sevoflurane / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., epinephrine / Generic mfg.
    DOES PARATHYROID HORMONE ACT AS A STRESS HORMONE IN RESPONSE TO ANESTHESIA AND SURGERY? () -  Oct 26, 2022 - Abstract #ATA2022ATA_282;    
    In contrast, those with hyperparathyroidism demonstrated variable changes to anesthesia and surgery. Elevated PTH levels during and after thyroidectomy is common and not an indication of undiagnosed hyperparathyroidism if there was no preoperative indication of such.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Journal:  Neostigmine versus sugammadex on post-operative recovery following bariatric surgery. (Pubmed Central) -  Oct 25, 2022   
    Elevated PTH levels during and after thyroidectomy is common and not an indication of undiagnosed hyperparathyroidism if there was no preoperative indication of such. Considering the high risk of post-operative respiratory insufficiency inmorbidly obese patients, SM could be a safer choice in this patient group.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Effectiveness of two extended-release buprenorphine formulations during postoperative period in neonatal rats. (Pubmed Central) -  Oct 25, 2022   
    Pups were anesthetized with sevoflurane in 100% O2 and a 5 mm long skin incision was made over the left lateral thigh and underlying muscle dissected...Plasma buprenorphine concentration for all treatment groups remained above the clinically effective concentration of 1 ng/mL for at least 4 h in the Bup-SR group, 8 h in XR-Lo and 24 h in XR-Hi group with no abnormal clinical observations. This study demonstrates that XR-Hi did not attenuate postoperative thermal hypersensitivity for a longer period than XR-Lo in 5-day-old rats; XR-Hi attenuated postoperative thermal hypersensitivity for up to 4 h while Bup-SR and XR-Lo for at least 8 h in this model.
  • ||||||||||  sevoflurane / Generic mfg.
    PULMONARY VASCULAR DYSFUNCTION COMPATIBLE WITH HEPATOPULMONARY SYNDROME IN RATS WITH CIRRHOSIS INDUCED BY CARBON TETRACHLORIDE (CCl4): THE RELEVANCE OF LIVER MASS () -  Oct 23, 2022 - Abstract #AASLD2022AASLD_1869;    
    Under inhalational sevoflurane -anaesthesia, the portal, pulmonary and systemic pressures were measured by catheterization of ileocolic vein, pulmonary artery and carotid artery, respectively...Conclusion : The development of liver atrophy in experimental CLD is associated with pathological changes in the pulmonary circulation that are compatible with the development of HPS, including failure of hypoxic pulmonary vasoconstriction and a generalized hyporresponsiveness to vasoconstrictive factors. The results suggest that parenchymal extinction with reduction of functional liver mass is a key factor for developing the pulmonary vascular complications associated to cirrhosis.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  The deleterious impact of exposure to different inhaled anesthetics is time dependent. (Pubmed Central) -  Oct 21, 2022   
    Similar results were observed in the exposure of SEV and DES compared to inflammation and redox imbalance in different periods. This study demonstrated that time is a determinant to promote a local and systemic inflammatory response to different inhalational anesthetics in a healthy murine model.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Identification and Validation of Ferroptosis-Related Genes in Sevoflurane-Induced Hippocampal Neurotoxicity. (Pubmed Central) -  Oct 21, 2022   
    Our results suggested that ferroptosis-related genes play roles in sevoflurane anesthesia-related hippocampal neuron injury and offered the hub genes and potential therapeutic agents for investigating and treatment of this neurotoxicity after sevoflurane exposure. Finally, therapeutic effect of these drug candidates and function of potential ferroptosis targets should be further investigated for treatment and clarifying mechanisms of sevoflurane anesthesia-induced neuron injury in future research.
  • ||||||||||  sevoflurane / Generic mfg.
