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77 Diseases |  |
69 Trials |
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69 Trials |  |
4434 News |  |
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- |||| lopinavir/ritonavir / Generic mfg.
#COVID19 response to Kaletra #stewardmeme (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: There was trend for improvement in primary end point (? underpowered). Median time in ICU 6 vs 11 days. Pts w/ Rx early in course did better than later & w/ clinical improvement day 14 higher w/ lopinavir-ritonavir (46 to 30). Need continued studies, including immunocompromised. (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Lopinavir/Ritonavir não funcionou ☹️ https://t.co/4By53Ij5t1 (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Important for transplant teams - updated @ASTCT guidelines now include Rx options & suggestions. https://t.co/CJ67f30Yhe Great work from members thruout US & led by @alpanaw As quickly as we get guidelines up new Kaletra data means it needs to change already - such is #COVID19 (Twitter) - Mar 18, 2020
- || lopinavir/ritonavir / Generic mfg.
I think kaletra is out https://t.co/60Riq162So (Twitter) - Mar 18, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: RCT #COVID19 Lopinavir-Ritonavir +SOC vs SOCin in 199 pts. 1st pt enrolled Jan 18. Primary endpoint: time to clinical improvement —No benefit over SOC. 25% mortality —sick hypoxic pts . @NEJM @mybetterdoctor https://t.co/bIZkk9gCwx (Twitter) - Mar 18, 2020
- |||| lopinavir/ritonavir / Generic mfg.
RCT of lopinavir/ritonavir (approved for HIV) for severe #COVID19 is negative via @nejm. Always tough to see neg results in high unmet need, but highlights value of RCTs. Hats off to Drs. Bin Cao, Chen Wang et al for solid work, esp during a pandemic! https://t.co/3uDWSC1ZA1 (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: Oh, Clinical improvement is somehow faster in patients who received Kaletra (Table 3, data on Clinical improvement, Day 7 and 14...) (Twitter) - Mar 18, 2020
- || Copegus (ribavirin) / Bausch Health, lopinavir/ritonavir / Generic mfg.
Imo this RCT won't provide final answer ⬇️ mortality those started therapy earlier <12d If lopinavir ritonavir used mono weak activity low conc probably will fail maybe you need to add Ribavirin or another antiviral ~15% didn't tolerate Kaletra, stop it ~15% NGT, prepare,conc 🤔 (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Agree on **need** for reducing viral load. This trial, though, is not encouraging for kaletra. Mean viral load did not drop on kaletra. Need data from another source to support idea that kaletra drops viral load. (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: Nobody has. It’s a hypothesis: if we are able to rapidly reduce viral load in mild/moderate cases, maybe we could reduce the number of days patients are contagious and the risk of evolution to a severe case. KALETRA alone must not be sufficient for severe cases. (Twitter) - Mar 18, 2020
- ||| remdesivir (GS-5734) / Gilead, hydroxychloroquine / Generic mfg., lopinavir/ritonavir / Generic mfg.
Clinical: KALETRA alone should be used in mild/moderate cases to reduce viral load. It’s absolutely not sufficient for severe cases: it should be combined with another drug (Remdesivir ++++ or hydroxychloroquine). So, in my humble opinion, keep on using KALETRA with another drug! (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: The "trial" was seemingly done months ago in China on already seriously ill patients. To delay #Kaletra just to go through bureaucratic hoops seems wrong to me. (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: Agree--was just reading it. The MITT population just dropped the 3 early deaths before receipt of kaletra. So not as grievous as the usual MITT. Underpowered, but subtle hint toward modest efficacy. I doubt it would work in ARDS--by then it's not really the viral titers. Seems (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: Super quick look at Kaletra trial in NEJM. only positive in MITT population. That should always raise an eyebrow. (Twitter) - Mar 18, 2020
- |||| Copegus (ribavirin) / Bausch Health, lopinavir/ritonavir / Generic mfg.
Clinical, Adverse events: Disappointing results from Lopinavir-Ritonavir in Adults with #COVID-19. Slightly decreased mortality, not significant. ?Need + ribavirin - but would add side effects. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 | NEJM https://t.co/Oo5ueftq3H (Twitter) - Mar 18, 2020
- || lopinavir/ritonavir / Generic mfg.
