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20 Trials |  |
1189 News |  |
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- | piperacillin sodium/tazobactam sodium / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Observational data, Retrospective data, Journal: Trends of antimicrobial resistance in patients with complicated urinary tract infection: Suggested empirical therapy and lessons learned from a retrospective observational study in Oman. (Pubmed Central) - Dec 13, 2022
Nitrofurantoin emerged as the most effective drug for cystitis...Higher resistance (30%) was observed against cephalosporins, fluoroquinolones, and trimethoprim/sulfamethoxazole...Synergistic combinations such as piperacillin-tazobactam plus aminoglycosides/fluoroquinolones may be prescribed. In sepsis, however, carbapenems are the drugs of choice.
- | Journal: Antibiotic resistance pattern of microorganisms causing urinary tract infection: a 10-year comparative analysis in a tertiary care hospital of Bangladesh. (Pubmed Central) - Dec 12, 2022
Resistance of uropathogens against conventional antibiotics used to treat UTI is high and the proportion has been increased over time. The situation might be grave in upcoming years if rational consumption of antibiotics is not warranted.
- || Zerbaxa (ceftolozane /tazobactam) / Merck (MSD), Recarbrio (relebactam/imepenem/cilastatin) / Merck (MSD), Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Review, Journal: Antibiotic therapy for pan-drug-resistant infections. (Pubmed Central) - Dec 10, 2022
The PDR K. pneumoniae has been treated in the last decades with tigecycline and colistin, but currently, nitrofurantoin, fosfomycin, and pivmecillinam seem to be the most effective agent for the therapy of PDR E. coli. While these drugs impressively struggle with PDR pathogens, due to the daily increase in antibiotic resistance in microorganisms worldwide, there is still an urgent need for the expansion of novel medicines and methods of combating resistance.
- | ampicillin / Generic mfg., amikacin sulfate / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Clinical Characteristics of 606 Patients with Community-Acquired Pyogenic Liver Abscess: A Six-Year Research in Yantai. (Pubmed Central) - Dec 10, 2022
Only 36 ESBL-positive strains had higher than 80% sensitivity to carbapenems, β-lactamase inhibitor compound, and amikacin...The main clinical manifestation is fever, so patients with fever of unknown cause should pay attention to possible liver abscesses. Based on drug sensitivity tests, the empirical use of antibiotics is somewhat unreasonable.
- || ciprofloxacin oral / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Clinical data, Retrospective data, Journal: Outpatient treatment and clinical outcomes of bacteriuria in veterans: A retrospective cohort analysis. (Pubmed Central) - Dec 10, 2022
Clinicians prescribed preferred therapy 46% of the time. Those prescribed preferred therapy had lower odds of clinical failure and of being hospitalized.
- || ciprofloxacin oral / Generic mfg., norfloxacin / Generic mfg., nitrofurantoin / Generic mfg.
Review, Journal: Pharmaceutical cocrystal of antibiotic drugs: A comprehensive review. (Pubmed Central) - Dec 9, 2022
This review highlights, classifies and compares all studied AB cocrystals. In addition, it urges research labs, which are interested in cocrystallization, to fill the gap of confronting antimicrobial resistance in their future work.
- | nitrofurantoin / Generic mfg.
Journal: Exploring the in situ evolution of nitrofurantoin resistance in clinically derived uropathogenic Escherichia coli isolates. (Pubmed Central) - Dec 9, 2022
In addition, it urges research labs, which are interested in cocrystallization, to fill the gap of confronting antimicrobial resistance in their future work. Correlation of these findings to nitrofurantoin pharmacokinetic data suggests that the low incidence of E. coli NitR, within the community, is driven by urine-based nitrofurantoin concentrations that selectively inhibit the growth of E. coli strains carrying the key first-step loss-of-function mutation.
