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13 Diseases |  |
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- | sevoflurane / Generic mfg.
Preclinical, Journal: Systemic inflammation exacerbates developmental neurotoxicity induced by sevoflurane in neonatal rats. (Pubmed Central) - Oct 6, 2022
Systemic inflammation promotes developmental neurotoxicity by worsening anaesthesia-induced neuronal damage with sex-specific behavioural outcomes. This highlights the importance of studying anaesthesia-induced neurotoxicity in more clinically relevant settings.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation. (Pubmed Central) - Oct 6, 2022
Collectively, the results suggest that ferroptosis may mediate sevoflurane-aggravated young rats' brain injury induced by liver transplantation. Our findings provide a potential therapeutic target for brain injury after pediatric liver transplantation.
- ||| Combination therapy: Dexmedetomidine (Clonidin as a low cost alternative) +/-Ketamin Sevoflurane/Isoflurane via Anaconda in combination with Sufentanil (Midazolam only if RASS<-3 needed) (Twitter) - Oct 5, 2022
- || sevoflurane / Generic mfg.
Sevoflurane or Dexmetomidine… in my humble opinion. (Twitter) - Oct 5, 2022
- | sevoflurane / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: CircRNA VIM silence synergizes with sevoflurane to inhibit immune escape and multiple oncogenic activities of esophageal cancer by simultaneously regulating miR-124/PD-L1 axis. (Pubmed Central) - Oct 5, 2022
Our findings provide a potential therapeutic target for brain injury after pediatric liver transplantation. Silencing circ-VIM and applying sevoflurane, by separately regulating miR-124/PD-L1 axis, presented synergistic effects in inhibiting immune escape and multiple malignant phenotypes of EC cells.
- || sevoflurane / Generic mfg.
Retrospective data, Review, Journal: Comparison of Intravenous and Inhalational Anesthetic on Postoperative Cognitive Outcomes in Elderly Patients Undergoing Cancer Surgery: Systematic Review and Meta-analysis. (Pubmed Central) - Oct 5, 2022
Silencing circ-VIM and applying sevoflurane, by separately regulating miR-124/PD-L1 axis, presented synergistic effects in inhibiting immune escape and multiple malignant phenotypes of EC cells. Inhalational anesthetics did not show a significant difference in postoperative cognitive outcomes, except delayed neurocognitive recovery, compared to intravenous anesthetic following cancer surgery.
- | sevoflurane / Generic mfg.
Journal: Sevoflurane dose and postoperative delirium: a prospective cohort analysis. (Pubmed Central) - Oct 5, 2022
P=N/A
Sevoflurane dose was not associated with delirium severity or incidence. Other biological mechanisms of delirium, such as inflammation and neuronal injury, appear more plausible than dose of sevoflurane.
- | sevoflurane / Generic mfg.
Clinical protocol, Retrospective data, Journal: Effect of anesthesia on the outcome of high-grade glioma patients undergoing supratentorial resection: study protocol for a pragmatic randomized controlled trial. (Pubmed Central) - Oct 5, 2022
P=N/A
This is a randomized controlled trial to compare the effect of intravenous and inhalation anesthesia maintenance on the outcome of supratentorial HGG patients. The results will contribute to optimizing the anesthesia methods in these patients.
- | fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Journal: Fentanyl Versus Dexmedetomidine for the Prevention of Emergence Agitation in Children After Sevoflurane Anaesthesia: A Comparative Clinical Study. (Pubmed Central) - Oct 4, 2022
Conclusion Prophylactic administration of dexmedetomidine (0.15 mcg/kg) or fentanyl (1 mcg/kg) administered is effective in preventing emergence agitation. Although we found emergence agitation was higher amongst children receiving fentanyl than those receiving dexmedetomidine during the early recovery period, this difference became insignificant as the postoperative period increased to 30 minutes.
- | sevoflurane / Generic mfg.
