- |||||||||| furosemide / Generic mfg., cinacalcet HCl / Generic mfg.
[VIRTUAL] A Case of Primary Hyperparathyroidism on the Third Trimester of Pregnancy () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_549;
This case shows that when two lives are at stake every step of the management, whether diagnostic or therapeutic, must be communicated well to the patient and to the other members of the team. It is ultimately a choice made by the expectant mother but through the proper guidance and updated knowledge of the team, combined with a good clinical eye especially in the treatment of pregnant women.
- |||||||||| furosemide / Generic mfg., pamidronate disodium / Generic mfg.
[VIRTUAL] Reversible Suppression of Serum 1,25-Dihydroxyvitamin D in Williams Syndrome () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_525;
Serum 1,25-dihydroxyvitamin D was undetectable and returned to normal only with resumption of PTH secretion required for its synthesis after hypercalcemia resolved. The balance between bone formation and resorption was shifted to resorption possibly to remove skeletal calcium excess, based on normal alkaline phosphatase (marker of osteoblast activity) and high collagen beta-crosslaps (marker of osteoclast activity).
- |||||||||| furosemide / Generic mfg., propranolol / Generic mfg.
[VIRTUAL] An Unusual Case of Symptomatic Hypercalcemia from Graves’ Disease in a Young Filipino Female () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_505;
Hydration with saline and Furosemide 20mg once daily was started though calcium levels remained elevated...She was started on propylthiouracil 50mg four times daily, along with propranolol 40mg three times daily...A concomitant primary hyperparathyroidism should also be evaluated. The definitive treatment for the hypercalcemia is correction of thyroid function.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
[VIRTUAL] Bilateral Aldosterone-Producing Adenomas: A New Subtype of Bilateral Primary Aldosteronism? () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_374;
Hypercortisolism investigation revealed a non-suppressible cortisol after an overnight 1 mg low-dose dexamethasone suppression [cortisol (C)= 2.9 μg/dL and dexamethasone= 701 (˃130 ng/dL)], and normal urinary free cortisol, midnight salivary cortisol, plasma DHEAS and ACTH levels...Currently, she doesn’t have symptoms of adrenal insufficiency after discontinuation of hydrocortisone... We herein described a very rare case of PA caused by bilateral-producing adenomas, confirmed by AVS and CYP11B2 staining after adrenal sparing surgery.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), metformin / Generic mfg.
[VIRTUAL] Delayed Diagnosis of Cushings Syndrome: Hiding in Plain Sight! () - Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_337;
2,3 Early recognition, diagnosis and control of CS is crucial to decrease morbidity and mortality. Our patient demonstrated rapid resolution of DM, hypokalemia and lymphedema after surgery; however, prolonged exposure to endogenous cortisol resulted in compression fractures and osteoporosis requiring follow up treatment.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Spot urine sodium predicts effectiveness of decongestion in acute heart failure () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_1198;
In the first 24 hours of admission all patients underwent a furosemide stress test (FST): a single bolus injection of furosemide (1 mg/kg in diuretic-naïve patients or 1.5 mg/kg in patients under chronic diuretic treatment) was administered...UNa > 83 mmol/l 2 hours after FST had a sensitivity of 94.3% and a specificity of 57.1% to predict a 30% reduction in NT pro-BNP levels. Conclusion UNa quantification two-hours after diuretic administration is able to identify those patients who will present an appropriate decongestive response to treatment.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Spot urinary sodium as a predictor of diuretic response in decompensated heart failure () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_1197;
Some methodological limitations (namely urine collection) are easily overcome to make this method feasible. Nevertheless, despite preliminary reports considering this method as an useful tool for guiding therapy, we were unable to show a predictive capacity of diuretic response.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, Rovi Pharmaceuticals Laboratories
[VIRTUAL] Sacubitril/valsartan: what does the real-life experience tell us? () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_1187;
In this study of a real-world population, although the majority of patients would have been excluded from the PARADIGM-HF trial and a significant proportion were prescribed off-label, the use of ARNI was safe, even in patients with low SBP, and was associated with improvements in functional class and NT-proBNP, although there was no improvement in CPET parameters. In our study, the predictors of the outcomes were the NT-proBNP, LVEF and the maximum HR in the CPET.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Prognostic impact of worsening renal function in B-type acute heart failure patients on decongestion () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_1135;
After adjusted Cox model (for age, EF, daily furosemide intake, number of comorbidities, admission hemoglobin, NTproBNP, and urea), this association remained significant (with AKI/no WRF (HR 1,880; 95%CI 1,114-3,172); no AKI/with WRF (HR 2,308; 95%CI 1,314-4,051); with AKI/with WRF (HR 2,625; 95%CI 1,170-5,888). CONCLUSION In this population of acute congestive HF patients (B-type profile), the presence of AKI on admission and the development of WRF with diuretic therapy were associated with increased incidence of all-cause mortality and cardiovascular hospitalization in patients with acute heart failure, and concomitant WRF and AKI confers worse prognosis.
