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20 Trials |  |
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- | nitrofurantoin / Generic mfg.
Preclinical, Journal: In Vitro and In Vivo Trypanocidal Efficacy of Synthesized Nitrofurantoin Analogs. (Pubmed Central) - Jul 14, 2021
In vivo experiments, involving oral treatment with nitrofurantoin, showed partial efficacy, whereas the selected analogs showed no treatment efficacy. These results indicate that nitrofurantoin analogs with high hydrophilicity are required for in vivo assessment to determine if they are promising leads for developing trypanocidal drugs.
- | fosfomycin tromethamine / Generic mfg.
New P4 trial: SCOUT: Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women. (clinicaltrials.gov) - Jul 13, 2021
P4, N=1000, Not yet recruiting, Sponsor: Jordi Gol i Gurina Foundation
- | amoxicillin / Generic mfg.
Journal: Significant association between genes encoding virulence factors with antibiotic resistance and phylogenetic groups in community acquired uropathogenic Escherichia coli isolates. (Pubmed Central) - Jul 11, 2021
We assume that the ability of UPEC isolates to upgrade their antibiotic resistance capacity may occurs in compliance with the preliminary existence of specific virulence associated genes. But, more investigation with higher number of bacterial isolates, further virulence associated genes and comparison of gene pools from CA-UPEC isolates with HA-UPEC are proposed to confirm these finding and discovering new aspects of this association.
- || nitrofurantoin / Generic mfg.
More details logically needed before condemning solely Nitrofurantoin (Twitter) - Jul 9, 2021
- || ampicillin / Generic mfg.
Clinical, Journal: Probiotic and Safety Properties Screening of Enterococcus faecalis from Healthy Chinese Infants. (Pubmed Central) - Jul 9, 2021
The virulence test of G. mellonella showed that, except for strains 106-1 and 113-1, the other strains had toxicity lower than 10%. Strain A3-1 may have the greatest potential to be developed as a probiotic.
- ||| nitrofurantoin / Generic mfg.
I loved Nitrofurantoin when I used it in Colombia to treat uncomplicated UTIs... Until now...Probably will have to stick with the pseudomembranous colitis of Betalactamics. (Twitter) - Jul 8, 2021
- || nitrofurantoin / Generic mfg.
😱😱😱 What was the time course before these findings developed/ how long had the pt been on Nitrofurantoin? (Twitter) - Jul 8, 2021
- |||| nitrofurantoin / Generic mfg.
Clinical: #RT @ctisus: RT @DanielVargasMD: Here is a nice example of Nitrofurantoin Induced Lung Toxicity - in this case an NSIP (+ OP) pattern of disease. @TLHM_MD @LucyModahlMD @jonherochung @LeahMuhmLin @JoannaEscalonMD @svweisman @LaurenGroner @DenPulm @thor… https://t.co/WmdytNhwL8 (Twitter) - Jul 8, 2021
- |||| nitrofurantoin / Generic mfg.
Clinical: Here is a nice example of Nitrofurantoin Induced Lung Toxicity - in this case an NSIP (+ OP) pattern of disease. @TLHM_MD @LucyModahlMD @jonherochung @LeahMuhmLin @JoannaEscalonMD @svweisman @LaurenGroner @DenPulm @thoracicrad @RadioGraphics #radres #chestrads #radiology (Twitter) - Jul 8, 2021
- ||| nitrofurantoin / Generic mfg.
Another jewel of a case from @DanielVargasMD. A great example of perilobular opacities/consolation from organizing pneumonia. Very common CT pattern in nitrofurantoin lung. @accpchest @AnnalsATS @atscommunity @PFFORG @UChicagoPCCM @UChicagoRADS (Twitter) - Jul 8, 2021
- | ampicillin / Generic mfg., amoxicillin / Generic mfg.
Journal: Characterization of Escherichia coli D7111 producing the β-LACTAMASE TEM-176. (Pubmed Central) - Jul 8, 2021
Quinolone resistance was related to the substitution Ser83Ala. The TEM sequencing showed the presence of the new substitution Ala222Val, which led to the description of the new β-lactamase bla TEM-176.
- || trimethoprim/sulfamethoxazole / Generic mfg., tetracycline / Generic mfg., nitrofurantoin / Generic mfg.