Trial completion date, Trial primary completion date, Surgery: Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery (clinicaltrials.gov) - Oct 4, 2022
P=N/A, N=270, Recruiting, Sponsor: Sir Ganga Ram Hospital
Although we found emergence agitation was higher amongst children receiving fentanyl than those receiving dexmedetomidine during the early recovery period, this difference became insignificant as the postoperative period increased to 30 minutes. Trial completion date: Sep 2022 --> Sep 2024 | Trial primary completion date: Aug 2022 --> Aug 2024
- | sevoflurane / Generic mfg.
Preclinical, Journal: Sevoflurane induces microRNA-18a to delay rat neurodevelopment via suppression of the RUNX1/Wnt/β-catenin axis. (Pubmed Central) - Oct 3, 2022
The behavioral experiments also showed that sevoflurane caused nerve injury in rats, whilst RUNX1 overexpression protected rat neurodevelopment. Our findings uncovered that sevoflurane attenuated NSC proliferation via the miR-18a-meidated RUNX1/Wnt/β-catenin pathway, thereby impairing rat neurodevelopment.
- | sevoflurane / Generic mfg.
Journal: Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids. (Pubmed Central) - Oct 1, 2022
The RNA-seq results showed long-term exposure to sevoflurane up regulates some transcription factors in the differentiation of dopaminergic neurons, while short-term exposure to sevoflurane has a weak up-regulation effect on these transcription factors. This study revealed that long-term exposure to sevoflurane could promote the premature differentiation of hMBOs, while short-term exposure had negligible effects, suggesting that long-term exposure to sevoflurane in pregnant women may lead to fetals' midbrain development disorder.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Role of GABA receptor depolarization-mediated VGCC activation in sevoflurane-induced cognitive impairment in neonatal mice. (Pubmed Central) - Oct 1, 2022
Sevoflurane activates VGCCs by inducing GABAR depolarization, resulting in cognitive impairment. Activated VGCCs cause an increase in intracellular calcium concentration and an inflammatory response, resulting in neurotoxicity and cognitive impairment.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Down-regulation of miR-204-5p ameliorates sevoflurane-induced brain injury in neonatal rats through targeting VCAM1. (Pubmed Central) - Oct 1, 2022
Furthermore down-regulation of VCAM1 reversed the trend of these indices. These results suggest that down-regulation of miR-204-5p ameliorates sevoflurane-induced cognitive impairment and hippocampal pathology and inhibits neuronal autophagy and apoptosis by targeting VCAM1.
- | sevoflurane / Generic mfg.
Journal: Sleep Deprivation Increases the Anesthetic Potency of Sevoflurane Regardless of Duration. (Pubmed Central) - Oct 1, 2022
These results suggest that down-regulation of miR-204-5p ameliorates sevoflurane-induced cognitive impairment and hippocampal pathology and inhibits neuronal autophagy and apoptosis by targeting VCAM1. Sleep deprivation can increase the anesthetic potency of sevoflurane regardless of duration of sleep deprivation.
- | sevoflurane / Generic mfg., clonidine / Generic mfg.
Journal: Effect of caudally administered clonidine on sevoflurane induced emergence agitation-A randomized trial. (Pubmed Central) - Oct 1, 2022
No adverse events were recorded in both the groups. Addition of clonidine (2mcg/kg) to ropivacaine 0.2% offers an advantage over 0.2% ropivacaine alone in decreasing the incidence of sevoflurane induced EA in children undergoing lower abdominal surgery without any adverse effects.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Repeated Sevoflurane Exposures in Neonatal Rats Increased the Brain Vulnerability to Future Stress Exposure and Resulted in Fear Extinction Deficit. (Pubmed Central) - Sep 30, 2022
Pretreatment of neonatal rats prior to sevoflurane exposures with bumetanide reduced the NKCC1/KCC2 ratio at P14 and ameliorated most of the subsequent adverse effects. Our study indicates that repeated sevoflurane exposures in neonatal rats might increase the brain vulnerability to future stress exposure and resulted in fear extinction deficit, which might be associated with the neonatal enhanced brain depolarizing GABAR activity.
