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77 Diseases |  |
69 Trials |
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69 Trials |  |
4434 News |  |
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- |||| Avigan (favipiravir) / Fujifilm Holdings, lopinavir/ritonavir / Generic mfg.
Clinical: More patients in #Kaletra group (n=43) had signs of “systemic” inflammation such as fever (n=37), chills (n=1) and headache/myalgia (n=5) as compared to #Favipiravir group (n=22+0+3=25). (Twitter) - Mar 22, 2020
- ||| Avigan (favipiravir) / Fujifilm Holdings, lopinavir/ritonavir / Generic mfg.
Clinical: At baseline, more ptnt in Favipiravir grp (n=19) had nasal congest (n=6), diarrhea (n=1) and cough(n=12) (signs associated with “local” viral effect) compared to Kaletra treated patients (n=2+0+10=12) 2/n (Twitter) - Mar 22, 2020
- || chloroquine phosphate / Generic mfg., lopinavir/ritonavir / Generic mfg.
Very interesting. Why is the drug #Kaletra not being used in conjunction with #chloroquine? That was the original report from Chinese and Australian scientists. (Twitter) - Mar 22, 2020
- || chloroquine phosphate / Generic mfg., lopinavir/ritonavir / Generic mfg.
3/3 Demain si je devais être atteint est-ce que je prendrai de la Oh chloroquine (si j’en trouve) ou du Kaletra ou rien ? Mon choix est fait. Alors oui qu’on avance très vite sur les études m si pas académiques ; il y a urgence (Twitter) - Mar 22, 2020
- ||| lopinavir/ritonavir / Generic mfg.
1/2 Je crois que de toute manière on va droit dans le mur. Les premières études sur le Kaletra / Covid19 ne sont pas faramineuses. Si on croise tout cela avec l’importance du portage asymptomatique chez les 20-30 ans qui sont pblt les principaux vecteurs de cette épidémie, (Twitter) - Mar 22, 2020
- ||| remdesivir (GS-5734) / Gilead, hydroxychloroquine / Generic mfg., lopinavir/ritonavir / Generic mfg.
five treatment modalities: ➡️ standard of care (SoC) ➡️ SoC + #remdesivir ➡️ SoC + #lopinavir/ritonavir (#LPV/r), ➡️ SoC+ #LPV/r + #interferonbeta ➡️ SoC + #hydroxychloroquine (Twitter) - Mar 22, 2020
- |||| hydroxychloroquine / Generic mfg., lopinavir/ritonavir / Generic mfg.
Clinical: In a secret trial, they were all given HIV medication, Kaletra and Malaria treatment hydroxychloroquine. The tests were truly successful that these drugs will now be rolled out to COVID-19 patients in at least 50 hospitals nationwide.The drugs were very much effective (Twitter) - Mar 22, 2020
- | Relenza (zanamivir) / GSK, Vaxart, lopinavir/ritonavir / Generic mfg.
Journal: Potential antiviral therapeutics for 2019 Novel Coronavirus (Pubmed Central) - Mar 22, 2020
Drugs are possibly effective for 2019-nCoV include: remdesivir, lopinavir/ritonavir, lopinavir/ritonavir combined with interferon-β, convalescent plasma, and monoclonal antibodies. But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials.
- | lopinavir/ritonavir / Generic mfg.
Retrospective data, Review, Journal: Pharmacotherapeutics for the new coronavirus pneumonia (Pubmed Central) - Mar 22, 2020
Systemic glucocorticosteroid is recommended as a short term use (1~2 mg·kg(-1)·d(-1), 3~5 d) by the 5(th) edition National Health Commission's Regimen (Revised Edition) yet RCTs are expected to confirm the effectiveness. Inappropriate application of antibiotics should be avoided, especially the combination of broad-spectrum antibiotics, for the NCP is not often complicated with bacterial infection.
- |||| lopinavir/ritonavir / Generic mfg.
Clinical, Clinical data: #KALETRA is still an option in my opinion! Check this => Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China. Wang Y et al. J Infect Dis. 2020 Mar 17. (Twitter) - Mar 22, 2020
- || lopinavir/ritonavir / Generic mfg.
Clinical: I agree,like italy protocol,if remdesevir is not available,i take Lopinavir/ritonavir plus oseltamivir.... (Twitter) - Mar 21, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: As discussed, I’d like to see Lopinavir-Ritonavir for prevention in covid negative patients undergoing cancer surgery. Let’s get randomisation up and running. Adaptive approach. Bring in/drop out arms based on early looks. (Twitter) - Mar 21, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Bad drug interaction? Plaquenil may interact with HIV/AIDS medications did they use lopinavir ritonavir? (Twitter) - Mar 21, 2020
- | lopinavir/ritonavir / Generic mfg.
