sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date:  Propofol Versus Sevoflurane for Induction of GA in Infants (clinicaltrials.gov) -  Jul 5, 2023   
    P=N/A,  N=122, Recruiting, 
    Trial completion date: Jan 2022 --> Jan 2024 | Trial primary completion date: Jan 2022 --> Jan 2024
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, HEOR, Surgery:  Environmental and Economic Impact of Using a Higher Efficiency Ventilator and Vaporizer During Surgery Under General Anesthesia: A Randomized Controlled Prospective Cohort. (Pubmed Central) -  Jun 27, 2023   
    Methodology Participants enrolled in the study (Institutional Review Board Identifier: 2014-1248) met the following inclusion criteria: 18-65 years old, scheduled for surgery requiring general anesthesia at the University of California Irvine Health, and expected to receive sevoflurane for the duration of the procedure...Conclusions Overall, our results from this study suggest that the MQ delivers statistically significantly less (~20%) volatile agent during routine elective surgery using a standardized anesthetic protocol and inclusion/exclusion criteria designed to minimize any patient or provider heterogeneity effects on the results. The results demonstrate an opportunity for economic and environmental benefits.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Exposure to anesthetic gases in the operating rooms and assessment of non-carcinogenic risk among health care workers. (Pubmed Central) -  Jun 26, 2023   
    Although the results show that overall occupational exposure to anesthetic gases is less than acceptable but long-term exposure to anesthetic gases may endanger the health of operating room staffs. Therefore, it is recommended to implement some technical controls, including regular inspection of ventilation systems, the use of advanced ventilation systems with high cleaning power, continuous control of anesthesia devices in terms of leakage, and periodic training of related staff.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Immunotoxicity induced by occupational inhalation exposure to waste anesthetic gases: a historical cohort study. (Pubmed Central) -  Jun 26, 2023   
    These findings provide corroborative evidence to further substantiate the contention that exposure to anesthetics agents (N2O, isoflurane, and sevoflurane) is associated with subtle, subclinical, prepathological changes in the parameters of immune function. The long-term ramification of these changes requires further investigation.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane upregulates neuron death process-related Ddit4 expression by NMDAR in the hippocampus. (Pubmed Central) -  Jun 22, 2023   
    NMDAR, the core target receptor of sevoflurane, rather than GABAR, mediates the sevoflurane regulation of DDIT4 expression. Our study screened sevoflurane-regulated DEGs and focused on the neuronal death process to reveal DDIT4 as a potential target mediated by NMDAR, which may provide a new target for the treatment of sevoflurane neurotoxicity.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, Adverse events:  Sevoflurane Versus Propofol for LMA (Pubmed Central) -  Jun 20, 2023   
    We urge more well-designed clinical and preclinical studies in this field. No abstract available
  • ||||||||||  sevoflurane / Generic mfg., midazolam hydrochloride / Generic mfg.
    Journal:  Transillumination facilitates coccygeal arterial cannulation in anaesthetised small-breed dogs. (Pubmed Central) -  Jun 19, 2023   
    Intraoperative body temperature may influence postoperative cognitive performance. The transillumination allows for a more accurate approach to the coccygeal artery, improving the success of arterial cannulation when combined with pulse palpation.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Selective Activation of NAc D1R-VP/LH Circuits Promotes Reanimation From Sevoflurane Anesthesia in Mice. (Pubmed Central) -  Jun 19, 2023   
    The transillumination allows for a more accurate approach to the coccygeal artery, improving the success of arterial cannulation when combined with pulse palpation. Both NAc D1R -VP and NAc D1R -LH circuits are sufficient to promote reanimation from sevoflurane GA by simultaneously inducing cortical and behavioral emergence.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Preclinical, Journal:  Effect of Sevoflurane and Isoflurane on Post-Anaesthesia Cognitive Dysfunction in Normal and Type II Diabetic Rats. (Pubmed Central) -  Jun 18, 2023   
