sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Effects of Propofol Versus Sevoflurane on Postoperative Breast Cancer Prognosis: A Narrative Review. (Pubmed Central) -  Feb 8, 2022   
    Furthermore, recent prospective studies did not identify significant differences between propofol and sevoflurane in breast cancer metastasis and recurrence. Therefore, more preclinical studies and randomized controlled studies are needed to guide the choice of anesthetics for breast cancer patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Aggravates the Progress of Alzheimer's Disease Through NLRP3/Caspase-1/Gasdermin D Pathway. (Pubmed Central) -  Feb 8, 2022   
    This study is the first to report that clinical doses of sevoflurane aggravate the progression of AD via the NLRP3/caspase-1/GSDMD axis. Collectively, our findings elucidate the crucial mechanisms of NLRP3/caspase-1 in pyroptosis and tau pathogenesis induced by sevoflurane and suggest that VX-765 could represent a novel therapeutic intervention for treating AD.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Surgery:  Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication (clinicaltrials.gov) -  Feb 7, 2022   
    P=N/A,  N=40, Completed, 
    Collectively, our findings elucidate the crucial mechanisms of NLRP3/caspase-1 in pyroptosis and tau pathogenesis induced by sevoflurane and suggest that VX-765 could represent a novel therapeutic intervention for treating AD. Recruiting --> Completed
  • ||||||||||  glibenclamide / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  Glibenclamide Ameliorates the Expression of Neurotrophic Factors in Sevoflurane Anaesthesia-induced Oxidative Stress and Cognitive Impairment in Hippocampal Neurons of Old Rats. (Pubmed Central) -  Feb 4, 2022   
    Time spent in the quadrant and crossing axis and the percentage of spontaneous alterations showed a substantial decrease in the low-dose Sevo group which received GBC at 10 mg/kg b.w. Significant increases were shown in IL-6 and TNF-α levels in the low-dose Sevo group, whereas a decrease was evident in the GBC group. Our results indicate that glibenclamide may be a novel drug to prevent sevoflurane inhalation-induced impaired learning and reduce brain-derived neurotrophic factor release, which may be a vital target for the development of potential therapies for cognitive deficits and neurodegeneration.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Effects of Apolipoprotein Ε ε4 allele on early postoperative cognitive dysfunction after anesthesia. (Pubmed Central) -  Feb 3, 2022   
    Our results indicate that glibenclamide may be a novel drug to prevent sevoflurane inhalation-induced impaired learning and reduce brain-derived neurotrophic factor release, which may be a vital target for the development of potential therapies for cognitive deficits and neurodegeneration. The results of the study indicated that the ApoΕ ε4/ε4 genotype was a risk factor for early POCD in older patients undergoing sevoflurane anesthesia.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  The Effect of Intraoperative Music Listening on Sevoflurane Consumption and Recovery Parameters (clinicaltrials.gov) -  Feb 1, 2022   
    P=N/A,  N=60, Recruiting, 
    In rabbits, fetal surgery through hysterotomy under maternal general anesthesia does not affect brain development, in addition to the effects of general anesthesia per se. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Increased resting state connectivity in the anterior default mode network of idiopathic epileptic dogs. (Pubmed Central) -  Jan 28, 2022   
    Group level independent component analysis with dimensionality of 20 components, dual regression and two-sample t test were performed and revealed significantly increased functional connectivity in the anterior default mode network of idiopathic epileptic dogs compared to healthy control dogs (p = 0.00060). This group level differences between epileptic dogs and healthy control dogs identified using a rather simple data driven approach could serve as a starting point for more advanced resting state network analysis in epileptic dogs.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Trial initiation date, Trial primary completion date:  Effect of Propfol Versus Sevoflurane on Auditory and Cognitive Function (clinicaltrials.gov) -  Jan 28, 2022   
    P1,  N=80, Completed, 
    This group level differences between epileptic dogs and healthy control dogs identified using a rather simple data driven approach could serve as a starting point for more advanced resting state network analysis in epileptic dogs. Recruiting --> Completed | Trial completion date: Aug 2021 --> Dec 2021 | Initiation date: Jan 2021 --> Jun 2021 | Trial primary completion date: Jul 2021 --> Dec 2021
