sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial withdrawal:  ANAISS: Sampling in ARDS Patients Under Inhaled Sedation (clinicaltrials.gov) -  Aug 30, 2021   
    P=N/A,  N=0, Withdrawn, 
    POA Tac1 neurons thus add causal support for the involvement of arousal-regulating systems in the state of general anesthesia. N=30 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical data, Journal:  The drug titration paradox: Correlation of more drug with less effect in clinical data. (Pubmed Central) -  Aug 27, 2021   
    The anesthetics propofol and sevoflurane and the catecholamine norepinephrine were titrated to defined effect targets, i.e., the processed electroencephalogram (Bispectral Index, BIS) and the blood pressure...During stepwise titration toward a target effect, the slope of the dose effect data for the population will be `reversed,' i.e., the correlation between dose and effect will not be positive, but will be negative, and will be `horizontal' when the titration is `perfect.' The titration paradox must be considered whenever data from clinical titration (flexible dose) studies is interpreted. Such data should not be used naively for the development of dosing guidelines.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Retrospective data, Review, Journal:  Sevoflurane in electroconvulsive therapy: A systematic review and meta-analysis of randomised trials. (Pubmed Central) -  Aug 27, 2021   
    The results of our study suggest that using sevoflurane for ECT significantly reduces seizure duration, increases maximum HR and brings about no difference in the adverse event risk compared with those using intravenous anaesthetics for ECT. Therefore, there may not be compelling evidence favouring sevoflurane use for ECT, except in cases where intravenous access is difficult.
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Acacia Pharma
    Enrollment open, Surgery:  Comparison of Postoperative QoR-15 Scores Between Sevoflurane and Remimazolam (clinicaltrials.gov) -  Aug 26, 2021   
    P=N/A,  N=72, Recruiting, 
    Therefore, there may not be compelling evidence favouring sevoflurane use for ECT, except in cases where intravenous access is difficult. Not yet recruiting --> Recruiting
  • ||||||||||  ketamine / Generic mfg.
    Review, Journal:  The Historical Struggles of Modified Electroconvulsive Therapy: How Anesthesia Came to the Rescue. (Pubmed Central) -  Aug 25, 2021   
    Fortunately, as advances in anesthesia and technology continued to develop, anesthesiologists helped ECT regain widespread usage improving the safety profile, cost effectiveness, quicker onset of seizures, and ease of control despite its stained past. This allowed more accessibility, especially for high-risk medical patients, to a relatively safe and effective treatment for psychiatric diseases.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Risk factors of delayed recovery from general anesthesia in patients undergoing radical biliary surgery: What can we prevent. (Pubmed Central) -  Aug 25, 2021   
    There were significant differences on the duration of surgery, duration of anesthesia, and use of intraoperative combined sevoflurane inhalation (all P  .05). Multivariable logistic regression analyses indicated that age ≥70 years (odd ratio [OR] 1.454, 95% confidence interval [CI] 1.146-1.904), body mass index ≥25 kg/m2 (OR 1.303, 95% CI 1.102-1.912), alcohol drinking (OR 2.041, 95% CI 1.336-3.085), smoking (OR 1.128, 95% CI 1.007-2.261), duration of surgery ≥220 minutes (OR 1.239, 95% CI 1.039-1.735), duration of anesthesia ≥230 minutes (OR 1.223, 95% CI 1.013-1.926), intraoperative combined sevoflurane inhalation (OR 1.207, 95% CI 1.008-1.764) were the independent risk factors for DR in patients with radical biliary surgery (all P < .05).It is clinically necessary to take early countermeasures against various risk factors to reduce the occurrence of DR, and to improve the prognosis of patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  The Mechanisms of Sevoflurane-Induced Neuroinflammation. (Pubmed Central) -  Aug 24, 2021   
    Although neuroinflammation was most widely mentioned among the established mechanisms of sevoflurane-induced cognitive dysfunction, its upstream mechanisms have yet to be illustrated. Thus, we reviewed the relevant literature and discussed the most mentioned mechanisms, including the modulation of the microglial function, blood-brain barrier (BBB) breakdown, changes in gut microbiota, and ease of cholinergic neurotransmission to help us understand the properties of sevoflurane, providing us new perspectives for the prevention of sevoflurane-induced cognitive impairment.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Inhibits Traumatic Brain Injury-Induced Neuron Apoptosis via EZH2-Downregulated KLF4/p38 Axis. (Pubmed Central) -  Aug 24, 2021   
    Mechanistically, sevoflurane exerted an inhibitory effect on neuron apoptosis by up-regulating enhancer of zeste homolog 2 (EZH2), which targeted Krüppel-like factor 4 (KLF4) and inhibited KLF4 transcription. Collectively, our findings indicate that sevoflurane suppresses neuron apoptosis induced by TBI through activation of the p38-MAPK signaling pathway via the EZH2/KLF4 axis, providing a novel mechanistic explanation for neuroprotection of sevoflurane in TBI.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial withdrawal:  Sevoflurane- Safety in Long-term Sedation Procedures (clinicaltrials.gov) -  Aug 24, 2021   