- |||||||||| [VIRTUAL] Heart failure and thromboembolic events in adults with left ventricular noncompaction () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_986;
Mortality rate is significantly associated with heart failure, lower LV EF, ?/?, VTI, VT, including non-sustained VT in patients with LVNC. Besides AF, low LV EF, the history of thrombosis/embolism other factors should considered indications for anticoagulants in patients with LVNC, including: NYHA HF class, LA volume > 98 ml, E/A, LV EDV > 153 ml, LV EDD > 6,3 cm, myocardial infarction of unknown etiology.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Early recurrent congestion after an acute heart failure event: experience from a dedicated clinic () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_917;
Recurrent congestion after AHF in our HF management program is a significant event in the vulnerable phase, and it was an independent predictor of major outcomes. These results further unveil the pervasiveness and prognostic value of recurrent congestion despite assertive measures to optimize outpatient diuretic treatment.
- |||||||||| [VIRTUAL] Diabetes and urea predict death among Brazilian outpatients with heart failure () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_893;
Patients were treated following the recommendations of the guidelines: 89.4% were using betablockers, 82.7% ACE inhibitors or ARBs, 48.6% ARMs, 0.5% ARNI, 26.9% digoxin, 66.3% furosemide, 16.9% anticoagulants, 5.3% amiodarone, 10.1% nitrate/hydralazine, and 2.9% ivabradine. Diabetes and urea levels were predictors of death among Brazilian patients with heart failure followed in a specialized clinic.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, Rovi Pharmaceuticals Laboratories, furosemide / Generic mfg., spironolactone / Generic mfg.
[VIRTUAL] Congestion guiding management for decompensated heart failure: CONGUIMA HF Registry () - Jun 20, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_876;
our preliminary 6-month outcomes rates were lower than those from Brazilian Heart Failure Registry. The protocol based on three pillars (congestion vigilance, evidence-based HF-prescribing and monthly patient education) in the vulnerable phase seems to be the key to decreasing outcomes.
- |||||||||| sirolimus / Generic mfg.
Journal: Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR. (Pubmed Central) - Jun 18, 2020
The results in the present study reveal that autophagy dysfunction is an important component of SGN degeneration, and TFEB may be a potential target for attenuating SGN degeneration following sensory epithelial cell loss in the cochlea of mice. Abbreviations: 3-NT: 3-nitrotyrosine; 4-HNE: 4-hydroxynonenal; 8-OHdG: 8-hydroxy-2'-deoxyguanosine; ABR: auditory brainstem response; APP: amyloid beta (A4) precursor protein; CLEAR: coordinated lysosomal expression and regulation; CTSB: cathespin B; CTSD: cathespin D; SAMR1: senescence-accelerated mouse/resistance 1; SAMP8: senescence-accelerated mouse/prone 8; MAPK1/ERK2: mitogen-activated protein kinase 1; MTOR: mechanistic target of rapamycin kinase; SGN: spiral ganglion neuron; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscope; TFEB: transcription factor EB.
- |||||||||| furosemide / Generic mfg.
Enrollment open: FURosemide Stress Test to Predict Need of Renal Replacement THERapy in Ischemic Acute Tubular Necrosis in ICU (clinicaltrials.gov) - Jun 18, 2020
P4, N=70, Recruiting,
Abbreviations: 3-NT: 3-nitrotyrosine; 4-HNE: 4-hydroxynonenal; 8-OHdG: 8-hydroxy-2'-deoxyguanosine; ABR: auditory brainstem response; APP: amyloid beta (A4) precursor protein; CLEAR: coordinated lysosomal expression and regulation; CTSB: cathespin B; CTSD: cathespin D; SAMR1: senescence-accelerated mouse/resistance 1; SAMP8: senescence-accelerated mouse/prone 8; MAPK1/ERK2: mitogen-activated protein kinase 1; MTOR: mechanistic target of rapamycin kinase; SGN: spiral ganglion neuron; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscope; TFEB: transcription factor EB. Suspended --> Recruiting
- |||||||||| furosemide / Generic mfg.
