furosemide / Generic mfg. 
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  • ||||||||||  citalopram / Generic mfg., venlafaxine / Generic mfg., fluoxetine / Generic mfg.
    Journal:  Association of QT-Prolonging Medication Use in CKD with Electrocardiographic Manifestations. (Pubmed Central) -  May 15, 2019   
    N=120 --> 14 | Recruiting --> Terminated; Lack of enrollment Use of medications associated with QT prolongation is common in CKD; the safety implications of these findings should be considered in these high-risk patients.
  • ||||||||||  furosemide / generics
    Journal:  Furosemide Response Predicts Acute Kidney Injury After Cardiac Surgery in Infants and Neonates. (Pubmed Central) -  May 7, 2019   
    This study demonstrates the utility of simulated Y-site study design to multi-drug combinations and increases the scientific body of knowledge related to medications used in a pediatric CVICU. Urine output response to furosemide within 24 hours of cardiopulmonary bypass predicts cardiac surgery-induced acute kidney injury development and other important morbidity in children younger than 90 days old; prospective validation is warranted.
  • ||||||||||  digoxin / Generic mfg., furosemide / Generic mfg.
    Trial primary completion date:  Topical Ionic Contra-Viral Therapy in Actinic Keratosis (clinicaltrials.gov) -  May 1, 2019   
    P2,  N=32, Recruiting, 
    This report provides data on medications needing further research to determine the risk of AKI with these new potential nephrotoxins. Trial primary completion date: Apr 2019 --> Sep 2019
  • ||||||||||  furosemide / generics
    Journal:  Diuretic state affects ascending thin limb tight junctions. (Pubmed Central) -  Apr 26, 2019   
    ...Three experimental groups of rats under different diuretic states were investigated on metabolic cages: waterload, furosemide-induced diuresis, and control (antidiuresis)...Claudins are main constituents of the tight junction responsible for paracellular selectivity, however, immunofluorescence did not show qualitative differences in claudin 4, 10 and 16 localization. Our results show that IMaTLs change tight junction properties in response to diuretic state to allow adaptation of NaCl reabsorption.
  • ||||||||||  Journal:  Geraniin is a diuretic by inhibiting the Na+:K+:2Cl- cotransporter, NKCC2. (Pubmed Central) -  Apr 26, 2019   
    In contrast with furosemide, the effect of geraniin on NKCC2 was irreversible, apparently due to its inhibitory effect on the heat shock protein 90. Our observations suggest that geraniin could have a potential role in the treatment of hypertension or edematous states.
  • ||||||||||  Lopressor (metoprolol tartrate) / Novartis
    Clinical, Journal:  Non-ST elevation myocardial infarction induced by carbon monoxide poisoning: A case report. (Pubmed Central) -  Apr 23, 2019   
    Therefore, patients with carbon monoxide poisoning should actively seek comprehensive cardiac examination to ensure early diagnosis. Whenever necessary, coronary angiography and stent implantation should be performed to improve the likelihood of the patient's survival.
  • ||||||||||  enalapril / Generic mfg., digoxin / Generic mfg., furosemide / Generic mfg.
    Enrollment change, Trial termination:  Effects of Amlodipine in the Management of Chronic Heart Failure (clinicaltrials.gov) -  Apr 21, 2019   
    P2,  N=7, Terminated, 
    Whenever necessary, coronary angiography and stent implantation should be performed to improve the likelihood of the patient's survival. N=24 --> 7 | Suspended --> Terminated
  • ||||||||||  ciprofloxacin / generics, ibuprofen / generics
    Journal:  Exposure and ecotoxicological risk assessment of mixtures of top prescribed pharmaceuticals in Swedish freshwaters. (Pubmed Central) -  Apr 20, 2019   
    In addition to the three substances contributing most to acute effects, the chronic effects are predominantly caused by another five substances: paracetamol, diclofenac, ethinylestradiol, erythromycin and ciprofloxacin. This study provides regulatory authorities and companies responsible for water quality valuable information for targeting remediation measures and monitoring on a substance and location basis.
  • ||||||||||  furosemide / generics
    Journal:  Peritoneal Ultrafiltration in the Long-Term Treatment of Chronic Heart Failure Refractory to Pharmacological Therapy. (Pubmed Central) -  Apr 20, 2019   
    ...Daily diuresis increased from 867 ± 413 to 1221 ± 680 ml; P = 0.25, while the dose of furosemide could be reduced from 620 ± 256 to 360 ± 110 mg/d; P = 0.0005, however, the kidney function deteriorated, with eGFR drop from 32 ± 11 to 25.6 ± 13 ml/min/1.73m; P = 0.01)...In patients with refractory HF, PUF with one overnight icodextrin exchange appears to be a promising therapeutic option as an adjunct to pharmacological management of those who are not transplant candidates. It should be emphasized that the treatment can have a great impact on the quality of life and the total costs of treating these patients.
  • ||||||||||  furosemide / Generic mfg.
    Enrollment closed, Trial completion date, Trial primary completion date:  The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury (clinicaltrials.gov) -  Apr 20, 2019   
    P=N/A,  N=200, Active, not recruiting, 
    It should be emphasized that the treatment can have a great impact on the quality of life and the total costs of treating these patients. Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Dec 2021 | Trial primary completion date: Dec 2018 --> Dec 2020
  • ||||||||||  Journal:  Environmental loadings of Active Pharmaceutical Ingredients from manufacturing facilities in Canada. (Pubmed Central) -  Apr 18, 2019   
    This survey demonstrates that direct point source discharges from pharmaceutical manufacturers represent a key source of pharmaceutical pollution to receiving sewersheds. Onsite recovery of product or treatment at pharmaceutical manufacturing or processing facilities to reduce the sewage loadings to receiving treatment plants, product loss and potential environmental loadings is strongly recommended.
  • ||||||||||  Zortress (everolimus) / Novartis, Rituxan (rituximab) / Roche, Biogen
    Clinical, Journal:  Extreme hypercalcemia in a kidney transplant recipient. (Pubmed Central) -  Apr 7, 2019   
    Despite all therapeutic interventions, the patient died of septic shock in the intensive care unit on the 10th day of emergency service admission. Importance of hemodialysis as an emergent treatment modality in extreme hypercalcemia, and unfavorable course of PTLD were underlined.
  • ||||||||||  furosemide / generics
    Preclinical, Journal:  Suppression of 18F-FDG signal in the bladder on small animal PET-CT. (Pubmed Central) -  Apr 7, 2019   
    We validated a non-invasive, easy, and harmless pre-imaging alternative for decreasing 18F-FDG bladder spillover. Our study shows the effect of furosemide on bladder spillover directly on 18F-FDG-PET images by measuring SUVmean in the bladder, colon, liver, muscle, and bone marrow.