sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Effect of Permissive Mild Hypercapnia on Cerebral Vasoreactivity in Infants: A Randomized Controlled Crossover Trial. (Pubmed Central) -  Nov 24, 2021   
    Allowing permissive mild hypercapnia during mechanical ventilation of infants led to lower driving pressure and comparable hemodynamic, respiratory, and cerebral oxygenation parameters than during normocapnia. Whereas a large scatter in NIRS-derived parameters was observed at all levels of Etco2, the correlation between TOI and MAP suggests that arterial pressure is an important component of cerebral oxygenation at mild hypercapnia.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, HEOR:  Evidence-Based Project: Cost Savings and Reduction in Environmental Release With Low-Flow Anesthesia. (Pubmed Central) -  Nov 24, 2021   
    Sevoflurane was the most commonly used volatile agent...Simulated low-flow anesthesia demonstrated cost savings and environmental conservation. Project findings align with current literature showing that lowering FGFs represents an area of cost containment and an opportunity to lessen the environmental impact of anesthesia.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Environmental and Occupational Considerations of Anesthesia: A Narrative Review and Update. (Pubmed Central) -  Nov 24, 2021   
    Overall, although their contributions are relatively low compared with those of other human-produced substances, inhaled anesthetics are intrinsically potent greenhouse gases and pose a risk to operating-room personnel if not properly managed and scavenged. Factors to reduce waste and minimize the future impact of these substances should be considered.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Sevoflurane sedation protocol in children with cerebral palsy undergoing botulinum toxin-A injections (Pubmed Central) -  Nov 21, 2021   
    Sevoflurane sedation shows promising results in terms of safety and effectiveness for the management of agitation and pain during BoNT-A infiltration in our daily clinical practice. In addition, it can facilitate infiltration, allowing examination under sedation and multilevel infiltration with good tolerance.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane but not propofol provided dual effects of cell survival in human neuroblastoma SH-SY5Y cells. (Pubmed Central) -  Nov 21, 2021   
    Calcium influx contributed to the general anesthetics mediated elevation of cytosolic or mitochondrial calcium, which is especially true for propofol. Sevoflurane has a greater potency to either promote or inhibit cell survival than propofol, which may be associated with its ability to affect cytosolic or mitochondrial calcium.
  • ||||||||||  dexamethasone / Generic mfg., ondansetron / Generic mfg., midazolam hydrochloride / Generic mfg.
    Clinical, Journal:  Effect of Adding Midazolam to Dual Prophylaxis for Preventing Postoperative Nausea and Vomiting. (Pubmed Central) -  Nov 17, 2021   
    In this prospective, randomized, double-blinded trial, 144 patients undergoing gynecological laparoscopic surgery under sevoflurane anesthesia were randomized to receive either normal saline (control group, n = 72) or midazolam 0.05 mg/kg (midazolam group, n = 72) intravenously at pre-induction...The incidence of nausea, severe nausea, retching/vomiting, and administration of rescue antiemetic was comparable between the two groups. The addition of 0.05 mg/kg midazolam at pre-induction to the dual prophylaxis had no additive preventive effect on PONV after gynecologic laparoscopy.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Increases Hippocampal Theta Oscillations and Impairs Memory Via TASK-3 Channels. (Pubmed Central) -  Nov 17, 2021   
    The knockdown of hippocampal TASK-3 channels significantly reduced the enhancing effect of sevoflurane on hippocampal theta rhythms and alleviated sevoflurane-induced memory impairment. Our data indicate that sevoflurane can increase hippocampal theta oscillations and impair memory function via TASK-3 channels.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion:  The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung (clinicaltrials.gov) -  Nov 12, 2021   
    P=N/A,  N=72, Completed, 
    The results indicate that VTA DA neurons may be involved in the delay in awakening from general anesthesia caused by anxiety. Enrolling by invitation --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Surgery:  Comparison of the Effects of Sevoflurane and Desflurane on Endothelial Glycocalyx (clinicaltrials.gov) -  Nov 9, 2021   
    P=N/A,  N=50, Completed, 
    The findings provide a new insight into the role of histaminergic neurons during general anesthesia in humans. Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg., paracetamol / Generic mfg.
    Preclinical, Journal:  Lidocaine and bupivacaine as part of multimodal pain management in a C57BL/6J laparotomy mouse model. (Pubmed Central) -  Nov 5, 2021   
    Surprisingly, Paracetamol treatment alone significantly increased the Mouse Grimace Scale. Taken together, mice treated with a combination of local anesthesia and systemic analgesia did not show fewer signs of post-surgical pain or improved recovery compared to animals treated with either local anesthesia or Paracetamol.