    Retrospective data, Review, Journal:  Epileptiform EEG discharges during sevoflurane anesthesia in children: A meta-analysis. (Pubmed Central) -  Oct 20, 2022   
    Epileptiform EEG discharges during sevoflurane anesthesia in children should arouse clinicians' attention. The use of low initial concentration technique and shorter exposure time of high concentration sevoflurane may be associated with a lower occurrence of these paradoxical events.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Comparison of Esketamine and Sevoflurane on Emergence Agitation (clinicaltrials.gov) -  Oct 18, 2022   
    P=N/A,  N=80, Recruiting, 
    Besides, it can obtain better recovery quality and have milder postoperative stress disorder than single use of propofol. Trial completion date: May 2022 --> Dec 2022 | Trial primary completion date: Apr 2022 --> Nov 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  A novel predictive strategy for the incidence of postoperative neurocognitive dysfunction in elderly patients with mild cognitive impairment. (Pubmed Central) -  Oct 18, 2022   
    A total of 210 patients aged 65-80 years undergoing spinal surgery were randomly assigned to three groups (n = 70 each): propofol, sevoflurane, and propofol/sevoflurane as anesthesia maintenance protocols...The AUC was predicted to be 0.872, and the sensitivity and specificity were 0.833 and 0.841, respectively. Under the conditions of preoperative Aβ-42 less than 28.34 pg/ml, the intraoperative fluctuation range of cerebral oxygen saturation should be maintained within 9.92% to reduce the occurrence of PND in geriatric patients with MCI.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  mTORC1-Dependent and GSDMD-Mediated Pyroptosis in Developmental Sevoflurane Neurotoxicity. (Pubmed Central) -  Oct 14, 2022   
    Taken together, these results indicate that mTORC1-dependent and GSDMD-mediated pyroptosis contributes to the developmental sevoflurane neurotoxicity. Characterizing these processes may provide experimental evidence for the possible prevention of developmental sevoflurane neurotoxicity.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Total Knee Replacement TIVA With Robotic Arm Assisted (clinicaltrials.gov) -  Oct 13, 2022   
    P4,  N=180, Recruiting, 
    However, a ceiling effect of the reduction was observed when the dose of dexmedetomidine was higher than 0.8 μg/kg. Unknown status --> Recruiting | Trial completion date: May 2021 --> May 2023 | Trial primary completion date: Dec 2020 --> Dec 2022
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Trial completion, Trial completion date:  Effects of TIVA With Propofol Versus Inhalational Anaesthesia on Postoperative Pain After Hepatectomy (clinicaltrials.gov) -  Oct 13, 2022   
    P4,  N=90, Completed, 
    Unknown status --> Recruiting | Trial completion date: May 2021 --> May 2023 | Trial primary completion date: Dec 2020 --> Dec 2022 Unknown status --> Completed | Trial completion date: Dec 2020 --> Dec 2021
  • ||||||||||  Journal:  Effect of sedatives or anesthetics on the measurement of resting brain function in common marmosets. (Pubmed Central) -  Oct 13, 2022   
    Moreover, alfaxalone, isoflurane, and sevoflurane have similar effects on resting state brain function, but only propofol exhibits different tendencies, as resting brain function is more preserved than it is following the administration of the other anesthetics. Co-administration of isoflurane and dexmedetomidine shows middle effect between sedatives and anesthetics.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Total intravenous anesthesia for liver resections: anesthetic implications and safety. (Pubmed Central) -  Oct 12, 2022   
    To examine the applicability of TIVA as a mainstay agent more rigorously, we discuss the safety and applicability of propofol-based TIVA in the context of complex major abdominal surgery, specifically, liver resection surgery. We also discuss the use of propofol-based TIVA in liver resection surgery with a broad, integrated approach, addressing general and specific clinical considerations, economic factors, and operating room turnover.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Sevoflurane alleviates lung injury and inflammatory response compared with propofol in a rat model of VV ECMO. (Pubmed Central) -  Oct 8, 2022   
    • Sevoflurane downregulated PEDF but upregulated the Erk pathway and HIF-1α, while propofol had the adverse effects on ovarian cancer cells. This study demonstrates that compared with propofol, sevoflurane was more efficacious in improving oxygenation and decreasing inflammatory response in rat models with ARDS subject to VV ECMO treatment.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Efficiency of inhaled anaesthetic recapture in clinical practice. (Pubmed Central) -  Oct 6, 2022   
    This study suggests that repeated sevoflurane exposure in newborn mice leads to depolarization of OPC, which leads to Ca influx through NCX and affects OPC proliferation, migration, differentiation, and myelination, ultimately leading to cognitive impairment. No abstract available