sevoflurane / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 13 Diseases   542 Trials   542 Trials   5582 News 


«12...3637383940414243444546...9293»
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Effects of sevoflurane exposure during different stages of pregnancy on the brain development of rat offspring. (Pubmed Central) -  Oct 22, 2021   
    A multimodal anxiolytic approach including oral melatonin, as opposed to oral midazolam, significantly reduced emergence delirium after sevoflurane anaesthesia. The neurotoxic effect of maternal sevoflurane anesthesia on the brain development of offspring is higher when the exposure occurs in early pregnancy than in late pregnancy, and its mechanism might involve the NR4A1/NF-κB pathway to increase the secretion of inflammatory cytokines.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Desflurane in Huntington Disease: a case report ([VIRTUAL]) -  Oct 21, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_240;    
    Sevoflurane has nonetheless been considered safe(2). Isoflurane has been reported to alter calcium homeostasis and there is no data on desflurane.
  • ||||||||||  sevoflurane / Generic mfg.
    Preoperative exercise ameliorates postoperative cognitive dysfunction in rats with muscle atrophy. ([VIRTUAL]) -  Oct 21, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_182;    
    In rats with muscle atrophy, preoperative exercise ameliorated the spatial and contextual memories with the hippocampal neurogenesis. These results indicate that preoperative exercise has beneficial effects on the prevention of POCD through neurogenesis, since muscle mass is an important factor in POCD.
  • ||||||||||  ketamine / Generic mfg.
    When laryngeal mask saves a newborn’s life - Case Report ([VIRTUAL]) -  Oct 21, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_104;    
    Despite having a successful first airway approach, complications can occur and should be anticipated. Learning points: LMA can be helpful as a rescue airway on CPR until a definitive airway is obtained, particularly in a difficult airway management.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  Comparison of the Anaesthetic Gases in Maintainance of General Anaesthesia in Paediatrics (clinicaltrials.gov) -  Oct 20, 2021   
    P1/2,  N=80, Recruiting, 
    Learning points: LMA can be helpful as a rescue airway on CPR until a definitive airway is obtained, particularly in a difficult airway management. Trial primary completion date: Sep 2021 --> Dec 2021
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Neurotoxicity of Anesthesia in Middle Aged Patients (clinicaltrials.gov) -  Oct 19, 2021   
    P=N/A,  N=600, Active, not recruiting, 
    Prophylactic dexmedetomidine improves recovery quality during the extubation period, but prolongs its duration, in sevoflurane-anesthetized healthy dogs administered fentanyl. Trial completion date: Aug 2021 --> May 2022 | Trial primary completion date: Jul 2021 --> Mar 2022
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Effects of Volatile Anesthetics on Postoperative Ischemic Stroke Incidence. (Pubmed Central) -  Oct 16, 2021   
    The effects were robust throughout various sensitivity analyses including adjustment for anesthesia providers as random effect. Conclusions Among patients undergoing noncardiac surgery, volatile anesthetics showed a dose-dependent protective effect on the incidence and severity of early postoperative ischemic stroke.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion date:  Evaluation of the Analgesia Nociception Index With Varying Remifentanil Concentrations Under Sevoflurane (clinicaltrials.gov) -  Oct 16, 2021   
    P=N/A,  N=45, Recruiting, 
    Conclusions Among patients undergoing noncardiac surgery, volatile anesthetics showed a dose-dependent protective effect on the incidence and severity of early postoperative ischemic stroke. Trial completion date: Dec 2023 --> Oct 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Enrollment change, Surgery:  Effect of Anaesthesia on ER Stress in Cancer Patients (clinicaltrials.gov) -  Oct 15, 2021   
    P=N/A,  N=53, Completed, 
    Trial completion date: Dec 2023 --> Oct 2022 Recruiting --> Completed | N=240 --> 53
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    [VIRTUAL] AN UNEXPECTED TRIAL: SEVOFLURANE USE IN STATUS ASTHMATICUS () -  Oct 13, 2021 - Abstract #CHEST2021CHEST_1950;    
    The growing body of case reports should prompt consideration of a formal study of inhalational volatile anesthetics as rescue therapies in severe asthma exacerbations. Additionally, further research is required on how to safely use inhaled anesthetics in the ICU setting where its use is currently limited.
  • ||||||||||  [VIRTUAL] DELAYED MALIGNANT HYPERTHERMIA AFTER RECENT SURGERY () -  Oct 13, 2021 - Abstract #CHEST2021CHEST_757;    
    Cases of malignant hyperthermia have been reported to occur as late as four days after depolarizing muscle relaxant administration. Therefore, it is important to consider malignant hyperthermia as a cause of hyperpyrexia in patients who have undergone recent surgery.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Journal:  Anesthesia for Electroconvulsive Therapy: A Niche Role for Sevoflurane. (Pubmed Central) -  Oct 10, 2021   
    Sevoflurane could also be useful in the final trimester of pregnancy because it may inhibit ECT-induced uterine contractions. Importantly, undesired effects of sevoflurane on seizure duration and the hemodynamic response to ECT can be attenuated by discontinuing its administration after induction.
  • ||||||||||  ketamine / Generic mfg., dexketoprofen trometamol / Generic mfg.