Clinical, Journal: Effect of inclusion of micronized camelina, sunflower, and flax seeds in the broiler chicken diet on performance productivity, nutrient utilization, and intestinal microbial populations. (Pubmed Central) - Jul 7, 2021
In comparison with the CAM.IR and control treatments, reduced numbers of multi-resistant strains were found in the cloaca isolates from the for FLA.IR and SUN.IR variants. Micronized camelina, flax, and sunflower seeds can be used as part of an effective nutritional strategy focused on optimization of the efficiency of rearing broiler chickens, as they positively modify intestinal microbial populations and increase bacterial sensitivity to the analyzed chemotherapeutic agents.
- | ceftriaxone / Generic mfg., ampicillin / Generic mfg., cefuroxime / Generic mfg.
Journal: Antimicrobial resistance patterns among different Escherichia coli isolates in the Kingdom of Saudi Arabia. (Pubmed Central) - Jul 6, 2021
The air sample isolates were most resistant to amoxicillin, ampicillin, amoxicillin/clavulanic acid, amoxicillin/sulbactam, piperacillin/tazobactam, cefalotin, cefuroxime, cefoxitin, cefixime, nitrofurantoin, and trimethoprim/sulfamethoxazol...The isolates from the human urine samples were most frequently resistant to norfloxacin (80%) followed by amoxicillin and ampicillin (70%), trimethoprim/sulfamethoxazole (55%), ciprofloxacin and ofloxacin (50%), cefalotin (30%), cefuroxime, cefixime and cefotaxime (25%), ceftazidime, ceftriaxone, cefepime and aztreonam (20%), amoxicillin/clavulanic acid, piperacillin/tazobactam and gentamicin (10%), and amoxicillin/sulbactam and cefoxitin (5%)...The quinolone resistance gene qnrS was detected in 25% (n = 6) of the E. coli strains isolated from urine (N = 5) and air (N = 1) samples. The considerable number of antimicrobial resistance genes detected among E. coli isolates tested here is alarming and should raise public health concern.
- || ceftriaxone / Generic mfg.
Review, Journal: Antimicrobial resistance among uropathogens in the Asia-Pacific region: a systematic review. (Pubmed Central) - Jul 6, 2021
Resistance against nitrofurantoin ranged between 2.7% and 31.4%...We show very high prevalence estimates of AMR against antibiotics commonly used for the empirical treatment of UTI, in the limited number of countries in the APAC for which data are available. Novel feasible and affordable approaches that facilitate population-based AMR surveillance are needed to increase knowledge on AMR prevalence across the region.
- nitrofurantoin / Generic mfg.
[VIRTUAL] A case of secondary syphilis resembling erythema multiforme: how histopathology clues can avoid a delayed diagnosis () - Jul 5, 2021 - Abstract #BAD2021BAD_253;
Based on a recent history of nitrofurantoin ingestion, a clinical diagnosis of erythema multiforme was made...Early recognition and treatment of syphilis is vital in limiting progression to the tertiary stage, which has a higher morbidity and mortality owing to its neurological and cardiovascular sequelae. Histopathology provides useful clues and pattern recognition helps to prompt serological testing and avoid diagnostic delay.
- || gentamicin sulfate / Generic mfg., nitrofurantoin / Generic mfg.
Clinical, Journal: Etiology and Antimicrobial Susceptibility of Pathogens Associated with Urinary Tract Infections among Women Attending Antenatal Care in Four South African Tertiary-Level Facilities, 2015-2019. (Pubmed Central) - Jul 4, 2021
Common uropathogens showed high susceptibility to first-line antibiotics, gentamicin and nitrofurantoin, as recommended for use in primary healthcare settings. Overall, our study provided an indication of the level of antimicrobial resistance in the four facilities.
- || ampicillin / Generic mfg.
Clinical, Journal: High Levels of Antibiotic Resistance Patterns in Two Referral Hospitals during the Post-Ebola Era in Free-Town, Sierra Leone: 2017-2019. (Pubmed Central) - Jul 4, 2021
Gram-negative bacteria were most resistant to ampicillin, gentamycin, streptomycin, tetracycline, cephalothin and penicillin (100%) and least resistant to novobiocin (0%). Antibiotic resistance for commonly prescribed antibiotics was high in two referral hospitals, highlighting the urgent need for antimicrobial stewardship and access to reserve antibiotics.
