sevoflurane / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Anesthetic management in acute fatty liver of pregnancy (Poster eBoard 4) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_127;    
    In this case, the presence of coagulopathy dictated the choice of general anesthesia. An early multidisciplinary approach involving obstetricians, anesthesiologist, ICU team and transplantation team allowed for a prompt diagnosis and positive outcome.
  • ||||||||||  sevoflurane / Generic mfg.
    Cerebral autoregulation improves during step-wise increases in blood pressure during anaesthesia (Amber 5) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_84;    
     During general anaesthesia, dynamic CA is dependent on MAP, also within the autoregulatory range. This phenomenon was more pronounced during propofol than during sevoflurane.Figure. Closed circles/solid lines, propofol; open circle/dashed lines, sevoflurane.
  • ||||||||||  Airway management of a paediatric patient with Goldenhar syndrome (Poster eBoard 5) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_36;    
    A ketamine bolus was also administered...Scoliosis, micrognathia and cervical extension restriction are risk factors for a difficult intubation. Reduction of functional, residual capacity and total lung capacity can also lead to ventilation problems.(2)
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Effects of an open lung ventilatory strategy on lung gas exchange during laparoscopic surgery. (Pubmed Central) -  Jun 11, 2022   
    There was no difference between groups in the sevoflurane consumption rate. The efficiency of sevoflurane uptake is not improved by open lung ventilation in laparoscopy, despite improved arterial oxygenation associated with effective and sustained recruitment of low alveolar ventilation-perfusion ratio lung segments.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Trial completion:  VAPOR-C: Volatile Anaesthesia and Perioperative Outcomes Related to Cancer Feasibility Study (clinicaltrials.gov) -  Jun 9, 2022   
    P4,  N=169, Completed, 
    The efficacy of dorsal penile nerve block plus dexmedetomidine anesthesia in pediatric circumcision is better than total inhalational anesthesia with sevoflurane. Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Molecular mechanism of sevoflurane preconditioning based on whole-transcriptome sequencing of Lipopolysaccharide-induced cardiac dysfunction in mice. (Pubmed Central) -  Jun 9, 2022   
    Furthermore, the Competing endogenous RNA (ceRNA) network revealed that 3 of the 13 key genes established the lncRNA-miRNA-mRNA network (ENSMUST00000192774 --- mmu-miR-7a-5p --- Hspa1b, TCONS_00188587 --- mmu-miR-204-3p --- Aff3 and ENSMUST00000138273 --- mmu-miR-1954 --- Ppp1r16b) may be associated with cardioprotection in septic mice. In general, the findings identified 11 potential essential genes (Hsph1, Otud1, Manf, Gbp2b, Stip1, Gbp3, Hspa1b, Aff3, Med12, Kdm4a, Gatad1, Cdkn1a, and Ppp1r16b) and MAPK signaling pathway involved in sevoflurane-induced cardioprotection in septic mice, In particular, sevoflurane may prevent myocardial injury by regulating the lncRNA-miRNA-mRNA network including (ENSMUST00000192774 - mmu-miR-7a-5p - Hspa1b, TCONS_00188587 - mmu-miR-204-3p - Aff3, and ENSMUST00000138273 - mmu-miR-1954 - Ppp1r16b networks) which may be a novel mechanism of sevoflurane-induced cardioprotection.
  • ||||||||||  morphine sulphate / Generic mfg.
    Journal:  Thoracic epidural anaesthesia vs intrathecal morphine in dogs undergoing major thoracic and abdominal surgery: clinical study. (Pubmed Central) -  Jun 5, 2022   
    Intraoperative rescue analgesia (iRA) was fentanyl 1 μg/kg administered if heart rate or mean arterial pressure increased by 30% above the pre-stimulation level...Side effects were urinary retention in 3/18 (16%) TEA group dogs and 2/18 (11%) ITM group dogs and prolonged sedation in 2/18 (11%) in ITM group dogs. TEA and ITM were effective in managing perioperative pain in dogs undergoing thoracic or cranial abdominal surgery.
  • ||||||||||  sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg., dexmedetomidine / Generic mfg.
