- |||||||||| furosemide / Generic mfg.
Journal: Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide. (Pubmed Central) - Jul 29, 2020
Accordingly, we conclude that furosemide is a reasonably potent inhibitor of IL-6 and TNF-α that is also safe, inexpensive and well-studied. Our pre-clinical data suggest that it may be a candidate for repurposing as an inhaled therapy against COVID-19.
- |||||||||| valsartan / Generic mfg.
Journal: Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. (Pubmed Central) - Jul 24, 2020
The recoveries (%) of methyldopa, hydrochlorothiazide, prazosin hydrochloride, furosemide, labetalol, propranolol, valsartan, losartan potassium, diltiazem, irbesartan, and spironolactone were 91.0, 85.2, 92.3, 90.4, 90.1, 85.6, 86.6, 86.2, 85.1, 86.6, and 85.7, respectively. These results showed that SPMMTE and HPLC methods can be applied to test the described drugs in several matrices.
- |||||||||| Journal: Myositis, rhabdomyolysis and severe hypercalcaemia in a body builder. (Pubmed Central) - Jul 24, 2020
Hypercalcaemia was possibly multifactorial - (1) calcium release following myositis, rhabdomyolysis and acute kidney injury; (2) possible primary hyperparathyroidism (a low but detectable PTH); and (3) hypervitaminosis A. He was hydrated and given pamidronate, mycophenolate and prednisolone...There may be several disparate causes for hypercalcaemia, although one usually predominates. Maintaining 'body image' even with the use of harmful drugs may be an overpowering emotion despite counselling about their dangers.
- |||||||||| Henletor (torsemide) / Orchid, furosemide / Generic mfg.
Retrospective data, Journal: Comparing torsemide versus furosemide in patients with heart failure: A meta-analysis. (Pubmed Central) - Jul 22, 2020
However, torsemide did not provide significant benefits in reducing mortality or rehospitalization rates for HF or CVD compared with furosemide. The authors suggest switching from furosemide to torsemide in patients with HF not achieving symptomatic control with the use of furosemide despite maximizing guideline-directed medical therapy and furosemide dosing.
- |||||||||| pecavaptan (BAY1753011) / Bayer
Enrollment change: AVANTI: A Trial to Study BAY1753011 in Patients With Congestive Heart Failure (clinicaltrials.gov) - Jul 22, 2020
P2, N=570, Recruiting,
The authors suggest switching from furosemide to torsemide in patients with HF not achieving symptomatic control with the use of furosemide despite maximizing guideline-directed medical therapy and furosemide dosing. N=414 --> 570
- |||||||||| furosemide / Generic mfg., prazosin / Generic mfg.
Review, Journal: α-Adrenoceptors: Challenges and Opportunities-Enlightenment from the Kidney. (Pubmed Central) - Jul 21, 2020
Now α-ARs lurk on the horizon involving hypertension causality, renal denervation for hypertension, injury from falling in the elderly and prazosin's mechanism of action in anxiety states such as posttraumatic stress disorder (PTSD)...In this model system and in the setting of furosemide-induced sodium excretion, α-AR activation inhibited adenylate cyclase, suppressed cAMP formation, and caused sodium retention...Here, we describe how this finding relates to a broader understanding of the role of α-ARs in diverse disease states. Because of the capacity for qualitative and quantitative monitoring of α-AR-induced regulatory mechanisms in the kidney, we looked to the kidney and found enlightenment.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] ACUTE-ON-CHRONIC LIVER FAILURE IS INDEPENDENTLY ASSOCIATED WITH HIGHER MORTALITY IN PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4919;
ACLF absent, male sex, use of PPI (proton-pump inhibitor), furosemide and NSBB (non-selective beta-blockers), inactive alcoholism, total bilirubin lower than 4 mg/dL, INR (International Normalizated Ratio) lower than 1.3, AST and ALT lower than 40 U/L, hemoglobin higher than 9 mg/dL, creatinine lower than 2 mg/dL, serum levels of albumin and lower MELD, CLIF-SOFA and CTP scores were associated with higher 28-day and 90-day survival, using as statistically significant a p value below 0.2 for inclusion in multivariate analysis... The presence of ACLF and higher CLIF-SOFA scores were independently associated with higher 28- and 90-day mortality in cirrhotic patients admitted due to SBP.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] ACUTE-ON-CHRONIC LIVER FAILURE IS INDEPENDENTLY ASSOCIATED WITH HIGHER MORTALITY IN PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2943;
