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13 Diseases |  |
542 Trials |
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542 Trials |  |
5582 News |  |
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- || sevoflurane / Generic mfg.
Clinical, Journal: Effects of sevoflurane anesthesia on intraoperative high-frequency oscillations in patients with temporal lobe epilepsy. (Pubmed Central) - Jul 2, 2021
The proconvulsant effect of sevoflurane on intraoperative HFOs in patients with TLE depends on the concentration. While HFOs induced by higher sevoflurane concentrations may be a useful biomarker for epileptogenic areas, careful interpretation is also needed because a higher sevoflurane concentration can also induce false-positive HFOs in nonepileptogenic areas.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Changes of CaM-CaMK-CREB signaling pathway and related neuron factors in hippocampus of rats after sevoflurane and propofol administration. (Pubmed Central) - Jul 2, 2021
While HFOs induced by higher sevoflurane concentrations may be a useful biomarker for epileptogenic areas, careful interpretation is also needed because a higher sevoflurane concentration can also induce false-positive HFOs in nonepileptogenic areas. Sevoflurane anesthesia on the CaM-CaMK-CREB signaling pathway and learning and memory function of rats is less volatile, which does better in safeguarding stability.
- | sevoflurane / Generic mfg., doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Sevoflurane ameliorates adriamycin-induced myocardial injury in rats through the PI3K/Akt/GSK-3β pathway. (Pubmed Central) - Jul 2, 2021
SEV pretreatment significantly alleviated the effect of ADR, manifested as significantly lowered content of AST, LDH and CK in the serum (p<0.01), distinctly elevated protein expression levels of p-GSK-3β, p-PI3K and p-Akt (p<0.01), notably reduced apoptosis rate (p<0.01), and relieved myocardial injury. LY294002 remarkably inhibited the protective effect of SEV against myocardial injury (p<0.01) SEV is able to prominently ameliorate ADR-induced myocardial injury by regulating the phosphorylation level of the PI3K/Akt/GSK-3β signaling pathway.
- || sevoflurane / Generic mfg.
Clinical, Journal: Effect of general inhalational anesthesia on intraocular pressure measurements in normal and glaucomatous children. (Pubmed Central) - Jul 2, 2021
Inhalational anesthesia has variable effects on IOP measurement at all stages of anesthesia. Caution should be taken when extrapolating the true IOP from these measurements.
- | sevoflurane / Generic mfg.
Journal: Changes in intraocular pressures associated with inhalational and mixed anesthetic agents currently used in ophthalmic surgery. (Pubmed Central) - Jul 2, 2021
Significant decreases in IOPs after GA were observed and the differences were not significantly different between sevoflurane and mixed anesthetic agents. For management decisions in pediatric glaucoma, the IOP measurements under GA are crucial, the underestimation of IOP as noted with currently used anesthetic agents has to be accounted for and decisions are taken appropriately.
- || paracetamol / Generic mfg.
Clinical, Journal: Is paracetamol responsible for fatal acute liver failure in pediatric patients after hip dysplasia surgery? (Pubmed Central) - Jul 1, 2021
The therapeutic dose of paracetamol remains uncertain in children who have been fasting for a long time and have been exposed to hepatotoxic drugs due to previous surgery. In conclusion, caution should be exercised in the use of paracetamol in children with DDH who will undergo surgery, and careful perioperative clinical and laboratory monitoring for ALF is essential.
- | sevoflurane / Generic mfg.
Journal: Sevoflurane inhibits malignant progression of colorectal cancer via hsa_circ_0000231-mediated miR-622. (Pubmed Central) - Jun 30, 2021
Hsa_circ_0000231 attenuated Sev-aroused repression impacts on CRC development by sponging miR-622. This findings may provide an appropriate anesthetic protocol for CRC sufferers undergoing surgery.
- | sevoflurane / Generic mfg.
New trial, Surgery: Pain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery (clinicaltrials.gov) - Jun 30, 2021
P=N/A, N=80, Not yet recruiting, Sponsor: Mansoura University
- | ketamine / Generic mfg., sevoflurane / Generic mfg.
