sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  Anesthesia and Postoperative Outcome in Colorectal Cancer Patients (clinicaltrials.gov) -  Jan 20, 2022   
    P1,  N=450, Recruiting, 
    However, Aβ and anesthetics affected neuronal activity in vitro, whereby xenon showed beneficial effects on Aβ 1-42 aggregation, LTP, and spine density. Trial primary completion date: Dec 2020 --> Aug 2022
  • ||||||||||  Trial completion, Enrollment change, Epigenetic controller:  EPOPED: Epigenetics in PostOperative Pediatric Emergence Delirium (clinicaltrials.gov) -  Jan 20, 2022   
    P=N/A,  N=175, Completed, 
    Trial primary completion date: Dec 2020 --> Aug 2022 Recruiting --> Completed | N=322 --> 175
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Takotsubo syndrome as an overlooked and elusive cause of a single episode of dyspnea in young women: a case report. (Pubmed Central) -  Jan 19, 2022   
    When atypical symptoms, such as transient dyspnea, manifest, it becomes necessary to suspect and diagnose Takotsubo syndrome to ensure timely and appropriate medical management, especially when a preceding stressful event, such as minor surgery has occurred. It might be helpful to perform bedside point-of-care echocardiography to check for regional wall motion abnormalities that are typically associated with Takotsubo syndrome.
  • ||||||||||  sevoflurane / Generic mfg.
    Biomarker, Retrospective data, Journal:  Inflammatory Biomarker Levels After Propofol or Sevoflurane Anesthesia: A Meta-analysis. (Pubmed Central) -  Jan 19, 2022   
    This absence of an effect suggests that patient and surgical variables may have a far more significant impact on the postoperative inflammatory responses than anesthetic technique. The majority of studies assessing perioperative cognition in older patients reported a benefit associated with the use of propofol; however, larger trials using homogenous outcomes are needed to demonstrate such an effect.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane-Induced miR-211-5p Promotes Neuronal Apoptosis by Inhibiting Efemp2. (Pubmed Central) -  Jan 18, 2022   
    In conclusion, sevoflurane-induced miR-211-5p promotes neuronal apoptosis via Efemp2 inhibition. Summary statement: This study revealed the significance of sevoflurane-induced increases in miR-211-5p on the promotion of neuronal apoptosis via inhibition of Efemp2 and its downstream targets.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  ICU sedation with sevoflurane: Clinical trial or n=1 experiment? (Pubmed Central) -  Jan 18, 2022   
    Summary statement: This study revealed the significance of sevoflurane-induced increases in miR-211-5p on the promotion of neuronal apoptosis via inhibition of Efemp2 and its downstream targets. No abstract available
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal, IO biomarker:  Effects of Sevoflurane on Apoptosis of Myocardial Cells in IRI Rats. (Pubmed Central) -  Jan 18, 2022   
    The expression of adhesion proteins such as intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in myocardium treated with sevoflurane was higher than that in myocardium treated with hypoxia, suggesting better connectivity of the myocardium. Sevoflurane treatment reduced the apoptosis of myocardial cells after hypoxia treatment.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Effects of Sevoflurane and Propofol Anesthesia on Cerebral Oxygenation in Patients Undergoing Carotid Endarterectomy. (Pubmed Central) -  Jan 14, 2022   
    Our NIRS monitoring results indicate that sevoflurane or propofol anesthesia does not generally cause significant differences in cerebral oxygenation during and after cross-clamping in patients undergoing CEA. The finding of sex-related differences in cerebral oxygenation in patients receiving propofol and decreased oxygenation during extubation in patients receiving sevoflurane warrants further studies.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Monitoring of Anesthesia by Bispectral Analysis of EEG Signals. (Pubmed Central) -  Jan 12, 2022   
    We showed that the BIS value must be maintained during the operation and the anesthesia at a value greater than 60. This study showed that the BIS technology led to an optimization of the anesthetic management, the adequacy of the hypnotic dosage, and a better postoperative recovery.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Clinical, Journal:  Validation of a new approach for distinguishing anesthetized from awake state in patients using directed transfer function applied to raw EEG. (Pubmed Central) -  Jan 8, 2022   
    We test whether a measure based on the directed transfer function (DTF) calculated from short segments of electroencephalography (EEG) time-series can be used to monitor the state of the patients also during sevoflurane anesthesia as it can for patients undergoing propofol anesthesia...The resulting connectivity parameters were compared to corresponding parameters from our previous study (n = 8, patients anesthetized with propofol and remifentanil, but otherwise using a similar protocol)...Optimizing the algorithm for simultaneously having high sensitivity and specificity in classification yielded an accuracy of 95.1% (SE = 0.96%), with sensitivity of 98.4% (SE = 0.80%) and specificity of 94.8% (SE = 0.10%). These findings indicate that the DTF changes in a similar manner when humans undergo general anesthesia caused by two distinct anesthetic agents with different molecular mechanisms of action.
