling. (Pubmed Central) -  May 20, 2021   
    Additionally, dexmedetomidine inhibited sevoflurane-induced cell apoptosis in hippocampus. In mechanism, dexmedetomidine activated mitophagy to mitigate neurotoxicity by enhancing LC3II/LC3I ratio, HSP60, Beclin-1, CypD, VDAC1 and Tom20 protein levels in hippocampus. Dexmedetomidine alleviates sevoflurane-induced neurotoxicity via mitophagy signaling, offering a potential strategy for sevoflurane-induced neurotoxicity treatment.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Dexmedetomidine attenuates sevoflurane‑induced neurocognitive impairment through α2‑adrenoceptors. (Pubmed Central) -  May 20, 2021   
    By contrast, co‑administration of yohimbine significantly attenuated the neuroprotective effects of dexmedetomidine. These findings suggested that dexmedetomidine exerted a neuroprotective effect against sevoflurane‑induced apoptosis, inflammation, oxidative stress and neurocognitive impairment, which was mediated, at least in part, by α2 adrenoceptors.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane protects the liver from ischemia-reperfusion injury by regulating Nrf2/HO-1 pathway. (Pubmed Central) -  May 20, 2021   
    4% SEV had the best mitigating effect on H/R-induced liver cell damage, as evidenced by reduced contents of LDH and MDA, decreased inflammatory factors, a lowered apoptosis rate, inhibited ROS production, effectively promoted Nrf2 nucleation, and activated Nrf/HO-1 pathway. ML385 pretreatment significantly inhibited the effect of SEV on hepatocytes.Sevoflurane protects the liver from ischemia-reperfusion injury by regulating the Nrf2/HO-1 pathway.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in Mice. (Pubmed Central) -  May 20, 2021   
    The fluorescence signals of dopamine decreased in the induction of and increased in the emergence from sevoflurane anesthesia.Activation of VTA-DA and the VTA-NAc pathway delayed the induction and facilitated the emergence accompanying with thereduction of delta band and the augmentation of the gamma band. These data demonstrate that VTA-DA neurons play a critical role in modulating sevofluraneanesthesia via the VTA-NAc pathway.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Comparison of Transmittance and Reflectance Pulse Oximetry in Anesthetized Dogs. (Pubmed Central) -  May 20, 2021   
    Anesthesia was induced with propofol and maintained with sevoflurane...Clinical Significance: The tail base, but not the tibia, is an acceptable position for reflectance pulse oximeter probes in dogs. The tongue remains the probe site of choice, if accessible.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Enrollment change, Surgery:  Difference Between Inhalation Anesthesia and Total Intravenous Anesthesia in Free Flap Surgery (clinicaltrials.gov) -  May 18, 2021   
    P=N/A,  N=78, Completed, 
    We found that pneumoperitoneum reduced splanchnic oxygenation during laparoscopic abdominal surgery in paediatric patients, which was measured using NIRS. Recruiting --> Completed | N=500 --> 78
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  Sevoflurane Human Biomonitoring in Operating Room Personnel (clinicaltrials.gov) -  May 18, 2021   
    P=N/A,  N=40, Completed, 
    NIRS-derived COX can be used to identify the optimal MAP range. Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial completion date, Trial primary completion date:  SPIDERMAN: Sevoflurane PharmacokInetics in ARDS (clinicaltrials.gov) -  May 17, 2021   
    P=N/A,  N=43, Recruiting, 
    Recruiting --> Completed N=30 --> 43 | Trial completion date: Jun 2022 --> Jun 2023 | Trial primary completion date: Mar 2022 --> Mar 2023