    Clinical, Journal:  Perioperative Intravenous Low-Dose Ketamine Infusion to Minimize Pain for Septorhinoplasty: A Prospective, Randomized, Double-Blind Study. (Pubmed Central) -  Oct 9, 2021   
    Furthermore, 50-mg dexketoprofen trometamol was administered to both groups 30 minutes before the end of the surgery...There was no significant difference between the groups in terms of intraoperative sevoflurane and remifentanil consumptions (P > .05)...Side effects were similar between the groups (P > .05). We recommend the administration of low-dose ketamine infusion during septorhinoplasty surgery because it reduces the requirement for rescue opioid analgesia and postoperative pain scores.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Machine learning of EEG spectra classifies unconsciousness during GABAergic anesthesia. (Pubmed Central) -  Oct 9, 2021   
    These results indicate that EEG spectral features can predict unconsciousness, even when tested on a different anesthetic that acts with a similar neural mechanism. With high performance predictions of unconsciousness, we can accurately monitor anesthetic state, and this approach may be used to engineer infusion pumps to intelligibly respond to patients' neural activity.
  • ||||||||||  sevoflurane / Generic mfg., dantrolene / Generic mfg.
    Journal:  Malignant hyperthermia syndrome: A rare entity. (Pubmed Central) -  Oct 8, 2021   
    The patient presented with tachycardia, hypercapnia, and hyperthermia, requiring two successive doses of dantrolene sodium administration, with an adequate response to the treatment. Malignant hyperthermia syndrome is a rare condition in pediatric patients that should be detected in early stages since it is essential to initiate the treatment as soon as possible.
  • ||||||||||  atorvastatin / Generic mfg., ketamine / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  Effects of Atorvastatin on Sevoflurane Postconditioning in in vivo Rabbit Hearts. (Pubmed Central) -  Oct 7, 2021   
    The combination of sevoflurane postconditioning and pre-administration of ATV further reduced the myocardial infarction size compared to that observed with sevoflurane postconditioning alone or ATV alone. Our data suggest that sevoflurane postconditioning and ATV may function additively to enhance cardioprotection.
  • ||||||||||  sevoflurane / Generic mfg., dantrolene / Generic mfg.
    Clinical, Journal:  Delayed-onset malignant hyperthermia in the postanesthetic care unit: a case report. (Pubmed Central) -  Oct 7, 2021   
    The patient was suspected to have MH, and 60 mg of dantrolene sodium (1 mg/kg) was administered via intravenous drip with symptomatic treatment...Therefore, suspicion and prompt diagnosis are absolutely essential. This case report emphasizes the importance of continuous education in the diagnosis and treatment of MH.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  A high concentration of sevoflurane induces gasping breaths in mice. (Pubmed Central) -  Oct 6, 2021   
    Also, the combination of mild hypoxia (inhalation of 10 % O in N) and moderate sevoflurane anesthesia (3.25 %: 1.0 MAC) consistently elicited the same gasping, while mild hypoxic and moderate anesthetic stress alone did not elicit any gasping. These findings suggest that both hypoxia-induced gasping and sevoflurane-induced gasping could be generated by the same intrinsic mechanism within the brainstem.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  LncRNA Rian ameliorates sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis. (Pubmed Central) -  Oct 6, 2021   
    Knockdown of LIMK1 aggravated sevoflurane-induced decrease of cell viability and increase of LDH and apoptosis in neurons, while over-expression attenuated LIMK1 silence-induced neuronal damage post-sevoflurane anesthesia. In conclusion, Rian demonstrated neuroprotective effects against sevoflurane anesthesia-induced cognitive dysfunction through regulation of miR-143-3p/LIMK1 axis, providing promising target for sevoflurane anesthesia-induced cognitive dysfunction.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  PROSEVNOL: NOL Index to Compare the Intraoperative Analgesic Effect of Propofol Versus Sevoflurane (clinicaltrials.gov) -  Oct 4, 2021   
    P4,  N=60, Recruiting, 
    In addition, Succinylcholine and pancronium which releases low levels of histamine has been used safely in asthmatics with little morbidity. Trial completion date: Jul 2021 --> Jul 2022 | Trial primary completion date: Apr 2021 --> Feb 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  MEMSEV: Evaluation of the Sevoflurane Consumption During General Anesthesia When Using the MemsorbTM Membrane (clinicaltrials.gov) -  Oct 4, 2021   
    P=N/A,  N=50, Recruiting, 
    Trial completion date: Jul 2021 --> Jul 2022 | Trial primary completion date: Apr 2021 --> Feb 2022 Not yet recruiting --> Recruiting | Trial completion date: Apr 2021 --> Aug 2022 | Trial primary completion date: Mar 2021 --> Mar 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Volatile Anesthetics in Cardiac Protection (clinicaltrials.gov) -  Sep 30, 2021   
    P4,  N=0, Recruiting, 
    The sevoflurane concentration should be adjusted after sufficient unconsciousness is reached. Trial completion date: Jun 2021 --> Dec 2021 | Trial primary completion date: May 2021 --> Dec 2021
  • ||||||||||  Sufenta (sufentanil) / Akorn
    Enrollment open, Trial completion date, Trial primary completion date, Surgery:  RUMBLE: Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery (clinicaltrials.gov) -  Sep 30, 2021   
    P3,  N=60, Recruiting, 
    Trial completion date: Jun 2021 --> Dec 2021 | Trial primary completion date: May 2021 --> Dec 2021 Not yet recruiting --> Recruiting | Trial completion date: Mar 2021 --> Sep 2022 | Trial primary completion date: Jan 2021 --> Jul 2022