furosemide / Generic mfg. 
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  • ||||||||||  Flagyl (metronidazole) / SLA, venlafaxine / Generic mfg.
    Clinical, Journal:  QT prolongation in patients with acute leukemia or high-risk myelodysplastic syndrome prescribed antifungal prophylaxis during chemotherapy-induced neutropenia. (Pubmed Central) -  Sep 21, 2020   
    This retrospective, single-center, study evaluated 316 adult acute leukemia and high-risk MDS patients who received 11,775 patient-days of voriconazole prophylaxis during induction chemotherapy...Medications associated with QTc prolongation included furosemide, haloperidol, metronidazole, mirtazapine, prochlorperazine, and venlafaxine...Serial ECG monitoring during induction chemotherapy can be tailored proportionally to QT-prolonging risk factors. Management should include aggressive electrolyte repletion and avoidance of concurrent QT prolonging medications.
  • ||||||||||  furosemide / Generic mfg.
    Retrospective data, Journal:  Neonatal Transport in the Practice of the Crews of the Polish Medical Air Rescue: A Retrospective Analysis. (Pubmed Central) -  Sep 21, 2020   
    The average transport time was 49.92 (SD 27.70) minutes with the average distance of 304.27 km (SD 93.05). Significant differences between premature babies and full-term newborns were noticed in terms of age and body weight at the moment of transport, diagnosis based on the International Statistical Classification of Diseases and Related Health Problems (ICD-10), the most commonly used medications (prostaglandin E1, glucose, furosemide, vitamins), National Advisory Committee for Aeronautics (NACA) scale rate as well as the mission type and the presence of an accompanying person.
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    [VIRTUAL] Main Results Of The Empagliflozin Evaluation By Measuring Impact On Hemodynamics In Patients With Heart Failure Trial (Scientific Session Theater C) -  Sep 17, 2020 - Abstract #HFSA2020HFSA_863;    
    There was no difference in loop diuretic dose (measured in daily furosemide equivalents) at baseline (90 mg empa, 85 mg pbo; p = 0.51), week 12 (92 mg empa, 86 mg pbo; p = 0.24), or any interim time point. EMBRACE-HF is the first randomized controlled trial to show a direct beneficial effect of SGLT2i on decongestion in patients with HF (reduced or preserved EF), with rapid reductions in PA pressures that were amplified over time and appeared to be independent of loop diuretic management.
  • ||||||||||  Spherazole (itraconazole) / RA Chem, JW Pharma, Spherics
    [VIRTUAL] Spelunking for a Cause of Heart Failure: A Fungus Amongst Us (OnDemand) -  Sep 17, 2020 - Abstract #AHA2020AHA_2091;    
    He was discharged on colchicine and furosemide; however, he presented to our institution two weeks later with persisting dyspnea and edema...He was initiated on 12 weeks of itraconazole; however, despite anti-inflammatory therapies, he had refractory congestion...In sum, we describe a rare diagnosis of effusive-constrictive pericarditis secondary to chronic histoplasmosis. Our case highlights the salient findings of pericardial constriction and the continued importance of a detailed clinical history.
  • ||||||||||  Lopressor (metoprolol tartrate) / Novartis
    [VIRTUAL] Fate of Dislodged Micra Transcatheter Pacing System in Coronary Sinus (OnDemand) -  Sep 17, 2020 - Abstract #AHA2020AHA_1246;    
    His medications included Lasix and Metoprolol. Embolization and dislodgement of Micra leadless pacemaker into the coronary sinus is possible and chronic management with serial imaging after abandoning the device is feasible.
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] Furosemide Promotes Myocardial Fibrosis in Swine Heart Failure (OnDemand) -  Sep 17, 2020 - Abstract #AHA2020AHA_395;    
    Histologic and biochemical analysis showed worsening HF in furosemide-treated paced swine was associated with consistent increases in fibrosis and indices of adverse ECM remodeling. The diuretic intended to reduce water retention during HF appeared to enhance myocardial fibrosis, paradoxically accelerating pathological processes responsible for HF.
  • ||||||||||  Entresto (sacubitril/valsartan) / Novartis, Rovi Pharmaceuticals Laboratories, furosemide / Generic mfg., firibastat (QGC-001) / Quantum Genomics, Biolab Pharma
    Review, Journal:  Approaches for the Management of Resistant Hypertension in 2020. (Pubmed Central) -  Sep 16, 2020   
    These patients should be treated with a loop diuretic such as furosemide every 12 h...Further research is needed on investigational drugs and device therapy for treating resistant hypertension. Clinical trials are indicated for the treatment of resistant hypertension by sacubitril/valsartan and also by firibastat.
  • ||||||||||  aspirin / Generic mfg., furosemide / Generic mfg.
    Journal:  Pathways in the Pathophysiology of Coronavirus 19 Lung Disease Accessible to Prevention and Treatment. (Pubmed Central) -  Sep 16, 2020   
    TNF alpha levels could also be reduced by statins, aspirin, and curcumin...Sodium and chloride transport could be further regulated to prevent accumulation of alveolar fluid by use of Na(+)/K(+)/2Cl(-) cotransporter type 1 inhibitors, which have been associated with improved outcome in adults ventilated for acute respiratory distress syndrome (ARDS) in randomized controlled trials. Primary prevention of coronavirus infection and TNF alpha release in response to it could be improved by induction of antimicrobial peptides LL-37 and human beta defensin-2 and reduction of TNF alpha production by vitamin D prophylaxis for the population as a whole.
