sevoflurane / Generic mfg. 
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  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Effect of Sevoflurane Anesthesia on Intraoperative Spikes, High-Frequency Oscillations, and Phase-Amplitude Coupling in MRI-Normal Hippocampus. (Pubmed Central) -  Nov 7, 2023   
    Our findings indicate that the administration of sevoflurane during intraoperative electrocorticography in patients with MRI-normal hippocampus can lead to a dose-dependent enhancement of epileptic biomarkers (spikes, ripples on spikes, fast ripples on spikes, and MI (HFO 3-4)) in the epileptogenic hippocampus, while paradoxically increasing the rate of ripples and fast ripple in the nonepileptogenic hippocampus. These results have significant implications for the identification of the MRI-normal hippocampus that requires surgical intervention and preservation of the nonepileptogenic hippocampus.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Anafilaxia perioperatoria a sevoflurano, un caso muy raro (Pubmed Central) -  Nov 7, 2023   
    Perioperative anaphylaxis due to sevoflurane is confirmed. All drugs involved in perioperative hypersensitivity reactions should be considered to establish adequate and safe treatment alternatives for this small group of patients.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations. (Pubmed Central) -  Nov 6, 2023   
    The possibility of identifying anesthetics (sevoflurane) in lacrimal fluid has been studied using a new electrochemical method of multisensory inversion voltammetry in the electronic tongue and electronic nose format...The list of organic substances that can be determined by multisensory stripping voltammetry has been extended. The class of organic substances determined by the method of multisensory inversion voltammetry has been expanded.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Journal:  Bibliometric Analysis of Anesthetic Drugs' Effects on Immune Function- Current Knowledge, Hotspots and Future Perspectives. (Pubmed Central) -  Nov 4, 2023   
    It is anticipated that forthcoming research endeavors will concentrate on exploring the impacts of isoflurane, sevoflurane, and ketamine on immune function. This study provided a thorough analysis of the research trends and developments in investigating the impact of anesthetic drugs on immune function, incorporating pertinent research and collaborative entities such as authors, institutions, and countries.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Journal:  Reversal of Rocuronium-Induced Neuromuscular Blockade by Sugammadex Under Sevoflurane and Desflurane Anesthesia in Children. (Pubmed Central) -  Nov 4, 2023   
    This study provided a thorough analysis of the research trends and developments in investigating the impact of anesthetic drugs on immune function, incorporating pertinent research and collaborative entities such as authors, institutions, and countries. Rapid and complete recovery was achieved from the block induced by a single dose of 0.6 mg/ kg rocuronium by the use of sugammadex which did not give rise to any side effects.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  PREVENTION OF PATHOLOGICAL EFFECT OF ISCHEMIA-REPERFUSION IN LIVER RESECTION BY SEVOFLURANE PRECONDITIONING. (Pubmed Central) -  Nov 3, 2023   
    Rapid and complete recovery was achieved from the block induced by a single dose of 0.6 mg/ kg rocuronium by the use of sugammadex which did not give rise to any side effects. The protective effect of sevoflurane on the postoperative function of the liver is manifested by the lower level of blood lactate and the stable level of transaminase activity.
  • ||||||||||  sevoflurane / Generic mfg.
    Retrospective data, Review, Journal:  Renal safety of critical care sedation with sevoflurane: a systematic review and meta-analysis. (Pubmed Central) -  Nov 3, 2023   
    Sevoflurane was not associated with renal failure when used for critical care sedation of fewer than 72-h duration, despite the elevation of serum fluoride. Longer-term studies are currently inadequate, including in patients with compromised renal function, to further evaluate the role of sevoflurane in this setting.Trial registration PROSPERO (CRD42022333099).
  • ||||||||||  sevoflurane / Generic mfg., isoflurane / Generic mfg.
    Review, Journal:  Neuroprotection Is in the Air-Inhaled Gases on Their Way to the Neurons. (Pubmed Central) -  Oct 31, 2023   
    However, utilizing medical gases, noble gases, and gaseous molecules as supportive treatment options may offer new perspectives for patients suffering neuronal damage. This review provides an overview of current research, potentials and mechanisms of these substances as a promising therapeutic alternative for the treatment of cerebral injury.
  • ||||||||||  sevoflurane / Generic mfg.
    Review, Journal:  Beneficial Effects of Halogenated Anesthetics in Cardiomyocytes: The Role of Mitochondria. (Pubmed Central) -  Oct 28, 2023   
    Halogenated anesthetics, mainly sevoflurane, have been used as a therapeutic tool in patients undergoing cardiac surgery, thanks to the beneficial effect of the cardiac protection they generate...The mechanisms through which mitochondrial homeostasis is maintained and its relationship with the clinical effect are the basis of our review. From a translational perspective, we provide information regarding mitochondrial physiology and physiopathology in cardiac failure and the role of halogenated anesthetics in modulating oxidative stress and inducing myocardial conditioning.
  • ||||||||||  rocuronium / Generic mfg.
    Journal:  Suspected Accidental Infiltration of Rocuronium During General Anesthesia Induction: A Case Report. (Pubmed Central) -  Oct 22, 2023   
    After induction with sevoflurane, an intravenous (IV) line was established in the left cephalic vein...Sugammadex was administered to prevent neuromuscular blockade recurrence...No neuromuscular block prolongation or recurrence were observed postoperatively. When rocuronium infiltration is suspected, it is important to eliminate swelling at the infiltration site and determine a management strategy based on neuromuscular monitoring.
  • ||||||||||  ketamine / Generic mfg., sevoflurane / Generic mfg.