Journal: Adaptation of Cochlear Amplification to Low Endocochlear Potential. (Pubmed Central) - Jun 12, 2020
An early study using furosemide to reversibly reduce EP showed that distortion product otoacoustic emissions (DPOAEs) recovered before EP...Furthermore, the cochlear amplifier and EP recovered with different time courses: cochlear amplification just started to recover after the EP was nearly fully recovered and stabilized. Using a Boltzmann model and the second harmonic of the LCM to estimate the mechanoelectric transducer channel operating point, we found that the recovery of cochlear amplification occurred with recentering of the operating point.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Temporal trends in the implementation of treatments for chronic heart failure: two decades in a nationwide registry () - Jun 9, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_758;
With increasing age class, the proportion of patients on furosemide (71;83;90%, p Table depicts treatment comparisons by epoch within each age category. During two decades in our nationwide registry we observed a consistent implementation of recommended treatments, except for a decline in ACE-i/ARB/ARNI use among older patients, which seems to be connected with temporal changes in the clinical characteristics/disease severity of CHF patients
- |||||||||| Henletor (torsemide) / Orchid, furosemide / Generic mfg.
[VIRTUAL] Efficacy of optimized torsemide versus furosemide in patients with acute heart failure () - Jun 9, 2020 - Abstract #HEARTFAILUREI2020HEART_FAILURE-I_686;
Perhaps torsemide is beneficial in setting of CKD and volume overload due to its increased half-life and bioavailability. Due to potential confounding factors and small sample size, future meta-analysis is needed to assess these clinical benefits of torsemide.
- |||||||||| furosemide / Generic mfg.
Journal: Thiamine Deficiency in a Nondrinker and Secondary Pulmonary Edema after Thiamine Replenishment. (Pubmed Central) - Jun 8, 2020
Furosemide treatment paradoxically worsened the systemic edema and induced confusion...Thiamine deficiency may occur in nondrinkers with an unbalanced diet. In this condition, diuretic therapy can worsen the symptoms before thiamine supplementation by promoting the flushing of water-soluble vitamins but is needed for the management of secondary pulmonary edema after thiamine replenishment.
- |||||||||| furosemide / Generic mfg.
Journal: Performance of Iris pseudacorus and Typha domingensis for furosemide removal in a hydroponic system. (Pubmed Central) - Jun 8, 2020
FUR removal by Iris follows a pseudo-first order while by Typha is divide in different phases. These results indicate that different plants species seem to have different mechanisms to remove pollutants from water.HighlightsPhACs removal potential of Iris pseudacorus and Typha domingensis was assessed.Plants were exposed to 2 mg L of furosemide during 21 days.Both macrophytes showed good removal efficiencies.Biodegradation of furosemide seems to be the main removal mechanism.Plants demonstrated different removal behavior along the experiment.Removal mechanisms of plants seem to differ between species.
- |||||||||| ceftriaxone / Generic mfg., meropenem / Generic mfg., Daewon Pharmaceutical
[VIRTUAL] Case report: Kidney abscess in horseshoe kidney - complex conservative therapy (Plenary 2) - Jun 7, 2020 - Abstract #NORDKONGRESS2020NORDKONGRESS_23;
Course: On the following day, when the infection (CRP 106 mg / l, PCT 113µg / l) and retention parameters (creatinine 2.76mg / dl) increased, the right DJ was introduced and a DJ splint inserted and therapy with ceftriaxone iv started...After escalation of the therapy to Pip / Taz iv and administration of furosemide iv for pleural effusions, there was initially a clinical improvement, but the patient reports for the first time bilateral hypacusis...After switching the therapy to Meropenem, there was a decrease in inflammation and improvement in symptoms... The case describes the fulminant course of urolithiasis in horseshoe kidney with massive kidney abscess (mortality 8%) and successful conservative therapy with iv antibiotic administration over 4 weeks despite simultaneous immunosuppression.
- |||||||||| furosemide / Generic mfg.
Clinical, Journal: Severe edema after cessation of laxative abuse and use of a loop diuretic: Case report. (Pubmed Central) - Jun 4, 2020
It also details the dosing and duration of furosemide used for diuresis in order to provide a precedent to inform future care. This case calls into question the best treatment approach for patients with severe edema after laxative cessation who do not meet criteria for Pseudo Bartter syndrome.
- |||||||||| furosemide / Generic mfg.
Journal: Mucoadhesive buccal films based on a graft co-polymer - A mucin-retentive hydrogel scaffold. (Pubmed Central) - Jun 4, 2020
This work illustrated that it is possible to manufacture dry, solid, dual polymer films containing an advanced drug delivery system with a cheap and simple method. The combination of a graft co-polymer with a mucoadhesive polymer transform into drug solubilising micelles in a mucin-retentive hydrogel scaffold with longer retention time on buccal mucosa for safe and enhanced advanced formulation.
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