- | sevoflurane / Generic mfg.
Journal: Application of Propofol Target-Controlled Infusion for Optimized Hemodynamic Status in ESRD Patients Receiving Arteriovenous Access Surgery: A Randomized Controlled Trial. (Pubmed Central) - Sep 30, 2022
Propofol TCI with brachial plexus block can be used as an effective anesthesia regimen for ESRD patients receiving AV access surgery. It can be used with less blood pressure fluctuation than inhalational anesthesia.
- | sevoflurane / Generic mfg.
Journal: Improved Pittsburgh Sleep Quality Index scores on first postoperative night achieved by propofol anesthesia in patients undergoing ambulatory gynecologic surgery. (Pubmed Central) - Sep 29, 2022
It can be used with less blood pressure fluctuation than inhalational anesthesia. Sleep quality assessed by the PSQI is better improved in ASA class I-II female patients receiving propofol anesthesia other than sevoflurane anesthesia for undergoing minor gynecologic surgeries.
- | sevoflurane / Generic mfg.
Journal: Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model. (Pubmed Central) - Sep 29, 2022
Further, the beneficial effects of SVF against SE are mediated by activation of silent information regulator 1 (SIRT1)-mediated reduction of reactive oxygen species (ROS) level, regulation of thioredoxin (TXN) and thioredoxin interacting protein (TIP) levels, reduction of inflammatory-pyroptotic signalling (NLRP3, caspase 1/11, GSDMD, TLR4 and TRIF) proteins, as well as a reduction of inflammatory cytokine (IL-1β and IL-18) levels. These findings suggest that SVF may have therapeutic potential for the treatment of SE and associated cognitive malfunction.
- | sevoflurane / Generic mfg.
Journal: The effect of different flow levels and concentrations of sevoflurane during the wash-in phase on volatile agent consumption: a randomized controlled trial. (Pubmed Central) - Sep 29, 2022
These findings suggest that SVF may have therapeutic potential for the treatment of SE and associated cognitive malfunction. The anesthetic agent consumption during the wash-in phase was approximately 3 times lower with the administration of sevoflurane at 1 L/minute FGF than the use of 4 L/minute FGF.
- | morphine sulphate / Generic mfg., sevoflurane / Generic mfg.
Journal: Sevoflurane sparing effect of morphine in tegus (Salvator merianae) - a preliminary study. (Pubmed Central) - Sep 29, 2022
Heart rate, MAP, and esophageal temperature did not differ between groups or within groups over time. Results showed that IM premedication with 10 mg/kg morphine produced a sevoflurane sparing effect in tegus with no significant impact on cardiovascular variables.
- | sevoflurane / Generic mfg.
Journal: Measurement of tracheal diameters using ultrasonography versus computed tomography in Beagle dogs. (Pubmed Central) - Sep 29, 2022
Ultrasonography can be applied for tracheal diameter measurement. Although further studies are required, an endotracheal tube selection method, using ultrasonography, could be proposed.
- | remifentanil / Generic mfg., sevoflurane / Generic mfg.
Journal: EEG-Parameter-Guided Anesthesia for Prevention of Emergence Delirium in Children. (Pubmed Central) - Sep 25, 2022
EEG-parameter-guided anesthesia management reduced the incidence of ED in children. Studies with larger sample sizes are needed to obtain more convincing results.
- | sevoflurane / Generic mfg.
Preclinical, Journal: IL-33 Alleviates Postoperative Cognitive Impairment by Inhibiting Hippocampal Inflammation and Upregulating Excitatory Synaptic Number in Aged Mice. (Pubmed Central) - Sep 25, 2022
We established a dNCR model in aged mice by laparotomy under sevoflurane anesthesia...Our findings indicated that IL-33 improved cognition by inhibiting the hippocampal inflammatory response and upregulating the number of excitatory synapses. Therefore, IL-33 is a potential drug for the treatment of dNCR.
- | sevoflurane / Generic mfg.
