sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial completion date, Trial withdrawal, Trial primary completion date:  Sevoflurane and Propofol for Botulinum Toxin Injection (clinicaltrials.gov) -  Feb 15, 2023   
    P=N/A,  N=0, Withdrawn, 
    Not yet recruiting --> Recruiting N=60 --> 0 | Trial completion date: Feb 2026 --> Dec 2022 | Not yet recruiting --> Withdrawn | Trial primary completion date: Feb 2026 --> Dec 2022
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Enrollment open, Surgery:  The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE) (clinicaltrials.gov) -  Feb 15, 2023   
    P=N/A,  N=84, Recruiting, 
    N=60 --> 0 | Trial completion date: Feb 2026 --> Dec 2022 | Not yet recruiting --> Withdrawn | Trial primary completion date: Feb 2026 --> Dec 2022 Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  The perceptions and adoption of environmentally sustainable practices among anesthesiologists-a qualitative study. (Pubmed Central) -  Feb 12, 2023   
    This study provides insight into the factors that influence the adoption of environmentally sustainable practices in the OR. Measures to promote these practices include education and training, feedback on efforts, engagement of senior anesthetists as role models and for change management, environmental restructuring, and policy designs that balance a top-down vs bottom-up approach to influencing change.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion date, Trial primary completion date:  A Study to Compare the Long-term Outcomes After Two Different Anaesthetics (clinicaltrials.gov) -  Feb 9, 2023   
    P3,  N=450, Recruiting, 
    The PREVENT AGITATION II trial will contribute valuable knowledge on efficacy for the prevention of emergence agitation and safety in infants. Trial completion date: Dec 2025 --> Jun 2026 | Trial primary completion date: Dec 2022 --> Jun 2023
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date, Surgery:  SPRV: Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery (clinicaltrials.gov) -  Feb 9, 2023   
    P4,  N=120, Recruiting, 
    Trial completion date: Dec 2025 --> Jun 2026 | Trial primary completion date: Dec 2022 --> Jun 2023 Unknown status --> Recruiting | Trial completion date: Dec 2020 --> Dec 2023 | Trial primary completion date: Dec 2020 --> Dec 2023
  • ||||||||||  Seizalam (midazolam intramuscular) / Pfizer
    Retrospective data, Journal:  Effect of midazolam in autism spectrum disorder: A retrospective observational analysis. (Pubmed Central) -  Feb 8, 2023   
    Both tramadol given as a CRI and a single intravenous bolus injection, induce decrease in heart rate, respiratory rate and in body temperature but the values of these parameters remain within physiological range in dogs undergoing ovariohysterectomy. Patients with autism spectrum disorder may be susceptible to premedication with midazolam; however, regular benzodiazepine administration may reduce the effect.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  The Effect of Intraoperative Music Listening on Sevoflurane Consumption and Recovery Parameters (clinicaltrials.gov) -  Feb 8, 2023   
    P=N/A,  N=60, Recruiting, 
    Patients with autism spectrum disorder may be susceptible to premedication with midazolam; however, regular benzodiazepine administration may reduce the effect. Trial completion date: Dec 2022 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2024
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal, Surgery:  Abdominal Surgery Plus Sevoflurane Exposure Induces Abnormal Emotional Changes and Cognitive Dysfunction in Aged Rats. (Pubmed Central) -  Feb 6, 2023   
    Neuraxial anesthesia combined with general anesthesia using an SGA device to maintain spontaneous ventilation in order to minimize the risk of rupture of pulmonary arteriovenous malformations could be an option. In this study, the aged rats exposed to abdominal surgery demonstrated both emotional changes and cognitive dysfunction, which may be associated with neuronal degeneration and reduced phosphorylated P38MAPK.
  • ||||||||||  ketorolac / Generic mfg.
