- |||||||||| nifedipine immediate release / Generic mfg., lercanidipine / Generic mfg., Lacidip (lacidipine) / Incepta Pharma
Journal: UHPLC-MS/MS method for the simultaneous quantification of five calcium channel antagonists' drugs in human plasma. (Pubmed Central) - Mar 2, 2025
Drug concentrations in the patient's serum or urine (also known as therapeutic drug monitoring, or TDM) and blood pressure measurements following supervised medication ingestion are two techniques for assessing treatment adherence. In alignment with guideline from the Food and Drug Administration (FDA) and European Medicines Agency (EMA), this study aims to design, develop, and validate a single UHPLC method for the plasma quantification of five antihypertensive drugs within the calcium channel blocker class: amlodipine, nifedipine, barnidipine, lercanidipine and lacidipine.
- |||||||||| nifedipine immediate release / Generic mfg., benidipine / Generic mfg., Lacidip (lacidipine) / Incepta Pharma
Clinical, Retrospective data, Journal: Efficacy and Safety of Dihydropyridine Calcium Channel Blockers for Primary Hypertension: A Bayesian Network Meta-analysis. (Pubmed Central) - Feb 25, 2025
In alignment with guideline from the Food and Drug Administration (FDA) and European Medicines Agency (EMA), this study aims to design, develop, and validate a single UHPLC method for the plasma quantification of five antihypertensive drugs within the calcium channel blocker class: amlodipine, nifedipine, barnidipine, lercanidipine and lacidipine. In the office setting, levamlodipine may be the best treatment for primary hypertension, and lacidipine shows good safety.
- |||||||||| Lacidip (lacidipine) / Incepta Pharma
Journal: Reproducibility and Treatment Effect on Office and Ambulatory Pressure Relation. (Pubmed Central) - Dec 18, 2024
In 2397 patients of the ELSA (European Lacidipine Study on Atherosclerosis) and PHYLLIS (Plaque Hypertension Lipid-Lowering Italian Study) trials, we calculated the office and 24-hour BP relationship according to the linear regression model, with office systolic BP as the independent variable, at baseline and yearly during a 3-year treatment...In treated patients with hypertension the slope of the office/24-hour BP linear regression is reproducible over time. However, the slopes are steeper in untreated individuals, indicating that information on ambulatory BP values corresponding to office BP values can be more accurate if separately estimated in these 2 conditions.
- |||||||||| Lacidip (lacidipine) / Incepta Pharma
Journal, IO biomarker: Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism. (Pubmed Central) - Nov 25, 2024
Mechanistically, lacidipine targets calcium channels (CaV1.2/1.3) to inhibit Pyk2-JAK1-calmodulin complex-mediated IDO1 transcription suppression, which suppresses the kynurenine pathway and maintains the total nicotinamide adenine dinucleotide (NAD) pool by regulating NAD biosynthesis. These results reveal a new function of calcium channels in IDO1-mediated tryptophan metabolism in tumor immunity and warrant further development of lacidipine for the metabolic immunotherapy in breast cancer.
- |||||||||| Lacidip (lacidipine) / Incepta Pharma
Journal, Metabolomic study: Dinotefuran exposure alters biochemical, metabolomic, gut microbiome, and growth responses in decapoda pacific white shrimp Penaeus vannamei. (Pubmed Central) - Apr 8, 2024
In conclusion, the LY-OFDS loaded with LCD-FNVs is a safe, and non-invasive approach that can deliver LCD effectively to the blood circulation via the buccal mucosa giving superior immediate capabilities of lowering high blood pressure and increasing the drug bioavailability. Biomarkers erythromycin-N-demethylase, alanine aminotransferase, and catalase increased in all exposed groups, while glutathione S-transferase is the opposite; aminopyrin-N-demethylase, malondialdehyde, and aspartate aminotransferase increased at 60 and 600
- |||||||||| Lacidip (lacidipine) / Incepta Pharma
Preclinical, Journal: Effects of adenosine triphosphate, Lacidipine, and Benidipine on 5-fluorouracil-induced kidney damage in rats. (Pubmed Central) - Apr 7, 2024
Biomarkers erythromycin-N-demethylase, alanine aminotransferase, and catalase increased in all exposed groups, while glutathione S-transferase is the opposite; aminopyrin-N-demethylase, malondialdehyde, and aspartate aminotransferase increased at 60 and 600 It may be possible to prevent nephrotoxicity by adding ATP + Benidipine or ATP to 5-FU treatment.
