sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Tolerance to Sevoflurane in Children Undergoing Repeated Drug Exposure (clinicaltrials.gov) -  Sep 24, 2021   
    P=N/A,  N=24, Completed, 
    These results indicate that sevoflurane inhibits MPB neurons through postsynaptic GABA-Rs and background potassium channels, which contributes to sevoflurane-induced hypnosis. Recruiting --> Completed | N=16 --> 24 | Trial completion date: Mar 2021 --> Sep 2021 | Trial primary completion date: Mar 2021 --> Aug 2021
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Use of volatile agents for sedation in the intensive care unit: A national survey in France. (Pubmed Central) -  Sep 24, 2021   
    Differences in education and knowledge, as well as the recent and relatively scarce literature on the use of volatile agents in the ICU, might explain the diverse practices that were observed. The low rate of mild adverse effects, as perceived by respondents, and the users' satisfaction, are promising for this potentially important tool for ICU sedation.
  • ||||||||||  midazolam hydrochloride / Generic mfg.
    PROLONGED QT DURING ANAESTHESIA FOR PEDIATRIC CADAVERIC LIVER TRANSPLANTATION: A CASE REPORT () -  Sep 23, 2021 - Abstract #ESOT2021ESOT_1864;    
    The anesthesia was induced with propofol 3 mg/kg, fentanyl 2 mcg/kg and rocuronium 1 mg/kg...Sevoflurane administration was stopped, and midazolam iv infusion (0.2 mg/kg/h) was started...The LQT is associated with liver dysfunction and hyperdynamic circulatory syndrome typical of cirrhotic patients 4 . Therefore, it is necessary to prevent severe ventricular arrhythmias during LT by optimizing electrolyte balance and avoiding drugs that can prolong QT through accurate hourly analysis of ECG and kalemia during LT.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Inhibitive Effect of Luteolin on Sevoflurane-Induced Neurotoxicity through Activation of the Autophagy Pathway by HMOX1. (Pubmed Central) -  Sep 22, 2021   
    This was confirmed by subsequent histological experiments in mice and behavioral results showing rescue cognitive impairment. Our findings uncovered an inhibitory role of luteolin in sevoflurane-induced neuronal apoptosis and inflammatory response through activation of autophagy arising from up-regulation of heme oxygenase-1, thereby alleviating sevoflurane-induced cognitive impairment in mice.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Fast-track anesthesia in lateral mini-thoracotomy for transapical transcatheter valve implantation. (Pubmed Central) -  Sep 18, 2021   
    Anesthesia was maintained with a volatile anesthetic (Sevoflurane MAC 1%)...An effective PVB, in addition to a double-lumen laryngeal mask, provide an alternative strategy to conventional general anesthesia. These promising results could encourage further consideration of this approach in similar cardiac surgery patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Intravenous Propofol Versus Volatile Anesthetics For Stroke Endovascular Thrombectomy. (Pubmed Central) -  Sep 15, 2021   
    In stroke patients undergoing endovascular thrombectomy treated using general anesthesia, there may be a differential effect between intravenous propofol and volatile inhalational agents. These results should be considered hypothesis-generating and be tested in future randomized controlled trials.
