sevoflurane / Generic mfg. 
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  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    ANESTHESIA EFFECTS ON THE PYLORUS OF GASTROPARESIS PATIENTS (South Hall A, Poster Hall - McCormick Place) -  Mar 23, 2023 - Abstract #DDW2023DDW_6753;    
    Variables studied included the doses of propofol, fentanyl, and succinylcholine given during induction, percent expired sevoflurane six minutes after induction, time from induction to visualization of the pylorus, and use of total intravenous anesthetic (TIVA). In this analysis TIVA showed an Odds Ratio (OR) 2.72 (1.30, 5.68
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs. (Pubmed Central) -  Mar 21, 2023   
    Herein, we reviewed the latest literature and compared the relationship between tau protein and cognitive impairment caused by different anesthetics. Our results substantiated that tau protein phosphorylation is essential in cognitive dysfunction caused by anesthetic drugs, and the possible mechanism can be summarized as "anesthetic drugs-kinase/phosphatase-p-Tau-cognitive impairment".
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Effect of sevoflurane anesthesia to neonatal rat hippocampus by RNA-seq. (Pubmed Central) -  Mar 20, 2023   
    Bckdhb interference experiments indicated that sevoflurane induces hippocampal neuronal cells apoptosis by regulating Bckdhb expression. Our study provided new insights into the molecular mechanism of sevoflurane-induced brain damage in pediatrics.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Recovery Benefit With Total Intravenous Anesthesia in Patients Receiving Rhinoplasty. (Pubmed Central) -  Mar 12, 2023   
    When utilizing TIVA over inhalational anesthesia, patients undergoing rhinoplasty had significantly increased benefits in terms of reduced phase I recovery times and decreased incidence of PONV. TIVA was demonstrated to be a safe and efficacious method of anesthesia for this patient population.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Intranasal Administration of a Polymeric Biodegradable Film to C57BL/6 Mice. (Pubmed Central) -  Mar 11, 2023   
    The method was performed in C57BL/6 (n = 10; age, 8 wk) under inhaled sevoflurane...Furthermore, postmortem evaluation revealed olfactory-centered placement of the polymeric films, confirming the accuracy and repeatability of the method. In conclusion, this study documented the use of, a novel, noninvasive, intranasal administration technique for nose-to-brain drug delivery in biodegradable films for use in mice.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Intergenerational Perioperative Neurocognitive Disorder in Young Adult Male Rats with Traumatic Brain Injury. (Pubmed Central) -  Mar 9, 2023   
    In conclusion, this study documented the use of, a novel, noninvasive, intranasal administration technique for nose-to-brain drug delivery in biodegradable films for use in mice. These findings in rats suggest that young adult males with traumatic brain injury are at an increased risk of developing perioperative neurocognitive disorder, as are their unexposed male but not female offspring.
  • ||||||||||  sevoflurane / Generic mfg.
    Retrospective data, Journal:  Inhalational Versus Propofol-based Intravenous Maintenance of Anesthesia for Emergence Delirium in Adults: A Meta-analysis and Trial Sequential Analysis. (Pubmed Central) -  Mar 9, 2023   
    This was confirmed by sensitivity analysis, trial sequential analysis, and subgroup analyses of studies that assessed ED via Aono's four-point scale (RR, 3.72; 95% CI: 1.48-9.31; P=0.005) and the Ricker Sedation Agitation Scale (RR, 3.48; 95% CI: 1.66-7.32; P=0.001), studies that included sevoflurane for maintenance of anesthesia (RR, 1.87; 95% CI: 1.13-3.09; P=0.02), studies that reported ED as the primary outcome (RR, 2.73; 95% CI: 1.53-4.86; P=0.0007), and studies that investigated ocular (RR, 2.98; 95% CI: 1.10-8.10; P=0.03), nasal (RR; 95% CI: 1.27-6.50; P=0.01), and abdominal (RR, 3.25; 95% CI: 1.12-9.40; P=0.03) surgeries, but not intracranial surgery (RR, 0.72; 95% CI: 0.34-1.54; P=0.40). In summary, inhalational maintenance of sevoflurane was a risk factor for ED compared with propofol-based intravenous maintenance in adults who underwent ocular, nasal, and abdominal surgeries but not intracranial surgery.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment change, Trial completion date, Trial primary completion date:  Volatile Anaesthesia and Perioperative Outcomes Related to Cancer: The VAPOR-C Trial (clinicaltrials.gov) -  Mar 9, 2023   