Journal: Effect of General Anesthesia Maintenance with Propofol or Sevoflurane on Fractional Exhaled Nitric Oxide and Eosinophil Blood Count: A Prospective, Single Blind, Randomized, Clinical Study on Patients Undergoing Thyroidectomy. (Pubmed Central) - Sep 24, 2022
The attenuation of NO exhalation by both agents may be one of the underlying mechanisms in the reduction in airway hyperreactivity. The clinical significance of this fluctuation remains to be studied in patients with respiratory disease.
- | ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
Enrollment open, Surgery: Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery (clinicaltrials.gov) - Sep 21, 2022
P=N/A, N=86, Recruiting, Sponsor: Second Affiliated Hospital of Nanchang University
The clinical significance of this fluctuation remains to be studied in patients with respiratory disease. Not yet recruiting --> Recruiting
- | sevoflurane / Generic mfg.
Journal: Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide. (Pubmed Central) - Sep 21, 2022
Activation of PPTg/LDTg is considered a mechanism underlying sleep reintegration. The recovery phenomenon shows potential for clinical application in cases of sleep disturbances induced by systemic inflammation.
- | remifentanil / Generic mfg., sevoflurane / Generic mfg.
Retrospective data, Journal: Inducibility of atrioventricular nodal reentrant tachycardia and ectopic atrial tachycardia in children under general anesthesia. (Pubmed Central) - Sep 21, 2022
Tachycardia induction succeeds with similar frequency under both inhalational and intravenous general anesthesia in children with AVNRT. In children with EAT, inhalational anesthesia is associated with a trend towards better inducibility.
- | sevoflurane / Generic mfg.
Journal, IO biomarker: Synthesis of oxymatrine hydrazone and its preventive action against sevoflurane induced neuron damage through ERK pathway up-regulation. (Pubmed Central) - Sep 21, 2022
Moreover, oxymatrine hydrazone pre-treatment promoted ERK1/2 phosphorylation in sevoflurane exposed neurons. Therefore, oxymatrine hydrazone has a great potential for prevention of neurotoxicity induced by sevoflurane.
- || sevoflurane / Generic mfg.
Clinical data, Journal: Influence of Sevoflurane Inhalation Anesthesia on Clinical Outcomes of Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery. (Pubmed Central) - Sep 21, 2022
Group A had a shorter time to open eyes, remove tracheal intubation, and restore directional force than Group B, with better recovery of HR, MAP, P, and P. Group A was also superior to Group B in the standard time out of PACU, postoperative FI, and LOS, with a lower complication rate. Sevo inhalation anesthesia is more effective and safer for MO patients undergoing LBS.
- | sevoflurane / Generic mfg.
Journal: PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders. (Pubmed Central) - Sep 20, 2022
HCN2 channel, as the target of sevoflurane action, mediates this process. HCN2 might be a target for the treatment and prevention of sevoflurane-induced PND.
- | sevoflurane / Generic mfg.
Journal: Sevoflurane alleviates myocardial ischemia/reperfusion injury via actitation of heat shock protein-70 in patients undergoing double valve replacement surgery. (Pubmed Central) - Sep 20, 2022
These results suggest a cardioprotective effect of sevoflurane during DVRS. Sevoflurane may reduce biomarkers of cardiac injury through its anti-inflammatory effects via upregulation of HSP70.
- | sevoflurane / Generic mfg.
Journal: Comparison of Antinociceptive Properties Between Sevoflurane and Desflurane Using Pupillary Dilation Reflex Under Equivalent Minimum Alveolar Concentration: A Randomized Controlled Trial. (Pubmed Central) - Sep 20, 2022
The amount of change in the PDR amplitude, MAP, and HR after SNT was not different between sevoflurane and desflurane anesthesia. This result might suggest that sevoflurane and desflurane may not have different antinociceptive properties at equivalent MAC.
- | sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
Preclinical, Journal: Dexmedetomidine Diminishes, but Does Not Prevent, Developmental Effects of Sevoflurane in Neonatal Rats. (Pubmed Central) - Sep 20, 2022
This study suggests that the ability of DEX to depress SEVO-induced neuronal excitation, despite increasing corticosterone release, is sufficient to weaken mechanisms leading to long-term neuroendocrine/neurobehavioral abnormalities. DEX may prevent changes in DNA methylation in the majority of genes affected by SEVO, epigenetic modifications that could predict abnormalities in a wide range of functions.
- | Bridion (sugammadex) / Merck (MSD)
Observational data, Journal: Characterizing the Heart Rate Effects From Administration of Sugammadex to Reverse Neuromuscular Blockade: An Observational Study in Patients. (Pubmed Central) - Sep 20, 2022
A difference in HR slowing as a function of dose did not achieve statistical significance. The observational nature of the investigation prevented a full understanding of the mechanism(s) of the HR slowing.
- | sevoflurane / Generic mfg.
Preclinical, Journal: Sevoflurane preconditioning alleviates myocardial ischemia reperfusion injury through mitochondrial NAD-SIRT3 pathway in rats. (Pubmed Central) - Sep 20, 2022
The observational nature of the investigation prevented a full understanding of the mechanism(s) of the HR slowing. Sevoflurane preconditioning attenuates myocardial IRI through activating the mitochondrial NAD-SIRT3 pathway to preserve the mitochondrial function.
- | sevoflurane / Generic mfg.
Journal, IO biomarker: Inhibition of miR-495-3p ameliorated sevoflurane induced damage through BDNF/ERK/CREB signaling pathways in HT22 cells. (Pubmed Central) - Sep 20, 2022
Sevoflurane preconditioning attenuates myocardial IRI through activating the mitochondrial NAD-SIRT3 pathway to preserve the mitochondrial function. Downregulation of miR-495-3p can decrease oxidative status in HT22 cells and alleviate sevoflurane-induced cytotoxicity through stimulating the BDNF/ERK/CREB pathway.
- | sevoflurane / Generic mfg., ropivacaine / Generic mfg., rocuronium / Generic mfg.
New trial: Ultrasound Guided Psoas Compartment Block vs Suprainguinal Fascia Iliaca Compartment Block (clinicaltrials.gov) - Sep 16, 2022
P=N/A, N=85, Enrolling by invitation, Sponsor: Tanta University
- | sevoflurane / Generic mfg.
Preclinical, Journal: Repeated early-life exposure to anaesthesia and surgery causes subsequent anxiety-like behaviour and gut microbiota dysbiosis in juvenile rats. (Pubmed Central) - Sep 14, 2022
Downregulation of miR-495-3p can decrease oxidative status in HT22 cells and alleviate sevoflurane-induced cytotoxicity through stimulating the BDNF/ERK/CREB pathway. Gut microbiota dysbiosis caused by early repeated exposure to anaesthesia and surgery affects long-term anxiety emotion behaviours in rats.
- | sevoflurane / Generic mfg.
Journal: Comparison of the Occurrence of Postoperative Shivering Between Sevoflurane and Desflurane Anesthesia. (Pubmed Central) - Sep 14, 2022
Similar results were obtained in the stratified analysis by sex and age. The occurrence of POS is not different between sevoflurane and desflurane anesthesia.
- | sevoflurane / Generic mfg.
Journal: Effects of sevoflurane versus propofol on cerebral autoregulation during anaesthesia for robot-assisted laparoscopic prostatectomy. (Pubmed Central) - Sep 14, 2022
However, it should be noted that some patients in the propofol group had impaired autoregulation on earlier tests. In conclusion, we found that autoregulation during robot-assisted laparoscopic prostatectomy is less likely to be impaired with propofol compared to sevoflurane anaesthesia, particularly towards the end of the surgery.
- | sevoflurane / Generic mfg.