Agree but hopefully you don’t have many people on Kaletra today! (Twitter) - Mar 18, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: Just out today #COVID19 #Kaletra #treatment shows no benefit A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 | NEJM https://t.co/ogIFQ5k5a7 (Twitter) - Mar 18, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: #Lopinavir–#Ritonavir did not help patients #Hospitalized with Severe #COVID19. Please stop using #kaletra. How important to do proper randomized trials. #DontCoverDiscover #SARSCoV2 .@InfectiousDz .@onisillos .@IDstewardship .@IDSAInfo https://t.co/w18Z3VKITr (Twitter) - Mar 18, 2020
- ||| remdesivir (GS-5734) / Gilead, lopinavir/ritonavir / Generic mfg.
Clinical: Lessons learned from Bin Cao in Wuhan… all confirmed patients should be in isolation. Critical strategy in his opinion. Rx was usual supportive treatment. He makes clear no specific antiviral shown beneficial. He is leading 3 clinical trials. Lopinavir/ritonavir; Remdesivir x2. (Twitter) - Mar 18, 2020
- |||| remdesivir (GS-5734) / Gilead, lopinavir/ritonavir / Generic mfg.
Clinical: In addition to remdesivir, protease inhibitors, lopinavir/ritonavir, and in combinar with interferon beta (LPV/RTV-INFb) has been shown some efficacy as well. https://t.co/KmW0DgnGXb (Twitter) - Mar 18, 2020
- || lopinavir/ritonavir / Generic mfg.
Lannett Company makes a generic form of Kaletra too. (Twitter) - Mar 18, 2020
- || lopinavir/ritonavir / Generic mfg.
Huh. Can you post the link to the Kaletra trial? (Can't clicky in the img) (Twitter) - Mar 17, 2020
- || lopinavir/ritonavir / Generic mfg.
Clinical, Journal: Case of the Index Patient Who Caused Tertiary Transmission of COVID-19 Infection in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Infected Pneumonia Monitored by Quantitative RT-PCR. (Pubmed Central) - Mar 17, 2020
Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed.
- | lopinavir/ritonavir / Generic mfg.
Journal: Management of corona virus disease-19 (COVID-19): the Zhejiang experience (Pubmed Central) - Mar 17, 2020
Early antiviral treatment could alleviate disease severity and prevent illness progression, and we found lopinavir/ritonavir combined with abidol showed antiviraleffects in COVID-19...Therefore, two weeks' quarantine for discharged patients was required and a regular following up was also needed.The Zhejiang experience above and suggestions have been implemented in our center and achieved good results. However, since COVID-19 was a newly emerging disease, more work was warranted to improve strategies of prevention, diagnosis and treatment for COVID-19.
- || chloroquine phosphate / Generic mfg., lopinavir/ritonavir / Generic mfg.
I have 3 accepted compassionate use applications. The most recent says "lopinavir/ritonavir, daruanvir/cobi and chloroquine must be stopped prior to starting RDV." The first one only listed lopinavir/ritonavir, so the list is getting longer day by day (Twitter) - Mar 17, 2020
- ||||| remdesivir (GS-5734) / Gilead, hydroxychloroquine / Generic mfg., lopinavir/ritonavir / Generic mfg.
Clinical: Many hospitals are recommending a mix of off label Kaletra plus hydroxychloroquine in patients with significant #COVID19 symptoms. In Seattle there are trials of remdesivir (made by Gilead); latter also available on compassionate basis. #PancChat #COVIDnCancer (Twitter) - Mar 17, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: Bradycardia (this morning one patient was on 35-38bpm), low blood count and liver damage (I think most of th are also due to Kaletra). (Twitter) - Mar 17, 2020
- || chloroquine phosphate / Generic mfg., lopinavir/ritonavir / Generic mfg.