Journal: Improved tracking of sevoflurane anesthetic states with drug-specific machine learning models. (Pubmed Central) - Jun 30, 2021
P2
This findings may provide an appropriate anesthetic protocol for CRC sufferers undergoing surgery. Instead of a one-algorithm-fits-all-drugs approach to anesthetic state monitoring, our results suggest that drug-specific models are necessary to improve the performance of automated anesthetic state monitors.
- || sevoflurane / Generic mfg.
Clinical, Review, Journal: Using Electroencephalography (EEG) to Guide Propofol and Sevoflurane Dosing in Pediatric Anesthesia. (Pubmed Central) - Jun 30, 2021
Application of sevoflurane and propofol pharmacology along with EEG parameters can more precisely guide dosing to achieve the desired anesthetic state for an individual pediatric patient. This article reviews the principles underlying EEG use for sevoflurane and propofol dosing in pediatric anesthesia and offers case examples to illustrate their use in individual patients.
- || sevoflurane / Generic mfg.
Clinical, Journal: Anesthetic effect and safety of sevoflurane combined with propofol in removing tracheobronchial foreign bodies in children. (Pubmed Central) - Jun 30, 2021
Sevoflurane combined with propofol is worth popularizing because of its high anesthetic effect and safety in the removal of tracheal foreign bodies in children. However, given the limited quantity and quality of the included studies, the above conclusions need to be verified by high-quality studies.
- memantine / Generic mfg.
[VIRTUAL] Glutaminase deletion in primary afferent nociceptors impairs development of mechanical hyperalgesia after nerve injury in mice () - Jun 29, 2021 - Abstract #IASP2021IASP_966;
Specific deletion of GLS in primary afferent nociceptors does not prevent detection of acute mechanical-induced pain; however, it is required for the development and maintenance of primary hyperalgesia. Modulation of Gls expression in peripheral sensory neurons would be an important target for chronic neuropathic pain therapy.
- ketamine / Generic mfg., dexketoprofen trometamol / Generic mfg.
[VIRTUAL] Not-intubated anesthesia in primary hiperparathyroidism patients () - Jun 29, 2021 - Abstract #IASP2021IASP_329;
Combine methods GA with BCSPB have some benefits over mono GA. Co-analgesics afford to achieve an opioid-sparing effect.
- dexmedetomidine / Generic mfg.
[VIRTUAL] Perioperative Intravenous Lidocaine or Dexmedetomidine for the Prevention of Acute and Chronic Postoperative Pain () - Jun 29, 2021 - Abstract #IASP2021IASP_219;
Lidocaine significantly reduced postoperative opioid consumption, while dexmedetomidine prevented early postoperative nausea. However, hypotension and need for vasopressors was common with both agents, especially with dexmedetomidine.
- | sevoflurane / Generic mfg.
Preclinical, Journal: A study of optimal concentration range and time window of sevoflurane preconditioning for brain protection in MCAO rats. (Pubmed Central) - Jun 26, 2021
However, hypotension and need for vasopressors was common with both agents, especially with dexmedetomidine. These results suggested that after inhalation of 1.3 MAC sevoflurane for 3 h of preconditioning, MCAO model established after 24 h demonstrated significant brain protective effects in MCAO rats.
- | sevoflurane / Generic mfg.
Journal: Volume kinetic analysis of fluid retention after induction of general anesthesia. (Pubmed Central) - Jun 26, 2021
Induction of general anesthesia interrupted the distribution of lactated Ringer's solution up to when 16.6 mL kg of crystalloid fluid had been infused. Plasma volume expansion during this period of time was pronounced.
- | sevoflurane / Generic mfg., methadone / Generic mfg.
Journal: Functional Modular Network Identifies the Key Genes of Preoperative Inhalation Anesthesia and Intravenous Anesthesia in Off-Pump Coronary Artery Bypass Grafting. (Pubmed Central) - Jun 26, 2021
Pivot analysis of potential drug regulators revealed 229 potential drugs for sevoflurane anesthesia surgery, among which zinc regulates three functional disorder modules via AHSG, F12, etc., and 67 potential drugs for propofol anesthesia surgery, among which are propofol, methadone, and buprenorphine, regulate two functional disorder modules through four genes, CYP2C8, OPRM1, CYP2C18, and CYP2C19. This study provides guidance on clinical use or treatment by comparing the effects of two anesthesias on surgery and its potential drugs.
- || fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
Clinical, Journal: Feasibility, safety and outcome of inguinal hernia repair under spinal versus general anesthesia in preterm and term infants. (Pubmed Central) - Jun 26, 2021
Additionally, it may help further define what patients may have a successful SA. Our experience suggests that SA is especially suitable in infants weighing <4000 g, and conversion to GA correlates with prolonged operative time.
- | sevoflurane / Generic mfg.
Retrospective data, Journal: Postoperative Vomiting Following Laparoscopic Cholecystectomy Is Associated with Intraoperative Fluid Administration: A Retrospective Cohort Study. (Pubmed Central) - Jun 26, 2021
The cutoff intraoperative crystalloid infusion rate was 2 mL/kg/h with 82% sensitivity and 49% specificity (≥2 mL/kg/h was associated with a lower POV incidence vs. <2 mL/kg/h (OR, 95% CI; 0.52 [0.33-0.83])). To decrease POV in these patients, identifying high-risk factors and an intraoperative crystalloid administration of ≥2 mL/kg/h should be considered in patients undergoing LC under sevoflurane-based general anesthesia.
- || sevoflurane / Generic mfg., dantrolene / Generic mfg.
Clinical, Journal: A case report of malignant hyperthermia in a patient with myotonic dystrophy type I: A CARE-compliant article. (Pubmed Central) - Jun 26, 2021
The authors suggest that possible MH susceptibility in DM1 patients may be refocused. Genetic testing can be a screening tool for MH susceptibility in these population, prior to receiving general anesthesia.
- | sevoflurane / Generic mfg.
Retrospective data, Journal: A new anesthesia scheme for parathyroidectomy under neuromonitoring: a retrospective cohort study. (Pubmed Central) - Jun 25, 2021
The serum calcium levels, phosphorus, urea, and creatinine at T2 in Group A were lower than those in Group B (P<0.05). Parathyroid nerve monitoring technology combined with preoperative complete anesthesia scheme, anesthesia induction with one time ED95 (95% effective drug dose) cis-atracurium, end breath gas, and sevoflurane maintenance anesthesia under BIS monitoring can improve the prognosis of patients, shorten the length of hospital stay, and is effective and safe.
- | sevoflurane / Generic mfg.
New trial: Nephrogenic Diabetes Insipidus During Prolonged Sevoflurane Sedation in the ICU: a Retrospective Analysis (clinicaltrials.gov) - Jun 25, 2021
P, N=1000, Not yet recruiting, Sponsor: Universitair Ziekenhuis Brussel
- || ketamine / Generic mfg.
Retrospective data, Review, Journal: Anesthetic management of children undergoing drug-induced sleep endoscopy: A retrospective review. (Pubmed Central) - Jun 24, 2021
The combination of ketamine and dexmedetomidine may be the ideal regimen. Limited data and lack of protocols/high-quality studies exist on anesthetic regimens for pediatric DISE.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Journal: Effect of volatile anesthetics on early and delayed outcomes in pancreas transplantation. (Pubmed Central) - Jun 24, 2021
Sevoflurane and desflurane are associated with lower peak amylase and lipase levels post-operatively in pancreas transplantation. Short and long-term clinical outcomes were equivalent for the three agents.
- || sevoflurane / Generic mfg.
Review, Journal: Impact of anesthesia exposure in early development on learning and sensory functions. (Pubmed Central) - Jun 23, 2021
Anesthesia may directly affect synaptic plasticity which is especially critical to learning acquisition. However, sensory systems appear to have better ability to compensate for damage than learning-specific networks.
- | sevoflurane / Generic mfg., isoflurane / Generic mfg.
