- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
Aging and metabolic pathways in lung fibrosis () - Feb 20, 2024 - Abstract #ERSLSC2024ERS_LSC_63; 2. Is mitochondrial homeostasis primordial for epithelial lung progenitor function and tissue repair?
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
Journal: Electrochemical N-Aroylation of Sulfoximines using Benzoyl Hydrazines with H2 Generation. (Pubmed Central) - Nov 22, 2023 The strategy is applied to late-stage sulfoximidation of L-menthol, (-)-borneol, D-glucose, vitamin-E derivatives, and marketed drugs such as probenecid, ibuprofen, flurbiprofen, ciprofibrate, and sulindac. In addition, the present methodology is mild, high functional group tolerance with broad substrate scope and scalable.
- |||||||||| albumin-bound paclitaxel / Generic mfg.
Review, Journal: Nab-Paclitaxel related cystoid macular edema. (Pubmed Central) - Jul 23, 2022 When discontinuation of treatment is not possible due to the systemic conditions of patients, effective alternative therapeutic modalities are topical dorzolamide or steroidal treatment. Given the higher complication hazards of intravitreal therapy topical treatment should be preferred owing to comparable efficacy.
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma, Visken (pindolol) / Novartis
Biomarker, Journal: Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs. (Pubmed Central) - Jan 27, 2022 Finally, we provide an example of how a report to doctors would look for a patient with depression, based on the panel of top biomarkers (12 for depression and bipolar, one for mania), with an objective depression score, risk for future depression, and risk for bipolar switching, as well as personalized lists of targeted prioritized existing psychiatric medications and new potential medications. Overall, our studies provide objective assessments, targeted therapeutics, and monitoring of response to treatment, that enable precision medicine for mood disorders.
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
Journal: Ciprofibrate-Loaded Nanoparticles Prepared by Nanoprecipitation: Synthesis, Characterization, and Drug Release. (Pubmed Central) - Sep 29, 2021 For Pluronic nanoparticles, we scanned different conditions for the CIP loading, and its encapsulation efficiency was reduced while the drug content increased in the nanoprecipitation protocol. We also performed in vitro release experiments; results demonstrate that probe release is driven by Fickian diffusion for the Pluronic NPs and a zero-order model for PEO-b-PCL NPs.
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
Journal: A prospective mechanism and source of cholesterol uptake by Plasmodium falciparum-infected erythrocytes co-cultured with HepG2 cells. (Pubmed Central) - Jun 22, 2021 Ezetimibe is known to inhibit cholesterol absorption by blocking the activity of Niemann-Pick C1 like 1 (NPC1L1) protein, and simvastatin is known to enhance NPC1L1 expression in the human body's small intestine. Collectively, our results support the possibility that cholesterol import by P. falciparum involves hepatocytes, and cholesterol uptake into the parasite occurs via NPC1L1 protein or an NPC1L1 homolog during the erythrocytic stages of the P. falciparum lifecycle.
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
[VIRTUAL] RARE XANTHOMATOSIS IN HYPERLIPIDEMIA CASE (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_8101; Collectively, our results support the possibility that cholesterol import by P. falciparum involves hepatocytes, and cholesterol uptake into the parasite occurs via NPC1L1 protein or an NPC1L1 homolog during the erythrocytic stages of the P. falciparum lifecycle. The most significant aspect was the unusual extensive xanthomatosis, rarely seen in phenotype IIb, what underlines the necessity of correct diagnosis and handling of such cases precociously by specialized services, so therapy can be effective and clinical complications are reduced.
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
Trial completion: Ciprofibrate and Pre-diabetes (clinicaltrials.gov) - Jan 8, 2021 P3, N=11, Completed, The ciprofibrate, a peroxisome proliferator, leads only to a weak stimulation of the mRNA expression as compared to thiolase B expression in the rat liver. Recruiting --> Completed
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
Preclinical, Journal: Ciprofibrate attenuates airway remodeling in cigarette smoke-exposed rats. (Pubmed Central) - Jun 8, 2020 Ciprofibrate also significantly reduced IL-1β, IL-12p70, IL-17A and IL-18 expression, which are related to airway remodeling, in the sera of CS-exposed rats. These findings indicate that ciprofibrate could attenuate airway remodeling in CS-exposed rats.
- |||||||||| clotrimazole / Generic mfg.
Preclinical, Journal: Acetoacetate Enhances Oxidative Metabolism and Response to Toxicants of Cultured Kidney Cells. (Pubmed Central) - Feb 28, 2020 There was a marked increase in uncoupled respiration in the presence of diclofenac, while clotrimazole and ciprofibrate significantly decreased respiration in the acetoacetate. The results indicate that acetoacetate complemented media can alter cellular metabolism and increase sensitization to toxicants.
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
Enrollment open: Ciprofibrate and Pre-diabetes (clinicaltrials.gov) - Nov 28, 2018 P3, N=12, Recruiting, The results indicate that acetoacetate complemented media can alter cellular metabolism and increase sensitization to toxicants. Not yet recruiting --> Recruiting
- |||||||||| Ciprol (ciprofibrate) / Sanofi, Cetaxin (ciprofibrat) / AC Farma
New P3 trial: Ciprofibrate and Pre-diabetes (clinicaltrials.gov) - Sep 10, 2018 P3, N=12, Not yet recruiting,
|