sevoflurane / Generic mfg. 
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  • ||||||||||  Journal:  Severe Bleeding During Orthognathic Surgery for a Noonan Syndrome Patient. (Pubmed Central) -  Dec 20, 2022   
    Despite mild hypotensive anesthesia (targeted mean arterial pressure of 65 mm Hg) with nitroglycerine and intravenous tranexamic acid for bleeding, adequate hemostasis was difficult to achieve and led to severe blood loss (1442 mL)...Her postoperative course proceeded uneventfully without abnormal postoperative bleeding. Because patients with NS can have difficulty with hemostasis, vascular malformations, and fragile blood vessels, extensive hematologic evaluation and thorough preparation for unexpected bleeding are crucial to accomplish orthognathic surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Editorial: Insights in integrative neuroscience: 2021. (Pubmed Central) -  Dec 16, 2022   
    Based on the simulated AUC values, we concluded that this neurotoxic effect may also occur in clinical settings, and concomitant use of CMS and Sevo should be avoided. No abstract available
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Disrupted relationship between intrinsic neural timescales and alpha peak frequency during unconscious states - A high-density EEG study. (Pubmed Central) -  Dec 13, 2022   
    In sum, we demonstrate the relevance of the brain's capacity for input processing on shorter (APF) and longer (ACW) timescales - including their relationship - for consciousness. Albeit indirectly, e.g., through the analysis of electrophysiological activity at rest, this supports the mechanism of temporo-spatial alignment to the environment's temporal input stochastics, through relating different neural timescales, as one key predisposing factor of consciousness.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Application of sevoflurane combined with remifentanil anesthesia in laparoscopic radical hysterectomy for cervical cancer. (Pubmed Central) -  Dec 13, 2022   
    Albeit indirectly, e.g., through the analysis of electrophysiological activity at rest, this supports the mechanism of temporo-spatial alignment to the environment's temporal input stochastics, through relating different neural timescales, as one key predisposing factor of consciousness. Sevoflurane combined with remifentanil anesthesia for patients undergoing laparoscopic radical hysterectomy for cervical cancer is superior to propofol and remifentanil, and can ensure stable hemodynamics and mitigate physical stress, so it is worthy of clinical application.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Spatial and temporal alterations of developing oligodendrocytes induced by repeated sevoflurane exposure in neonatal mice. (Pubmed Central) -  Dec 12, 2022   
    Collectively, we first demonstrated the bi-directional influence of early sevoflurane exposures on oligodendrocyte maturation and proliferation, which contributes to the cognitive impairment induced by general anesthesia. These findings illustrated the dynamic changes in oligodendrocytes in the developing brain following anesthetic exposures, as well as possible therapeutic strategies for multiple general anesthesia associated cognitive impairment.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Effects of Sevoflurane Exposure on Fetal Brain Development Using Cerebral Organoids. (Pubmed Central) -  Dec 9, 2022   
    Our results suggest that maternal sevoflurane exposure during the first trimester of pregnancy can cause abnormal neuronal differentiation in the fetal brain. However, considering the recovery observed in later periods, sevoflurane exposure might not have lasting impacts on fetal brain development.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Comparison of Esketamine and Sevoflurane on Emergence Agitation (clinicaltrials.gov) -  Dec 6, 2022   
    P=N/A,  N=80, Recruiting, 
    However, considering the recovery observed in later periods, sevoflurane exposure might not have lasting impacts on fetal brain development. Trial completion date: Dec 2022 --> Apr 2023 | Trial primary completion date: Nov 2022 --> Feb 2023
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Trial completion date:  Inhalational Anesthesia and Precipitation of Dementia: is There a Link? (clinicaltrials.gov) -  Dec 5, 2022   
    P=N/A,  N=500, Active, not recruiting, 
    Trial completion date: Dec 2022 --> Apr 2023 | Trial primary completion date: Nov 2022 --> Feb 2023 Trial completion date: Dec 2021 --> Jul 2023
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Hemodynamic and ventilatory changes in pediatric patients with special needs: A comparative clinical study. (Pubmed Central) -  Dec 3, 2022   
    The purpose was to determine the hemodynamic and ventilatory changes after propofol and sevoflurane administration in children with special needs (CSN) versus healthy children (HC) during dental treatment...Patients with special needs had lower HR and BIS values than healthy patients, while BP, SaO2 and exhaled CO2 showed similar results in both groups. Key words:Bispectral index, hemodynamic changes, ventilatory changes, pediatric patients, special needs.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial primary completion date:  Confirmatory Study of HFVI Guided Analgesic Administration in Surgical Subjects (clinicaltrials.gov) -  Nov 29, 2022   
    P=N/A,  N=104, Enrolling by invitation, 
    Increasing SIRT1 function represents a promising therapeutic strategy for prevention and treatment of POCD. Trial primary completion date: Oct 2022 --> Jan 2023
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Usefulness of Intraoperative Electrocorticography for the Localization of Epileptogenic Zones. (Pubmed Central) -  Nov 28, 2022   
    Subdural electrodes were implanted with iECoG under general anesthesia (2% sevoflurane)...The resection of iECoG spike areas significantly correlated with good surgical outcomes. The indication and limitations of iECoG need to be realized, and the complementary use of iECoG and cECoG may enhance clinical utility.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  The Potential of Bemegride as an Activation Agent in Electroencephalography in Dogs. (Pubmed Central) -  Nov 27, 2022   
    The dogs were anesthetized using sevoflurane during EEG recordings...There were no other adverse effects, including seizures. The present results demonstrated the potential of bemegride as a safe and effective pharmacological activation agent of EDs in anesthetized dogs with epilepsy and provided more options for the diagnosis and therapeutic planning of epilepsy, including presurgical evaluations, in dogs.
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Anesthesia and the renal sympathetic nervous system in perioperative AKI. (Pubmed Central) -  Nov 22, 2022   
    Increased renal sympathetic nerve activity may impair renal excretory function and oxygenation and induce structural injury in ischemic AKI models and could therefore be a contributing factor to AKI in the perioperative setting. This review summarizes anesthetic agents' effects on the renal sympathetic nervous system that may be important in the pathogenesis of perioperative AKI.