Biomarker, Journal: Association between genotoxic properties of inhalation anesthetics and oxidative stress biomarkers. (Pubmed Central) - Jun 23, 2021
After adjusting for potential confounders, there were statistically significant associations between exposure to IAs, gender, SOD, and TAC with MN frequency and between exposure to IAs and SOD with numbers of CA. The findings of the present study indicated that exposure to IAs was associated with OS, and this, in turn, may be causally linked with DNA damage.
- | Disalcid (salsalate) / Bausch Health
Preclinical, Journal: Sevoflurane-induced hyperglycemia is attenuated by salsalate in obese insulin-resistant mice. (Pubmed Central) - Jun 23, 2021
These data show that salsalate can reduce sevoflurane-induced hyperglycemia in mice. This indicates that salsalate may represent a new class of therapeutics that, in addition to its anti-inflammatory and analgesic properties, may be useful to reduce perioperative hyperglycemia.
- | sevoflurane / Generic mfg.
Journal: Effects of Sevoflurane Exposure During Late Pregnancy on Brain Development and Beneficial Effects of Enriched Environment on Offspring Cognition. (Pubmed Central) - Jun 22, 2021
Lower error rates and greater dendritic spine densities and LTP were found in the Sev × 6 + EE vs. Sev × 6 + SE group. Collectively, we showed that exposing rats to 1 MAC sevoflurane for 3 h during late pregnancy increased neuronal apoptosis in neonates but did not impair neuronal development or cognitive function in juvenile rats, whereas a 6-h exposure impaired neuronal development and cognitive function in juvenile rats, effects that were attenuated by an EE.
- | sevoflurane / Generic mfg.
Preclinical, Journal: PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure. (Pubmed Central) - Jun 22, 2021
Mechanistically, BRL-50481 administration suppressed sevoflurane-induced neurodegenerative disorders through restoring cAMP and activating cAMP/CREB signaling in the hippocampus. PDE7 inhibitor may be a potential therapeutic agent for sevoflurane-induced neurodegeneration and long-term memory deficits.
- | sevoflurane / Generic mfg.
Journal: Open-channel blocking action of volatile anesthetics desflurane and sevoflurane on human voltage-gated Kv1.5 channel. (Pubmed Central) - Jun 22, 2021
Desflurane and sevoflurane exert an open-channel blocking action on hKv1.5 channel by functionally interacting with specific amino acids located within the channel pore. This study thus identifies a novel molecular basis mediating inhibitory modulation of hKv1.5 channel by desflurane and sevoflurane.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice. (Pubmed Central) - Jun 22, 2021
These results indicate that repeated sevoflurane exposures at the critical time induce impulsive behavior accompanied with overactivation of mPFC excitatory neurons in adult stages. This work may further extend to understand the ADHD-like impulsive behavior of the anesthetic neurotoxicity.
- | sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Preclinical, Journal: Dexmedetomidine Attenuates Neurotoxicity in Developing Rats Induced by Sevoflurane through Upregulating BDNF-TrkB-CREB and Downregulating ProBDNF-P75NRT-RhoA Signaling Pathway. (Pubmed Central) - Jun 22, 2021
In sevoflurane groups, the number of crossing platform was significantly reduced, the synaptic protein decreased significantly, and this effect was reversed in rats of the dexmedetomidine group. Dexmedetomidine could reduce synaptic plasticity decline in developing rats induced by sevoflurane, through downregulating the proBDNF-p75NTR-RhoA pathway and upregulating BDNF-TrkB-CREB.
- || sevoflurane / Generic mfg.
Clinical, Journal: Neuroplasticity induced by general anaesthesia: study protocol for a randomised cross-over clinical trial exploring the effects of sevoflurane and propofol on the brain - A 3-T magnetic resonance imaging study of healthy volunteers. (Pubmed Central) - Jun 22, 2021
P=N/A
To the best of our knowledge, this is the most extensive and advanced series of studies with head-to-head comparison of two widely used methods for general anaesthesia. Recruitment was initiated in September 2019.
- | sevoflurane / Generic mfg.
