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0 Diseases |  |
79 Trials |
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79 Trials |  |
6783 News |  |
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- ||| digoxin / Generic mfg., furosemide / Generic mfg., spironolactone / Generic mfg.
Clinical: I read this as you can be confidant that spironolactone reduces mortality in patients on digoxin, but if not on digoxin, you cannot be confident of mortality benefit. Regardless, I start spironolactone every time I start furosemide providing no contra-indication. (Twitter) - Nov 15, 2020
- ||| furosemide / Generic mfg.
Clinical: Can’t agree more, have seen patient getting 40IV lasix for 2 days with 3+ edema... not sure what they are scared off (Twitter) - Nov 14, 2020
- | furosemide / Generic mfg.
Journal: Impact of Loop Diuretic Use on Outcomes Following Transcatheter Aortic Valve Implantation. (Pubmed Central) - Nov 14, 2020
LDT doses were normalized to oral furosemide daily equivalents...On propensity-score matching, death within one year post-TAVI was borderline significantly higher in the pre-LDT as compared with no-LDT group (16.9% vs 10.4 %, p = 0.068). In conclusion, use of pre-TAVI LDT for severe symptomatic AS is associated with a trend towards worse 1-year mortality and is a marker of high-risk, frail individuals with advanced left ventricular remodeling.
- | carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Journal: Modelling the fate of micropollutants in integrated urban wastewater systems: Extending the applicability to pharmaceuticals. (Pubmed Central) - Nov 14, 2020
Despite data uncertainty and the simplicity of the modelling approach, chosen to minimize data requirements, model prediction uncertainty overlapped with the measurements ranges across both systems, stressing the robustness of the proposed modelling approach. Possible applications of the extended IUWS_MP model library are presented, illustrating how this tool can support urban water managers in reducing environmental impacts from PhACs discharges.
- | furosemide / Generic mfg.
Journal: Canadian survey on the rates of use of intraoperative diuretics and justification for their use during renal allograft reperfusion. (Pubmed Central) - Nov 14, 2020
A substantial proportion of surgeons use these medications on the basis of dogma alone. A randomized controlled trial is needed to clarify the role of intraoperative diuretics in kidney transplant surgery.
- || furosemide / Generic mfg.
isovolemic or not, by giving furosemide you are bypassing any and all autoregulating systems of the kidney (Twitter) - Nov 13, 2020
- | furosemide / Generic mfg.
New P3 trial: Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) (clinicaltrials.gov) - Nov 13, 2020
P3, N=136, Completed, Sponsor: University of Palermo
- || Natrecor (nesiritide) / J&J
Clinical, Journal: Lower urine sodium predicts longer length of stay in acute heart failure patients: Insights from the ROSE AHF trial. (Pubmed Central) - Nov 12, 2020
A randomized controlled trial is needed to clarify the role of intraoperative diuretics in kidney transplant surgery. In patients hospitalized for AHF and renal dysfunction, U ≤ 60 mmol/L during the first 24 hours of diuresis identifies patients at risk for prolonged hospitalization but does not provide an indication for adjunctive dopamine or nesiritide.
- || Jynarque (tolvaptan) / Otsuka
Clinical, Journal: Analysis of factors associated with the prognosis of cirrhotic patients who were treated with tolvaptan for hepatic edema. (Pubmed Central) - Nov 12, 2020
In patients hospitalized for AHF and renal dysfunction, U ≤ 60 mmol/L during the first 24 hours of diuresis identifies patients at risk for prolonged hospitalization but does not provide an indication for adjunctive dopamine or nesiritide. The present study suggests that the short-term response to tolvaptan and low dosages of conventional diuretics during tolvaptan treatment might improve the 1-year and long-term survival rates in cirrhotic patients with hepatic edema.
- | furosemide / Generic mfg.
Journal: Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching. (Pubmed Central) - Nov 11, 2020
Here, we investigate the effect of hot punching on the drug distribution as well as drug release from the loaded drug-polymer matrices. Zero-order sustained drug release is observed for the model drug Furosemide embedded in biodegradable polymer, Poly-ε-caprolactone, which is attributed to the unique spatial distribution of Furosemide during the loading process.
