sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg., rocuronium / Generic mfg.
    New trial:  Effects of Anesthetics on High-Dose Rocuronium (clinicaltrials.gov) -  Sep 21, 2023   
    P=N/A,  N=75, Not yet recruiting, 
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Oxygen Consumption and Sevoflurane Uptake Based on Physiological Dead Space Estimation (clinicaltrials.gov) -  Sep 21, 2023   
    P=N/A,  N=17, Recruiting, 
    Trial completion date: Dec 2023 --> Sep 2024 | Trial primary completion date: Jun 2023 --> Jun 2024 Not yet recruiting --> Recruiting | Trial completion date: Oct 2023 --> Oct 2024 | Trial primary completion date: Mar 2023 --> Mar 2024
  • ||||||||||  sevoflurane / Generic mfg.
    Journal, Surgery:  Effect of sevoflurane on CD4+CD25+FOXP3+ regulatory T cells in patients with gastric cancer undergoing radical surgery. (Pubmed Central) -  Sep 20, 2023   
    The results showed that the expression of CD4+CD25+FOXP3+ Treg cells might be related to the TNM stage of gastric cancer and sevoflurane could alleviate the inhibition of postoperative immune function more than propofol. Sevoflurane effectively reduced the expression level of CD4+CD25+FOXP3+ Treg cells in peripheral blood of T2 and T3 of patients with gastric cancer, providing the theoretical basis for the selection of surgical anesthetics for patients with gastric cancer.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Sevoflurane and propofol's effects on postoperative vomiting and nausea. (Pubmed Central) -  Sep 18, 2023   
    Sevoflurane effectively reduced the expression level of CD4+CD25+FOXP3+ Treg cells in peripheral blood of T2 and T3 of patients with gastric cancer, providing the theoretical basis for the selection of surgical anesthetics for patients with gastric cancer. No abstract available
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  The protective effects of sevoflurane on subarachnoid hemorrhage. (Pubmed Central) -  Sep 18, 2023   
    In light of these discoveries, we maintain that sevoflurane exhibits significant promise in the management of SAH, and it merits additional investigation to facilitate its prompt clinical implementation. Therefore, a thorough understanding of the neuroprotective properties of sevoflurane is beneficial to exploring novel therapeutic solutions for SAH and providing clinicians with alternative treatment modalities.
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Modern approaches to the components of multimodal antinociceptive protection in patients with ovarian cancer (Pubmed Central) -  Sep 18, 2023   
    It was concluded that increased induction times of sevoflurane may be due to the olfactory bulb lesion. The introduction of Remaxol into MMA improves the quality of antinociceptive protection, promotes regression of POL products, and prevents the progression of hepatopathy and EI, contributing to the development of stress-limiting mechanisms of long-term adaptation in patients with ovarian cancer in the intra and near perioperative period.
  • ||||||||||  sevoflurane / Generic mfg.
    Preclinical, Journal:  Sevoflurane-induced hypotension causes cognitive dysfunction and hippocampal inflammation in mice. (Pubmed Central) -  Sep 16, 2023   
    Moreover, sevoflurane-induced hypotension was associated with the impaired cognitive function and the increased levels of NLRP3 inflammasome activation and oxidative stress in hippocampus. These findings suggest that sevoflurane-induced hypotension may lead to the cognitive dysfunction and hippocampal inflammation.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Postanesthesia Care Unit Recovery Time According to Volatile Anesthetic Used in Clinical Practice. (Pubmed Central) -  Sep 15, 2023   
    Although oversedation was associated with increased PACU recovery time, differences in the rate of oversedation among agents were insufficient to produce meaningful differences in overall PACU recovery time across the 3 volatile agents. Practical attempts to decrease PACU recovery time should address factors other than volatile agent selection.
  • ||||||||||  ketorolac / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Ketorolac on Post Adenotonsillectomy Pain (clinicaltrials.gov) -  Sep 13, 2023   
    P4,  N=120, Recruiting, 
    Our study revealed that sevoflurane can more effectively prevent the development of glioma after surgery than propofol, and SERPINI1 can be used as a new independent prognostic factor for glioma. Trial completion date: Aug 2023 --> Sep 2024 | Trial primary completion date: Aug 2023 --> Sep 2024
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Surgery:  RAPID-II: The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium (clinicaltrials.gov) -  Sep 6, 2023   
    P4,  N=1332, Recruiting, 
    Clinical trial The Korean Clinical Research Registry (study identifier: KCT0006917, principal investigator's name: MiHye Park, date of registration: January 12, 2022). Not yet recruiting --> Recruiting
  • ||||||||||  isoflurane / Generic mfg.
    Preclinical, Journal:  Isoflurane alters presynaptic endoplasmic reticulum calcium dynamics in wild-type and malignant hyperthermia-susceptible rodent hippocampal neurons. (Pubmed Central) -  Aug 31, 2023   
    We identify neuronal endoplasmic reticulum Ca regulation as a novel target for volatile anesthetic action and as a potential target in malignant hyperthermia. While depression of CNS electrical activity in vivo by anesthesia has been observed in another model of malignant hyperthermia, our study reveals fundamental presynaptic mechanisms of volatile anesthetics with implications for the development of more selective anesthetics and for prevention and treatment of malignant hyperthermia.
  • ||||||||||  sevoflurane / Generic mfg.