  • ||||||||||  simvastatin / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  Impact of statin intake on malignant hyperthermia: an in vitro and in vivo swine study. (Pubmed Central) -  Sep 15, 2021   
    Evidence of modest enhancement in cardiovascular and metabolic signs of MH, as well as masked pathognomonic muscle rigor observed under simvastatin therapy suggest a potentially misleading influence on the clinical presentation of MH. The findings deserve further study to include other statins and therapeutic regimes.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  A Comparative Study of the ProSeal Laryngeal Mask Airway Versus Endotracheal Tube in Neonates With Anorectal Malformations. (Pubmed Central) -  Sep 14, 2021   
    ESP block is effective in reducing postoperative pain scores and lowering opioid utilization (both intraoperatively and postoperatively), resulting in improved patient satisfaction for pain management in lumbar laminoplasty. The ProSeal LMA can be a better alternative to the endotracheal tube in neonates due to the ease of insertion, lesser changes in hemodynamic parameters and minimal postoperative complications.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, IO biomarker:  Inhibition of RhoA Activity Does Not Rescue Synaptic Development Abnormalities and Long-Term Cognitive Impairment After Sevoflurane Exposure. (Pubmed Central) -  Sep 9, 2021   
    Sevoflurane disturbed dendritic morphogenesis, reduced the number of dendritic spines, decreased proteins expression of PSD-95, drebrin and synaptophysin, inhibited LTP in hippocampal slices and impaired memory ability in the adolescent rats, while inhibition of RhoA activity did not rescue the changes above induced by sevoflurane. RhoA signal pathway did not participate in sevoflurane-induced dendritic and synaptic development abnormalities and cognitive dysfunction in developing rats.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Review, Journal:  The Effects of Volatile Anesthetics on Lung Ischemia-Reperfusion Injury: Basic to Clinical Studies. (Pubmed Central) -  Sep 9, 2021   
    Multiple animal studies have reported that with regards to LIRI, sevoflurane demonstrates an anti-inflammatory effect in immunocompetent cells and an anti-apoptotic effect on lung tissue...One study, although limited due to its small sample size, found that the use of volatile anesthetics in organ procurement surgery involving "death by neurologic criteria" donors did not improve lung graft survival. Future studies on the protective effect of volatile anesthetics against LIRI must examine not only the mechanism of the protective effect but also differences in the effects of different types of volatile anesthetics, their optimal dosage, and the appropriateness of their use in the event of marked alveolar capillary barrier damage.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Transient changes in white matter microstructure during general anesthesia. (Pubmed Central) -  Sep 9, 2021   
    In spite of the transient effects of sevoflurane anesthesia there were no measurable effects on brain white matter as determined by the DTI metrics at 2 days and 7 days following anesthesia. The role of white matter in the loss of consciousness under anesthesia will need to be studied and MRI studies with subjects under anesthesia will need to take these results into account.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Journal:  Effect of low-dose ketamine on MAC of sevoflurane in laparoscopic cholecystectomy: A randomized controlled trial. (Pubmed Central) -  Sep 8, 2021   
    Mechanisms of action and clinical advantages of desflurane anesthesia based on Treg immunomodulation should be investigated in the future. A loading dose of 0.5 mg/kg ketamine followed by a continuous infusion of 10.0 μg/kg/min led to a significant decrease in the MAC of sevoflurane in patients undergoing laparoscopic cholecystectomy.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Phase classification, Enrollment change, Trial completion date, Trial primary completion date, Surgery:  The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery (clinicaltrials.gov) -  Sep 5, 2021   
    P1,  N=47, Completed, 
    Based on our findings we recommend using 1 mg/kg propofol at the end of surgery to reduce the occurrence of emergency agitation. Recruiting --> Completed | Phase classification: P4 --> P1 | N=80 --> 47 | Trial completion date: Feb 2022 --> Jun 2021 | Trial primary completion date: Feb 2022 --> Jun 2021
  • ||||||||||  ketamine / Generic mfg.
    Review, Journal:  Understanding the Effects of Anesthesia on Cortical Electrophysiological Recordings: A Scoping Review. (Pubmed Central) -  Sep 5, 2021   
    Therefore, for a given experimental protocol, it is relevant to identify the appropriate anesthetic, to minimize the impact on neuronal circuits and related signals under investigation. This review focuses on the effect of different anesthetics on cortical electrical recordings, examining their molecular mechanisms of action, their influence on neuronal microcircuits and, consequently, their impact on cortical measurements.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Effects of propofol and sevoflurane on hepatic blood flow: a randomized controlled trial. (Pubmed Central) -  Sep 4, 2021   
    P4
    Hepatic blood flow was similar under a propofol-based and a sevoflurane-based anesthetic regimen. Related to the application of GDHT, pre-set hemodynamic goals were maintained in both groups, but sevoflurane-anaesthetized patients had a significantly higher need for vasopressor support.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Effects of Occupational Exposure to Waste Anesthetic Gas on Oxidative Stress and DNA Damage. (Pubmed Central) -  Sep 4, 2021   
    Air samples were collected in the OR, and the sevoflurane concentrations in the samples were determined...Long-term occupational exposure to waste anesthetic gas may affect the antioxidant defense system and probably affects vital organ functions to some extent. No correlation between DNA damage and chronic exposure to WAG was observed.
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., paracetamol / Generic mfg.
    Journal:  Wide range of perioperative drugs and doses used in inguinal hernia repairs for premature infants. (Pubmed Central) -  Sep 2, 2021   
    There is wide variability in the drugs and doses used for a common surgical procedure in this population, even within a single center. Future research should focus on the safety and efficacy of the most commonly used perioperative drugs described in this study.