  • ||||||||||  Review, Journal:  Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives. (Pubmed Central) -  Jan 27, 2022   
    This review summarized the current research about the effects of different anesthetics in regulating cancer, with a particular emphasis on the role of miRNAs. A significant number of studies conducted in this area of research illuminate the effects of anesthetics on the regulation of miRNA expression; therefore, we hope that a thorough understanding of the underlying mechanisms involved in the regulation of miRNA in the context of anesthesia-induced cancer regulation could help to define optimal anesthetic regimens and provide better perspectives for further studies.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Triiodothyronine attenuates neurocognitive dysfunction induced by sevoflurane in the developing brain of neonatal rats. (Pubmed Central) -  Jan 27, 2022   
    A significant number of studies conducted in this area of research illuminate the effects of anesthetics on the regulation of miRNA expression; therefore, we hope that a thorough understanding of the underlying mechanisms involved in the regulation of miRNA in the context of anesthesia-induced cancer regulation could help to define optimal anesthetic regimens and provide better perspectives for further studies. A potential therapeutic role of T3 in protecting general anaesthetic induced neuronal injury in the developing brain is likely to occur through enhancing expression of PSD-95 and the NMDA NR2A and NR2B expression.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal, IO biomarker:  Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice. (Pubmed Central) -  Jan 26, 2022   
    Western blot demonstrated that the expression of Bax, LC3II, P62 and KIF3B proteins were elevated, and the expression of Bcl-2 and DIC proteins were reduced in the sevoflurane group. Sevoflurane impaired acquisition learning and memory function, promoted the apoptosis of hippocampal neurons in APPswe/PS1ΔE9 double-transgenic mice, and the mechanism might be related to the activation of autophagy along with the disruption of autophagosomes retrograde transport in axons.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Evaluation of Anesthetic Specific EEG Dynamics during State Transitions between Loss and Return of Responsiveness. (Pubmed Central) -  Jan 26, 2022   
    Sevoflurane impaired acquisition learning and memory function, promoted the apoptosis of hippocampal neurons in APPswe/PS1ΔE9 double-transgenic mice, and the mechanism might be related to the activation of autophagy along with the disruption of autophagosomes retrograde transport in axons. our results highlight substance-specific differences in the emergence from anesthesia that can influence the EEG-based monitoring that probably have to be considered in order to improve neuromonitoring during general anesthesia.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  FESSSPI: SPI-guided Analgesia During FESS for Intraoperative Blood Loss (clinicaltrials.gov) -  Jan 25, 2022   
    P=N/A,  N=120, Recruiting, 
    There was no difference in short- or long-term postoperative analgesia. Trial completion date: Jul 2021 --> Jul 2023 | Trial primary completion date: Jul 2021 --> Jul 2023
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  ANI Versus Standard Care in Surgical Patients Receiving Balanced Sevoflurane-Fentanyl Anesthesia (clinicaltrials.gov) -  Jan 25, 2022   
    P=N/A,  N=60, Active, not recruiting, 
    Trial completion date: Jul 2021 --> Jul 2023 | Trial primary completion date: Jul 2021 --> Jul 2023 Trial completion date: Dec 2021 --> Jun 2022 | Trial primary completion date: Dec 2021 --> Jun 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  microRNA-148a-3p enhances the effects of sevoflurane on hepatocellular carcinoma cell progression via ROCK1 repression. (Pubmed Central) -  Jan 20, 2022   
    Our results demonstrate the time-dependent effects of common volatile anesthetics and implicate that desflurane has the potential benefits to prolonged anesthetic exposure in AD patients. Our study elucidates that microRNA-148a-3p enhances the effects of sevoflurane on inhibiting proliferation, invasion and migration and enhancing apoptosis of HCC cells through suppression of ROCK1.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  Anesthesia and Postoperative Outcome in Colorectal Cancer Patients (clinicaltrials.gov) -  Jan 20, 2022   
    P1,  N=450, Recruiting, 
    However, Aβ and anesthetics affected neuronal activity in vitro, whereby xenon showed beneficial effects on Aβ 1-42 aggregation, LTP, and spine density. Trial primary completion date: Dec 2020 --> Aug 2022