- | sulphadiazine / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Simultaneous and rapid determination of malachite green and leucomalachite green by a label-free colorimetric aptasensor (Pubmed Central) - Jul 3, 2021
The relative standard deviations (RSDs) of MG and LMG ranged from 2.27% to 3.55% and 2.62% to 3.75%, respectively. This colorimetric method is simple, rapid, sensitive, and allows visual, and it can provide a new method for the simultaneous and rapid determination of the MG and LMG in aquatic products.
- | nitrofurantoin / Generic mfg.
Journal: Nanostructured perovskite type gadolinium orthoferrite decorated RGO nanocomposite for the detection of nitrofurantoin in human urine and river water samples. (Pubmed Central) - Jul 3, 2021
In addition, the investigation of storage time on the CV response of the GdFeO/RGO sensor indicates superior stability. Owing to these extraordinary analytical advantages, the as-fabricated sensor was applied to detect the NFT levels in human urine and river water samples with satisfactory results.
- || Clinical, Journal: Susceptibility of hospital-acquired uropathogens to first-line antimicrobial agents at a tertiary health-care hospital, Saudi Arabia. (Pubmed Central) - Jul 2, 2021
The present study recommends the use of fosfomycin, cefoxitin, nitrofurantoin, and amoxicillin/clavulanate as the first choice UTIs treatment given their relatively high in vitro activity against major uropathogens. Knowledge of the bacterial species and their antimicrobial sensitivity patterns are always necessary to serve as a base for selecting the empirical treatment of UTIs as resistance rates vary geographically and with time.
- || ceftriaxone / Generic mfg., ampicillin / Generic mfg.
Retrospective data, Review, Journal: Group B streptococcus drug resistance in pregnant women in Iran: a meta-analysis. (Pubmed Central) - Jul 2, 2021
Additionally, resistance to penicillin (4.2%), ampicillin (2.7%), cefazolin (7.6%), vancomycin (2.4%), ceftriaxone (12.5%), ciprofloxacin (13.6%) and nitrofurantoin (0%) was low. Our results revealed that penicillin and ampicillin among penicillin-tolerant Iranian pregnant women, and vancomycin and cefazolin among penicillin-allergic women are still drugs of choice in intrapartum prophylaxis for preventing S. agalactiae vertical transmission and early-onset neonatal disease.
- | ampicillin / Generic mfg.
Preclinical, Journal: Carbapenemases producing Klebsiella pneumoniae from the pus of hospitalized patients: In-vitro antibiotic properties of Streptomyces against multidrug resistant infectious bacteria. (Pubmed Central) - Jul 2, 2021
Further studies are warranted to analyze the drug hydrolyzing pathways of bacteria and to identify the mechanism of action of secondary metabolites from Streptomyces sp. AC14.
- || ampicillin / Generic mfg.
Clinical, Retrospective data, Journal: Evaluation of sensitivity profiles to fosfomycin in bacterial urine samples from outpatients. (Pubmed Central) - Jul 1, 2021
The microbiological profile established here shows substantial sensitivity to fosfomycin in the urine samples analysed. In most cases, there was a sensitivity profile that was favourable to the use of fosfomycin or at least comparable to the other antibiotics studied.
- || nitrofurantoin / Generic mfg.
Clinical, Journal: Outpatient prescribing and prophylactic antibiotic use for recurrent urinary tract infections in British Columbia, Canada. (Pubmed Central) - Jun 29, 2021
Implementation of numerous antimicrobial stewardship efforts may have contributed to the decrease in antibiotic prescribing, particularly for quinolones. In line with local antibiograms and guidelines, nitrofurantoin is the most used antibiotic for rUTI by far, distinctly preferred over other antibiotics secondary to the lack of E. coli resistance.
- | cefazolin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Retrospective data, Journal: Fluoroquinolone resistance in Escherichia coli isolates after exposure to non-fluoroquinolone antibiotics: a retrospective case-control study. (Pubmed Central) - Jun 26, 2021
Assuming no residual confounding or other biases, this study suggests that exposure to non-fluoroquinolone antibiotics, i.e. trimethoprim/sulfamethoxazole and nitrofurantoin, might be causally related to fluoroquinolone resistance in E. coli isolates from urinary samples. Future prospective research is needed to confirm non-fluoroquinolone antibiotics as potential drivers of fluoroquinolone resistance.
