- |||||||||| sevoflurane / Generic mfg.
Preclinical, Journal: Effects of anesthesia with sevoflurane on outcome parameters in murine experimental studies. (Pubmed Central) - Jul 9, 2024
Therefore, further studies are required to clarify the effects of different anesthetic drugs. Overall, the inclusion of a control group subjected to the same anesthesia protocol as the experimental groups of interest seems helpful to precisely define the inherent impact of the anesthetic when investigating immuno-pathophysiologic conditions in vivo.
- |||||||||| sevoflurane / Generic mfg.
Journal: Sevoflurane and Propofol Co-affect the Development of Colorectal Cancer by Regulating TM2D1. (Pubmed Central) - Jun 26, 2024
Our study elucidated that the miR-182-5p/GPX4 pathway was implicated in sevoflurane-induced ototoxicity by promoting ferroptosis. Our results showed a novel anti-tumor mechanism of sevoflurane and propofol in colorectal cancer cells, and TM2D1 might be an underlying therapeutic target for treating colorectal cancer patients.
- |||||||||| Dynastat (parecoxib) / Pfizer
A Four-Year-Old Child Scheduled for Elective Outpatient Adenotonsillectomy: Avoiding the Pitfalls (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3251;
Our results showed a novel anti-tumor mechanism of sevoflurane and propofol in colorectal cancer cells, and TM2D1 might be an underlying therapeutic target for treating colorectal cancer patients. Case continuation: After the usual monitors are applied you proceed with a sevoflurane inhalation induction and you notice that the patient
- |||||||||| Oh My God! This Is the Worst Headache of My Life; I Can (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3145;
Case continuation: After the usual monitors are applied you proceed with a sevoflurane inhalation induction and you notice that the patient She also has a history of well-controlled hypertension treated with losartan...Desflurane, sevoflurane or isoflurane?...Would you add remifentanil and dexmedetomidine to your TIVA technique?The patient
- |||||||||| sevoflurane / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Radiographic Opacity in a Child Who Vomited at Induction: Is It Aspiration? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2873;
Should prokinetics be administered preoperatively?Case Continuation: Upon arrival in the operating room, induction is initiated with gradual increments of sevoflurane inhalation in a mixture of nitrous oxide and oxygen...Empiric antibiotic therapy is started with Amoxycillin-Clavulanate administration...The radiologist interpreted the radiographic opacity as the stomach shadow in the chest due to the gastric pull-up and not pulmonary aspiration. Esophageal dilatation was performed the following week uneventfully.18.What are the clues distinguishing aspiration from the stomach shadow in this child?
- |||||||||| Emla-cream / Akorn, AstraZeneca, Spravato (esketamine intranasal) / J&J
I Didn (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2667;
First, we applied EMLA cream one hour before the surgery...After the time-out, we administered Fentanyl at a dose of 2 mcg/kg, followed by a propofol bolus of 4 mg/kg and a Remifentanil bolus of 1 mcg/kg...Sevoflurane was also started at an inspiratory level of 4%...However, to cover any potential bacterial cause, the patient received ceftriaxone and erythromycin according to local antibiotic treatment guidelines...A chest X-ray was taken five weeks after the initial anesthesia to assess any signs of lingering pneumonia.Pre-Treatment: The patient will receive pre-treatment with salbutamol/albuterol 24 hours before surgery.Anesthesia Team: A second anesthesiologist will be present throughout the procedure, and all necessary medications (including succinylcholine, intravenous salbutamol/albuterol, magnesium, adrenaline, and esketamine) will be readily available for administration in the operating room.High Alert: The procedure will be promptly canceled at the first indication of any complications.Clinical Admission: Instead of an outpatient setting, the procedure will be performed during a clinical admission.Eight weeks after the initial anesthesia, the tonsillectomy was successfully completed without incident, both during the operation and in the post-surgical period. Furthermore, the patient remains healthy, exhibits no neurological symptoms, and continues to develop similarly to their twin sibling.
- |||||||||| Catastrophic Airway Emergency and Bleeding in Endotracheal Tube After Pulmonary Angioplasty in the Cardiac Catheterization Laboratory! What Is Next? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2563;
Case Description:A 14-year-old girl, who has a previous medical history of DiGeorge syndrome, Tetralogy of Fallot, and MAPCAs, repaired by Unifocalization, right ventricle to pulmonary artery (RV-PA) Conduit, and VSD repair in 2009, presented for elective left pulmonary artery (LPA) rehabilitation and pulmonary vasodilator testing in the interventional cardiac catheterization lab.Her history of cardiac repairs and interventions included; Unifocalization and RV-PA conduit (2009), Left BT shunt to left pulmonary artery (LPA), right pulmonary artery (RPA) angioplasty, RV-PA replacement (2011), Unifocalization LUPA, RV-PA conduit replacement (2021), VSD patch (2022), and multiple catheterization-based interventions for RPA / RPV stenosis.Her medications included home oxygen, sildenafil and furosemide...Qp:Qs 1.5After uneventful induction with IV midazolam, fentanyl, propofol and rocuronium, and endotracheal intubation the anesthesia maintenance was conducted by 1% Sevoflurane and boluses of rocuronium...Was there further patient optimization in preparation for the procedure? What could be done better next time?
