- |||||||||| furosemide / generics
BLUNTING OF ADRENERGIC FUNCTION HAS AQUARETIC EFFECTS IN EXPERIMENTAL ASCITIC CIRRHOSIS (Poster Exhibition - Hall 7) - Aug 18, 2019 - Abstract #UEGW2019UEGW_3010;
In ascitic cirrhosis, reduced volaemia, secondary aldosteronism and adrenergic hyperfunction, especially when exacerbated by potassium-depleting diuretics (furosemide), contribute to tubular retention of water and dilutional hyponatremia. Low-dose sympatholytic agents are as effective as V 2 antagonists to achieve aquaretic effects in this setting.
- |||||||||| furosemide / generics
Journal: Transfusion-associated circulatory overload with pulmonary alveolar hemorrhage following allogeneic bone marrow transplantation (Pubmed Central) - Aug 17, 2019
...Although the patient developed slight edema, pleural effusion, and cardiac effusion 6 months after BMT, his clinical condition improved with furosemide treatment...Therefore, the possibility of cardiac failure is considered when patients with hematological malignancies have fluid retention, such as cardiac enlargement, edema, and pleural effusion. Moreover, the body fluids should be monitored before and after blood transfusion.
- |||||||||| furosemide / generics
Clinical, Journal: Role of Response-to-Diuretic in Predicting Prognosis in Discharged Heart Failure Patients After an Acute Decompensation. (Pubmed Central) - Aug 9, 2019
Acute kidney injury is a frequent complication after hip fracture surgery in elderly diabetic patients and is associated with increased 1-year mortality; however, it was not found to be associated with angiotensin-converting enzyme inhibitor/angiotensin receptor blocker pre-fracture treatment. Adding R-to-D to Gal-3 and BNP, a single pre-discharge strategy testing seemed to obtain a satisfactorily predictive value in alive HF patients discharged after an ADHF episode.
- |||||||||| alprazolam / generics
Clinical, Journal: Clinical efficacy of Unani medicine Renax for treatment of Urolithiasis. (Pubmed Central) - Aug 8, 2019
A Total of 24 patients were completely cured out of 50 by use of Renax while a total of 9 patients was cured out of 50 with allopathic medicine (Spironolactone + Furosemide). This study validated the claim of traditional healer for use of Unani medicine in the treatment of urolithiasis.
- |||||||||| Tirosint (levothyroxine) / IBSA Institute Biochemical SA
A Rare Case of Myxedema Ascites and Ischemic Colitis (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2449;
She was started on levothyroxine for severe hypothyroidism...She was managed with diuretics (furosemide and spironolactone) and therapeutic paracentesis...Ascites with SAAG 2.5 g/dL and other causes such as portal hypertension, malignancy, and infections are ruled out. It is easy to treat, can lead to complete resolution of ascites and decrease morbidity.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J, Humira (adalimumab) / Eisai, AbbVie
Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome) (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1904;
Our case presentation is unique since patient developed Sweet syndrome while being on IV infliximab therapy. In patients with recurrent Sweet syndrome malignancy should strongly be considered.
- |||||||||| Rare Case of Duodenal Melanosis in a 72-Year-Old Male (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1293;
In our patient, his medical conditions and anti-hypertensive medications likely contributed to this benign finding. Although, considered a benign condition, it is imperative to identify this condition during endoscopy to exclude other serious conditions.
- |||||||||| Lopressor (metoprolol tartrate) / Novartis, aspirin / Generic Mfg., Tirosint (levothyroxine) / IBSA Institute Biochemical SA
Black Speckled Duodenal Mucosa (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1291;
To date there is no evidence that this condition is a precursor for neoplasia or any other progressive pathology. Therapeutic chelation or endoscopic follow-up for pseudomelanosis duodeni is not recommended.
- |||||||||| furosemide / generics
Too Much TAE: A Case of Tumor Lysis Syndrome After Repeat Transarterial Embolization of Hepatocellular Carcinoma (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1187;
TLS was diagnosed & treated with intravenous fluids for dilution, rasburicase for hyperuricemia, furosemide for renal dysfunction & minimal urine output, & insulin for hyperkalemia...Early recognition of TLS is key for treatment & involves awareness of the propensity for development of TLS in large tumor burdens, rapidly dividing tumors, multiple treatment sessions, & pretreatment renal dysfunction. Oliguria after IR treatment of HCC should raise the suspicion for possible TLS & not be easily dismissed as the common but less fatal contrast induced nephropathy.