  • ||||||||||  carvedilol / Generic mfg., furosemide / Generic mfg., milrinone / Generic mfg.
    [VIRTUAL] Rare Case of a Trifecta: CardioHepatoRenal Syndrome () -  Sep 15, 2020 - Abstract #ACG2020ACG_2954;    
    However, in our CHF patient, chronic use of milrinone was contraindicated due to ischemia and arrhythmia concerns. Establishing a better treatment paradigm for patients with cardiorenal syndrome, particularly when complicated by hypoxic hepatitis and rhabdomyolysis, is important.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    [VIRTUAL] Hepatic Hydrothorax Caused by Transthoracic Percutaneous Radiofrequency Ablation () -  Sep 15, 2020 - Abstract #ACG2020ACG_2855;    
    Additionally, RFA may not be anatomically feasible for lesions near the liver dome or blood vessels due to damage resulting from frictional heating of tissue and subsequent necrosis. As a general conclusion, caution should be exercised when planning percutaneous approaches to the liver in patients with cirrhosis and ascites.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    [VIRTUAL] An Unexpected Cause of Dysphagia in a Patient Hospitalized for Nephrectomy () -  Sep 15, 2020 - Abstract #ACG2020ACG_1557;    
    He was placed on high dose PPI, prolonged steroid taper, rituximab, and topical clobetasol...The patient’s BP was postulated as being medication-related (either from furosemide or amlodipine) with the flare during hospitalization possibly from reduction in his steroid dose in anticipation of surgery or the stress involved in the operative procedure...Though rare esophageal manifestations of BP exist and should be considered in patients that develop swallowing symptoms over the background of ongoing issues with this blistering skin condition. Close follow up with dermatology for treatment of underlying BP is an important step in the overall management of these patients.
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] Role of hypertonic saline solution in acute heart failure associated with renal failure. () -  Sep 12, 2020 - Abstract #EUSEM2020EUSEM_867;    
    The patients were divided into two groups : a first group (HSS) receiving diuretics (250mg of furosemide) with HSS ( 50ml of 10% NaCl) and a second group (Placebo) receiving diuretics (250mg of furosemide) with placebo (50ml of dextrose 5%)...On the other hand, the rate of readmission with acute heart failure at month was 33% in the placebo group and 22% in the HSS group (p=0.5) Conclusion : According to these priliminary results, HSS in conjunction with diuretics do not seem beneficial in the treatment of acute hear failure. That being said, this study needs a larger population
  • ||||||||||  colchicine / Generic mfg., acenocoumarol / Generic mfg., furosemide / Generic mfg.
    [VIRTUAL] Emphysematous cystitis discovered following a VKA overdose in a non-diabetic woman. () -  Sep 12, 2020 - Abstract #EUSEM2020EUSEM_560;    
    Elderly patients may present atypical patterns that can make the diagnosis process difficult. Thus, the role of the emergency physician is crucial in detecting initial severity for the better patient guidance, managing vital distress and recommending the necessary complementary examinations
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Diuretic Responsiveness and its Prognostic Significance in Children with Heart Failure. (Pubmed Central) -  Sep 11, 2020   
    In AHF, low spot UNa+ and lack to increase UNa in response to intravenous diuretics are associated with poor diuretic response, markers of tubular injury and high risk of 1-year mortality. In children hospitalized with acute decompensated heart failure, early diminished loop DR during decongestion therapy is common and portends a poor prognosis.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Review, Journal:  Furosemide as a functional marker of acute kidney injury in ICU patients: a new role for an old drug. (Pubmed Central) -  Sep 11, 2020   
    In this review we summarized all these recent updates, also suggesting that the diuretic response under continuous infusion may allow assessing glomerular and tubular functions with increased reliability than a bolus dose. However, validation studies are still needed to support continuous infusion as a stress test.
  • ||||||||||  [VIRTUAL] Avoiding Treatment in the Hospital with Furoscix for the Management of Congestion in Heart Failure - A Pilot Study (OnDemand) -  Sep 10, 2020 - Abstract #HFSA2020HFSA_569;    
    Furoscix is a pH neutral formulation of furosemide that being developed for self-administration by patients in a home setting via a wearable, pre-programmed on-body subcutaneous delivery system...Secondary endpoints include 1.) days alive and heart failure event free days 2.) global visual analog scale 3.) composite congestion score (CCS) 4.) Dyspnea Status - 7 Point Likert scale 5.) Current Dyspnea Status - 5 point Likert scale 6.) health-related quality of life (Kansas City Cardiomyopathy Questionnaire (KCCQ-12)) 7.) renal function and electrolytes 8.) weight and 9.) exercise tolerance (Six Minute Walking Test (6MWT)) at 30 days. Fifty (50) evaluable subjects will be included and randomly assigned (2:1) to receive Furoscix or continued medical therapy in the home setting with 30 days of follow-up.
  • ||||||||||  [VIRTUAL] Furoscix Real-World Evaluation for Decreasing Hospital Admissions in Heart Failure (OnDemand) -  Sep 10, 2020 - Abstract #HFSA2020HFSA_568;    
    Furoscix is a pH neutral formulation of furosemide that is being developed for self-administeration by patients in a home setting via a wearable, pre-programmed on-body subcutaneous delivery system...In addition, change in health-related quality of life outcomes measured by KCCQ-12 questionnaire will be assessed. The sample size of the Furoscix cohort will be 34-75 subjects.