- |||||||||| fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., rocuronium / Generic mfg.
An Unanticipated Critically Obstructed Neonatal Airway. A Missed Opportunity for an Exit Procedure (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2369;
(How would you mange anesthesia and the airway at this point ??.) The anesthesia team continued positive pressure mask ventilation, started Sevoflurane anesthesia while maintaining spontaneous respiratory drive...Rocuronium and Fentanyl were then administered and the newborn was transferred in a stable condition to the neonatal ICU...What are the airway management options for the infant during EXIT-to Airway procedure ?? What else could be done if intubation and tracheostomy are both impossible?$$graphic_{4CACF98A-2538-4365-B841-F1BAA7DEB457}$$$$graphic_{1C0FB099-9AE8-473F-87A6-0B70C365CC92}$$$$graphic_{1FF1DBBE-20D4-4126-B897-C4BB2CFCA541}$$$$graphic_{39BA95B2-55E8-47D3-8DA1-A26098D0C1AD}$$$$graphic_{93A1B763-CAAA-4A69-BD9F-F7DEC76548F5}$$
- |||||||||| Emla-cream / Akorn, AstraZeneca, Spravato (esketamine intranasal) / J&J
I Didn (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2235;
First, we applied EMLA cream one hour before the surgery...After the time-out, we administered Fentanyl at a dose of 2 mcg/kg, followed by a propofol bolus of 4 mg/kg and a Remifentanil bolus of 1 mcg/kg...Sevoflurane was also started at an inspiratory level of 4%...However, to cover any potential bacterial cause, the patient received ceftriaxone and erythromycin according to local antibiotic treatment guidelines...A chest X-ray was taken five weeks after the initial anesthesia to assess any signs of lingering pneumonia.Pre-Treatment: The patient will receive pre-treatment with salbutamol/albuterol 24 hours before surgery.Anesthesia Team: A second anesthesiologist will be present throughout the procedure, and all necessary medications (including succinylcholine, intravenous salbutamol/albuterol, magnesium, adrenaline, and esketamine) will be readily available for administration in the operating room.High Alert: The procedure will be promptly canceled at the first indication of any complications.Clinical Admission: Instead of an outpatient setting, the procedure will be performed during a clinical admission.Eight weeks after the initial anesthesia, the tonsillectomy was successfully completed without incident, both during the operation and in the post-surgical period. Furthermore, the patient remains healthy, exhibits no neurological symptoms, and continues to develop similarly to their twin sibling.
- |||||||||| fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., rocuronium / Generic mfg.
An Unanticipated Critically Obstructed Neonatal Airway. A Missed Opportunity for an Exit Procedure (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2227;
(How would you mange anesthesia and the airway at this point ??.) The anesthesia team continued positive pressure mask ventilation, started Sevoflurane anesthesia while maintaining spontaneous respiratory drive...Rocuronium and Fentanyl were then administered and the newborn was transferred in a stable condition to the neonatal ICU...What are the airway management options for the infant during EXIT-to Airway procedure ?? What else could be done if intubation and tracheostomy are both impossible?
- |||||||||| sevoflurane / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Radiographic Opacity in a Child Who Vomited at Induction: Is It Aspiration? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1573;
Should prokinetics be administered preoperatively?Case Continuation: Upon arrival in the operating room, induction is initiated with gradual increments of sevoflurane inhalation in a mixture of nitrous oxide and oxygen...Empiric antibiotic therapy is started with Amoxycillin-Clavulanate administration...The radiologist interpreted the radiographic opacity as the stomach shadow in the chest due to the gastric pull-up and not pulmonary aspiration. Esophageal dilatation was performed the following week uneventfully.18.What are the clues distinguishing aspiration from the stomach shadow in this child?
