Rupex (rupatadine) / Incepta Pharma, Medexus 
Welcome,         Profile    Billing    Logout  
 0 Diseases   4 Trials   4 Trials   149 News 


«123»
  • ||||||||||  Rupex (rupatadine) / Incepta Pharma, Medexus
    Targeting PAF in allergic rhinitis: a responder analysis to rupatadine () -  May 30, 2021 - Abstract #EAACI2021EAACI_1819;    
    The dosage strategy adjusted by body weight in children 2-11 years old (2.5 mL if weight 10-25 kg, and 5 mL if ≥ 25 kg) provides similar exposure between the two groups of age, and to that obtained in adults with the 10 mg dose tablet formulation. Sponsored by Uriach
  • ||||||||||  Rupex (rupatadine) / Incepta Pharma, Medexus
    Yes!!!!! Rupatadine (Twitter) -  Apr 28, 2021   
  • ||||||||||  celecoxib oral / Generic mfg.
    Patch testing in fixed drug eruptions: a 10-year retrospective study () -  Apr 20, 2021 - Abstract #EAACI2021EAACI_837;    
    Patch tests on residual lesions were reactive already at D1 in 17 patients (42.5%), almost all (14) to NSAIDs (etoricoxib 7, nimesulide 3, celecoxib 1, etodolac 1, ibuprofen 1, tenoxicam 1), 2 to metamizole and 1 to the antihistamine rupatadine...In this study, with 42.5% of positive tests, we confirmed that patch testing is a simple and safe method and can help identify the culprits(s), although this is much dependent on the responsible drug. Culprits have changed over time in our Department with etoricoxib replacing piroxicam, the most frequent drug in the previous decade.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Preclinical, Journal:  H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies. (Pubmed Central) -  Feb 2, 2021   
    Although the worm burden reductions achieved are all only moderate, comparatively, treatment with any of the three antihistamines is more effective in early infection than praziquantel. On the other hand, the clinical use of H1-antihistamines for the treatment of schistosomiasis is highly unlikely.
  • ||||||||||  Rupex (rupatadine) / Incepta
    [VIRTUAL] Mixed Progestogen Hypersensitivity in a Patient Using a Combined Contraceptive Skin Patch: A Case Report () -  Jan 30, 2021 - Abstract #CDAI2020CDA-I_34;    
    She was treated with IM epinephrine, antihistamines and a course of prednisone...The patient was sent home on norgestimate/Ethinyl estradiol for contraception and rupatadine for dermographism and allergic rhinitis...It has been associated with endogenous as well as exogenous sources of progestogens and can evolve over time. Exogenous progesterone intakes must be considered in the diagnosis.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Review, Journal:  COVID-19, microthromboses, inflammation, and platelet activating factor. (Pubmed Central) -  Jan 5, 2021   
    The histamine-1 receptor antagonist rupatadine was developed to have anti-PAF activity, and also inhibits activation of human mast cells in response to PAF. Rupatadine could be repurposed for COVID-19 prophylaxis alone or together with other PAF-inhibitors of natural origin such as the flavonoids quercetin and luteolin, which have antiviral, anti-inflammatory, and anti-PAF actions.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Journal:  Coronavirus 2019, Microthromboses, and Platelet Activating Factor. (Pubmed Central) -  Nov 26, 2020   
    The histamine receptor antagonist rupatadine was developed to have anti-PAF activity and inhibits activation of human mast cells in response to PAF. Rupatadine could be repurposed for COVID-19 prophylaxis.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Journal:  COVID-19 and Multisystem Inflammatory Syndrome, or is it mast cell activation syndrome? (Pubmed Central) -  Nov 18, 2020   
    Hence, the possibility of MCAS should be evaluated in any patient with MIS and/or multisystem inflammatory symptoms. In either case, these syndromes should be addressed with liposomal formulation (in olive pomace oil) of the flavone luteolin (e.g. PureLut® or FibroProtek®) together with the antihistamine rupatadine, which also has anti-platelet activating factor (PAF) activity and inhibits mast cells that have been implicated in the pathogenesis of cytokine storms in COVID-19.
  • ||||||||||  levocetirizine / Generic mfg.