- ||| furosemide / Generic mfg.
Clinical: Dear @GiuseppeGalati_ there was any difference in pts already on furosemide vs those with new onset HF? Thanks for sharing (Twitter) - Nov 11, 2020
- ||| furosemide / Generic mfg.
Clinical: In Italy we considered “relevant” 500cc of uop. If so we gave lasix every day and yes it helped volume and K. But was a clinical impression.. no data (Twitter) - Nov 10, 2020
- ||| furosemide / Generic mfg.
Italy same as Denmark, 1g of lasix is the daily max. We have an actual 500mg pill that you can make in quarters. In ICU they use either 1g IV continuous in 24h or 4 boluses of 250mg. The rule is less then 4mg/min speed. In ESRD 500mg BID or 250 QID. Now in NY max 120... (Twitter) - Nov 10, 2020
- ||| furosemide / Generic mfg.
My wife was peds intern (in 20th century) came home in tears: “we put a preemie into pulmonary edema with 5 ml of PRBCs”. Me: “no prob, give 0.5 mg Lasix”. @rheault_m what’s your lowest dose? (Twitter) - Nov 10, 2020
- ||| furosemide / Generic mfg.
Clinical: Our usual max is 480 mg iv, although I did once double the dose. Ototoxicity usually occurs above furosemide levels of 50 mg/l; in this paper doses of 2x1000 mg/day in CAPD patients resulted in furosemide levels of 29,5 mg/l. https://t.co/p3glrniVZ8 (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
Do you have those special 250 mg furosemide formulations? (Twitter) - Nov 10, 2020
- |||| furosemide / Generic mfg.
Clinical: In Denmark the rule of thumb is max. 1000 mg daily dose for oral furosemide and max. 500 mg daily for iv furosemide. Typically use 500 mg tablets bid in ESKD and take the off when daily UOP <400 mL. Not aware of any cases of ototoxicity but have seen dermatitis with sun exposure. (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
That’s probably pretty close to the lowest for Lasix. I did recently prescribe 0.05 mg of amlodipine and was pretty proud of that. 😂 (Twitter) - Nov 10, 2020
- ||| furosemide / Generic mfg.
also known as "a pinch of Lasix" (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
Is AGE + BUN = Lasix dose no longer standard of care?! (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
True story - have seen Lasix FIVE mg IV given before (Twitter) - Nov 10, 2020
- |||| furosemide / Generic mfg.
Clinical: Stressing the importance of a Door-2-Furosemide <60 min in #AHF A target too often not achieved in our clinical practice. This simply ⬇️ Intra-Hospital 💀 @SABOURETCardio @MarcoMetra @MicheleSenni @DrNasrien @ShelleyZieroth @hvanspall @DrMarthaGulati https://t.co/JMbct2e4iL (Twitter) - Nov 10, 2020
- ||| furosemide / Generic mfg.
Clinical: Clearly important, but: Be careful in interpreting such observational non-randomised data: bias and confounding is likely.... results may also not be applicable to different systems, eg in Germany furosemide is also given pre-hospital phase. (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
I also enjoy weird numbers like: “he got 50 mg of Lasix” - 50!? (Twitter) - Nov 10, 2020
- | furosemide / Generic mfg.
New P2 trial: Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis (clinicaltrials.gov) - Nov 10, 2020
P2, N=36, Recruiting, Sponsor: University of North Carolina, Chapel Hill
- ||| furosemide / Generic mfg.
Clinical: Is there any evidence for Lasix infusion being better than intermittent boluses in inducing diuresis ? What is the maximum dose per day of Lasix that maybe used for a CKD 5 patient before we can truly term him resistant .? (Twitter) - Nov 10, 2020
- ||||| furosemide / Generic mfg.
Clinical: Or *gasp* the patient is in AKI so hold the lasix (Twitter) - Nov 10, 2020
- |||| furosemide / Generic mfg.