    Journal:  Altered brain dynamics index levels of arousal in complete locked-in syndrome. (Pubmed Central) -  Oct 22, 2023   
    In conclusion, changes in brain dynamics indicate altered arousal in CLIS. Specifically, PLE and LZC are potentially relevant biomarkers to identify or diagnose the arousal level in CLIS and to determine the optimal time point for treatment, including communication attempts.
  • ||||||||||  ubidecarenone IV (BPM 31510 IV) / BPGbio
    Preclinical, Journal:  Effects of coenzyme Q10 in a propofol infusion syndrome model of rabbits. (Pubmed Central) -  Oct 20, 2023   
    The propofol and sevoflurane organ toxicities were attenuated with CoQ10 in liver, gallbladder, urinary bladder, and spleen. The addition of CoQ10 to propofol and sevoflurane anesthesia prevented the propofol-associated increase in troponin T levels at the 12th hour of infusion and decreased anesthetic-induced total liver and organ injury scores.
  • ||||||||||  sevoflurane / Generic mfg.
    Enrollment open, Surgery:  Cerebral Flow-metabolism Coupling During Adult Surgery (clinicaltrials.gov) -  Oct 17, 2023   
    P4,  N=80, Recruiting, 
    The addition of CoQ10 to propofol and sevoflurane anesthesia prevented the propofol-associated increase in troponin T levels at the 12th hour of infusion and decreased anesthetic-induced total liver and organ injury scores. Not yet recruiting --> Recruiting
  • ||||||||||  sevoflurane / Generic mfg.
    Phase classification, Trial termination:  OPCare: Does Optimized General Anesthesia Care Reduce Postoperative Delirium? (clinicaltrials.gov) -  Oct 17, 2023   
    P=N/A,  N=145, Terminated, 
    Not yet recruiting --> Recruiting Phase classification: P4 --> P=N/A | Unknown status --> Terminated; Limited availability of subjects meeting inclusion criteria resulting in early termination (lack of funding) before meeting target enrollment.
  • ||||||||||  sevoflurane / Generic mfg.
    Journal:  Evaluation of the Effect of Induced Endotoxemia on ROTEM S and Platelet Parameters in Beagle Dogs Anaesthetized with Sevoflurane. (Pubmed Central) -  Oct 14, 2023   
    Phase classification: P4 --> P=N/A | Unknown status --> Terminated; Limited availability of subjects meeting inclusion criteria resulting in early termination (lack of funding) before meeting target enrollment. In this study, blood samples from six beagle dogs receiving 1 mg/kg E. coli lipopolysaccharide (LPS) intravenously were analyzed to describe the concurrent changes in platelet count, platelet function assessed with impedance thromboaggregometry, thromboelastometry and d-dimers during artificially induced endotoxemia and its therapy with fluids and vasopressors at five timepoints (baseline, after LPS and 30 mL/kg Ringer's acetate, during noradrenaline
  • ||||||||||  sevoflurane / Generic mfg.
    Trial completion, Trial completion date, Surgery:  Melatonin for Pediatric Emergence Agitation (clinicaltrials.gov) -  Oct 12, 2023   
    P4,  N=117, Completed, 
    The presented survey showed that inhalative sedatives were used in a significant number of intensive care units in Germany to treat severely brain-injured patients. Recruiting --> Completed | Trial completion date: May 2022 --> Dec 2022
  • ||||||||||  ropivacaine / Generic mfg.
    Clinical, Journal, Surgery:  Efficacy of lumbosacral and sacrococcygeal epidural ropivacaine in dogs undergoing surgery for perineal hernia. (Pubmed Central) -  Oct 9, 2023   
    After premedication with IM acepromazine 0.02?mg/kg and butorphanol 0.3?mg/kg, general anesthesia was induced with propofol and maintained with sevoflurane in oxygen...Clinical failure was defined as the need of more than two boluses of fentanyl/h each dog received meloxicam 0.2?mg/kg IV at the end of the surgery...No significant differences between groups were detected in the GCPS-SF score, tactile sensitivity, pressure pain thresholds, need of post-operative methadone, or motor blockade. Both epidural techniques are valuable analgesic options for perineal hernia repair in dogs.
  • ||||||||||  fentanyl citrate / Generic mfg., ketamine / Generic mfg., sevoflurane / Generic mfg.
    Preclinical, Journal:  Comparison of the respiratory effects of commonly utilized general anaesthesia regimes in male Sprague-Dawley rats. (Pubmed Central) -  Oct 4, 2023   
    Bronchial hyperresponsiveness in response to ketamine-xylazine anaesthesia should be considered when designing experiments using this regime. The findings of the present study indicate commonly used anaesthetic regimes allow fair comparison of respiratory mechanics in experimental animals undergoing any of the examined anaesthesia protocols.
  • ||||||||||  sevoflurane / Generic mfg., dexmedetomidine / Generic mfg.
    Review, Journal:  Research progress on the effects and mechanisms of anesthetics on neural stem cells. (Pubmed Central) -  Oct 3, 2023   
    This may be attributed to the downregulation of NR2B-CREB-BDNF pathway, reducing the inflammatory response and oxidative stress damage in hippocampal tissue. It was concluded that propofol and sevoflurane may be the safest options for NSCs during pregnancy and in pediatric clinical procedures, while dexmedetomidine has been found to reduce opioid-related damage
  • ||||||||||  ByFavo (remimazolam) / PAION, Cosmo Pharma, Mundipharma, Pharmascience, Eagle Pharma
    PK/PD data, Journal:  Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children. (Pubmed Central) -  Sep 23, 2023   
    Remimazolam in children was characterised by a high clearance and short context-sensitive half-time. When normalised to weight, pharmacokinetic properties were similar to those reported for adults.