ACLF absent, male sex, use of PPI (proton-pump inhibitor), furosemide and NSBB (non-selective beta-blockers), inactive alcoholism, total bilirubin lower than 4 mg/dL, INR (International Normalizated Ratio) lower than 1.3, AST and ALT lower than 40 U/L, hemoglobin higher than 9 mg/dL, creatinine lower than 2 mg/dL, serum levels of albumin and lower MELD, CLIF-SOFA and CTP scores were associated with higher 28-day and 90-day survival, using as statistically significant a p value below 0.2 for inclusion in multivariate analysis... The presence of ACLF and higher CLIF-SOFA scores were independently associated with higher 28- and 90-day mortality in cirrhotic patients admitted due to SBP.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] ACUTE-ON-CHRONIC LIVER FAILURE IS INDEPENDENTLY ASSOCIATED WITH HIGHER MORTALITY IN PATIENTS WITH SPONTANEOUS BACTERIAL PERITONITIS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_959;
ACLF absent, male sex, use of PPI (proton-pump inhibitor), furosemide and NSBB (non-selective beta-blockers), inactive alcoholism, total bilirubin lower than 4 mg/dL, INR (International Normalizated Ratio) lower than 1.3, AST and ALT lower than 40 U/L, hemoglobin higher than 9 mg/dL, creatinine lower than 2 mg/dL, serum levels of albumin and lower MELD, CLIF-SOFA and CTP scores were associated with higher 28-day and 90-day survival, using as statistically significant a p value below 0.2 for inclusion in multivariate analysis... The presence of ACLF and higher CLIF-SOFA scores were independently associated with higher 28- and 90-day mortality in cirrhotic patients admitted due to SBP.
- |||||||||| furosemide / Generic mfg.
Clinical, Journal: Effect of diuretic infusion clinic in preventing hospitalization for patients with decompensating heart failure. (Pubmed Central) - Jul 17, 2020
Heart failure with reduced ejection fraction was observed in 70 (76.9%) responders with a mean ejection fraction of 23% and in 9 (64.3%) non-responders with mean ejection fraction of 19.9%. Outpatient intravenous furosemide infusion protocol is effective in preventing hospitalization for decompensating heart failure and a viable clinical pathway for heart failure programs.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Pulmonary Hypertension in Childhood (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_1161;
Mean age of diagnosis was 4.07±5.1 years. Mean age of diagnosis was 3.14±4.85 years in patients with cardiac or pulmonary anomaly and 6.01±5.28 years in patients with idiopathic PH (p>0.05).
- |||||||||| furosemide / Generic mfg., spironolactone / Generic mfg.
[VIRTUAL] A UK survey of the management of infants with bronchopulmonary dysplasia (BPD) (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_1092;
Tracheostomies were uncommon: 39 units reported in one year there were no tracheostomies, four units one tracheostomy and two units two tracheostomies. Conclusion : Our survey demonstrates there is no consensus for the management of infants with BPD and emphasizes the need for appropriately designed trials to establish evidence based management.
- |||||||||| furosemide / Generic mfg.
Clinical, Journal: Torsemid oder Furosemid bei Patienten mit einer Herzinsuffizienz? (Pubmed Central) - Jul 11, 2020
Conclusion : Our survey demonstrates there is no consensus for the management of infants with BPD and emphasizes the need for appropriately designed trials to establish evidence based management. No abstract available
- |||||||||| furosemide / Generic mfg.
Journal: Furosemide in end-stage heart failure: community subcutaneous infusions. (Pubmed Central) - Jul 11, 2020
Subcutaneous furosemide can be successfully delivered in the community. In addition to palliation in the final days of life, community subcutaneous furosemide can be an effective treatment leading to weight loss and improved symptoms with survival for several months.
- |||||||||| furosemide / Generic mfg.
Journal: Rethinking furosemide use for infants with bronchopulmonary dysplasia. (Pubmed Central) - Jul 10, 2020
While furosemide likely has a role in the management of infants with BPD, clinicians are encouraged to recognize these potential complications associated with furosemide administration. Specifically, a deeper understanding of the impact of diuretics on sodium metabolism neurohumoral regulation of cardiopulmonary physiology is required.
- |||||||||| furosemide / Generic mfg.