Journal: Maternal sevoflurane exposure affects differentiation of hippocampal neural stem cells by regulating miR-410-3p and ATN1. (Pubmed Central) - Jun 22, 2021
Recruitment was initiated in September 2019. The results from the present study demonstrated that repeated exposure to sevoflurane leads to early differentiation of NSCs and long-term effects via the miR-410-3p/ATN1 pathway.
- | sevoflurane / Generic mfg.
Journal: Observed links between cannabis consumption and volatile anesthetic requirements warrant skepticism. (Pubmed Central) - Jun 22, 2021
The results from the present study demonstrated that repeated exposure to sevoflurane leads to early differentiation of NSCs and long-term effects via the miR-410-3p/ATN1 pathway. No abstract available
- || sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
Clinical, Journal, Combination therapy: A multimodal sevoflurane-based sedation regimen in combination with targeted temperature management in post-cardiac arrest patients reduces the incidence of delirium: an observational propensity score-matched study. (Pubmed Central) - Jun 22, 2021
No abstract available A multimodal sevoflurane-based sedation regimen together with targeted temperature management resulted in a lower incidence of delirium and a shorter duration for mechanical ventilation and ICU length of stay than did the treatment with intravenous sedation combined with the classical cooling protocol.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1/NF-κB pathway in neonatal mice. (Pubmed Central) - Jun 22, 2021
Resveratrol pretreatment ameliorated cognitive impairment in developing mice received sevoflurane exposure by modulating SIRT1-NF-κB pathway in microglia. In this regard, our findings open novel directions to explore promising therapeutic targets for preventing the developmental neurotoxicity of sevoflurane.
- || sevoflurane / Generic mfg.
Clinical, Journal: Effect of sevoflurane on the inflammatory response during cardiopulmonary bypass in cardiac surgery: the study protocol for a randomized controlled trial. (Pubmed Central) - Jun 22, 2021
P=N/A
In this regard, our findings open novel directions to explore promising therapeutic targets for preventing the developmental neurotoxicity of sevoflurane. The trial may determine whether adding volatile anesthetic during cardiopulmonary bypass will attenuate the inflammatory response.
- || sevoflurane / Generic mfg.
Clinical, Journal: Determination of the optimal dose of ephedrine in the treatment of arterial hypotension due to general anesthesia in neonates and infants below 6 months old: the ephedrine study protocol for a randomized, open-label, controlled, dose escalation trial. (Pubmed Central) - Jun 22, 2021
P2
The trial may determine whether adding volatile anesthetic during cardiopulmonary bypass will attenuate the inflammatory response. This study is the first randomized, controlled trial intending to determine the optimal dose of ephedrine to treat hypotension in neonates and infants below 6 months old.
- || sevoflurane / Generic mfg., isoflurane / Generic mfg.
Clinical, Retrospective data, Journal: Sustainable veterinary anaesthesia: single centre audit of oxygen and inhaled anaesthetic consumption and comparisons to a hypothetical model. (Pubmed Central) - Jun 22, 2021
This study is the first randomized, controlled trial intending to determine the optimal dose of ephedrine to treat hypotension in neonates and infants below 6 months old. Large reductions in oxygen and inhaled anaesthetic agent consumption and therefore greenhouse gas emission and financial expenditure can be made if we audit and adapt our practices.
- | sevoflurane / Generic mfg.
Journal: Regulation of glial cell-derived neurotrophic factor in sevoflurane-induced neuronal apoptosis by long non-coding RNA CDKN2B-AS1 as a ceRNA to adsorb miR-133. (Pubmed Central) - Jun 22, 2021
Large reductions in oxygen and inhaled anaesthetic agent consumption and therefore greenhouse gas emission and financial expenditure can be made if we audit and adapt our practices. lncRNA CDKN2B-AS1 can up-regulate the expression of GDNF, inhibit neuronal apoptosis, and ease the toxic effect of sevoflurane on neural cells by acting as a sponge to adsorb miR-133.
- | sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
New trial: INTENS: Induction Agent and Incidence of Hypotension in Heart Failure Patients Undergoing LVAD-Implantation (clinicaltrials.gov) - Jun 22, 2021
P, N=50, Not yet recruiting, Sponsor: Heidelberg University
- | sevoflurane / Generic mfg.