- |||||||||| Lacidip (lacidipine) / Incepta Pharma
Journal: Management of amlodipine-induced ankle oedema. (Pubmed Central) - May 2, 2023
To cause as few side effects as possible, options for managing are prioritised in this review: Reduce dosage, switch to lercanidipine/lacidipine, switch to another group, add/increase dosage of an ACE-inhibitor/angiotensin II-receptor blocker, administer at night, or switch to verapamil/diltiazem. Non-pharmacologic actions or observation may be considered when the oedemas are mild and not bothersome.
- |||||||||| Lacidip (lacidipine) / Incepta
Review, Journal: Reproducibility of blood pressure phenotypes identified by office and ambulatory blood pressure in treated hypertensive patients. Data from the PHYLLIS study. (Pubmed Central) - Sep 20, 2022
The results were similar for treatment with a thiazide diuretic or an ACE inhibitor and are in line with those of the European Lacidipine Study on Atherosclerosis (ELSA) trial, i.e., the only other available trial with multiple on-treatment office and ambulatory BP measurements, in which patients were treated with a calcium channel blocker or a beta-blocker. All the BP patterns identified in hypertensive patients treated by joint office and ambulatory BP measurements display poor reproducibility, and this is unrelated to the type of antihypertensive treatment used.
- |||||||||| Lacidip (lacidipine) / Incepta
Preclinical, Journal: In vitro Effects of Thirty-eight Cardiac Drugs on Human Serum Paraoxonase. (Pubmed Central) - Jun 22, 2022
Bisoprolol hemifumarate (K : 269.31 µM) is also other weak PON1 inhibitor...Conversely, the most potent inhibitors against PON1 were propafenone (Ki: 0.35 µM), Lacidipine (Ki: 0.78 µM), Lidocaine HCl (Ki: 1.78 µM) and Propranolol (Ki: 1.86 µM). Molecular docking was also applied to confirm the activity of some cardiac drugs on PON1.
- |||||||||| Lacidip (lacidipine) / Incepta
Journal: The calcium channel inhibitor lacidipine inhibits Zika virus replication in neural progenitor cells. (Pubmed Central) - May 18, 2022
Lacidipine altered the subcellular distribution of free cholesterol and neutral lipids, suggesting that the antiviral effect of lacidipine is mediated by altered trafficking of lipids. Together, these results identify lacidipine as a novel inhibitor of ZIKV replication that likely disturbs trafficking of lipids needed for replication organelle formation.
- |||||||||| Lacidip (lacidipine) / Incepta
Preclinical, Journal: Lacidipine Attenuates Symptoms of Nicotine Withdrawal in Mice. (Pubmed Central) - Mar 31, 2022
Bay-K8644 significantly abolished improvement in somatic and affective symptoms, and antioxidant effects by lacidipine in mice subjected to nicotine-withdrawal. Lacidipine mitigated nicotine-withdrawal triggered somatic and affective symptoms owing to decrease in brain oxido-nitrosative stress.
- |||||||||| Lacidip (lacidipine) / Incepta
Journal: Short- and Long-Term Reproducibility of Nighttime Blood Pressure Phenotypes and Nocturnal Blood Pressure Reduction. (Pubmed Central) - Jan 15, 2022
Data were similar for diastolic BP and in subgroups differing for the type of treatment, the treatment complexity, and the achieved on-treatment BP value Poor reproducibility characterized also the absolute nighttime BP reduction as measured by the nighttime BP fall and the night/day BP ratio. Thus nighttime BP phenotypes are all largely inconsistent, their detection over the entire treatment period involving just a minute fraction of the entire patients' cohort.
- |||||||||| Lacidip (lacidipine) / Incepta
Review, Journal: Lacidipine: review of analytical methods developed for pharmaceutical dosage forms and biological fluids. (Pubmed Central) - Nov 21, 2021
Ultra violet/visible spectrophotometric, spectroflourimetric, high performance liquid chromatography, high performance thin layer chromatography, electro-analytical, bioanalytical and miscellaneous methods such as microbiological assay, X-ray diffraction, differential scanning calorimetry, were discussed. Various parameters such as system suitability, selectivity, linearity, precision, accuracy, limit of detection, limit of quantification and robustness have been discussed for the employed methods.
- |||||||||| Lacidip (lacidipine) / Incepta
Journal: Lacidipine Ameliorates the Endothelial Senescence and Inflammatory Injury Through CXCR7/P38/C/EBP-β Signaling Pathway. (Pubmed Central) - Jul 28, 2021
In vitro experiments further demonstrated that Lacidipine increased the cell viability and function of ECs under oxidative stress, cell senescence, and inflammatory activation via the CXCR7/P38/signaling pathway. Our results suggested that Lacidipine plays a protective role in EC senescence, oxidative stress, and inflammatory injury through the regulation of CXCR7/P38/C/EBP-β signaling pathway.