  • ||||||||||  sevoflurane / Generic mfg., ropivacaine / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Comparison of different anesthesia modalities during percutaneous kyphoplasty of osteoporotic vertebral compression fractures. (Pubmed Central) -  Nov 4, 2021   
    Monitored anesthesia had the highest perioperative satisfaction and the lowest VAS 2 h postoperatively; however, the monitored anesthesia group had the lowest MAP and heart rate 2 h postoperatively. Based on better sedation and analgesia, monitored anesthesia with dexmedetomidine achieved better patient cooperation, a shorter operative time, and lower adverse events during PKP; however, the MAP and heart rate in the monitored anesthesia group should be closely observed after surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Confirmatory Study of HFVI Guided Analgesic Administration in Surgical Subjects (clinicaltrials.gov) -  Nov 2, 2021   
    P=N/A,  N=104, Enrolling by invitation, 
    Based on better sedation and analgesia, monitored anesthesia with dexmedetomidine achieved better patient cooperation, a shorter operative time, and lower adverse events during PKP; however, the MAP and heart rate in the monitored anesthesia group should be closely observed after surgery. Trial completion date: Dec 2021 --> Jan 2023 | Trial primary completion date: Oct 2021 --> Oct 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Effects of Intravenous Anesthesia and Balanced Anesthesia on Flash Visual Evoked Potentials (clinicaltrials.gov) -  Nov 2, 2021   
    P=N/A,  N=84, Recruiting, 
    Trial completion date: Dec 2021 --> Jan 2023 | Trial primary completion date: Oct 2021 --> Oct 2022 Trial completion date: Oct 2021 --> Dec 2022 | Trial primary completion date: Sep 2021 --> Dec 2022
  • ||||||||||  Soliris (eculizumab) / AstraZeneca
    Paroxysmal Nocturnal Hemoglobinuria in the OR: case report ([VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_860;    
    We believe that the induction of anesthesia associated with the surgical stress and the low platelet count could have triggered this complication. Learning points: Managing surgical stress as a key factor.
  • ||||||||||  sevoflurane / Generic mfg., rocuronium / Generic mfg.
    Pediatric polytrauma with massive transfusion and secondary extremity compartment syndrome ([VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_835;    
    Fortunately, most of them were avoided, and she succesfully recovered. Learning points:Early hemostatic resuscitation with blood products is crucial in order to preserve hemodynamic stability and to prevent trauma induced coagulopaty
  • ||||||||||  An unusual presentation of Malignant Hyperthermia (MH) ([VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_827;    
    Maintenance of anaesthesia was with sevoflurane/oxygen/air, combined with a remifentanil infusion...MH was declared and the patient treated in accordance with Association guidance, requiring the use of charcoal filters, dantrolene and onward ICU care for 24 hours...As MH is rare, it is important to share experience of cases to help recognition and management. Ensuring patients receive appropriate follow up is crucial and is the responsibility of the anaesthetist.
  • ||||||||||  sevoflurane / Generic mfg.
    Postoperative shivering following sevoflurane and desflurane anesthesia ([VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_812;    
    Multivariable adjustment was performed using age, gender, BMI, surgical technique, volume of blood loss, operative time, whether flurbiprofen or acetaminophen were administered or not, and peripheral and central temperature at the end of surgery. The occurrence of postoperative shivering was not difference between after sevoflurane and desflurane inhalation anesthetics.
  • ||||||||||  sevoflurane / Generic mfg.
    High-flow nasal cannula oxygen therapy implementation at emergency tracheostomy in the operating room ([VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_807;    
    Inhalation anesthesia was maintained with sevoflurane and 100% FiO2 with bag-mask ventilation under spontaneous ventilation and local anesthetic was infiltrated to the skin by the surgeons...In this case, we used the HFCN after the start of the operation, for improving oxygenation and helping CO2 elimination when the patient’s spontaneous ventilation pattern worsened due to possible hypercarbia.We consider that HFNC improved outcomes in that emergency tracheostomy case. Learning points: HFNC can be useful in emergency situations where airway management is difficult.
  • ||||||||||  ketamine / Generic mfg.
    Medium-chain acyl-CoA dehydrogenase deficiency (MCADD): The importance of anesthetic approach ([VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_746;    
    Sevoflurane was used for maintenance and sugammadex 50mg was administered for complete reversal of the block...Althout not contraindicated, anesthesiologist should consider risk:benefit of agents such as volatile anesthetics, propofol and neuromuscular blocking agents, because these patients may present hypotonia and impaired hepatic metabolism with prolonged effect of many drugs and increased risk of propofol infusion syndrome. In case of use, adequate neuromuscular blocking monitorization should also be applied.
  • ||||||||||  sevoflurane / Generic mfg.
    Investigation of the DNA methylation profile in children presenting emergence delirium (Channel 1 - ePosters [VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_682;    
    Premilinary Results of this currently underpowered study suggest that patients with lower intraoperative average α power might have a higher risk of developing POD after cardiac surgery  Our Results suggest that DNA methylation profiles may present significant differences between children with emergence delirium and controls, including specific genomic regions. Therefore, we emphasize the importance of investigating and identifying epigenetic alterations to understand this relevant clinical adverse event.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Accidental overheating of a child during ear surgery (Channel 1 - ePosters [VIRTUAL]) -  Oct 31, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_679;    
    Learning points: Be aware that the choice of the type of temperature monitoring can affect the perioperative outcomes. Keep in mind the differential diagnoses facing a hyperthermia.