    Enrollment open, Trial primary completion date:  An Evaluation of Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision (clinicaltrials.gov) -  Feb 6, 2023   
    P2,  N=100, Recruiting, 
    In this study, the aged rats exposed to abdominal surgery demonstrated both emotional changes and cognitive dysfunction, which may be associated with neuronal degeneration and reduced phosphorylated P38MAPK. Not yet recruiting --> Recruiting | Trial primary completion date: Jan 2023 --> Jul 2023
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Review, Journal:  Diabetes insipidus related to sedation in the intensive care unit: A review of the literature. (Pubmed Central) -  Feb 5, 2023   
    Not yet recruiting --> Recruiting | Trial primary completion date: Jan 2023 --> Jul 2023 Awareness of the potential for sedatives to cause DI may lead to greater identification with swifter medication discontinuation and subsequent resolution of DI.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Long-term sevoflurane exposure resulted in temporary rather than lasting cognitive impairment in Drosophila. (Pubmed Central) -  Feb 5, 2023   
    And mRNA levels of antioxidants, such as SOD2 and CAT, increased and decreased simultaneously with the rise and fall of the ROS level, indicating a possible contribution to the recovery from the sevoflurane impairment. In conclusion, our results suggest that one early prolonged sevoflurane-based general anesthesia can induce neuroapoptosis and learning and memory deficit transiently but not permanently in Drosophila.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Performance of the SEDLine Monitor: Age Dependency and Time Delay. (Pubmed Central) -  Feb 3, 2023   
    Additionally, a delay of the PSI to react to sudden neurophysiologic changes due to dose of the maintenance anesthetic is of a time course that is clinically significant. These factors should be considered when navigating anesthesia relying on only the proprietary index for the SEDLine monitor.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons. (Pubmed Central) -  Feb 3, 2023   
    192-sap blocked the cholinergic system activation in the basal forebrain and hippocampus and inhibited taVNS-mediated neuroprotection and anti-inflammation effects in the hippocampus. Generally, our study indicated that taVNS might alleviate sevoflurane-induced hippocampal neuronal apoptosis, necroptosis and microglial activation though activating cholinergic system in the basal forebrain.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Enrollment open:  Effect of Ketamine Versus Sevoflurane On The Right Ventricular Pressure (clinicaltrials.gov) -  Feb 2, 2023   
    P=N/A,  N=40, Recruiting, 
    Generally, our study indicated that taVNS might alleviate sevoflurane-induced hippocampal neuronal apoptosis, necroptosis and microglial activation though activating cholinergic system in the basal forebrain. Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Review, Journal:  Long-term effect of anesthesia choice on patients with hepatocellular carcinoma undergoing open liver resection. (Pubmed Central) -  Jan 31, 2023   
    This review summarized the relations between different anesthesia choices and HCC patients' long-term outcomes as well as their underlying mechanisms. Due to the complexity of molecules interactions and signaling pathways, further studies are warranted to confirm these results so as to optimize anesthesia strategy for HCC patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Endoplasmic Reticulum Stress-Activated Neuronal and Microglial Autophagy Contributes to Postoperative Cognitive Dysfunction in Neonatal rats. (Pubmed Central) -  Jan 31, 2023   
    Seven-day old neonatal rats (P7) had right common carotid artery exposure under anesthesia with 3% sevoflurane for 2 h...The ER stress activator tunicamycin and inhibitor tauroursodeoxycholic acid increased the markers for autophagy in control rats and decreased the autophagy markers in rats with surgery, respectively. Our results suggest that surgery in neonatal rats induces ER stress that then activates neuronal and microglial autophagy, which contributes to learning and memory impairment later in life.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Maternal sevoflurane exposure induces neurotoxicity in offspring rats via the CB1R/CDK5/p-tau pathway. (Pubmed Central) -  Jan 28, 2023   
    The present study suggests that a single exposure to 3.5% sevoflurane of rats at mid-gestation impairs neurobehavioral abilities and cognitive memory in offspring. cannabinoid 1 receptor is a possible target for the amelioration of postnatal neurobehavioral ability and cognitive memory impairments induced by maternal anesthesia.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Role of sevoflurane in myocardial ischemia-reperfusion injury via the ubiquitin-specific protease 22/lysine-specific demethylase 3A axis. (Pubmed Central) -  Jan 27, 2023   
    The interaction between USP22 and KDM3A and between KDM3A and YAP1 was further validated. USP 22, KDM3A, and YAP1 were found to be down-regulated in MI/RI and SPC protected MI/RI rats, as evidenced by up-regulated expressions of USP22, KDM3A, and YAP1, reduced pathological injury in the myocardium, myocardial infarction areas, apoptosis, and levels of CK-MB, cTnI, and LDH, and enhanced H9c2 cell viability; while the protective effects of Sevo were counteracted by silencing of USP22, KDM3A, and SPC upregulated USP22, which stabilized KDM3A protein levels via deubiquitination, and KDM3A inhibited histone 3 lysine 9 di-methylation (H3K9me2) levels in the YAP1 promoter to encourage YAP1 transcription, to reduce MI/RI.