- |||||||||| Lacidip (lacidipine) / Incepta
Journal: Limited reproducibility of MUCH and WUCH: evidence from the ELSA study. (Pubmed Central) - May 15, 2021
Both MUCH and WUCH display poor reproducibility over time. This should be taken into account in studies assessing the long-term prognostic value of these conditions based on only one set of BP measurements.
- |||||||||| paclitaxel / Generic mfg.
Journal, Cancer stem cells: Calcium Channels as Novel Therapeutic Targets for Ovarian Cancer Stem Cells. (Pubmed Central) - Jan 6, 2021
Moreover, combinatorial usage of manidipine and paclitaxel showed enhanced effect in ovarian CSCs xenograft mouse models. Our results suggested that four CCBs may be potential therapeutic drugs for preventing ovarian cancer recurrence.
- |||||||||| Lacidip (lacidipine) / Incepta
Preclinical, Journal: Exploration of supersaturable lacidipine ternary amorphous solid dispersion for enhanced dissolution and in vivo absorption. (Pubmed Central) - Feb 28, 2020
Moreover, compared to the LCDP/SOL formulation, approximately 3.3 and 3.7-fold increase in C and AUC was achieved with LCDP/SOL/SDS based formulation. In conclusion, the presented SDS could not only be regarded as solubility enhancer but also dissolution or bioavailability promoter, highlighting its potential application in ternary supersaturable amorphous solid dispersion for further increasing the dissolution and in vivo absorption of poorly water soluble drugs.
- |||||||||| Lacidip (lacidipine) / Incepta
Journal: Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress. (Pubmed Central) - Feb 1, 2020
In conclusion, the presented SDS could not only be regarded as solubility enhancer but also dissolution or bioavailability promoter, highlighting its potential application in ternary supersaturable amorphous solid dispersion for further increasing the dissolution and in vivo absorption of poorly water soluble drugs. LCD (I-type Ca-channel antagonist) pretreatment attenuated caffeine-induced oxido-nitrosative stress and anxiety-like behavior.
- |||||||||| Lacidip (lacidipine) / Incepta
Journal: New taxa of Tateidae (Caenogastropoda, Truncatelloidea) from springs associated with the Great Artesian Basin and Einasleigh Uplands, Queensland, with the description of two related taxa from eastern coastal drainages. (Pubmed Central) - Nov 17, 2019
The genus Edgbastonia is extended to include eight previously described species, in addition to the type species, and four new species-group taxa from the Barcaldine Supergroup springs; all but the type species are included in the new subgenus Barcaldinia...The genus Jardinella, previously used for all the Queensland spring tateids, is here restricted to three species found in coastal rivers and streams in northeast Queensland. A molecular phylogenetic analysis using COI and 16S mitochondrial genes in combination suggests that the Queensland Great Artesian Basin taxa may be more closely related to the tateid genera Austropyrgus, Pseudotricula, Posticobia and Potamopyrgus than to the South Australian GAB taxa, thus indicating the separate origins of these two desert spring faunas.
- |||||||||| Larcadip (lercanidipine) / Incepta
Journal: Lercanidipine and T-type calcium current. (Pubmed Central) - Oct 29, 2019
All CCBs examined in this study showed both T- and L-channel blocking activities and can be differentiated based on their relative affinity. Among tested dihydropyridines, lercanidipine showed the highest T/L selectivity.
- |||||||||| Lacidip (lacidipine) / Incepta
Clinical, Journal: Beneficial effects of combined therapy with lacidipine and candesartan in obese hypertensive patients. (Pubmed Central) - Sep 28, 2019
Among tested dihydropyridines, lercanidipine showed the highest T/L selectivity. The improvement of endothelial function due to lower level of oxidative stress and a significant decrease of immune activation has been observed in hypertensive patients with overweight and obesity under the influence of combined antihypertensive therapy with lacidipine and candesartan.
- |||||||||| Lacidip (lacidipine) / Incepta Pharma
Trial completion date, Trial initiation date, Trial primary completion date: Effects of TENS and IES on the Autonomous Balance of Normotens Volunteers and Hypertensive Patients (clinicaltrials.gov) - Oct 11, 2018
P=N/A, N=60, Recruiting,
These findings support A3AR-based therapy as a viable approach to alleviate pain in different pathologies. Trial completion date: Dec 2018 --> Dec 2019 | Initiation date: Sep 2017 --> Jul 2018 | Trial primary completion date: Aug 2018 --> Dec 2019
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