Whenever we fellows were hesitant for a higher PO furosemide dose, the late Dr. Schulman would say “They have 500mg furosemide tablets in Europe.” I quote that at least monthly when pushing doses up (though admittedly in the 240-360 range) in ESRD. (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
I once gave 40mg iv lasix to a young man with hypokalemic periodic paralysis with rebound hyperk to avoid giving insulin/dex. Thought he was never going to stop peeing. Learned a very valuable lesson. (Twitter) - Nov 10, 2020
- ||| furosemide / Generic mfg.
Clinical: When I was a fellow one of my attendings actually wrote in the chart “patient is on a laughable dose of lasix!” 🤦♀️ (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
I usually say that there are 2 doses of IV lasix - 80 and 200 (Twitter) - Nov 10, 2020
- ||| furosemide / Generic mfg.
Clinical: Lasix usually used in pts with edema or ⬇️ GFR so need >20 mg. BUT, I have occas used it in SIADH, and with the high GFR and mild volume expansion you can get a real diuresis. Take 20 sometime and see. As a resident an attending once gave 10mg, now that was where i draw the line (Twitter) - Nov 10, 2020
- || furosemide / Generic mfg.
They are lasix naive... gave them 10 mg IV push (true story 🤦🏼♂️) (Twitter) - Nov 9, 2020
- || furosemide / Generic mfg.
What ever happened to “age plus BUN (imperial units) equals lasix dose!? (Twitter) - Nov 9, 2020
- || furosemide / Generic mfg.
Not many things in House of God remain valid, but Age+BUN=Lasix dose does 🙃 (Twitter) - Nov 9, 2020
- || furosemide / Generic mfg.
Lasix gtt—> the control is so satisfying (Twitter) - Nov 9, 2020
- |||| furosemide / Generic mfg.
Clinical: Floor team: “hi, is it OK to give 20 mg IV Lasix for this pt in AKI?” Nephrology fellow: “20 mg? You could give that to me if you want, how about 200 mg for the patient, please?” #DiuresisJedi 😏 @ashraf_dwal (Twitter) - Nov 9, 2020
- furosemide / Generic mfg.
[VIRTUAL] Features of the development of severe allergic reactions in oncohaematological diseases: a clinical case of toxic-allergic dermatitis in a patient with acute leukemia () - Nov 9, 2020 - Abstract #ECP2020ECP_4480;
Results The results of the biopsy revealed necrosis with the formation of pustules, perivascular mixed infiltrate with a predominance of neutrophilic and eosinophilic granulocytes, destruction and infiltration of the vessel walls by granulocytes, and fibrin deposits in the vessel walls. Conclusion The appearance of severe toxic-allergic dermatitis is due to the reaction to the introduction of furosemide against the background of an altered immuno-inflammatory response, since the chemical structure of furosemide contains sulfone groups that give cross-allergic reactions.
- hydralazine hydrochloride / Generic mfg., furosemide / Generic mfg.
[VIRTUAL] Searching for the etiology of gastric mucosa pigmentation – sometimes a team work () - Nov 9, 2020 - Abstract #ECP2020ECP_4236;
Conclusion These cases highlight the need for the differential diagnosis and show the importance of communication between the gastroenterologist and pathologist. Bismuth is known to induce oral pigmentation and even mucosal esophageal necrosis when associated with salicylates.
- furosemide / Generic mfg.
[VIRTUAL] Features of the development of severe allergic reactions in oncohaematological diseases: a clinical case of toxic-allergic dermatitis in a patient with acute leukemia () - Nov 9, 2020 - Abstract #ECP2020ECP_2786;
Results The results of the biopsy revealed necrosis with the formation of pustules, perivascular mixed infiltrate with a predominance of neutrophilic and eosinophilic granulocytes, destruction and infiltration of the vessel walls by granulocytes, and fibrin deposits in the vessel walls. Conclusion The appearance of severe toxic-allergic dermatitis is due to the reaction to the introduction of furosemide against the background of an altered immuno-inflammatory response, since the chemical structure of furosemide contains sulfone groups that give cross-allergic reactions.
- hydralazine hydrochloride / Generic mfg., furosemide / Generic mfg.