South Korea has been using hydrochloroquine. And they I believe have had one of the lowest mortality rates. Supposed to work better and better tolerated than chloroquine. Neither is to be taken with kaletra. If zinc deficient a supplement is recommended. (Twitter) - Mar 17, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: R u treating them with lopinavir/ritonavir? In association with HCQ it can cause severe rithm disturbance, avoid aniodarone in this case. Long QTc is a concern. (Twitter) - Mar 17, 2020
- |||| hydroxychloroquine / Generic mfg., lopinavir/ritonavir / Generic mfg.
Clinical: And to follow this- when we get positive #COVID19 #IBD patients, any thoughts about use of #Hydroxychloroquine, #LopinavirRitonavir, or other possible therapies? @Dana_Lukin @MondayNightIBD (Twitter) - Mar 16, 2020
- || Copegus (ribavirin) / Bausch Health, lopinavir/ritonavir / Generic mfg.
BTW, did you end up using ribavirin with Kaletra, or just straight lopanivir/r? Curious of how they're comparing. (Twitter) - Mar 16, 2020
- || lopinavir/ritonavir / Generic mfg.
Important info great resource re:Kaletra dosing and interactions (Twitter) - Mar 16, 2020
- lamivudine / Generic mfg., abacavir/lamivudine / Generic mfg., lopinavir/ritonavir / Generic mfg.
Small Airway Disease and Brochodialator Response in Children with HIV in Sub Saharan Africa (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area F) - Mar 15, 2020 - Abstract #ATS2020ATS_9845;
The study participants were on a combination of either Abacavir, Lamivudine, Lopinavir Ritonavir, Zidovudine or Nevirapine. The mean z scores for all acceptable spirometry were: %FEV/FVC 82%; FEV: pre BDR zFEV1 -2.27, postBDR zFEV1 -2.03; % change postBDR 4.28%; least changes in FVC: pre BDR zFVC -1,92 post BDR zFVC -1,88; % change post BDR 0.62%; with significant changes in FEF 25-75: pre BDR zFEF 25-75 -1.63; post BDR zFEF 25-75 -1,14; % change post BDR 21.07%CONCLUSIONS.Spirometric values of FEF 25-75 BDR is useful to diagnose SAD in children and helps identify children that require long term follow-up of their lung function.
- ||||| lopinavir/ritonavir / Generic mfg.
Clinical: I have one. 40yo women recently diagnosed with RRMS (had not yet received DMT). High fever, dry cough and shortness of breath due to bilateral neumonia. Grade 4 lymphopenia and elevated C-reactive protein in the blood. Treatment with Kaletra and Dolquine has been initiated. (Twitter) - Mar 15, 2020
- || remdesivir (GS-5734) / Gilead, lopinavir/ritonavir / Generic mfg.
I don’t know yet what is best but I’ve seen programs using either kaletra or remdesivir (compassionate use). Lots of drug drug interactions though in our transplant folks. (Twitter) - Mar 14, 2020
- ||| Mucomyst (N-acetylcysteine) / AstraZeneca, lopinavir/ritonavir / Generic mfg.
Potential Treatments for #COVID19 : 1. Hydroxychloroquin. 2. Lopinavir/Ritonavir. 3. Remdesvir. 4. Chinese medicine. 5. Mixed hydrogen and oxygen. 6. Inhaled Mucomyst. Above is based on Chinese experience. S Korea adopted it. @AmirLotfi9 @Mike_Mikolaj @yourheartdoc1 @EricTopol (Twitter) - Mar 14, 2020
- || Clinical, PK/PD data, Journal: Pharmacokinetic Interactions Between the HCV Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, or Darunavir in Healthy Participants. (Pubmed Central) - Mar 14, 2020
Coadministration of elbasvir/grazoprevir with atazanavir/ritonavir, lopinavir/ritonavir, or darunavir/ritonavir is contraindicated owing to an increase in grazoprevir exposure. As such, HIV treatment regimens without HIV protease inhibitors should be considered in HCV/HIV-coinfected individuals who are treated with elbasvir/grazoprevir.
- || lopinavir/ritonavir / Generic mfg.
Using Kaletra or another antiviral combo? (Twitter) - Mar 13, 2020
- | hydroxychloroquine / Generic mfg., lopinavir/ritonavir / Generic mfg.