    P3,  N=3500, Recruiting, 
    In summary, inhalational maintenance of sevoflurane was a risk factor for ED compared with propofol-based intravenous maintenance in adults who underwent ocular, nasal, and abdominal surgeries but not intracranial surgery. N=5736 --> 3500 | Trial completion date: Mar 2028 --> Jun 2028 | Trial primary completion date: Dec 2024 --> Dec 2027
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
    Trial completion:  Quality of Recovery of Remimazolam Versus Sevoflurane in Transurethral Bladder Resection. (clinicaltrials.gov) -  Mar 9, 2023   
    P=N/A,  N=36, Completed, 
    N=5736 --> 3500 | Trial completion date: Mar 2028 --> Jun 2028 | Trial primary completion date: Dec 2024 --> Dec 2027 Recruiting --> Completed
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, Surgery:  Effect of Sevoflurane and Propofol on the Optic Nerve Sheath Diameter (clinicaltrials.gov) -  Mar 8, 2023   
    P=N/A,  N=58, Completed, 
    Recruiting --> Completed Not yet recruiting --> Completed | Trial completion date: Oct 2021 --> Aug 2022 | Trial primary completion date: Oct 2021 --> Aug 2022
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  GABAergic neurons in the nucleus accumbens core mediate the antidepressant effects of sevoflurane. (Pubmed Central) -  Mar 4, 2023   
    Activation of GABAergic (?-aminobutyric acidergic) neurons in the nucleus accumbens core by chemogenetics was shown to mimic the antidepressant effects of inhaled sevoflurane, whereas inhibition of these neurons significantly prevented these effects. Considered together, these results suggested that sevoflurane might exert rapid and long-lasting antidepressant effects via modulation of neuronal activities in the nucleus accumbens core nucleus.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Anaesthesia, analgesia, and cancer outcomes: time to think like oncologists? (Pubmed Central) -  Mar 3, 2023   
    Cao and colleagues present a follow-up analysis of a previous RCT among >1200 older adults (mean age 72 yr) undergoing cancer surgery, originally designed to evaluate the effect of propofol or sevoflurane general anaesthesia on delirium, here to evaluate the effect of anaesthetic technique on overall survival and recurrence-free survival...We suggest that although it is entirely plausible that the observed results are truly robust neutral findings, the present study could be limited, like most published studies in the field, by its heterogeneity and understandable absence of underlying individual patient-specific tumour genomic data. We argue for a precision oncology approach to onco-anaesthesiology research that recognises that cancer is not one but rather many diseases and that tumour genomics (and multi-omics) is a fundamental determinant relating drugs to longer-term outcomes.
  • ||||||||||  sevoflurane / Generic mfg.
    Observational data, Retrospective data, Journal, Surgery:  Outcomes of intravenous and inhalation anesthesia on patients undergoing esophageal cancer surgery: a retrospective observational study. (Pubmed Central) -  Mar 3, 2023   
    We argue for a precision oncology approach to onco-anaesthesiology research that recognises that cancer is not one but rather many diseases and that tumour genomics (and multi-omics) is a fundamental determinant relating drugs to longer-term outcomes. In conclusion, there were no significant difference in overall survival and disease-free survival between total intravenous anesthesia and inhalational anesthesia in patients undergoing esophageal cancer surgery.
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg., paracetamol / Generic mfg.
    Journal, Surgery:  INTERFASCIAL PLANE BLOCKS IN OBSTETRIC AND GYNECOLOGIC SURGERY. (Pubmed Central) -  Feb 24, 2023   
    Decreased usage of fentanyl and sevoflurane was noticed in the cases where IPB was performed preoperatively...There were no complications regarding block performance. QLB and ESPB have great potential to improve and facilitate postoperative pain management in obstetric and gynecologic surgery.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane (clinicaltrials.gov) -  Feb 24, 2023   
    P4,  N=180, Recruiting, 
    QLB and ESPB have great potential to improve and facilitate postoperative pain management in obstetric and gynecologic surgery. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024