    Clinical, Journal:  Protective effect of propofol compared with (Pubmed Central) -  Aug 28, 2023   
    The former agent significantly affected postoperative transaminases (AST hazard ratio -192.2, 95% confidence interval [-332.1 to -52.4], p = 0.00; ALT hazard ratio -140.2, 95% confidence interval [-240.0 to -40.7], p = 0.007). In conclusion, propofol had a greater hepatoprotective effect than sevoflurane as assessed by postoperative transaminases after hepatectomy with Pringle maneuver for metastatic liver tumors.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Predictors of Low Risk for Delirium during Anesthesia Emergence. (Pubmed Central) -  Aug 24, 2023   
    This animal model could be an alternative organ injury research on organ injury of patients undergoing cardiac surgery. In this study we developed an easily applicable exploratory method to analyze a single frontal EEG channel and to identify patterns specific for patients at low risk for delirium.
  • ||||||||||  remifentanil / Generic mfg., sevoflurane / Generic mfg., methamphetamine / Generic mfg.
    Anesthetic Management of Extremely Large (8 cm) Meningioma (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6235;    
    The Neurosurgery team decided to proceed with a craniotomy due to the patient's progressive decline.Given the extensive size of the tumor, the decision was made to use 0.5 MAC of volatile agent (sevoflurane) and half intravenous agent (propofol and remifentanil). The procedure lasted 12 hours, and the patient was transferred to the neurosurgical ICU for post-operative management.
  • ||||||||||  sevoflurane / Generic mfg.
    Incident of Emergence Delirium in an Autistic Adolescent (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6204;    
    A 12-year-old male patient with autism began showing signs of emergence delirium in PACU after a tympanostomy that utilized sevoflurane for inhalation induction...The patient was facing heightened sensory processing difficulties and was at an increased risk for self-injury by removing intravenous catheters, which was distressing for the patient, family and caregivers involved. This presentation will discuss the risk factors, prevention, and treatment of emergence delirium in the pediatric setting.
  • ||||||||||  Interesting Case: Anesthesia in Molybdenum Cofactor deficiency (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6197;    
    This presentation will discuss the risk factors, prevention, and treatment of emergence delirium in the pediatric setting. Maintenance: sevoflurane 2%, fentanyl 2 ?g/kg, propofol 2 mg/kg, dexmedetomidine 0.5
  • ||||||||||  Flu Unresponsive to Steroids . . . Or is It? (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6194;    
    It is common that diagnosis of SGS is delayed due to similar presentation with URI. Fortunately, a quick diagnosis of SGS was made based on previous intubation history and failure to pass decreasing ETT size.
  • ||||||||||  sevoflurane / Generic mfg.
    A Near Miss Event of Renal Transplantation into a Malignant Hyperthermia Patient (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_5795;    
    MH crisis was averted after error identification, conversion of the donor's anesthetic to TIVA and allowance of time for sevoflurane concentration to read 0.0% prior to renal vessel clamping. This case illustrates the importance of understanding medical history of both recipient and donor when performing living donor kidney transplants.
  • ||||||||||  rocuronium / Generic mfg.
    Perivascular Infiltration of Rocuronium in Patient With Chronic Renal Disease (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_5790;    
    Mask induction was performed with sevoflurane 8%, followed by intubation...Despite CKD (Cr 2.5), we chose to reverse rocuronium with sugammadex 160 mg. She was extubated with no residual blockade postoperatively.
  • ||||||||||  fentanyl citrate / Generic mfg., sevoflurane / Generic mfg.
    Anesthesia-Induced Rhabdomyolysis - A Case Report of an Uncommon but Serious Risk to Consider (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_5766;    
    Laboratory tests revealed severe metabolic acidosis (pH 7.06), acute renal injury (Cr 11.73), elevated CK (7410), and severe hyperkalemia (8.5). Supportive measures and intensive care were provided, with discharge after 48 hours.
  • ||||||||||  sevoflurane / Generic mfg., rocuronium / Generic mfg.
    Bronchospasm Management: Overcoming the Challenges of Treating Patients with Severe Airway Constriction (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_5762;    
    The patient's respiratory status improved, and she was transferred to the recovery room. We discuss strategies in reducing the risk of bronchospasms during anesthesia, which requires a multifaceted approach that includes preoperative evaluation, agent selection, depth of anesthesia management, and vigilant monitoring.
  • ||||||||||  sevoflurane / Generic mfg.
    Reductions in Perioperative Greenhouse Gas Emissions: A Collaborative Sustainability Initiative (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_5656;    
    The FDA maintains sevoflurane FGF should remain above 1L/min and within 1-2L/min for 2 MAC-hour, despite inconclusive nephrotoxic effects in humans and modernized CO2 absorbents eliminating the production of compound A. We present the collaborative implementation of low FGF at our institution and descriptive statistics demonstrating significant reductions in inhaled anesthetic usage and GHG emissions (Figure 1B). In the future, we aim to share UC-wide data lead by collaborative efforts in sustainability initiatives.
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Quality Improvement Initiative to Reduce Environmental Impact through Low-Flow Anesthesia (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_5584;    
    Two weeks following our intervention, rates had decreased by 50% for sevoflurane (1.18 L/m) and by 39% for isoflurane (1.15 L/m). These findings suggest that a multifaceted departmental intervention effectively reduced maintenance phase volatile flow rates and in turn our carbon footprint.