Journal: Invasive and non-invasive assessment of macro- and microcirculatory effects of vasopressors during sevoflurane anesthesia in a pediatric experimental model: a randomized trial. (Pubmed Central) - Sep 14, 2022
The results of this study suggest that non-invasive cardiac output measurements may not accurately reflect changes in macrocirculation after hemodynamic optimization by vasopressors. Due to the incoherence between macro- and micro-circulation, monitoring microcirculation is essential to guide patient management.
- || sevoflurane / Generic mfg.
Review, Journal: Induction of anesthesia with sevoflurane in children: curiosities & controversies. (Pubmed Central) - Sep 14, 2022
More recently, a shift away from the use of nitrous oxide has prompted some to question whether sevoflurane has a role as an induction agent in children. The preponderance of evidence supports the practice of safely inducing anesthesia with 8% sevoflurane with or without nitrous oxide in children but recommended strategies to mitigate against epileptiform discharges may be more harmful than beneficial.
- | sevoflurane / Generic mfg.
Journal: Comparative study of a modified double-lumen tube ventilation control connector and traditional connector in clinical use: a randomised-controlled trial. (Pubmed Central) - Sep 14, 2022
The preponderance of evidence supports the practice of safely inducing anesthesia with 8% sevoflurane with or without nitrous oxide in children but recommended strategies to mitigate against epileptiform discharges may be more harmful than beneficial. Compared with YC, YRC was beneficial for maintaining depth of anesthesia, improves efficiency for the switch between one-lung and two-lung ventilation, and shortens the tube positioning time.
- sevoflurane / Generic mfg.
Volatile Organic Compound Biomarkers Identification for Prediction of Lung Cancer Based on Exhaled Breath Analysis (Ballroom FGH) - Sep 14, 2022 - Abstract #IASLCNACLC2022IASLC_NACLC_125;
VOC biomarkers of breath of the LC patients was significantly different from that of both LC and HC. We concluded that the VOC in exhaled breath has a potential to help improve early diagnosis of LC.
- | sevoflurane / Generic mfg.
Journal: Dynamic alpha-gamma phase-amplitude coupling signatures during sevoflurane-induced loss and recovery of consciousness. (Pubmed Central) - Sep 12, 2022
Our results show that, in addition to the delta-alpha PAC, unconsciousness induced by sevoflurane was accompanied by spatial non-uniform alpha-gamma PAC in the cortical network, and dynamic PAC patterns between the anterior and posterior brain were observed during the unconscious phase. The dynamic transition of PAC network patterns indicates that brain states under sevoflurane-induced unconsciousness emerge from the regulation of functional integration and segregation instantiated by delta-alpha and alpha-gamma PAC.
- sevoflurane / Generic mfg.
SEVOFLURANE-INDUCED DIFFUSE ALVEOLAR HEMORRHAGE: A RARE CAUSE OF POSTOPERATIVE HEMOPTYSIS IN YOUNG PATIENTS (Convention Center Exhibit Hall: Rapid Area 3C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4211;
Sevoflurane-induced diffuse alveolar hemorrhage is a rare complication of the inhaled anesthetic. It typically occurs in younger patients after surgery and is usually managed conservatively.
- | sevoflurane / Generic mfg.
Biomarker, Journal: Anesthetics to Prevent Lung Injury in Cardiac Surgery: A Randomized Controlled Trial. (Pubmed Central) - Sep 10, 2022
Sevoflurane anesthesia during cardiac surgery did not consistently prevent lung inflammation or prevent postoperative pulmonary complications compared to propofol. There were significantly lower levels of 2 plasma biomarkers specific for lung injury and inflammation in the sevoflurane group.
- || sevoflurane / Generic mfg.
Clinical, Journal: Effect of Volatile Anesthesia Versus Total Intravenous Anesthesia on Postoperative Pulmonary Complications in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial. (Pubmed Central) - Sep 10, 2022
There were significantly lower levels of 2 plasma biomarkers specific for lung injury and inflammation in the sevoflurane group. In adult patients undergoing cardiac surgery with cardiopulmonary bypass, general anesthesia with a volatile anesthetic compared with propofol-based TIVA had not reduced pulmonary complications within the first 7 days after surgery.