- || ciprofloxacin oral / Generic mfg., nitrofurantoin / Generic mfg.
Clinical, Journal: Trends, seasonality and the association between outpatient antibiotic use and antimicrobial resistance among urinary bacteria in the Netherlands. (Pubmed Central) - Jun 26, 2021
We found a relatively low use of antibiotics and resistance levels over a 9 year period. Although the correlations were weak, variations in antibiotic use for these four antibiotics were associated with subsequent variations in AMR in urinary pathogens.
- | nitrofurantoin / Generic mfg.
Preclinical, Journal: In vitro and in vivo antibacterial activity of nitrofurantoin against clinical isolates of E. coli in Japan and evaluation of biological cost of nitrofurantoin resistant strains using a mouse urinary tract infection model. (Pubmed Central) - Jun 26, 2021
Although the correlations were weak, variations in antibiotic use for these four antibiotics were associated with subsequent variations in AMR in urinary pathogens. We demonstrated promising in vitro and in vivo activity of nitrofurantoin against E. coli clinical isolates in Japan, and lower in vivo fitness of the resistant strain of nitrofurantoin.
- || ceftriaxone / Generic mfg.
Clinical, Journal: Antibiotic resistance: a comparison between inpatient and outpatient uropathogens. (Pubmed Central) - Jun 26, 2021
Uropathogen resistant rates in inpatients were higher than outpatient rates. The use of imipenem and amikacin instead of traditional first-line empirical therapy (fluoroquinolone and sulfamethoxazole-trimethoprim) is advised for hospitalized patients with urinary tract infections.
- || ampicillin / Generic mfg.
Clinical, Journal: Antibiogram Profiles of Bacteria Isolated from Different Body Site Infections Among Patients Admitted to GAMBY Teaching General Hospital, Northwest Ethiopia. (Pubmed Central) - Jun 25, 2021
Gram-negative bacteria also revealed from 20% resistance for the antibiotic nitrofurantoin and 100% of resistance for ampicillin and penicillin...Most of the identified bacteria were resistant to the routinely used antibiotics, and MDR isolates are alarmingly high. Therefore, clinicians should practice rational choice of antibiotics and treatment should be guided by antimicrobial susceptibility testing.
- | ampicillin / Generic mfg., cefuroxime / Generic mfg.
Clinical, Journal: Distribution and antibiotic resistance profile of key gram-negative bacteria that cause community-onset urinary tract infections in the Russian Federation: RESOURCE multicentre surveillance 2017 study. (Pubmed Central) - Jun 24, 2021
Therefore, clinicians should practice rational choice of antibiotics and treatment should be guided by antimicrobial susceptibility testing. The prevalence of fluoroquinolone and cephalosporin resistance among common UTI-causing gram-negative bacteria highlights the growing challenge of successfully treating community-onsetUTIs.
- | nitrofurantoin / Generic mfg.
Clinical, Journal: Molecular epidemiology and nitrofurantoin resistance determinants from nitrofurantoin non-susceptible Escherichia coli isolated from urinary tract infections. (Pubmed Central) - Jun 24, 2021
It is concluded that NIT resistance in the studied NIT-RE. coli isolates was mainly mediated by nfsA and nfsB alterations.
- || nitrofurantoin / Generic mfg.
Retrospective data, Review, Journal, Head-to-Head: Systematic Review and Meta-analysis to Estimate the Antibacterial Treatment Effect of Nitrofurantoin for a Non-Inferiority Trial in Uncomplicated Urinary Tract Infection. (Pubmed Central) - Jun 24, 2021
The corresponding treatment effect estimate for nitrofurantoin was 26.8%, which supports a conservative non-inferiority margin of 12.5% and is consistent with the recently published draft FDA guidance. The findings from this systematic review and meta-analysis inform future antibacterial trials by providing non-inferiority margin justification.
- || vancomycin / Generic mfg., nitrofurantoin / Generic mfg.
Clinical, Journal: A synergistic association between adhesion-related genes and multidrug resistance patterns of Staphylococcus aureus isolates from different patients and healthy individuals. (Pubmed Central) - Jun 24, 2021
Prevalence rate of adhesion- related genes was high in S. aureus from isolates in Iran ;so these genes might be expressed under certain conditions and cause emergence of MDR strains. Therefore, further investigations are necessary to prevent initial attachment based on new candidate adhesion genes for vaccine design.