Kaletra?? @abbvie makes it. Have you tried that?? (Twitter) - Mar 21, 2020
- | remdesivir (GS-5734) / Gilead, lopinavir/ritonavir / Generic mfg.
Nu weten we hoe de vork aan de steel zit.. het tekort wordt weggemoffeld onder de noemer "experimenteel" dan samen met "Kaletra" wordt een amalgaam gemaakt om deze noemer te staven. Ze hebben er geen. Remdesivir: Bewezen effectief china en in Afrika mee geëxperimenteerd. (Twitter) - Mar 21, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Don @ANPEasturias que hay con otros medicamentos como Interferon ó Aluvia (Lopinavir/Ritonavir)? Se sabe que tambien se utiliza para tratar al Covir_19🤔 Es conveniente que el gobierno los compre para esta pandemia? (Twitter) - Mar 20, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: 33% of the all the enrolled patients in the lopinavir-ritonavir in severe COVID-19 trial received steroids. Median time to initiation from onset of illness = 13 days & the treatment duration = 6 days. I emailed the Lead author about outcomes. Will update you once I hear back. (Twitter) - Mar 20, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Lopinavir/ritonavir doesn’t help with COVID19 (see: NEJM this week), problem is steroids have unknown effect on COVID19 and even choloroquine etc may potentiate cardiac risk on osi (Twitter) - Mar 20, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: Hold the treatment. We do the same. In addition, if pneumonia is seen in chest Rx we start on doble or triple therapy. In this case, major risk of drug interaction with lopinavir/ritonavir is another reason for osi discontinuation. (Twitter) - Mar 20, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: Ok. Protocol only specified lopinavir-ritonavir. Thank you! (Twitter) - Mar 20, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: "We suggest against the routine use of lopinavir/ritonavir. There is insufficient evidence to issue a recommendation on the use of other antiviral agents in critically ill adults with COVID-19" [including CQ/HCQ]. (Twitter) - Mar 20, 2020
- | Evusheld (cilgavimab/tixagevimab) / AstraZeneca, Rebif (human IFN-?-1a) / EMD Serono
New P3 trial: DisCoVeRy: Trial of Treatments for COVID-19 in Hospitalized Adults (clinicaltrials.gov) - Mar 19, 2020
P3, N=3200, Not yet recruiting, Sponsor: Institut National de la Sant
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: They crushed tablets and made 5 mL suspension (Lopinavir-ritonavir 400-100mg) per protocol. (Twitter) - Mar 19, 2020
- || lopinavir/ritonavir / Generic mfg.
Clinical, Retrospective data, Journal: Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. (Pubmed Central) - Mar 19, 2020
Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study.
- || lopinavir/ritonavir / Generic mfg.
Clinical, Journal: Letter to the Editor: Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR. (Pubmed Central) - Mar 19, 2020
The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study. No abstract available
- || lopinavir/ritonavir / Generic mfg.
Clinical, Journal: The Author's Response: Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR. (Pubmed Central) - Mar 19, 2020
No abstract available No abstract available
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: Nous on est plus lopinavir/ritonavir ou abstention thérapeutique. Malgré un essai randomisé sur 199 patients mais c’est quoi 199 patients pour cette pathologie. (Twitter) - Mar 19, 2020
- |||| chloroquine phosphate / Generic mfg., hydroxychloroquine / Generic mfg., lopinavir/ritonavir / Generic mfg.
Clinical: Hydroxychloroquine 400 mg. bid x 1 day. Then 200 mg. x 4 days is being given to Covid-19 patients. Toxic dose for Chloroquine is 20 mg/kg Lethal dose for adults is 3-4 gms. Also: *Keletra (Lopinavir/Ritonavir) an anti-viral used in HIV. (Twitter) - Mar 19, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: Nope that doesn't work 😟. Lopinavir-ritonavir fails to improve severe COVID-19, GI symptoms are common in COVID-19, and clinical characteristics of refractory COVID-19. https://t.co/onwHW2EYHj https://t.co/Pe1tbYJGyI (Twitter) - Mar 19, 2020
- ||| lopinavir/ritonavir / Generic mfg.
On a Zoom meeting re: #covid19 and it had the phrase “this was published a few hours ago”. I imagine that is a commonality among these meetings. The Kaletra @NEJM study feels like it was a month ago. On another note, I’m proud to see the preparations being made. (Twitter) - Mar 19, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: Not that disappointing! 45.5% have improved on day 14 in KALETRA group v/s 30%, which is great! Look also at the ICU length of stay: it is significantly shorter in patients who received KALETRA (6 v/s 11 days). We cannot ask one drug to do miracles in severe Covid19! 🙂 (Twitter) - Mar 19, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: We have the discouraging data of this paper and as a sample, viral load of this korean patient where Kaletra doesn’t seem to inhibit viral load till ten days after taking the drug. Kaletra or the response of the inmune system? (Twitter) - Mar 19, 2020
- || lopinavir/ritonavir / Generic mfg.