- |||||||||| Eliquis (apixaban) / BMS
Silent Propafenone-Induced Liver Injury: Case Report (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1142;
Two weeks prior, he had atrial fibrillation treated with ablation, apixaban, and propafenone...He was treated with IV diltiazem and furosemide with improvement of SOB...Unlike previous cases where jaundice, pruritis, and abdominal pain were presenting symptoms; hepatotoxicity was incidentally discovered in our patient. Although very rare, clinicians should be aware of propafenone-associated hepatotoxicity and routine monitoring of hepatic function may be warranted.
- |||||||||| furosemide / generics
CHF - Chronic Hernial Failure Presenting as Congestive Heart Failure (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_921;
Patient was commenced on oral furosemide; urgent lab work, chest x-ray and echo were requested...Our patient likely had high-output cardiac failure due to profound anemia in the setting of Cameron’s lesions from a large PEH. Other common causes of chest symptoms and anemia should be excluded before attributing these symptoms to a large PEH.
- |||||||||| furosemide / generics, spironolactone / generics
Superior Mesenteric Arteriovenous Fistula Mimicking Hepatic Cirrhosis With Spontaneous Bacterial Peritonitis (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_884;
Treatment with endovascular with coil embolization is often preferred over surgical repair. In summary, we discuss an unusual presentation of idiopathic arteriovenous fistula of the superior mesenteric vasculature with portal vein thrombosis, abdominal pain and ascites mimicking hepatic cirrhosis with spontaneous bacterial peritonitis.
- |||||||||| Coverex/Covercard (perindopril) / Egis, Coversyl (perindopril arginine) / Servier
Journal: Drugs for chronic heart failure. (Pubmed Central) - Aug 6, 2019
A mechanistic hypothesis is provided based on increasing evidence for a cerebellar contribution in cognitive functioning including sensorimotor gating. No abstract available
- |||||||||| Coverex/Covercard (perindopril) / Egis, Coversyl (perindopril arginine) / Servier
Journal: Expanded table: Some drugs for HFrEF. (Pubmed Central) - Aug 6, 2019
No abstract available No abstract available
- |||||||||| furosemide / generics, spironolactone / generics
Clinical, Journal: Fluid balance in pediatric patients in prone position: a pragmatic study. (Pubmed Central) - Aug 6, 2019
No abstract available The prone position was not associated with increased diuresis or decreased cumulative fluid balance in critically ill pediatric patients who underwent to MV for pulmonary causes.
- |||||||||| furosemide / Generic mfg.
Journal: Spot Urine Sodium as Triage for Effective Diuretic Infusion in an Ambulatory Heart Failure Unit. (Pubmed Central) - Aug 3, 2019
The prone position was not associated with increased diuresis or decreased cumulative fluid balance in critically ill pediatric patients who underwent to MV for pulmonary causes. High spot urine sodium after diuretic administration identifies HF patients likely to respond to an ambulatory diuretic infusion with lower rates of hospitalization or ED visits at 30 days.
- |||||||||| glimepiride / generics
Journal: Experiment stands corrected: accurate prediction of the aqueous pK values of sulfonamide drugs using equilibrium bond lengths. (Pubmed Central) - Jul 26, 2019
...Models are constructed for three variants of the SONHR group: primary benzene sulfonamide derivatives (e.g. diuretic drugs furosemide and hydrochlorothiazide), N-phenyl substituted 4-amino-N-phenylbenzenesulfonamide analogues (e.g. the sulfa antibiotic sulfadiazine) and phenylsulfonylureas (e.g. insulin secretagogue, glimepiride)...Using bond lengths as a powerful descriptor of ionization feasibility, we also identify that literature values for drug compounds celecoxib, glimepiride and glipizide are inaccurate...For glimepiride, our corrected value denotes a percentage of ionization at intracellular pH, which is only now in excellent agreement with its known therapeutic efficacy. We propose that linear relationships between bond lengths and pK should emerge for any set of congeners, thus providing a powerful method of pK prediction in instances where pK data exist for close congeners, thereby obviating the need for thermodynamic cycles.
- |||||||||| Jynarque (tolvaptan) / Otsuka, Vaprisol (conivaptan injection) / Cumberland
Journal: Vasopressin antagonism for decompensated right-sided heart failure. (Pubmed Central) - Jul 26, 2019
Vaptans were associated with a significant increase in urine output and serum sodium with an apparent reduction or stabilization of furosemide equivalent dosing in the early treatment period in patients with decompensated RHF. Vaptans may offer a management option for patients failing conventional diuretic-based treatment.
