sevoflurane / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 13 Diseases   542 Trials   542 Trials   5582 News 


«12...2728293031323334353637...9293»
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  The neuroprotective mechanism of sevoflurane in rats with traumatic brain injury via FGF2. (Pubmed Central) -  Apr 8, 2022   
    SEV inhibited the malignant progression of glioma cells partly by regulating the circ_0037655/miR-130a-5p/RPN2 axis. Our results provided a novel insight to the neuroprotective mechanism of Sevo in TBI rats by downregulating HES1 via FGF2/EZH2 axis activation.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane (clinicaltrials.gov) -  Apr 6, 2022   
    P4,  N=180, Recruiting, 
    Solasonine alleviates sevoflurane-induced neurotoxicity through activating the AMPK/FoxO3a signaling pathway. Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Pleiotrophin Potentiates Sevoflurane Anesthesia-induced Learning Deficits in Mice. (Pubmed Central) -  Apr 5, 2022   
    Treatment with small molecule inhibitors targeting RPTP β/ζ inhibited sevoflurane-induced neuroinflammation. In summary, pleiotrophin was shown to potentiate sevoflurane anesthesia-induced cognitive dysfunction and learning deficits in mice.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Clinical, Journal:  On no man's land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents. (Pubmed Central) -  Apr 5, 2022   
    Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  LncRNA Riken Attenuated Sevoflurane-Induced Neuroinflammation by Regulating the MicroRNA-101a/MKP-1/JNK Pathway. (Pubmed Central) -  Apr 5, 2022   
    Finally, we also demonstrated that MAPK phosphatase 1 (MKP-1) was a downstream target of miR-101a, and lncRNA Riken can regulate the expression of MKP-1; the JNK signal transduction pathway has been implicated in sevoflurane-induced IL-6 secretion. Our findings demonstrated that lncRNA Riken alleviated the sevoflurane-induced neurotoxic effects, and the lncRNA Riken/miR-101a/MKP-1/JNK axis plays an important role in the cognitive disorder.
  • ||||||||||  progesterone / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Does inflammation mediate behavioural alterations in anaesthesia-induced developmental neurotoxicity? (Pubmed Central) -  Apr 5, 2022   
    The protective mechanism is proposed to relate to anti-inflammatory properties of progesterone, which brings up important questions regarding the role of inflammation in mediating the neurobehavioural alterations in anaesthesia-induced developmental neurotoxicity. We discuss this mechanism and encourage new research that may clarify the underlying mechanisms of progesterone-induced protection and extend these findings into a translational model.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Analysis of Influencing Factors of Serum Stress Index and Prognosis of HICH Patients by Different Anesthesia Methods Combined with Small Bone Window Microsurgery. (Pubmed Central) -  Apr 5, 2022   
    Sevoflurane interventional anesthesia has a high anesthetic effect in small bone window microsurgery, which has positive effects on controlling blood pressure of HICH patients, shortening postoperative recovery time and improving patients' stress response and neurological function. This paper conducts an in-depth analysis of the prognosis of HICH patients, indicating that the prognosis of HICH patients is closely related to their serum stress indicators T-AOC, GSH-Px, MDA, and 8-OHDG, providing a new direction for follow-up clinical diagnosis and treatment of HICH patients and accurate prognosis assessment.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Perioperative Anesthesia and Acute Smell Alterations in Spine Surgery: A "Sniffing Impairment" Influencing Refeeding? (Pubmed Central) -  Apr 5, 2022   
    This research aims to observe detectable dysosmias after spine surgery, to explore any amplified affection of halogenates (DESflurane and SEVoflurane) against total intravenous anesthesia (TIVA), and to spot potential repercussions on the refeeding...These results confirmed the evidence on inhalation anesthetics to cause smell alterations in spine patients. Furthermore, the poor early oral intake after complex procedures suggests that spinal deformity surgery could be a practical challenge to early oral nutrition.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open:  Comparison of Sedation by Esketamine and Sevoflurane (clinicaltrials.gov) -  Apr 5, 2022   
    P4,  N=60, Enrolling by invitation, 
    Trial primary completion date: Feb 2022 --> Jun 2022 Not yet recruiting --> Enrolling by invitation