    Both isoflurane and Sevoflurane in diabetic rats demonstrated a decline in long-term/reference memory, non-spatial working memory, exploratory activity and caspase 3 expression in hippocampus homogenate compared with normal control rats. Diabetes revealed significant post-anaesthesia cognitive dysfunction after anaesthesia with Sevoflurane or isoflurane in all the studied domains compared to standard control or diabetic control.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date, Surgery:  RAPID: The Effect of Desflurane Versus Sevoflurane on Postoperative Recovery (clinicaltrials.gov) -  Jun 15, 2023   
    P4,  N=190, Completed, 
    Sevoflurane treatment ameliorated myocardial injury and pyroptosis in MIRI via circPAN3/miR-29b-3p/SDF4 axis. Recruiting --> Completed | Trial completion date: Sep 2024 --> Jun 2023 | Trial primary completion date: May 2024 --> Jun 2023
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Review, Journal:  Neuroprotective strategies in anesthesia-induced neurotoxicity. (Pubmed Central) -  Jun 14, 2023   
    A consideration of neuroprotective strategies is important, as scientists and clinicians alike ponder methods to potentially improve the neurodevelopmental outcomes of the millions of infants and children who undergo surgery and anesthesia annually around the world. This review will address plausible neuroprotective strategies and include alternative anesthetics, neuroprotective nonanesthetic drugs, and physiologic neuroprotection.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial initiation date, Surgery:  BISCAR: Anaesthetic Depth and Short Term Delirium Post Cardiac Surgery Intervention (clinicaltrials.gov) -  Jun 13, 2023   
    P=N/A,  N=200, Not yet recruiting, 
    This review will address plausible neuroprotective strategies and include alternative anesthetics, neuroprotective nonanesthetic drugs, and physiologic neuroprotection. Initiation date: May 2023 --> Sep 2023
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Long-lasting GABAA receptor overactivity in the hippocampus after surgery in mice (Montreal Bonaventure Hotel (CAN meeting headquarters)) -  Jun 10, 2023 - Abstract #CANACN2023CAN_ACN_765;    
    Cell-surface expression of extrasynaptic GABAA receptors increased following anesthesia and surgery. Ongoing electrophysiological studies will examine whether tonic inhibition is further increased.
  • ||||||||||  sevoflurane / Generic mfg.
    Retrospective data, Journal:  Bilateral Transient Dilated and Fixed Pupils After Microvascular Decompression: Rare Clinical Experience. (Pubmed Central) -  Jun 5, 2023   
    They underwent MVD under general anesthesia and used propofol and sevoflurane...Therefore, the authors think if MVD is successfully carried out, bilateral transient mydriasis may not necessarily indicate brain stem hemorrhage, cerebral herniation, and other emergency conditions, which can be recovered within a short time. The causes could be related to stimulation of the sympathetic pathway in the brain stem during MVD and side effects of anesthetics.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane-induced P300 promotes neuron apoptosis via Sp1/SDK9 pathway. (Pubmed Central) -  Jun 5, 2023   
    Mice exposed to sevoflurane using P300 inhibitor also showed decreased levels of apoptosis of cortical cells and a decrease in recent cognitive impairment. In summary, sevoflurane-induced P300 inhibited activity of Sp1 by increasing Sp1 acetylation modification, down-modulates CDK9 expression, and promotes the occurrence of neuronal apoptosis.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation. (clinicaltrials.gov) -  Jun 5, 2023   
    P=N/A,  N=126, Recruiting, 
    In summary, sevoflurane-induced P300 inhibited activity of Sp1 by increasing Sp1 acetylation modification, down-modulates CDK9 expression, and promotes the occurrence of neuronal apoptosis. Completed --> Recruiting | Trial completion date: Jan 2023 --> Mar 2024 | Trial primary completion date: Jun 2022 --> Oct 2023
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Preclinical, Journal:  Anesthetics inhibit phosphorylation of the ribosomal protein S6 in mouse cultured cortical cells and developing brain. (Pubmed Central) -  Jun 1, 2023   
    Using a systems approach, we determined that propofol, etomidate, dexmedetomidine, and APV/TTX all similarly modulate a signaling module that includes pS6 and other cell mediators of the mTOR-signaling pathway. Reduction in S6 phosphorylation and subsequent suppression of the mTOR pathway may be a common and novel signaling event that mediates the impact of general anesthetics on neural circuit development.
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  The Impact of a Preoperative Nerve Block in Foot and Ankle Surgery on the Consumption of Sevoflurane (clinicaltrials.gov) -  May 24, 2023   
    P2/3,  N=100, Recruiting, 
    Trial completion date: Aug 2024 --> Aug 2026 | Trial primary completion date: Aug 2024 --> Aug 2026 Trial completion date: Aug 2024 --> Aug 2026 | Trial primary completion date: Aug 2024 --> Aug 2026