Journal: Renal medullary tonicity regulates RNF183 expression in the collecting ducts via NFAT5. (Pubmed Central) - Jul 7, 2020
Furosemide treatment of mIMCD-3 cells did not affect mRNA expression and RNF183 promoter activities. These results indicated that RNF183 is predominantly expressed in the renal medullary collecting ducts, and that decreased renal medullary tonicity by furosemide treatment decreases RNF183 expression by NFAT5 downregulation.
- |||||||||| paclitaxel / Generic mfg.
Review, Journal: A guide to establishing a hyperthermic intraperitoneal chemotherapy program in gynecologic oncology. (Pubmed Central) - Jul 7, 2020
Close attention to temperature and glycemic control is essential during the procedure, as electrolyte derangements including hyperglycemia, lactic acidosis and hypokalemia may occur. Continuous patient monitoring and proactive management of abnormalities that arise during HIPEC is imperative to decrease patient morbidity and mortality.
- |||||||||| ceftriaxone / Generic mfg., doxycycline / Generic mfg., Pierre Fabre
[VIRTUAL] A Case of Pulmonary Actinomycosis, with Cryptogenic Organizing Pneumonia (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_7234;
We started intravenous diuresis with furosemide, prednisone and doxycycline...He was started on piperacillin- tazobactam and vancomycin...Ceftriaxone was completed and then penicillin V was started for 6 months...It can be confused with tuberculosis and lung cancer. Treatment is high dose intravenous penicillin for 2-6 weeks followed by penicillin V orally for 6-12 months.
- |||||||||| Inlyta (axitinib) / Pfizer, Keytruda (pembrolizumab) / Merck (MSD), furosemide / Generic mfg.
[VIRTUAL] Upper Lobe Predominant Cardiogenic Pulmonary Edema in Cancer Patient (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_7221;
She was being treated with pembrolizumab (check-point inhibitor) and axitinib (tyrosine kinase inhibitor); the last dose of both was 10 days prior to presentation...She was diuresed with IV furosemide & symptomatically improved to baseline...This occurs infrequently in systolic CHF, unilaterally on the right with mitral valve regurgitation, and in patients with CTEPH. 1 In the right clinical context, considering cardiogenic pulmonary edema can prevent unnecessary procedures, antibiotics & steroids if patients improve with diuresis.
- |||||||||| hydroxyurea / Generic mfg., furosemide / Generic mfg.
[VIRTUAL] Successful Treatment of Severe Acute Chest Syndrome in a Patient with Hemoglobin SC Disease (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_7104;
ACS can occur in as many as half of patients with SCD and is a major reason for hospitalization and the cause of mortality. It is important to recognize signs of ACS in HbSC disease and use preventative measures to reduce future hospitalizations such as prophylactic antibiotics, hydroxyurea and blood transfusions.
- |||||||||| methylprednisolone oral / Generic mfg., furosemide / Generic mfg.
[VIRTUAL] Vape Induced Lung Injury with Rapid Improvement Following Systemic Steroid Therapy (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6543;
Pulmonary team was consulted, with IV Levofloxacin and IV furosemide initiated...Then the patient was placed on IV methylprednisolone 40mg every 8 hours...The definitive treatment has yet to be determined, however, this case demonstrates the potential benefit in systemic steroid therapy (2). Ultimately vaping is extremely dangerous and systemic steroids are appearing to be the treatment of choice as shown by this case.
- |||||||||| furosemide / Generic mfg., apixaban / Generic mfg.
[VIRTUAL] Clots, Clots, Clots! A Case Report of Extensive Arterial Thromboembolic Disease in the Setting of Metastatic Adenocarcinoma of the Lung in an Anti-Coagulated Patient (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6180;
Case Report:A 78-year-old gentleman with history of Atrial fibrillation on Eliquis, COPD, Heart failure and recently diagnosed metastatic adenocarcinoma of the lung presented to the ED with complaints of shortness of breath...Chest x ray was inconclusive, and he received Duo Nebs, Lasix and Steroids in the ED and was transferred to the ICU for further management...Based certain studies looking at the Surveillance, Epidemiology and Results database, the incidence of arterial thromboembolic events in patients with cancer at 6 months is 4.7% and the presence of it is predictive of worse outcomes. Unfortunately, there have not been enough studies to investigate optimal prophylaxis, surveillance strategies and treatment of cancer related arterial thromboembolic disease.
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