- |||||||||| Oh My God! This Is the Worst Headache of My Life; I Can (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1441;
Abstract is embargoed at this time. She also has a history of well-controlled hypertension treated with losartan...Desflurane, sevoflurane or isoflurane?...Would you add remifentanil and dexmedetomidine to your TIVA technique?The patient
- |||||||||| Betadine (povidone iodine) / Egis
Everything You Ever Wanted to Know About Perioperative Hypersensitivity Reactions Before It's Too Late (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1425;
Maintenance included sevoflurane...Preoperatively, betadine skin prep was used, and he was pretreated with corticosteroids and antihistamines...An awake arterial line was placed, and he was then induced with dexmedetomidine, etomidate, and methadone...He was stable for 18 minutes and then hypotensive and tachycardic but responded very rapidly to boluses of epinephrine, vasopressin, phenylephrine and fluid resuscitation...Table 1 summarizes the anesthetics used and the tryptase levels. What is the significance of these results?$$graphic_{906E5046-3C50-4A47-9837-748270DA6A29}$$
- |||||||||| High Risk Transvenous Lead Extractions (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1217;
Abstract is embargoed at this time. Her outpatient medications are metformin, amlodipine, aspirin and furosemide...General anesthesia is maintained with sevoflurane/oxygen mixture...What is
- |||||||||| Catastrophic Airway Emergency and Bleeding in Endotracheal Tube After Pulmonary Angioplasty in the Cardiac Catheterization Laboratory! What Is Next? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1068;
Case Description:A 14-year-old girl, who has a previous medical history of DiGeorge syndrome, Tetralogy of Fallot, and MAPCAs, repaired by Unifocalization, right ventricle to pulmonary artery (RV-PA) Conduit, and VSD repair in 2009, presented for elective left pulmonary artery (LPA) rehabilitation and pulmonary vasodilator testing in the interventional cardiac catheterization lab.Her history of cardiac repairs and interventions included; Unifocalization and RV-PA conduit (2009), Left BT shunt to left pulmonary artery (LPA), right pulmonary artery (RPA) angioplasty, RV-PA replacement (2011), Unifocalization LUPA, RV-PA conduit replacement (2021), VSD patch (2022), and multiple catheterization-based interventions for RPA / RPV stenosis.Her medications included home oxygen, sildenafil and furosemide...Qp:Qs 1.5After uneventful induction with IV midazolam, fentanyl, propofol and rocuronium, and endotracheal intubation the anesthesia maintenance was conducted by 1% Sevoflurane and boluses of rocuronium...Was there further patient optimization in preparation for the procedure? What could be done better next time?
- |||||||||| High Risk Transvenous Lead Extractions (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_679;
Case continuation: After the usual monitors are applied you proceed with a sevoflurane inhalation induction and you notice that the patient Her outpatient medications are metformin, amlodipine, aspirin and furosemide...General anesthesia is maintained with sevoflurane/oxygen mixture...What is
- |||||||||| Betadine (povidone iodine) / Egis
Everything You Ever Wanted to Know About Perioperative Hypersensitivity Reactions Before It's Too Late (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_469;
Maintenance included sevoflurane...Preoperatively, betadine skin prep was used, and he was pretreated with corticosteroids and antihistamines...An awake arterial line was placed, and he was then induced with dexmedetomidine, etomidate, and methadone...He was stable for 18 minutes and then hypotensive and tachycardic but responded very rapidly to boluses of epinephrine, vasopressin, phenylephrine and fluid resuscitation...Table 1 summarizes the anesthetics used and the tryptase levels. What is the significance of these results?
- |||||||||| sevoflurane / Generic mfg.
Attention deficits in the TgF344-AD rat model of Alzheimer (Exhibit (Pennsylvania Convention Center); In-Person) - Jun 19, 2024 - Abstract #AAIC2024AAIC_2708;
Here we demonstrate that in the prodromal stage of AD, prior to the onset of memory impairments, TgF344-AD rats develop progressive sustained attention deficits. Moreover, we identified a connection between baseline attention deficits and susceptibility to POD-like symptoms following sevoflurane anesthesia.
- |||||||||| sevoflurane / Generic mfg.
Journal: Early and late effects of volatile sedation with sevoflurane on respiratory mechanics of critically ill COPD patients. (Pubmed Central) - Jun 18, 2024
Our findings will be conducive to substantially expanding our comprehension of the neural circuit mechanisms underlying sevoflurane anesthesia and provide a potential target for modulating consciousness, ultimately leading to a reduction in anesthetic dose requirements and side effects. In critically ill patients intubated with COPD exacerbation, there was no significant difference in respiratory mechanics between sevoflurane and propofol from inclusion to H4 and H48.
- |||||||||| Clinical, Journal, Surgery: Opioid-free versus opioid-based anesthesia in major spine surgery: a prospective, randomized, controlled clinical trial. (Pubmed Central) - Jun 13, 2024
All patients received intraoperative sevoflurane, propofol, rocuronium, ketamine, dexamethasone, ondansetron and postoperative paracetamol and patient-controlled analgesia device set to deliver intravenous morphine for 48 hours after surgery...OFA can be an alternative to OBA in patients undergoing multilevel spine fusion surgery. OFA reduces opioids consumption in the first 24 hours and PONV.
- |||||||||| sevoflurane / Generic mfg.
Journal: Anesthetic Management and Considerations in a Rare Case of Parietal Bone Hemangioma. (Pubmed Central) - Jun 11, 2024
We discuss a 31-year-old female with chronic headaches who underwent surgery for the removal of a large parietal bone hemangioma, necessitating considerations for stable hemodynamics, intracranial pressure (ICP), and bleeding risks. There is no standard anesthetic for these cases, so a mixed anesthetic approach was used, combining intravenous anesthesia with sevoflurane, aimed at optimizing control during the procedure.
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