[VIRTUAL] Searching for the etiology of gastric mucosa pigmentation – sometimes a team work () - Nov 9, 2020 - Abstract #ECP2020ECP_2543;
Conclusion These cases highlight the need for the differential diagnosis and show the importance of communication between the gastroenterologist and pathologist. Bismuth is known to induce oral pigmentation and even mucosal esophageal necrosis when associated with salicylates.
- furosemide / Generic mfg.
[VIRTUAL] Features of the development of severe allergic reactions in oncohaematological diseases: a clinical case of toxic-allergic dermatitis in a patient with acute leukemia () - Nov 9, 2020 - Abstract #ECP2020ECP_1112;
Results The results of the biopsy revealed necrosis with the formation of pustules, perivascular mixed infiltrate with a predominance of neutrophilic and eosinophilic granulocytes, destruction and infiltration of the vessel walls by granulocytes, and fibrin deposits in the vessel walls. Conclusion The appearance of severe toxic-allergic dermatitis is due to the reaction to the introduction of furosemide against the background of an altered immuno-inflammatory response, since the chemical structure of furosemide contains sulfone groups that give cross-allergic reactions.
- hydralazine hydrochloride / Generic mfg., furosemide / Generic mfg.
[VIRTUAL] Searching for the etiology of gastric mucosa pigmentation – sometimes a team work () - Nov 9, 2020 - Abstract #ECP2020ECP_868;
Conclusion These cases highlight the need for the differential diagnosis and show the importance of communication between the gastroenterologist and pathologist. Bismuth is known to induce oral pigmentation and even mucosal esophageal necrosis when associated with salicylates.
- |||| Clinical: I recommend Tea and Toast as good therapeutic agents for many of my frail elderly inpatients - seems to go down better than Alendronic acid, Omeprazole, Aspirin, Simvastatin, Ramipril, Furosemide, Bisoprolol and Apixaban cocktail (Twitter) - Nov 7, 2020
- |||| furosemide / Generic mfg.
Clinical: Intermittent (low dose) furosemide is not detrimental in the prevention and early treatment of perioperative and periprocedural AKI. Especially if you hydrate the patient properly. 4/n https://t.co/cz2rz5qvSG (Twitter) - Nov 6, 2020
- | acetazolamide / Generic mfg., topiramate / Generic mfg., furosemide / Generic mfg.
Journal: The role of opening CSF pressure in response to treatment for idiopathic intracranial hypertension (IIH). (Pubmed Central) - Nov 6, 2020
Our results suggested that higher CSF pressure could be the risk factors of poor response to therapy, which may raise need for more intensive treatment. Furthermore, suffering of headache without blurred vision can consider as a prognostic factor for mild severity and good response to treatment.
- || furosemide / Generic mfg.
Clinical, Journal: Elastic Bandage vs Hypertonic Albumin for Diuretic-Resistant Volume-Overloaded Patients in Intensive Care Unit: A Propensity-Match Study. (Pubmed Central) - Nov 6, 2020
EB use is associated with greater DE than hypertonic albumin solution during the deescalation phase of sepsis resuscitation. Prospective clinical trials would validate the findings of this hypothesis-generating study.
- | furosemide / Generic mfg.
New P3 trial: Furosemide vs. Placebo for Severe Antepartum Hypertension (clinicaltrials.gov) - Nov 4, 2020
P3, N=70, Not yet recruiting, Sponsor: Melanie Maykin, MD
- | Trial completion date: ACEI or ARB and COVID-19 Severity and Mortality in US Veterans (clinicaltrials.gov) - Nov 3, 2020
P=N/A, N=10000, Active, not recruiting, Sponsor: University of Utah
Prospective clinical trials would validate the findings of this hypothesis-generating study. Trial completion date: Jul 2020 --> Dec 2020
- | cefuroxime / Generic mfg., gentamicin sulfate / Generic mfg.
Preclinical, Journal: In vitro effects of some antibiotics on glucose-6-phosphate dehydrogenase from rat (Rattus norvegicus) erythrocyte. (Pubmed Central) - Nov 2, 2020
All inhibition types were analyzed by Lineweaver-Burk diagram showing noncompetitive inhibition for furosemide and gentamicin while clindamycin inhibited the activity competitively. On the other hand, cefazolin and cefuroxime increased the activity of the enzyme.