- |||||||||| sevoflurane / Generic mfg.
Journal: Sevoflurane Aggravates the Progress of Alzheimer's Disease Through NLRP3/Caspase-1/Gasdermin D Pathway. (Pubmed Central) - Feb 8, 2022 This study is the first to report that clinical doses of sevoflurane aggravate the progression of AD via the NLRP3/caspase-1/GSDMD axis. Collectively, our findings elucidate the crucial mechanisms of NLRP3/caspase-1 in pyroptosis and tau pathogenesis induced by sevoflurane and suggest that VX-765 could represent a novel therapeutic intervention for treating AD.
- |||||||||| glibenclamide / Generic mfg., sevoflurane / Generic mfg.
Preclinical, Journal: Glibenclamide Ameliorates the Expression of Neurotrophic Factors in Sevoflurane Anaesthesia-induced Oxidative Stress and Cognitive Impairment in Hippocampal Neurons of Old Rats. (Pubmed Central) - Feb 4, 2022 Time spent in the quadrant and crossing axis and the percentage of spontaneous alterations showed a substantial decrease in the low-dose Sevo group which received GBC at 10 mg/kg b.w. Significant increases were shown in IL-6 and TNF-α levels in the low-dose Sevo group, whereas a decrease was evident in the GBC group. Our results indicate that glibenclamide may be a novel drug to prevent sevoflurane inhalation-induced impaired learning and reduce brain-derived neurotrophic factor release, which may be a vital target for the development of potential therapies for cognitive deficits and neurodegeneration.
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Journal: Effects of Apolipoprotein Ε ε4 allele on early postoperative cognitive dysfunction after anesthesia. (Pubmed Central) - Feb 3, 2022 Our results indicate that glibenclamide may be a novel drug to prevent sevoflurane inhalation-induced impaired learning and reduce brain-derived neurotrophic factor release, which may be a vital target for the development of potential therapies for cognitive deficits and neurodegeneration. The results of the study indicated that the ApoΕ ε4/ε4 genotype was a risk factor for early POCD in older patients undergoing sevoflurane anesthesia.
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Trial completion date, Trial primary completion date: The Effect of Intraoperative Music Listening on Sevoflurane Consumption and Recovery Parameters (clinicaltrials.gov) - Feb 1, 2022 P=N/A, N=60, Recruiting, In rabbits, fetal surgery through hysterotomy under maternal general anesthesia does not affect brain development, in addition to the effects of general anesthesia per se. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Dec 2021 --> Dec 2022
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Journal: Increased resting state connectivity in the anterior default mode network of idiopathic epileptic dogs. (Pubmed Central) - Jan 28, 2022 Group level independent component analysis with dimensionality of 20 components, dual regression and two-sample t test were performed and revealed significantly increased functional connectivity in the anterior default mode network of idiopathic epileptic dogs compared to healthy control dogs (p = 0.00060). This group level differences between epileptic dogs and healthy control dogs identified using a rather simple data driven approach could serve as a starting point for more advanced resting state network analysis in epileptic dogs.
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Trial completion, Trial completion date, Trial initiation date, Trial primary completion date: Effect of Propfol Versus Sevoflurane on Auditory and Cognitive Function (clinicaltrials.gov) - Jan 28, 2022 P1, N=80, Completed, This group level differences between epileptic dogs and healthy control dogs identified using a rather simple data driven approach could serve as a starting point for more advanced resting state network analysis in epileptic dogs. Recruiting --> Completed | Trial completion date: Aug 2021 --> Dec 2021 | Initiation date: Jan 2021 --> Jun 2021 | Trial primary completion date: Jul 2021 --> Dec 2021
- |||||||||| Review, Journal: Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives. (Pubmed Central) - Jan 27, 2022
This review summarized the current research about the effects of different anesthetics in regulating cancer, with a particular emphasis on the role of miRNAs. A significant number of studies conducted in this area of research illuminate the effects of anesthetics on the regulation of miRNA expression; therefore, we hope that a thorough understanding of the underlying mechanisms involved in the regulation of miRNA in the context of anesthesia-induced cancer regulation could help to define optimal anesthetic regimens and provide better perspectives for further studies.
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Preclinical, Journal: Triiodothyronine attenuates neurocognitive dysfunction induced by sevoflurane in the developing brain of neonatal rats. (Pubmed Central) - Jan 27, 2022 A significant number of studies conducted in this area of research illuminate the effects of anesthetics on the regulation of miRNA expression; therefore, we hope that a thorough understanding of the underlying mechanisms involved in the regulation of miRNA in the context of anesthesia-induced cancer regulation could help to define optimal anesthetic regimens and provide better perspectives for further studies. A potential therapeutic role of T3 in protecting general anaesthetic induced neuronal injury in the developing brain is likely to occur through enhancing expression of PSD-95 and the NMDA NR2A and NR2B expression.
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Preclinical, Journal, IO biomarker: Blocking retrograde axonal transport of autophagosomes contributes to sevoflurane-induced neuron apoptosis in APP/PS1 mice. (Pubmed Central) - Jan 26, 2022 Western blot demonstrated that the expression of Bax, LC3II, P62 and KIF3B proteins were elevated, and the expression of Bcl-2 and DIC proteins were reduced in the sevoflurane group. Sevoflurane impaired acquisition learning and memory function, promoted the apoptosis of hippocampal neurons in APPswe/PS1ΔE9 double-transgenic mice, and the mechanism might be related to the activation of autophagy along with the disruption of autophagosomes retrograde transport in axons.
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Journal: Evaluation of Anesthetic Specific EEG Dynamics during State Transitions between Loss and Return of Responsiveness. (Pubmed Central) - Jan 26, 2022 Sevoflurane impaired acquisition learning and memory function, promoted the apoptosis of hippocampal neurons in APPswe/PS1ΔE9 double-transgenic mice, and the mechanism might be related to the activation of autophagy along with the disruption of autophagosomes retrograde transport in axons. our results highlight substance-specific differences in the emergence from anesthesia that can influence the EEG-based monitoring that probably have to be considered in order to improve neuromonitoring during general anesthesia.
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Trial completion date, Trial primary completion date, Surgery: FESSSPI: SPI-guided Analgesia During FESS for Intraoperative Blood Loss (clinicaltrials.gov) - Jan 25, 2022 P=N/A, N=120, Recruiting, There was no difference in short- or long-term postoperative analgesia. Trial completion date: Jul 2021 --> Jul 2023 | Trial primary completion date: Jul 2021 --> Jul 2023
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Trial primary completion date: Anesthesia and Postoperative Outcome in Colorectal Cancer Patients (clinicaltrials.gov) - Jan 20, 2022 P1, N=450, Recruiting, However, Aβ and anesthetics affected neuronal activity in vitro, whereby xenon showed beneficial effects on Aβ 1-42 aggregation, LTP, and spine density. Trial primary completion date: Dec 2020 --> Aug 2022
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