- |||||||||| sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Trial completion date, Trial primary completion date: Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane (clinicaltrials.gov) - Apr 6, 2022 P4, N=180, Recruiting, Solasonine alleviates sevoflurane-induced neurotoxicity through activating the AMPK/FoxO3a signaling pathway. Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
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Preclinical, Journal: Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. (Pubmed Central) - Apr 5, 2022 Treatment with small molecule inhibitors targeting RPTP β/ζ inhibited sevoflurane-induced neuroinflammation. In summary, pleiotrophin was shown to potentiate sevoflurane anesthesia-induced cognitive dysfunction and learning deficits in mice.
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Clinical, Journal: On no man's land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents. (Pubmed Central) - Apr 5, 2022 Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.
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Journal: LncRNA Riken Attenuated Sevoflurane-Induced Neuroinflammation by Regulating the MicroRNA-101a/MKP-1/JNK Pathway. (Pubmed Central) - Apr 5, 2022 Finally, we also demonstrated that MAPK phosphatase 1 (MKP-1) was a downstream target of miR-101a, and lncRNA Riken can regulate the expression of MKP-1; the JNK signal transduction pathway has been implicated in sevoflurane-induced IL-6 secretion. Our findings demonstrated that lncRNA Riken alleviated the sevoflurane-induced neurotoxic effects, and the lncRNA Riken/miR-101a/MKP-1/JNK axis plays an important role in the cognitive disorder.
- |||||||||| progesterone / Generic mfg., sevoflurane / Generic mfg.
Journal: Does inflammation mediate behavioural alterations in anaesthesia-induced developmental neurotoxicity? (Pubmed Central) - Apr 5, 2022 The protective mechanism is proposed to relate to anti-inflammatory properties of progesterone, which brings up important questions regarding the role of inflammation in mediating the neurobehavioural alterations in anaesthesia-induced developmental neurotoxicity. We discuss this mechanism and encourage new research that may clarify the underlying mechanisms of progesterone-induced protection and extend these findings into a translational model.
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Journal: Analysis of Influencing Factors of Serum Stress Index and Prognosis of HICH Patients by Different Anesthesia Methods Combined with Small Bone Window Microsurgery. (Pubmed Central) - Apr 5, 2022 Sevoflurane interventional anesthesia has a high anesthetic effect in small bone window microsurgery, which has positive effects on controlling blood pressure of HICH patients, shortening postoperative recovery time and improving patients' stress response and neurological function. This paper conducts an in-depth analysis of the prognosis of HICH patients, indicating that the prognosis of HICH patients is closely related to their serum stress indicators T-AOC, GSH-Px, MDA, and 8-OHDG, providing a new direction for follow-up clinical diagnosis and treatment of HICH patients and accurate prognosis assessment.
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Journal: Perioperative Anesthesia and Acute Smell Alterations in Spine Surgery: A "Sniffing Impairment" Influencing Refeeding? (Pubmed Central) - Apr 5, 2022 This research aims to observe detectable dysosmias after spine surgery, to explore any amplified affection of halogenates (DESflurane and SEVoflurane) against total intravenous anesthesia (TIVA), and to spot potential repercussions on the refeeding...These results confirmed the evidence on inhalation anesthetics to cause smell alterations in spine patients. Furthermore, the poor early oral intake after complex procedures suggests that spinal deformity surgery could be a practical challenge to early oral nutrition.
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Enrollment open: Comparison of Sedation by Esketamine and Sevoflurane (clinicaltrials.gov) - Apr 5, 2022 P4, N=60, Enrolling by invitation, Trial primary completion date: Feb 2022 --> Jun 2022 Not yet recruiting --> Enrolling by invitation
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Journal, IO biomarker: The Role of Klotho Protein Against Sevoflurane-Induced Neuronal Injury. (Pubmed Central) - Apr 1, 2022 While overexpression of Klotho alleviated the above changes, knockdown of Klotho aggravated the injury of sevoflurane. Klotho protein could reduce oxidative stress and mitochondrial injury induced by sevoflurane in the neuron.
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Journal: Role of P2X4/NLRP3 Pathway-Mediated Neuroinflammation in Perioperative Neurocognitive Disorders. (Pubmed Central) - Apr 1, 2022 12-14-month-old male C57BL/6 mice undergoing open tibial fracture surgery by sevoflurane anesthesia were administered P2X4R inhibitor 5-BDBD or saline was intraperitoneally for 3 consecutive days after surgery...However, intraperitoneal injection of 5-BDBD attenuated these effects. In conclusion, these findings indicated that the P2X4/NLRP3 pathway might be involved in the pathophysiology of PND.
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Journal: Effect of Flumazenil on Emergence Agitation after Orthognathic Surgery: A Randomized Controlled Trial. (Pubmed Central) - Mar 26, 2022 There were no significant differences in the time intervals between the discontinuation of anesthetics, first response, and extubation. Although flumazenil did not reduce the incidence of emergence agitation in patients undergoing orthognathic surgery with sevoflurane anesthesia, it can be considered as an option for awakening patients in terms of improving emergence profiles.
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Journal: Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane. (Pubmed Central) - Mar 25, 2022 Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub-state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery.
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Journal: Opioid-free versus opioid-based anesthesia in pancreatic surgery. (Pubmed Central) - Mar 24, 2022 OFA included a combination of continuous infusions of dexmedetomidine, lidocaine, and esketamine...All patients received intraoperative propofol, sevoflurane, dexamethasone, diclofenac, neuromuscular blockade...In this series, OFA during pancreatic resection is feasible and independently associated with a better outcome, in particular pain outcomes. The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay.
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Journal: Sevoflurane suppresses glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis. (Pubmed Central) - Mar 23, 2022 The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay. Sevoflurane repressed glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis, suggesting a new insight into the application of sevoflurane in glioma therapy.
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Preclinical, Journal, IO biomarker: Role of RGS2 in sevoflurane-induced cognitive dysfunction in aged rats. (Pubmed Central) - Mar 23, 2022 After continuous inhalation of 3% sevoflurane for 8h, the expression of RGS2 in the hippocampi of aged rats is down regulated. RGS2 may be an important factor that leads to cognitive dysfunction in rats.
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STATUS ASTHMATICUS BREAKS WITH SEVOFLURANE WHILE ON VENOVENOUS EXTRACORPOREAL MEMBRANE OXYGENATION ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_2156; VV ECMO and inhaled anesthetics remain non-conventional therapies for SA due to resources, potential side-effects, difficulty scavenging sevoflurane in the ICU, and lack of guidelines. Our case illustrates the successful use of sevoflurane to break severe bronchospasm in a patient with refractory SA while VV ECMO allowed adequate gas exchange and lung protection.
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