    Preclinical, Journal:  Effects of anesthetics on expression of dopamine and acetylcholine receptors in the rat brain in vivo. (Pubmed Central) -  Jun 4, 2022   
    There were no significant differences among the groups regarding Drd2 and Chrm1 mRNA expression of each region of the brain. Postsynaptic changes of dopamine D and acetylcholine M receptors due to administration of dexmedetomidine, propofol, midazolam, sevoflurane, and nitrous oxide are unlikely to occur at the doses of each anesthetic used in the present study.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  Electroencephalogram Mechanism of Dexmedetomidine Deepening Sevoflurane Anesthesia. (Pubmed Central) -  Jun 4, 2022   
    After dexmedetomidine infusion, the mean α power peak decreased from 6.09 to 5.43 dB and shifted to a lower frequency, the mean θ bicoherence peak increased from 29.57 to 41.25% and shifted to a lower frequency, and the median α bicoherence peak increased from 41.49 to 46.36% and shifted to a lower frequency. These results demonstrate that dexmedetomidine deepens sevoflurane anesthesia, and enhances α and θ bicoherences while shifting peak values of these bands to lower frequencies through regulating thalamo-cortical reverberation networks probably.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Biomarker, Journal:  Combined sevoflurane-dexmedetomidine and nerve blockade on post-surgical serum oxidative stress biomarker levels in thyroid cancer patients. (Pubmed Central) -  Jun 4, 2022   
    These results demonstrate that dexmedetomidine deepens sevoflurane anesthesia, and enhances α and θ bicoherences while shifting peak values of these bands to lower frequencies through regulating thalamo-cortical reverberation networks probably. Sevoflurane-dexmedetomidine inhalation general anesthesia combined with cervical plexus nerve block can reduce the postoperative stress and inflammatory responses in thyroid cancer patients, while maintaining high anesthesia effectiveness and safety.
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
    New trial, Surgery:  Safety and Efficacy of Remimazolam in OPCAB Surgery (clinicaltrials.gov) -  May 30, 2022   
    P=N/A,  N=94, Not yet recruiting, 
  • ||||||||||  fentanyl citrate / Generic mfg., remifentanil / Generic mfg.
    Journal:  The Effects of Remifentanil and Fentanyl on Emergence Agitation in Pediatric Strabismus Surgery. (Pubmed Central) -  May 30, 2022   
    Differences in FLACC scores were not found to be statistically significant. A single bolus administration of fentanyl during anesthetic induction and continuous infusion of remifentanil during surgery had similar effects on the EA incidence in these pediatric patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date, Surgery:  The Impact of an Epidural Anesthetic on the Consumption of Sevoflurane in Major Abdominal Surgery (clinicaltrials.gov) -  May 27, 2022   
    P2/3,  N=0, Withdrawn, 
    The results of this study might be helpful to find an effective medical solution for the treatment of POCD caused by sevoflurane anesthesia. N=50 --> 0 | Trial completion date: Aug 2021 --> Jan 2022 | Recruiting --> Withdrawn | Trial primary completion date: Aug 2020 --> Jan 2022
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Preclinical, Journal:  Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents. (Pubmed Central) -  May 25, 2022   
    The burst-suppression maps revealed a marked inter-species difference: in rats, the entire neocortex engaged in burst-suppression, while in primates most sensory areas were excluded-predominantly the primary visual cortex. We anticipate that the identified species-specific fMRI signatures and whole-brain maps will guide future targeted studies investigating the cellular and molecular mechanisms of burst-suppression in unconscious states.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open:  Topical Sevoflurane for Treatment of Chronic Leg Ulcers (clinicaltrials.gov) -  May 25, 2022   
    P4,  N=50, Recruiting, 
    We anticipate that the identified species-specific fMRI signatures and whole-brain maps will guide future targeted studies investigating the cellular and molecular mechanisms of burst-suppression in unconscious states. Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Immunomodulating:  Sevoflurane Sedation in Patients With Septic Shock (clinicaltrials.gov) -  May 24, 2022   
    P2,  N=153, Not yet recruiting, 
    Trial completion date: Sep 2022 --> Dec 2027 Trial completion date: Nov 2024 --> Nov 2025 | Trial primary completion date: Feb 2024 --> Feb 2025