- | gepotidacin (GSK2140944) / GSK
Preclinical, Journal: In vitro activity of gepotidacin against urine isolates of Escherichia coli from outpatient departments in Germany. (Pubmed Central) - Dec 7, 2022
Correlation of these findings to nitrofurantoin pharmacokinetic data suggests that the low incidence of E. coli NitR, within the community, is driven by urine-based nitrofurantoin concentrations that selectively inhibit the growth of E. coli strains carrying the key first-step loss-of-function mutation. Gepotidacin showed promising in vitro activity against urine isolates of E. coli, including ciprofloxacin-resistant isolates, ESBL-producing isolates and isolates resistant to oral standard-of-care antibiotics.
- | ciprofloxacin oral / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Antimicrobial resistance patterns of bacterial pathogens recovered from the urine of patients at Canadian hospitals from 2009 to 2020. (Pubmed Central) - Dec 6, 2022
coli was the pathogen most frequently recovered from the urine of Canadian patients, and the proportion of isolates that were ESBL producers increased over time. Susceptibility data presented here suggest that ciprofloxacin and trimethoprim/sulfamethoxazole may be suboptimal for the empirical treatment of complicated urinary infections.
- | Journal: Combination of isothiocyanates and antibiotics increases susceptibility against Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens. (Pubmed Central) - Dec 4, 2022
The combination of ITC and antibiotics is a promising approach for the treatment of UTI caused by MDRO. The ITC combination with selected antibiotics had synergistic and additive effects.
- ||||| gepotidacin (GSK2140944) / GSK
Enrollment closed, Trial completion date, Trial primary completion date: EAGLE-3: Comparative Study to Evaluate Efficacy and Safety of Gepotidacin to Nitrofurantoin in Treatment of Uncomplicated Urinary Tract Infection (UTI) (clinicaltrials.gov) - Dec 1, 2022
P3, N=2500, Active, not recruiting, Sponsor: GlaxoSmithKline
The ITC combination with selected antibiotics had synergistic and additive effects. Recruiting --> Active, not recruiting | Trial completion date: Mar 2024 --> Dec 2022 | Trial primary completion date: Mar 2024 --> Dec 2022
- |||||||||| gepotidacin (GSK2140944) / GSK
New P3 trial: EAGLE-J: A Study to Investigate the Efficacy and Safety With Gepotidacin in Japanese Female Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis) (clinicaltrials.gov) - Nov 30, 2022
P3, N=300, Not yet recruiting, Sponsor: GlaxoSmithKline
- | Invanz (ertapenem) / Merck (MSD), amikacin/fosfomycin inhalation (AFIS) / Savara
Journal: Limited Therapeutic Options in Mexico for the Treatment of Urinary Tract Infections. (Pubmed Central) - Nov 25, 2022
Bacteria were classified as susceptible or resistant to ampicillin-sulbactam, amikacin, gentamicin, ciprofloxacin, norfloxacin, nitrofurantoin, trimethoprim-sulfamethoxazole (TMP/SMZ), ertapenem, meropenem, and fosfomycin...For E. coli isolates, resistance was <20% for amikacin, fosfomycin, and nitrofurantoin; for K. pneumoniae, amikacin, fosfomycin, chloramphenicol, and norfloxacin...In total, multidrug-resistant bacteria represented 61% of all isolates. Isolates demonstrated high resistance to beta-lactams, fluoro-quinolones, and TMP/SMZ.
- ||||| gepotidacin (GSK2140944) / GSK
Enrollment closed, Trial completion date, Trial primary completion date: EAGLE-2: A Study to Evaluate Efficacy and Safety of Gepotidacin in the Treatment of Uncomplicated Urinary Tract Infection (UTI) (clinicaltrials.gov) - Nov 25, 2022
P3, N=2500, Active, not recruiting, Sponsor: GlaxoSmithKline
Isolates demonstrated high resistance to beta-lactams, fluoro-quinolones, and TMP/SMZ. Recruiting --> Active, not recruiting | Trial completion date: Mar 2024 --> Dec 2022 | Trial primary completion date: Mar 2024 --> Dec 2022
- | nitrofurantoin / Generic mfg.