    Clinical, Journal:  Cardiac safety of second-generation H -antihistamines when updosed in chronic spontaneous urticaria. (Pubmed Central) -  Sep 21, 2020   
    Blockade of these channels causes QT prolongation leading to torsade de pointes that may possibly degenerate into ventricular fibrillation and sudden death. We considered in detail bilastine, cetirizine, levocetirizine, ebastine, fexofenadine, loratadine, desloratadine, mizolastine and rupatadine and conclude that all these drugs have an excellent safety profile with no evidence of cardiotoxicity even when updosed up to four times their standard licensed dose, provided that the prescribers carefully consider and rule out potential risk factors for cardiotoxicity, such as the presence of inherited long QT syndrome, older age, cardiovascular disorders, hypokalemia and hypomagnesemia, or the use of drugs that either have direct QT prolonging effects or inhibit sgAH metabolism.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Clinical, Clinical Trial,Phase III, Journal:  USEFULNESS OF RUPATADINE FOR PRURITUS OF PATIENTS WITH ATOPIC DERMATITIS (Pubmed Central) -  Aug 14, 2020   
    We considered in detail bilastine, cetirizine, levocetirizine, ebastine, fexofenadine, loratadine, desloratadine, mizolastine and rupatadine and conclude that all these drugs have an excellent safety profile with no evidence of cardiotoxicity even when updosed up to four times their standard licensed dose, provided that the prescribers carefully consider and rule out potential risk factors for cardiotoxicity, such as the presence of inherited long QT syndrome, older age, cardiovascular disorders, hypokalemia and hypomagnesemia, or the use of drugs that either have direct QT prolonging effects or inhibit sgAH metabolism. These results suggest the long-term usefulness of rupatadine for pruritus in AD.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Journal:  Utilization of Ethylcellulose Microparticles with Rupatadine Fumarate in Designing Orodispersible Minitablets with Taste Masking Effect. (Pubmed Central) -  Jun 19, 2020   
    The accessed data indicated that all obtained minitablets were characterized by beneficial pharmaceutical properties. Three independent in vivo with healthy volunteers, in vitro drug dissolution, and "electronic tongue" confirmed that all designed formulations provided satisfactory taste masking rate and that formulation F15 (prepared with Pearlitol Flash and Surelease microparticles with rupatadine fumarate) was characterized by the lowest bitterness score.
  • ||||||||||  Rupex (rupatadine) / Incepta, levocetirizine / Generic mfg., desloratadine / Kaken, Incepta, Merck (MSD), Generic mfg.
    Journal:  Route to Prolonged Residence Time at the Histamine H Receptor: Growing from Desloratadine to Rupatadine. (Pubmed Central) -  Jun 18, 2020   
    However, cycloaliphatic substituents directly attached to the piperidine amine (i.e., lacking the spacer) have decreased binding affinity and residence time compared to their methylene-linked structural analogues. Guided by docking studies, steric constraints within the binding pocket are hypothesized to explain the observed differences in affinity and binding kinetics between analogues.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Clinical, Journal:  A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection. (Pubmed Central) -  Oct 31, 2019   
    Although the primary end-point of a significant reduction in fluid leakage (development of pleural effusions or ascites) was not met, post-hoc analyses revealed small but significant differences in several parameters on individual illness days - higher platelet counts and lower aspartate-aminotransferase levels on day 7 in the rupatadine group compared to the placebo group, and smaller effusions on day 8 in the subgroup of patients with pleural effusions. However, due to the small sample size and range of recruitment time, the potential beneficial effects of rupatadine require further evaluation in large studies focused on recruitment during the early febrile phase.
  • ||||||||||  Rupex (rupatadine) / Incepta Pharma, Medexus
    Trial termination:  Chronic Urticaria - Long Term Assessment of Effects of Rupatadine (clinicaltrials.gov) -  Sep 17, 2019   
    P3,  N=192, Terminated, 
    Rupatadine promoted higher proportions of responders according to stringent response criteria and in a dose-dependent manner, with faster and higher response rates in the 20 mg group. Recruiting --> Terminated; poor recruitment
  • ||||||||||  Rupex (rupatadine) / Incepta
    Clinical, Review, Journal:  Platelet-Activating Factor (PAF) in Allergic Rhinitis: Clinical and Therapeutic Implications. (Pubmed Central) -  Sep 1, 2019   
    However, rupatadine, a second-generation antihistamine with dual antihistamine and anti-PAF effects has shown promising results by both blocking nasal symptoms and inhibiting mast cell activation induced by PAF, in comparison to antihistamine receptor drugs. In conclusion, the inhibition of PAF may be an interesting approach in the treatment of allergic rhinitis as part of a global strategy directed at blocking as many relevant inflammatory mediators as possible.
  • ||||||||||  Rupex (rupatadine) / Incepta
    Rupatadine too! (Twitter) -  Apr 23, 2019