  • ||||||||||  ketamine / Generic mfg.
    Journal:  Comparison of the Conox (qCON) and Sedline (PSI) depth of anaesthesia indices to predict the hypnotic effect during desflurane general anaesthesia with ketamine. (Pubmed Central) -  Jan 8, 2022   
    However, during desflurane anesthesia the qCON index did not change significantly after ketamine administration, qCON (before = 33 (4), after = 30 (17); Wilcoxon, p = 0.89), while the PSI experienced a significant increase, PSI (before = 31(6), after = 39(16) Wilcoxon, p = 0.013).This study shows that qCON and PSI have similar performance under desflurane with good discrimination between the awake and anesthetized states. While both indices exhibited similar behavior under ketamine boluses under a sevoflurane-propofol anesthesia, the qCON index had a better performance under ketamine during desflurane anesthesia.
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation. (Pubmed Central) -  Jan 8, 2022   
    Inhalational and intravenous anesthetics can alter cancer cell biology through various cellular signaling pathways induced by miRNAs' modification. However, this area of research is insufficient and further study is needed to figure out optimal anesthesia regimens for cancer patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  The potential role of stress and sex steroids in heritable effects of sevoflurane. (Pubmed Central) -  Jan 5, 2022   
    This minireview is focused on the authors' published results and data in the literature supporting the notion that GABAergic GAs, in particular sevoflurane, may upregulate systemic levels of stress and sex steroids and alter expressions of genes that are essential for the functioning of these steroid systems. The authors hypothesize that stress and sex steroids are involved in the mediation of sex-specific heritable effects of sevoflurane.
  • ||||||||||  lithium carbonate ER / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. (Pubmed Central) -  Jan 4, 2022   
    In addition, lithium chloride reduced hippocampal neuron apoptosis and oxidative stress induced by sevoflurane anesthesia. These results suggest that lithium chloride may have potential for development into a therapeutic agent for treatment of sevoflurane anesthesia-induced cognitive dysfunction.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  NF-kB signaling in cardiomyocytes is inhibited by sevoflurane and promoted by propofol. (Pubmed Central) -  Jan 4, 2022   
    Moreover, nuclear accumulation of p65 and transcription of NF-kB-regulated genes were suppressed in sevoflurane-administered mice, suggesting that sevoflurane inhibits the NF-kB signaling pathway. Our data demonstrate that NF-kB signaling is inhibited by sevoflurane and promoted by propofol. As NF-kB signaling plays an important role in myocardial remodeling, our results suggest that anesthetics may affect myocardial remodeling through NF-kB.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Changes of Neuronal Plasticity in Postoperative Cognitive Dysfunction (POCD). (Pubmed Central) -  Jan 4, 2022   
    The increase in the presynapse release ability indicated the glutamatergic neuron abnormalities without altering the GABAergic neuron's function. Our result suggested that postoperative cognitive dysfunctions may be related to surgical trauma and glutamate neurons abnormalities.