Journal: Nitrofurantoin-induced liver injury: long-term follow-up in two prospective DILI registries. (Pubmed Central) - Nov 24, 2022
Five patients (22%) developed nitrofurantoin-induced autoimmune-like hepatitis (NI-AILH), of whom two were characterized by a persistent increase in transaminases that required immunosuppressive treatment to achieve normalization of liver enzymes. Clinicians who prescribe nitrofurantoin should be aware that patients who had taken nitrofurantoin for a long term may be at risk of developing nitrofurantoin-induced autoimmune-like hepatitis.
- | Journal: Determination of Enterococcus faecalis and Enterococcus faecium Antimicrobial Resistance and Virulence Factors and Their Association with Clinical and Demographic Factors in Kenya. (Pubmed Central) - Nov 22, 2022
All isolates were susceptible to tigecycline, vancomycin, and linezolid...The study highlights the high levels of erythromycin resistance in E. faecalis and E. faecium, the demographic factors influencing the species distribution among patients, and the accumulation of multiple virulence genes in E. faecalis. The significant association of gelE, asa1, and esp virulence genes with drug resistance could explain the pathogenic success of E. faecalis and provides a guide for future studies.
- || nitrofurantoin / Generic mfg.
Next up An RCT of Nitrofurantoin vs Oxidane for women with cystitis (Twitter) - Nov 22, 2022
- | nitrofurantoin / Generic mfg.
Journal: Improved management of cystitis in primary care following the implementation of a simple multifaceted intervention. (Pubmed Central) - Nov 22, 2022
The significant association of gelE, asa1, and esp virulence genes with drug resistance could explain the pathogenic success of E. faecalis and provides a guide for future studies. A low-intensity multifaceted intervention on management of cystitis, with strong institutional support, resulted in a better choice of antibiotic in antibiotic prescribing, but the intervention had less impact on the adequacy of urine cultures.
- || minocycline / Generic mfg., nitrofurantoin / Generic mfg.
Review, Journal: Nitrofurantoin and Minocycline-Associated Vasculitic Neuropathy: Case Reports and Literature Review. (Pubmed Central) - Nov 22, 2022
Medications should be considered as a trigger for medication-induced vasculitic neuropathy. Accurate diagnosis would ensure timely treatment.
- | Omnicef (cefdinir) / Abbott
Journal: Antibiotic-Specific Risk for Community-Acquired Clostridioides difficile Infection in the United States from 2008 to 2020. (Pubmed Central) - Nov 17, 2022
Among older patients with an elevated baseline risk for CA-CDI, multiple antibiotics, including nitrofurantoin, had strong associations with CA-CDI. These results may guide antibiotic selection and future stewardship efforts.
- | ampicillin / Generic mfg., nitrofurantoin / Generic mfg., fosfomycin tromethamine / Generic mfg.
Journal: Has the COVID-19 Pandemic Affected Community-Acquired Urinary Tract Infections in Children? (Pubmed Central) - Nov 16, 2022
Our study demonstrates that the ongoing COVID-19 pandemic process has caused alterations in community-acquired UTIs in children. More hygienic lifestyle may be considered as the main factor in this change.
- | Journal: Occurrence and antibiotic resistance of Vibrio parahaemolyticus isolated from the Tunisian coastal seawater. (Pubmed Central) - Nov 15, 2022
The detection of virulence genes, thermostable direct haemolysin (tdh) and thermostable-related haemolysin (trh), by the polymerase chain reaction (PCR) showed the presence of only two trh-positive isolates. The assessment of antibiotic susceptibility of the V. parahaemolyticus isolated revealed a complete resistance to colistin, amikacin, penicillin and cefotaxime and a total sensitivity to chloramphenicol, nitrofurantoin and sulfamethoxazole-trimethoprim with a multiple antibiotic resistance index (MAR) ranging from 0.4 to 0.5.
