sevoflurane / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 13 Diseases   542 Trials   542 Trials   5582 News 


«12...2627282930313233343536...9293»
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, IO biomarker:  miR-424 inhibits apoptosis and inflammatory responses induced by sevoflurane through TLR4/MyD88/NF-κB pathway. (Pubmed Central) -  Apr 29, 2022   
    In vitro, sevoflurane induces activation of the endogenous TLR4 signaling pathway, thereby promoting apoptosis and inflammatory cytokine expression. Exogenous TLR4 acts as an agonist to stimulate TLR4 signaling, whereas miR-424 inhibits both endogenous and exogenous TLR4 signaling, thereby preserving proliferation and differentiation of neuronal cells.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane and Hypercapnia Blunt the Physiological Variability of Spontaneous Breathing: A Comparative Interventional Study. (Pubmed Central) -  Apr 29, 2022   
    The variability of spontaneous breathing during physiological sleep and sevoflurane-induced anesthesia differed fundamentally, with the volatile agent diminishing markedly the fluctuations in respiratory volume, inspiratory airflow and breathing frequency. These findings may suggest the increased risk of lung derecruitment during procedures under sevoflurane in which spontaneous breathing is maintained.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Disruption of hippocampal P2RX2/CaMKII/NF-κB signaling contributes to learning and memory impairment in C57BL/6 mice induced by surgery plus anesthesia in neonatal period. (Pubmed Central) -  Apr 28, 2022   
    Six-day-old C57BL/6 mice were randomized to receive either anesthesia with 3% sevoflurane, abdominal surgery under the same anesthesia, or the control condition...Together, these results indicate that neonatal surgery plus anesthesia may cause long-term cognitive dysfunction, with potential mechanism of increasing P2RX2 and downstream signaling of phosphorylated-CaMKII and NF-κB. Our findings will promote more studies to assess detrimental effects of surgery and accompanying inflammation, diverse anesthetics and even sleeping deprivation on mouse neurodevelopment and neurobehavioral performance.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Neonatal Anesthesia and Oxidative Stress. (Pubmed Central) -  Apr 24, 2022   
    We review a large body of literature describing oxidative stress to be evident during and immediately following neonatal anesthesia. Moreover, our review suggests that the short-term pathway has a temporally limited effect on oxidative stress, while the long-term pathway can manifest years later due to the altered development of neurons and neurovascular interactions.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis. (Pubmed Central) -  Apr 21, 2022   
    Our results showed that sevoflurane exposure inhibited small conductance Ca-activated potassium channel type2 channel endocytosis in both hippocampi of postnatal day 7 rats and hemagglutinin-tagged small conductance Ca-activated potassium channel type2 channel transfected COS-7 cells and the memory and learning ability was impaired in the juvenile period after sevoflurane exposure to neonatal rats. Herein, our results demonstrated that exposing neonates to sevoflurane caused memory and learning impairment via dysregulating small conductance Ca-activated potassium channel type2 channels endocytosis.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Differential Effects of Sevoflurane Exposure on Long-Term Fear Memory in Neonatal and Adult Rats. (Pubmed Central) -  Apr 21, 2022   
    However, sevoflurane exposure in adult rats has no effects on hippocampus-dependent fear memory and hippocampal synapse density, and the expressions of PSD-95 and kalirin-7 in the adult hippocampus are not significantly altered following sevoflurane treatment. Our results indicate that sevoflurane exposure produces differential effects on long-term fear memory in neonatal and adult rats and that PSD-95 signaling may be involved in the molecular mechanism for early sevoflurane exposure-caused long-term fear memory impairment.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Performance of the bispectral index and electroencephalograph derived parameters of anesthetic depth during emergence from xenon and sevoflurane anesthesia. (Pubmed Central) -  Apr 21, 2022   
    The spectral edge frequency and composite cortical state parameters increased significantly in both groups during emergence. The BIS index is lower at equivalent stages of behavioural response during emergence from xenon anesthesia when compared to sevoflurane anesthesia, most likely due to differences in how these two agents influence the relative beta ratio. The spectral edge frequency and composite cortical state might better reflect emergence from xenon anaesthesia.Clinical trial number and registry Australia New Zealand Clinical Trials Registry Number: ACTRN12618000916246.