- | colistin sulphate / Generic mfg.
Journal: Occurrence and genetic characteristics of mcr-1 positive colistin resistant E. coli from poultry environments in Bangladesh. (Pubmed Central) - Jun 24, 2021
Therefore, further investigations are necessary to prevent initial attachment based on new candidate adhesion genes for vaccine design. We report a 13.5% prevalence of mcr-1 positive MDR E. coli in poultry fecal samples predominantly from LBMs in Bangladesh accentuating the need for safe disposal of poultry feces and hygiene practices among people exposed to poultry.
- || trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Clinical, Journal: Antimicrobial susceptibility and cross-resistance patterns among common complicated urinary tract infections in US hospitals, 2013-2018. (Pubmed Central) - Jun 22, 2021
Among the most common pathogens isolated from hospitalized patients with cUTI, the rates of single resistance to common treatments and of cross-resistance to these regimens are substantial. Knowing the patterns of cross-resistance may help clinicians tailor empiric therapy more precisely.
- | ampicillin / Generic mfg.
Retrospective data, Journal: Multidrug-Resistant Bacteria Among Culture Isolates at University of Gondar, Specialized Referral Hospital, Northwest Ethiopia: a Five-Year Retrospective Study. (Pubmed Central) - Jun 22, 2021
Hospital admission is highly associated with the isolation of multidrug-resistant bacteria. Hence patient hospital stay should be considered in the prevention of multidrug resistant bacterial infections.
- | vancomycin / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Pathogenic characteristics of Staphylococcus aureus isolates from arthroplasty infections. (Pubmed Central) - Jun 22, 2021
The results reflect the potential risks of S. aureus infection in postoperative arthroplasty patients. Our study provides a powerful basis for the clinical treatment, infection control and monitoring of outbreaks of epidemic strains.
- | nitrofurantoin / Generic mfg.
Journal: Reciprocal Cooperation of Type A Procyanidin and Nitrofurantoin Against Multi-Drug Resistant (MDR) UPEC: A pH-Dependent Study. (Pubmed Central) - Jun 22, 2021
The results conclude that the TAP has an antibiofilm activity against the multidrug-resistant strain of UPEC, without affecting the growth. Also, TAP reciprocally cooperates with nitrofurantoin at different pH by downregulating the adhesins of UPEC.
- | nitrofurantoin / Generic mfg.
Journal: Novel particles conferring eradication of deep tissue bacterial reservoirs for the treatment of chronic urinary tract infection. (Pubmed Central) - Jun 22, 2021
This work investigates the use of nitrofurantoin loaded poly(lactic-co-glycolic acid) (PLGA) particles to improve delivery to intracellular targets for the treatment of chronic UTI...These results illustrate the potential for using antibiotic-loaded microparticles to effectively treat chronic UTIs. Such a delivery method could be extrapolated to other clinical indications where robust intracellular delivery is required, such as oncology and gene therapy.
- || trimethoprim/sulfamethoxazole / Generic mfg., nitrofurantoin / Generic mfg.
Clinical, Journal: Effect of continuous antibiotic prophylaxis in children with postoperative JJ stents: A prospective randomized study. (Pubmed Central) - Jun 22, 2021
Such a delivery method could be extrapolated to other clinical indications where robust intracellular delivery is required, such as oncology and gene therapy. CAP in the presence of JJ stents reduced the incidence of febrile urinary tract infections in a short period, especially in children with the previous history of febrile urinary tract infections and lower urinary tract symptoms.
- | nitrofurantoin / Generic mfg.
Journal: Metabolites potentiate nitrofurans in non-growing Escherichia coli. (Pubmed Central) - Jun 22, 2021
Nitrofurantoin (NIT) is a broad-spectrum bactericidal antibiotic used in the treatment of urinary tract infections...In addition, we observed that NIT activity against stationary-phase uropathogenic E. coli (UPEC) could also be potentiated through metabolite supplementation. These findings suggest that the combination of nitrofurans with specific metabolites could improve the outcome of uncomplicated urinary tract infections (UTIs).