- |||||||||| Journal: Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. (Pubmed Central) - Jul 24, 2019
...We investigated this issue using the NKCC1 inhibitors bumetanide and furosemide, which are commonly used loop diuretics...Immunofluorescence analyses of myofiber cross-sections revealed more large myofibers after exercise, but this was impaired by daily intraperitoneal bumetanide injections (0.2 or 10 mg/kg/day). NKCC1 plays an essential role in myogenesis and exercise-induced skeletal muscle hypertrophy, and sarcopenia in patients with renal or heart failure may be attributable to treatment with loop diuretics.
- |||||||||| furosemide / generics
Clinical, Journal: A High-Demanding Strategy to Ensure the Highest Quality Standards of Oral Liquid Individualized Medicines for Pediatric Use. (Pubmed Central) - Jul 23, 2019
...Furosemide was used as an example of the validation of an individualized liquid solution for pediatric use...In this study, a general high-demanding strategy was elaborated to validate oral liquid dosage forms, including validation of the analytical method used to test their quality. A second part focuses on the elaboration of liquid formulations for pediatrics with the highest standards of quality taking into account CQAs that were not contemplated by official compendial such as content uniformity and physical stability.
- |||||||||| gentamicin sulfate / generics
Preclinical, Journal: Functional and morphological analysis of different aminoglycoside treatment regimens inducing hearing loss in mice. (Pubmed Central) - Jul 19, 2019
It was revealed that an ototoxic regimen with kanamycin twice daily for 15 consecutive days is safe, well tolerated and produces an early significant hearing threshold shift detected by DPOAE in a small cohort of mice. The study compared ABR and DPOAE in mentioned regimens for the first time and illustrated that DPOAE is well suited for detecting hearing threshold shifts in high frequencies before ABR threshold shifts occur in accordance with predominating outer hair cell damage mainly in the basal turn of the cochlea.
- |||||||||| furosemide / generics, celecoxib oral / generics
Journal: Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides. (Pubmed Central) - Jul 19, 2019
Furthermore, the electrostatic potential of previously reported cocrystals has been recalculated to show that the negative electrostatic potential on the lactam and syn-amide O atom is higher compared with the charge on carboxamide and pyridine N-oxide O atoms. The potential of sulfonamide molecules to form cocrystals with syn-amides and lactams are evaluated in terms of the electrostatic potential energy for the designed supramolecular synthons.
- |||||||||| gentamicin sulfate / generics
Journal, IO Biomarker: Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress. (Pubmed Central) - Jul 18, 2019
...AVN-C also strongly protected against deterioration in hearing due to kanamycin and furosemide (K + F)...AVN-C reduced the dichlorofluorescin (DCF)-positive population in gentamicin-treated HEI-OC1 in vitro...The results of this study show that AVN-C crosses the blood-labyrinth barrier and provide a significant protection against noise- and drug-induced ototoxicity. Hence, AVN-C is a good candidate for future therapy aimed at protecting against sensorineural HL.
- |||||||||| furosemide / generics
Retrospective data, Journal: Postmortem evaluation of renal tubular vacuolization in critically ill dogs. (Pubmed Central) - Jul 17, 2019
Administration of 6% HES (670/0.75) and presenting serum creatinine concentration were significant predictors of RTV severity. Larger prospective studies are needed to determine the etiology and significance of RTV in dogs.
- |||||||||| Actimab-A (lintuzumab-Ac225) / Actinium
Trial completion date: Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients (clinicaltrials.gov) - Jul 15, 2019
P1/2, N=72, Active, not recruiting,
Larger prospective studies are needed to determine the etiology and significance of RTV in dogs. Trial completion date: May 2019 --> Aug 2019
- |||||||||| Lacromid (bezafibrate) / Remedica
Journal: The internal medicine articles that struck us the most in 2018 (Pubmed Central) - Jul 13, 2019
From bezafibrate in primary biliary cholangitis to the new Clostridioides difficile guidelines, passing by use of procalcitonine, cristalloids, copeptin and how to administer furosemide, internal medicine journals are full of novelties. Every year, the chief residents of the CHUV internal medicine ward meet up to share their readings : here is their selection of 12 articles, chosen, summarized and commented for you.
|