Ping @davidantibiotic. Views on this NEJM study's Lopinavir-Ritonavir conclusions? (Twitter) - Mar 19, 2020
- ||| Drugs being tested in U.S. in race to find #coronavirus.#COVID19 #ARDS #hydroxychloroquine #Losartan #remdesivir #Kevzara #Actemra #Kaletra (not working?) https://t.co/Ket5YG7MnU (Twitter) - Mar 19, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Great to see more studies starting for COVID-19. We need data as we found with the lopinavir-ritonavir study. They are looking for sites. https://t.co/GN25BD870g (Twitter) - Mar 19, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Just out in @NEJM, no benefit was observed with lopinavir–ritonavir (Kaletra) Rx in #COVID19. @UTSWIMchief @UTSWInfDis @UTSWInternalMed @drbbrodrick @dhjutsw1 @TperlTrish @RicardoLaHozMD @michael_shiloh @DinoKazi https://t.co/dnKvpJHWi1 (Twitter) - Mar 19, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: Will you still use kaletra in CoVid 19 patients? It is just too many unknown 🤔 (Twitter) - Mar 19, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Clinical: I only have one HIV patient who loves her Kaletra and won't give it up. I wonder what percentage of HIV patients in north america are even on a PI anymore? (Twitter) - Mar 19, 2020
- ||| lopinavir/ritonavir / Generic mfg.
We show very weak antiviral effect (~1/2 log) in mice and only with prophylactic lopinavir/ritonavir. We coupled that with IFNb because that was what was in trial in KSA for MERS-CoV in KSA. Paper can be found here https://t.co/ZcWUKDPhwr (Twitter) - Mar 19, 2020
- |||| lopinavir/ritonavir / Generic mfg.
Adverse events: Yes 15%" stopped Kaletra coz of adverse effects, combining more antivirals will make it worse, but the 1 million question, should we abandon lopinavir ritonavir based on this RCT for #COVID19 #COVID19RX given we have limited options If No, insights 🙏 @PaulSaxMD @MichaelIsonMD (Twitter) - Mar 19, 2020
- || lopinavir/ritonavir / Generic mfg.
Median days from starting kaletra was 13d, would it be the same treatring earlier? Or does it needs other treatment besides kaletra? I wouldnt rulled it out so easy (Twitter) - Mar 19, 2020
- ||||| lopinavir/ritonavir / Generic mfg.
Clinical: Oh no 🤦🏻♀️ ⚠️ wrong conclusion on Kaletra #COVID19 based on p-value “Patients assigned to lopinavir–ritonavir did not have a time to clinical improvement differen[ce]... hazard ratio... 1.31; 95% confidence interval [CI], 0.95 to 1.85; P=0.09)” (ITT, n=200) @vamrhein (Twitter) - Mar 19, 2020
- | azithromycin / Generic mfg., lopinavir/ritonavir / Generic mfg.
New trial, Adverse events: CovidTox: Adverse Events Related to Treatments Used Against Coronavirus Disease 2019 (clinicaltrials.gov) - Mar 18, 2020
P, N=1000, Recruiting, Sponsor: Groupe Hospitalier Pitie-Salpetriere
- || remdesivir (GS-5734) / Gilead, lopinavir/ritonavir / Generic mfg.
Good thing it puts Lopinavir-Ritonavir on the backseat for now. Would expect Remdesivir and CQ data to come out soon, hopefully that shows some benefit! (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: Update in the NEJM published hours ago: No significant mortality benefit (at 28 days) identified in 199 COVID patients randomized to lopinavir-ritonavir vs standard care @Pranay_md @YaleMedicine @KaminskiMed https://t.co/yZzoQgetvk (Twitter) - Mar 18, 2020
- | lopinavir/ritonavir / Generic mfg.
Strange how observation made months ago in China suddenly appear after Australian good outcomes #Kaletra (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical, Observational data: Maybe but the oseltamivir observational data is highly confounded by severity and often doesn't account for immortal time properly. Kaletra is down, but probably not out until a larger study follows and helps look at earlier initiation and mortality outcome (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
Clinical: 😔 I wonder how many pats needed Kaletra via nasogastric tube. Did they give the solution in those cases and if so, correctly? Only tablets are mentioned in the paper; unfortunately protocol is in Chinese only. Probably not that relevant though... (Twitter) - Mar 18, 2020
- ||| lopinavir/ritonavir / Generic mfg.
ID/Abx question: From what I understand, secondary bacterial infections are not common with Covid-19, whereas influenza often leads to secondary SA infection. Why so much Abx use in the Kaletra study? Should we expect that here? (Twitter) - Mar 18, 2020