New P2 trial: Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19) (clinicaltrials.gov) - Mar 12, 2020
P2, N=150, Recruiting, Sponsor: Asan Medical Center
- | lopinavir/ritonavir / Generic mfg.
Compra acciones de @abbvie q es la farmaceutica q hace el medicamento (Kaletra) que detiene el virus y que China ya aprobo para utilizarse... Cuando FDA apruebe en USA va a reventar esas acciones... (Twitter) - Mar 12, 2020
- ||| remdesivir (GS-5734) / Gilead, lopinavir/ritonavir / Generic mfg.
19. kopusinem taze cykan @GileadSciences yn dermany Remdesivir, @abbvie in Kaletrasy yada damardan steroidler bilen licenya edipdirler. Yone hicbirinim peydasy doly belli dal. Mundan basgada reanimasiya dusen hassalar ortaca 7 gun icinde yogalypdyr. #Turkmenistan #coronavirus (Twitter) - Mar 12, 2020
- ||||||| Descovy (emtricitabine/tenofovir alafenamide) / Gilead
Trial completion: Switch Study to Evaluate F/TAF in HIV-1 Positive Participants Who Are Virologically Suppressed on Regimens Containing FTC/TDF (clinicaltrials.gov) - Mar 12, 2020
P3, N=668, Completed, Sponsor: Gilead Sciences
As such, HIV treatment regimens without HIV protease inhibitors should be considered in HCV/HIV-coinfected individuals who are treated with elbasvir/grazoprevir. Active, not recruiting --> Completed
- || lopinavir/ritonavir / Generic mfg.
Clinical, Journal: The 2019 Novel Coronavirus Outbreak - A Global Threat. (Pubmed Central) - Mar 11, 2020
Isolation of symptomatic cases and home quarantine of asymptomatic contacts is recommended. To conclude, controlling this highly transmissible disease requires international co-ordination.
- || Copegus (ribavirin) / Bausch Health, lopinavir/ritonavir / Generic mfg.
Ribavirin in conjunction with lopinavir/ritonavir? (Twitter) - Mar 11, 2020
- |||| Clinical data: Draft includes Data about mech. Action. Place in treatment of #COVID19 Dose RCTs clinical data. Remdesivir chloroquine or interferon lopinavir/ritonavir, darunavir/cobicistat Favipiravir Plasma convalescent Others : Tamiflu /steroids / antimicrobials..etc Open to suggestions. (Twitter) - Mar 11, 2020
- | New P3 trial: THDMS-COVID19: Fight COVID-19 Trial (clinicaltrials.gov) - Mar 11, 2020
P3, N=80, Not yet recruiting, Sponsor: Rajavithi Hospital
- | oseltamivir / Generic mfg., lopinavir/ritonavir / Generic mfg.
Enrollment open: A Prospective/Retrospective,Randomized Controlled Clinical Study of Antiviral Therapy in the 2019-nCoV Pneumonia (clinicaltrials.gov) - Mar 11, 2020
P4, N=400, Recruiting, Sponsor: Tongji Hospital
To conclude, controlling this highly transmissible disease requires international co-ordination. Not yet recruiting --> Recruiting
- || lamivudine / Generic mfg., lopinavir/ritonavir / Generic mfg.
Biomarker, Clinical, Journal: Inflammatory biomarker levels over 48 weeks with dual vs triple lopinavir/ritonavir-based therapy: Substudy of a randomized trial. (Pubmed Central) - Mar 10, 2020
In addition to having virologic non-inferiority, LPV/r+3TC dual therapy is generally associated with similar inflammatory biomarker levels over 48 weeks compared to LPV/r+2NRTIs triple therapy in treatment-naïve adults. Further study of dual treatment regimens is warranted.
- |||| lopinavir/ritonavir / Generic mfg.
Un fármaco contra el sida tiene éxito en la cura del primer contagio por coronavirus | Sociedad | EL PAÍS kaletra+interferon beta for Corona #hiv @drmt @DrJLi @paulsaxmd @DrDemetre https://t.co/fR6jREE4A2 (Twitter) - Mar 5, 2020