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane Preconditioning Increases Stress Resistance via IMB-2/DAF-16 in Caenorhabditis Elegans. (Pubmed Central) -  Apr 2, 2022   
    Furthermore, suppression of IMB-2 by RNAi prevented the upregulation of DAF-16 and enhancement of stress resistance caused by sevoflurane preconditioning. Overall, this work reveals that sevoflurane preconditioning increases the expression of DAF-16 via IMB-2 to enhance the stress resistance of C.elegans.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, IO biomarker:  The Role of Klotho Protein Against Sevoflurane-Induced Neuronal Injury. (Pubmed Central) -  Apr 1, 2022   
    While overexpression of Klotho alleviated the above changes, knockdown of Klotho aggravated the injury of sevoflurane. Klotho protein could reduce oxidative stress and mitochondrial injury induced by sevoflurane in the neuron.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Role of P2X4/NLRP3 Pathway-Mediated Neuroinflammation in Perioperative Neurocognitive Disorders. (Pubmed Central) -  Apr 1, 2022   
    12-14-month-old male C57BL/6 mice undergoing open tibial fracture surgery by sevoflurane anesthesia were administered P2X4R inhibitor 5-BDBD or saline was intraperitoneally for 3 consecutive days after surgery...However, intraperitoneal injection of 5-BDBD attenuated these effects. In conclusion, these findings indicated that the P2X4/NLRP3 pathway might be involved in the pathophysiology of PND.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Effect of Flumazenil on Emergence Agitation after Orthognathic Surgery: A Randomized Controlled Trial. (Pubmed Central) -  Mar 26, 2022   
    There were no significant differences in the time intervals between the discontinuation of anesthetics, first response, and extubation. Although flumazenil did not reduce the incidence of emergence agitation in patients undergoing orthognathic surgery with sevoflurane anesthesia, it can be considered as an option for awakening patients in terms of improving emergence profiles.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane. (Pubmed Central) -  Mar 25, 2022   
    Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub-state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Opioid-free versus opioid-based anesthesia in pancreatic surgery. (Pubmed Central) -  Mar 24, 2022   
    OFA included a combination of continuous infusions of dexmedetomidine, lidocaine, and esketamine...All patients received intraoperative propofol, sevoflurane, dexamethasone, diclofenac, neuromuscular blockade...In this series, OFA during pancreatic resection is feasible and independently associated with a better outcome, in particular pain outcomes. The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane suppresses glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis. (Pubmed Central) -  Mar 23, 2022   
    The lower rate of postoperative complications may justify future randomized trials to test the hypothesis that OFA may improve outcomes and shorten length of stay. Sevoflurane repressed glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis, suggesting a new insight into the application of sevoflurane in glioma therapy.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal, IO biomarker:  Role of RGS2 in sevoflurane-induced cognitive dysfunction in aged rats. (Pubmed Central) -  Mar 23, 2022   
    After continuous inhalation of 3% sevoflurane for 8h, the expression of RGS2 in the hippocampi of aged rats is down regulated. RGS2 may be an important factor that leads to cognitive dysfunction in rats.
  • ||||||||||  sevoflurane / Generic mfg.
    STATUS ASTHMATICUS BREAKS WITH SEVOFLURANE WHILE ON VENOVENOUS EXTRACORPOREAL MEMBRANE OXYGENATION ([VIRTUAL]) -  Mar 23, 2022 - Abstract #SCCM2022SCCM_2156;    
    VV ECMO and inhaled anesthetics remain non-conventional therapies for SA due to resources, potential side-effects, difficulty scavenging sevoflurane in the ICU, and lack of guidelines. Our case illustrates the successful use of sevoflurane to break severe bronchospasm in a patient with refractory SA while VV ECMO allowed adequate gas exchange and lung protection.
  • ||||||||||  Kineret (anakinra) / SOBI
    Journal:  Sevoflurane as Bridge Therapy for Plasma-Exchange and Anakinra in Febrile Infection-Related Epilepsy Syndrome. (Pubmed Central) -  Mar 19, 2022   
    was started seven days after sevoflurane and plasma-exchange had been discontinued, and was effective in ensuring non-recurrence of SE. Sevoflurane as bridge therapy for immunosuppressive treatment could be considered an early, safe and effective option in treating convulsive SE in which an autoimmune-inflammatory etiology can reasonably be hypothesized.