- | ciprofloxacin oral / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Retrospective data, Journal: Impact of suboptimal or inappropriate treatment on healthcare resource use and cost among patients with uncomplicated urinary tract infection: an analysis of integrated delivery network electronic health records. (Pubmed Central) - Nov 13, 2022
These findings highlight how the increasing prevalence of antibiotic resistance combined with suboptimal treatment of patients with uUTI increases the burden on healthcare systems. The finding underlines the need for improved prescribing accuracy by better understanding regional resistance rates and developing improved diagnostic tests.
- || nitrofurantoin / Generic mfg.
Nitrofurantoin can be given in first and second trimester and should be avoided in third trimester as per NICE and RCP guidelines (Twitter) - Nov 13, 2022
- | meropenem / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Prevalence and distribution of ampc beta-lactamase producing escherichia coli and klebsiella pneumoniae isolates obtained from urine samples at a tertiary care hospital in the caribbean. (Pubmed Central) - Nov 12, 2022
AmpC BL prevalence among E. coli and K. pneumoniae, common urinary pathogens, in the studied isolates is low. Although cefoxitin screening is helpful, phenotypic screening using the DAT can yield indeterminate results best clarified by molecular testing.
- ||| nitrofurantoin / Generic mfg.
Of course nitrofurantoin is contraindicated at term due to risk of neonatal hemolysis. Possibly also in last month of pregnancy as risk of neonatal jaundice. But safe in earlier pregnancy though the advice is to use the shortest course possible. I always treat ASB in pregnancy (Twitter) - Nov 12, 2022
- || nitrofurantoin / Generic mfg., fosfomycin tromethamine / Generic mfg.
Nitrofurantoin and Fosfomycin are my go to drugs in these circumstances. Also depends on the sensitivity pattern. #askrenal (Twitter) - Nov 12, 2022
- || Felexin (cefalexin monohydrate) / Remedica, nitrofurantoin / Generic mfg.
Nitrofurantoin if good function and early or more commonly cefelexin #askrenal (Twitter) - Nov 12, 2022
- || nitrofurantoin / Generic mfg.
Nitrofurantoin fine in early pregnancy, less likely to cause emergence of resistance etc. but need good function to get into lower urinary tract Amoxyl fine in #pregnancy (Twitter) - Nov 12, 2022
- cephalexin / Generic mfg., nitrofurantoin / Generic mfg., amoxicillin / Generic mfg.
Increasing Use of Narrow-spectrum Antibiotics in an Urgent Care Organization (H0344: Section on Urgent Care Medicine) - Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2261;
This was likely explained by the introduction of the revised UTI guideline in the beginning of 2021, and the educational webinar presented in March 2021 both of which created an awareness of the initiative before the official roll out. The goal of 80 percent has been sustained till date for the entire organization (Figure 2).
- | ciprofloxacin oral / Generic mfg., amoxycillin/clavulanate / Generic mfg., nitrofurantoin / Generic mfg.
Journal: E. coli bacteraemia and antimicrobial resistance following antimicrobial prescribing for urinary tract infection in the community. (Pubmed Central) - Nov 5, 2022
The goal of 80 percent has been sustained till date for the entire organization (Figure 2). Increasing age, increasing co-morbidity, lower socioeconomic status, and prior community antibiotic exposure were significantly associated with a resistant E. coli bacteraemia, which leads to increased mortality.
- || colistin sulphate / Generic mfg., amoxycillin/clavulanate / Generic mfg., nitrofurantoin / Generic mfg.
Intrinsic resistance to: Ampi, amoxi, amoxi/clav, ampi/sulba, Cephalos 1, tetrascyclines except Tyge, colistin and nitrofurantoin. It has inducible AmpC, GyrA and ParC mutation, AAC(3)-I mutation, probably OprD? Tyge is not an option, Norflox and Cefoxitin should be reported as R (Twitter) - Nov 4, 2022
- | Journal: Asymptomatic bacteriuria of pregnant women in a tertiary care centre. (Pubmed Central) - Nov 4, 2022
However, it poses a risk for severe maternal and fetal outcomes and hence, should be screened for on a regular basis. Thus, this study emphasizes the importance of screening pregnant women for ASB for promoting better maternal and fetal health.