    P3,  N=0, Withdrawn, 
    Collectively, our findings indicate that sevoflurane suppresses neuron apoptosis induced by TBI through activation of the p38-MAPK signaling pathway via the EZH2/KLF4 axis, providing a novel mechanistic explanation for neuroprotection of sevoflurane in TBI. N=50 --> 0 | Recruiting --> Withdrawn
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Airway Complications After LMA in Children (clinicaltrials.gov) -  Aug 24, 2021   
    P=N/A,  N=135, Completed, 
    Trial completion date: Dec 2021 --> Jul 2022 | Trial primary completion date: Dec 2021 --> Jun 2022 Trial primary completion date: Dec 2021 --> May 2021 | Recruiting --> Completed | Trial completion date: Dec 2021 --> May 2021
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Optimization of Ultrasound Backscatter Spectroscopy to Assess Neurotoxic Effects of Anesthesia in the Newborn Non-human Primate Brain. (Pubmed Central) -  Aug 22, 2021   
    Following the successful use of ultrasound backscatter spectroscopy (UBS) to monitor in vivo cell death in breast tumors, we aimed to use UBS to assess the neurotoxicity of the anesthetic sevoflurane (SEVO) in a non-human primate (NHP) model...Data with a low prevalence of diffuse scattering corresponded to possibly biased results. Thus, ESS has the potential to detect changes in brain microstructure related to anesthesia-induced apoptosis.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  AMPK-SIRT1-PGC1α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia. (Pubmed Central) -  Aug 21, 2021   
    However, sevoflurane-induced changes above were improved after the administration of AICAR, and EX527 could reverse AICAR-induced improvements in Sevo-anesthetized aged rats. Activating AMPK-SIRT1-PGC1α pathway can improve the cognitive function and mitigate the neuronal injury in Sevo-anesthetized aged rats by antagonizing the oxidative stress and maintaining the mitochondrial function.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Enrollment change, Trial completion date:  DANA1: Neuroplasticity Induced by General Anaesthesia (clinicaltrials.gov) -  Aug 20, 2021   
    P=N/A,  N=20, Completed, 
    Sevoflurane inhalation anesthesia in the treatment of ankyloglossia resulted in rapid onset and recovery, with few adverse reactions and significant clinical efficacy, and was suited to uncooperative pediatric outpatients. Recruiting --> Completed | N=30 --> 20 | Trial completion date: Dec 2021 --> Aug 2021
  • ||||||||||  ketorolac / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Ketorolac on Post Adenotonsillectomy Pain (clinicaltrials.gov) -  Aug 18, 2021   
    P4,  N=120, Recruiting, 
    N=50 --> 19 | Recruiting --> Terminated; Low recruitment ratio Trial completion date: Aug 2021 --> Aug 2022 | Trial primary completion date: Aug 2021 --> Aug 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Application of sevoflurane inhalation sedation in dental treatment: a mini review. (Pubmed Central) -  Aug 17, 2021   
    Moreover, in Korea, the use of sevoflurane for conscious or deep sedation in dental care for children and the disabled is increasing, primarily by dental anesthesiologists. In this article, we reviewed a sedation method using sevoflurane.
  • ||||||||||  sevoflurane / Generic mfg.
    New trial:  Sevoflurane for Treatment-Resistant Depression (clinicaltrials.gov) -  Aug 16, 2021   
    P=N/A,  N=15, Not yet recruiting, 
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Effects of anesthetics on postoperative 3-month neuroendocrine function after endoscopic transsphenoidal non-functional pituitary adenoma surgery. (Pubmed Central) -  Aug 15, 2021   
    It seems that propofol may have a survival advantage compared with sevoflurane among breast cancer patients, but the inherent weaknesses of retrospective analyses were made apparent. In patients undergoing ETS for removal of NFPAs, the effects of both sevoflurane-remifentanil and propofol-remifentanil anesthetic techniques on postoperative 3-month neuroendocrine functional outcomes were similar, suggesting that propofol and sevoflurane can be freely used in such patients in terms of postoperative intermediate-term neuroendocrine functional outcome.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Inhibiting PDE7A enhances the protective effects of neural stem cells on neurodegeneration and memory deficits in sevoflurane-exposed mice. (Pubmed Central) -  Aug 15, 2021   
    Inhibition of PDE7A in NSCs exhibited profound improved effects on long-term memory and learning ability of mice exposed to sevoflurane. Our results for the first time show that knockdown of PDE7A improves the neurogenesis of NSCs in vitro and in vivo, and is beneficial for alleviating sevoflurane-induced brain damage in infant mice.Significance StatementOur results for the first time show that knockdown of PDE7A improves the neurogenesis of NSCs in vitro and in vivo, and is beneficial for alleviating sevoflurane-induced brain damage in infant mice.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1. (Pubmed Central) -  Aug 13, 2021   
    This blocked the activation of the downstream TrkB signaling pathway and reduced hippocampal synaptic plasticity, leading to long-term learning and memory dysfunction. Therefore, Sevoflurane exposure could lead to learning and memory dysfunction by inhibiting BDNF cleavage via breaking the balance of tPA/PAI-1.