Trial completion date, Trial primary completion date: The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung (clinicaltrials.gov) - Jun 21, 2021
P=N/A, N=75, Enrolling by invitation, Sponsor: Inonu University
lncRNA CDKN2B-AS1 can up-regulate the expression of GDNF, inhibit neuronal apoptosis, and ease the toxic effect of sevoflurane on neural cells by acting as a sponge to adsorb miR-133. Trial completion date: Mar 2021 --> Jun 2021 | Trial primary completion date: Mar 2021 --> Jun 2021
- High-Risk Transvenous Lead Extractions (Mezzanine 16AB) - Jun 20, 2021 - Abstract #ASA2021ASA_2868;
Her outpatient medications were metformin, amlodipine, aspirin and furosemide...General anesthesia is maintained with sevoflurane/oxygen mixture...What is "ghost"? and what is the significance of its presence for the patient?
- Seizalam (midazolam intramuscular) / Pfizer
A Not-So-Normal Day in the Labor and Delivery Suite: A Parturient with Worsening Preeclampsia Requiring Urgent Cesarean Delivery Complicated by Post-partum Hemorrhage, Uterine Atony, Placental Abruption, and Coagulopathy (Mezzanine 16AB) - Jun 20, 2021 - Abstract #ASA2021ASA_2863;
Midazolam (2 mg) and hydromorphone (2 mg) were given intravenously over divided doses for amnesia and analgesia...Would you consider tranexamic acid at this time for treatment of uterine atony?...Where should the patient recover postoperatively? Post-operatively, her coagulation status improved over several days, and she was discharged home along with her baby in stable condition on POD-8 with a 1-week follow-up.
- fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., rocuronium / Generic mfg.
[VIRTUAL] Increased Prevalence Of Perioperative Hyperglycemia In Non-diabetic Patients Undergoing General Anesthesia For Total Joint Arthroplasty (Virtual) - Jun 20, 2021 - Abstract #ASA2021ASA_2820;
While glucose levels decreased significantly over the first 24 hours after surgery, they remained elevated from preoperative levels. These findings may represent a sustained neuro-endocrine stress response following general anesthesia.
- morphine sulphate / Generic mfg., sevoflurane / Generic mfg.
[VIRTUAL] Combined Intravenous/volatile Vs Volatile Anesthesia Alone And Postoperative Rescue Antiemetics In Spine Surgery (Virtual) - Jun 20, 2021 - Abstract #ASA2021ASA_2810;
There was no significant difference between groups for overall, PACU or floor PRAA incidence or number of doses between groups. Patients undergoing CIVA received significantly less sevoflurane.
- ketamine / Generic mfg.
[VIRTUAL] Effect Of Subhypnotic Infusion Of Propofol During General Balanced Anesthesia On Postoperative Nausea And Vomiting (Virtual) - Jun 20, 2021 - Abstract #ASA2021ASA_2794;
Moreover, it is associated with decreased LOS and increased time to extubation. However, latter outcomes were not clinically significant.
- sevoflurane / Generic mfg.
[VIRTUAL] Mapping Of Frontal Cortex During Sevoflurane Anaesthesia In Children Using Functional Near-infrared Spectroscopy: Do We See A Pattern For Emergence Delirium? (Virtual) - Jun 20, 2021 - Abstract #ASA2021ASA_2598;
The right middle frontal cortex contributes to attention networks while the left superior frontal cortex is responsible for working memory and spatially oriented processing. During anaesthesia, these functions are usually lost which is important for an effective anaesthetic.
- sevoflurane / Generic mfg.
Propofol and Sevoflurane Have Differential Effects on Cellular Long Non-coding RNAS During Colon Cancer Resection (Upper 9) - Jun 20, 2021 - Abstract #ASA2021ASA_2570;
Canonical pathways identified for propofol were cancer specific and suggest anti-tumor effects whereas the possible impact of sevoflurane on tumor progression was less clear. These preliminary findings provide evidence of a novel lncRNA-mediated mechanism of anesthetic action that could influence tumor outcome among other immunoregulatory effects.