- || nitrofurantoin / Generic mfg., fosfomycin tromethamine / Generic mfg.
Typical consult is a susceptible isolate at time nitrofurantoin given, then comes back with ongoing symptoms a week later, repeat sample now resistant. I used to see a ton, but seems less now that ED has moved to fosfomycin. But again, I’m sure I’m biased (Twitter) - Nov 2, 2022
- || nitrofurantoin / Generic mfg.
I am totally biased because I get called on all the nitrofurantoin failures. Sampling bias. (Twitter) - Nov 2, 2022
- || nitrofurantoin / Generic mfg., fosfomycin tromethamine / Generic mfg.
I picked nitrofurantoin. But came here to mention that in some countries that are not the 🇺🇸: cost of fosfomycin not so prohibitive. So an acceptable answer. That one study used 100 mg tid of nitrofurantoin, response rates, diassponting overall, and not just E. coli (Twitter) - Nov 2, 2022
- | nitrofurantoin / Generic mfg.
Journal: Nitrofurantoin plasma- and urine exposure in eight healthy beagle dogs following standard nitrofurantoin dosing regimen. (Pubmed Central) - Nov 2, 2022
The data presented in this study combined with in vitro sensitivity data from common urine pathogens and the lack of observed adverse effects suggest that nitrofurantoin in a standard dosing regimen could be effective in sporadic bacterial cystitis treatment in dogs. Further clinical studies are highly warranted to verify the effectiveness in clinical cases.
- || nitrofurantoin / Generic mfg., fosfomycin tromethamine / Generic mfg.
Review, Journal: Rationale for choosing an antibiotic for the treatment of cystitis: recommendations of clinical pharmacologists: A review (Pubmed Central) - Nov 2, 2022
The ACCESS group of drugs for the treatment of cystitis includes nitrofurantoin and furazidine as agents with minimal collateral effect, while fosfomycin trometamol and cephalosporins are listed in the WATCH group. Thus, from the standpoint of ecological safety, WHO experts recommend prescribing nitrofurans in the treatment of cystitis in the first line of therapy.
- | Retrospective data, Journal: Etiology and Antibiotic Susceptibility Patterns of Urinary Tract Infections in Children in A General Hospital in Kuwait: A 5-Year Retrospective Study. (Pubmed Central) - Nov 1, 2022
ESBL-producing bacteria are highly prevalent in children in our hospital. Local antibiograms should be used to assist with empirical UTI treatment.
- | trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Analysis of recurrent urinary tract infection management in women seen in outpatient settings reveals opportunities for antibiotic stewardship interventions. (Pubmed Central) - Nov 1, 2022
We found low guideline concordance for antibiotic choice, duration of therapy and cultures obtained among rUTI patients. These factors represent new targets for outpatient antibiotic stewardship interventions.
- || Retrospective data, Review, Journal: Prevalence of ESBL-Producing Enterobacter Species Resistant to Carbapenems in Iran: A Systematic Review and Meta-Analysis. (Pubmed Central) - Nov 1, 2022
However, the resistance rate to carbapenems was relatively low, and these drugs can still be considered as drugs of choice for the treatment of Enterobacter infections in Iran. Nevertheless, continuous monitoring of drug resistance along with antibiotic therapy based on the local data and evaluation of the therapeutic efficacy of new antibiotics or combination therapeutic strategies, such as ceftazidime/avibactam, meropenem/vaborbactam, plazomicin, and eravacycline, is recommended.