  • ||||||||||  morphine sulphate / Generic mfg., tramadol hydrochloride / Generic mfg.
    Journal:  Comparison of the analgesic effects of morphine and tramadol after tumor surgery in dogs. (Pubmed Central) -  Apr 19, 2022   
    Intravenous fentanyl citrate was used for intraoperative analgesia after stabilization of the anesthesia...Pain scores were lower in the morphine group than in the tramadol group during all postoperative processes. As a result, it was determined that tramadol has immediate analgesic effects than morphine; however, morphine provides better analgesia than tramadol.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Inhibition of unfolded protein response prevents post-anesthesia neuronal hyperactivity and synapse loss in aged mice. (Pubmed Central) -  Apr 19, 2022   
    Moreover, we showed that PERK suppression also reversed various molecular and synaptic changes induced by sevoflurane anesthesia, including alterations of synaptic NMDA receptors, tau protein phosphorylation, and dendritic spine loss. Together, these findings suggest that sevoflurane anesthesia causes abnormal UPR in the aged brain, which contributes to neuronal hyperactivity, synapse loss and cognitive decline in aged mice.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Study on the ameliorating effect of miR-221-3p on the nerve cells injury induced by sevoflurane. (Pubmed Central) -  Apr 14, 2022   
    In conclusion, the equilibrated blood sevoflurane concentrations showed a rapid decrease when switching from sevoflurane ventilation for the HL to CPB unless it was introduced to the oxygenator until completion of the switch. Sevoflurane can cause nerve cell injury, and miR-221-3p may promote cell activity and inhibit apoptosis by inhibiting CDKN1B expression, thereby ameliorating cell injury induced by sevoflurane.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal, IO biomarker:  Sevoflurane protects mice from cerebral ischemic injury by regulating microRNA-203-3p/HDAC4/Bcl-2 axis. (Pubmed Central) -  Apr 14, 2022   
    The targeting relation existed between miR-203-3p and HDAC4, as well as between HDAC4 and Bcl-2. It is clearly elucidated that miR-203-3p enhances the protective effects of Sevo on MCAO mice through elevating Bcl-2 and down-regulating HDAC4, potentially and clinically offering an effective treatment method with Sevo for cerebral ischemic injury.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Preclinical, Journal:  Kidney cell DNA damage caused by combined exposure to volatile anaesthetics and 1 Gy or 2 Gy radiotherapy dose in vivo. (Pubmed Central) -  Apr 14, 2022   
    This study confirmed that volatile anaesthetics are capable of damaging DNA, while combined VA and 1 Gy or 2 Gy treatment did not have a synergistic damaging effect on DNA. Further studies on the mechanisms of action are needed to determine the extent of damage in kidney cells after longer periods of observation and how efficiently the cells can recover from exposure to single and multiple doses of volatile anaesthetics and radiotherapy.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Enrollment open:  Nalbuphine Versus Dexmedetomidine for Prevention of Emergence Agitation in Pediatrics (clinicaltrials.gov) -  Apr 8, 2022   
    P4,  N=126, Recruiting, 
    Mitochondrial function remained intact under sevoflurane, suggesting a better metabolic profile than isoflurane or propofol. Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane impedes glioma progression via regulating circ_0000215/miR-1200/NCR3LG1 axis. (Pubmed Central) -  Apr 8, 2022   
    Besides that, rescue assay suggested that circ_0000215 attenuated the inhibitory effects of sevoflurane on glioma cell growth and metastasis, which were reversed by miR-1200 overexpression or NCR3LG1 knockdown. Our study revealed that sevoflurane could suppress glioma tumorigenesis by regulating circ_0000215/miR-1200/NCR3LG1 axis, suggesting a new insight into the therapeutic potential of sevoflurane in glioma treatment.