- | amikacin sulfate / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Nitrofurantoin Combined With Amikacin: A Promising Alternative Strategy for Combating MDR Uropathogenic Escherichia coli. (Pubmed Central) - Jun 22, 2021
Importantly, amikacin or nitrofurantoin at half of the clinical doses were not effective in the treatment of UPEC infections in the G. mellonella model but the combination therapy significantly increased G. mellonella survival from infections caused by all 12 study UPEC strains. Taken together, these results demonstrated synergy effects between nitrofurantoin and amikacin against MDR UPEC.
- || nitrofurantoin / Generic mfg.
Wow, the FQ downtrend vs. nitrofurantoin uptrend over the past 5 years give me hope. Interesting trends overall, looking forward to this one @ClancyNeil (Twitter) - Jun 22, 2021
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Antioxidant molecules as a source of mitigation of antibiotic resistance genes dissemination. (Pubmed Central) - Jun 22, 2021
Furthermore, we showed that some antioxidant molecules currently approved for unrelated clinical uses such as edaravone, p-Coumaric acid and N-acetylcysteine may antagonize the inducibility effect of antibiotics in term of increased plasmid conjugation rates. These results suggest that several antioxidative molecules might be used in combination with those "inducer" antibiotics to mitigate the unwanted increased resistance plasmid dissemination.
- || ceftriaxone / Generic mfg., ampicillin / Generic mfg., cefuroxime / Generic mfg.
Clinical, Journal: Causative Agents of Urinary Tract Infections in Elderly Men with Benign Prostatic Hyperplasia: a Microbiological Evaluation. (Pubmed Central) - Jun 22, 2021
Therefore, identifying resistance patterns is important to contribute to rational antibiotic use policies. In addition, the risk of Candida-related urinary tract infections and bacteremia should be considered in these patients.
- || nitrofurantoin / Generic mfg.
Clinical, Journal: Prevalence and Associated Factors of Methicillin Resistance Staphylococcus aureus (MRSA) Among Urinary Tract Infection Suspected Patients Attending at Arba Minch General Hospital, Southern Ethiopia. (Pubmed Central) - Jun 22, 2021
From all the MRSA isolates, 53.7% were resistant against Nitrofurantoin. This study revealed that MRSA could be prevalent in isolates from patients suspected of urinary tract infection and exhibiting different resistance pattern for antibiotics commonly used for treatment of staphylococcal infections.
- | Retrospective data, Journal: A retrospective study on the microbial spectrum and antibiogram of uropathogens in children in a secondary care hospital in Rural Vellore, South India. (Pubmed Central) - Jun 16, 2021
This was similar with the studies done at other secondary care hospitals, in Oman and Oddanchathram, South India. With the increasing resistance, cephalosporins should not be used in treating paediatric UTI, whereas nitrofurantoin can be started as an empiric antibiotic, which can later be changed according to the susceptibility pattern.
- nitrofurantoin / Generic mfg.
[VIRTUAL] Employing DOZN™ 2.0 tool for mechanochemistry to assess risk () - Jun 14, 2021 - Abstract #ACSGCE2021ACS_GCE_433;
DOZN™ 2.0 – MilliporeSigma’s Green Chemistry Evaluator tool was successfully employed the first time to mechanochemical synthesis of the Active Pharmaceutical Ingredient (API), nitrofurantoin in batch and in continuous processes via Twin Screw Extrusion. Advantages of DOZN™ 2.0 results will be presented.
- | nalidixic acid / Generic mfg., nitrofurantoin / Generic mfg.
Journal: Mutations that increase expression of the EmrAB-TolC efflux pump confer increased resistance to nitroxoline in Escherichia coli. (Pubmed Central) - Jun 10, 2021
Mutations in different genes causing increased expression of the EmrAB-TolC pump lead to an increased resistance to nitroxoline. The structurally similar antibiotics nitroxoline and nitrofurantoin appear to have different modes of action and resistance mechanisms.
- | nitrofurantoin / Generic mfg.
Preclinical, Journal: Antibacterial properties and in vivo efficacy of a novel nitrofuran, IITR06144, against MDR pathogens. (Pubmed Central) - Jun 10, 2021
The structurally similar antibiotics nitroxoline and nitrofurantoin appear to have different modes of action and resistance mechanisms. In the light of excellent in vitro properties displayed by IITR06144 coupled with its considerable in vivo efficacy, further evaluation of IITR06144 as a therapeutic lead against antibiotic-resistant infections is warranted.