- | ciprofloxacin oral / Generic mfg., ampicillin / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Defects in DNA double-strand break repair resensitize antibiotic-resistant Escherichia coli to multiple bactericidal antibiotics. (Pubmed Central) - Nov 1, 2022
For ciprofloxacin and nitrofurantoin, sensitization manifested as a reduction in the minimum inhibitory concentration...For ampicillin, repair defects dramatically reduced antibiotic tolerance...Disruption of double-strand break repair strongly dampened the induction of SOS by these antibiotics. Our findings suggest that if break-repair inhibitors can be developed they could resensitize antibiotic-resistant bacteria to multiple classes of existing antibiotics and may suppress the development of de novo antibiotic-resistance mutations.
- | nitrofurantoin / Generic mfg.
New P4 trial: The Effectiveness of Single Antibiotic Paste Nitrofurantoin Versus Double Antibiotic Paste (clinicaltrials.gov) - Oct 31, 2022
P4, N=60, Completed, Sponsor: Altamash Institute of Dental Medicine
- ||| nitrofurantoin / Generic mfg.
These are GREAT! A few more mini-myths: - if PCN allergy➡️allergy to ALL beta lactams - if SSRI➡️never linezolid - FQs: too toxic to use in outpt setting -- ever - Never use nitrofurantoin w/⬇️GFR - Linezolid is 💰 - Doxy is a "weak" abx - Dental work + prosthetic joint = Abx (Twitter) - Oct 30, 2022
- | Journal: Occurrence and Molecular Characterization of Multidrug-Resistant Vegetable-Borne Listeria monocytogenes Isolates. (Pubmed Central) - Oct 29, 2022
Some of the highly detected ARG subtypes included SulI (100%), TEM (76.9%), tetA (59%), and tetM (54.7%). The findings show a high occurrence of multidrug-resistant L. monocytogenes and clinical ARGs in fresh vegetables, which constitutes an immediate danger for the health security of the public.
- | nitrofurantoin / Generic mfg.
Journal: Prior Antibiotic Use Increases Risk of Urinary Tract Infections Caused by Resistant Escherichia coli among Elderly in Primary Care: A Case-Control Study. (Pubmed Central) - Oct 29, 2022
We investigated whether prior use of antibiotics affects the risk of mecillinam/trimethoprim/nitrofurantoin/multi-resistant Escherichia coli urinary tract infection (UTI) among elderly patients in general practice...In general, mecillinam showed the lowest increase in the odds for selection of resistance. The results indicate that mecillinam is a favorable antibiotic choice in terms of selection of resistance.
- | nitrofurantoin / Generic mfg.
Journal: Zinc Oxide/Phosphorus-Doped Carbon Nitride Composite as Potential Scaffold for Electrochemical Detection of Nitrofurantoin. (Pubmed Central) - Oct 28, 2022
We further demonstrated the feasibility of the proposed ZnO HPs/P-CN sensor for detecting NF in samples of water and human urine. All the above features make our proposed ZnO HPs/P-CN sensor a most promising probe for detecting NF in natural samples.
- || Gatiflox (gatifloxacin) / Orient Europharma
Retrospective data, Review, Journal: Globally Vibrio cholera antibiotics resistance to RNA and DNA effective antibiotics: A systematic review and meta-analysis. (Pubmed Central) - Oct 28, 2022
The resistance rate to furazolidone, nalidixic acid, nitrofurantoin, and cephalothin has increased over the years. Monitoring antibiotic resistance and prescribing an appropriate antibiotic is vital to control resistance.
- | nitrofurantoin / Generic mfg.
Journal: Dual-color aggregation-induced emission nanoparticles for simultaneous lateral flow immunoassay of nitrofuran metabolites in aquatic products. (Pubmed Central) - Oct 28, 2022
Nitrofurans such as furaltadone and nitrofurantoin are a type of synthetic broad-spectrum antibiotics...These values are at least 166-and 200-fold higher than those of the commercial gold nanoparticles (GNPs)-based test strip, respectively. Furthermore, the test strip was successfully applied to the samples, with acceptable recoveries in the range of 83.0-98.2%.