furosemide / Generic mfg. 
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  • ||||||||||  furosemide / Generic mfg.
    Journal:  Distal Convoluted Tubule Sexual Dimorphism Revealed by Advanced 3D-Imaging. (Pubmed Central) -  Dec 16, 2020   
    Here, optical clearing techniques were combined with antibody labeling of DCT segment markers, state-of-the-art high-speed volumetric imaging, and analysis tools to visualize and quantify DCT morphology in male and female mice and study the DCT remodeling response to furosemide...Females express a greater density of NCC transporters in a shorter structure to protect sodium balance in the face of greater basal distal sodium delivery yet have a larger reserve and structural remodeling capacity to adapt to unique physiological stresses. These observations provide insight into mechanisms that may drive sex differences in the therapeutic responses to diuretics.
  • ||||||||||  furosemide / Generic mfg.
    Biomarker, Journal:  Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse. (Pubmed Central) -  Dec 16, 2020   
    Mitochondria within vesicles were only observed in the FS-treated mice raising the possibility that mitophagy might account for reduced release of GLDH in the FS-treated mice. Although our results show that plasma GLDH is not clinically useful for evaluating mitotoxicity, the GLDH:ALT ratio as a measure of mitophagy needs to be further studied.
  • ||||||||||  Lopressor (metoprolol tartrate) / Novartis
    Clinical, Journal:  Seizures after percutaneous endoscopic lumbar discectomy: A case report. (Pubmed Central) -  Dec 15, 2020   
    This case illustrates the fact that irrigation should be performed cautiously in PELD procedure. And anesthesiologists should be familiar with the management strategies of perioperative acute seizures.
  • ||||||||||  furosemide / Generic mfg.
    Enrollment open:  FaST-1: Furosemide as Supportive Therapy for COVID-19 Respiratory Failure (clinicaltrials.gov) -  Dec 13, 2020   
    P2/3,  N=640, Recruiting, 
    And anesthesiologists should be familiar with the management strategies of perioperative acute seizures. Not yet recruiting --> Recruiting
  • ||||||||||  metformin / Generic mfg., rifampicin / Generic mfg.
    Journal:  Ion Transport Modulators as Antimycobacterial Agents. (Pubmed Central) -  Dec 10, 2020   
    Rifampicin was also synergistic with ambroxol HCl, diazoxide, digoxin, furosemide, HCTZ, omeprazole, pantoprazole, phenytoin, verapamil, and drug X against intracellular M. bovis BCG. The antimycobacterial properties exhibited by the ion transport modulators in this study make them viable candidates as adjuncts to the current anti-TB regimens.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide. (Pubmed Central) -  Dec 6, 2020   
    Nevertheless, this absorption window so early on in the SI rules out the suitability of controlled-release furosemide formulations, as confirmed by the in-silico results. The potential link between segmental-dependent intestinal permeability and adequate oral absorption of BCS Class IV drugs may aid to develop challenging drugs as successful oral products.
  • ||||||||||  Ibrance (palbociclib) / Pfizer
    [VIRTUAL] Palbociclib-induced Interstitial Granulomatous Dermatitis: A Case Report () -  Dec 2, 2020 - Abstract #ASDP2020ASDP_326;    
    Drug-induced IGD has been reported in patients treated with TNF inhibitors, PD-1 inhibitors, ACE inhibitors and furosemide...A 57-year-old female with a past medical history of metastatic breast cancer treated with anastrozole and palbociclib for one year, presented with a 5-month history of a pruritic rash...To our knowledge, this is the first reported case of IGD induced by palbociclib in the literature. It is important for clinicians to be aware of this cutaneous complication as palbociclib is increasingly being used for the treatment of advanced breast cancer.
  • ||||||||||  Simdax (levosimendan IV) / AbbVie
    Journal:  Old And New Drugs For Treatment Of Advanced Heart Failure. (Pubmed Central) -  Dec 1, 2020   
    Traditional drug associations and newer inotropes represent promising agents for the treatment of end-stage heart failure. Large trials are desirable in order to improve prognosis of these life-threatening patients.
  • ||||||||||  Isorem (isosorbide dinitrate) / Remedica
    [VIRTUAL] IMMUNOHEMATOLOGICAL TESTS FOR DETECTION OF DRUG-INDUCED HEMOLYTIC ANEMIA () -  Nov 26, 2020 - Abstract #HEMO2020HEMO_95;    
    The drugs hydralazine, furosemide and isosorbide dinitrate were tested, diluted in 40mg / mL and 1mg / mL solutions. Although the diagnosis is difficult, with rare cases of clinical suspicion associated with difficulties in standardization and availability of immunohematology tests for the investigation of antibodies directed against drugs, this practice should be incorporated into clinical practice given the possible morbidity and mortality of AHIF and evolution favorable if it is diagnosed.
  • ||||||||||  Actimab-A (lintuzumab-Ac225) / Actinium
    Trial completion date, Trial primary completion date:  Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients (clinicaltrials.gov) -  Nov 20, 2020   
    P1/2,  N=72, Active, not recruiting, 
    The absence of such signs of unwanted interactions allowed for the co-administration of the mentioned loop diuretics and PN at each of the studied ratios. Trial completion date: Dec 2020 --> Mar 2021 | Trial primary completion date: Jun 2020 --> Dec 2020
  • ||||||||||  furosemide / Generic mfg., spironolactone / Generic mfg.
    Clinical, Journal:  Case report: horse or zebra, ascites or pseudo-ascites? Care for pictural details! (Pubmed Central) -  Nov 19, 2020   
    Increased awareness about pseudo-ascites is necessary, as the diagnosis is often overlooked, and treatment delayed. Targeted imaging may be helpful, as some specific, although not pathognomonic, features exist which may aid in the diagnosis.
  • ||||||||||  meropenem / Generic mfg., Daewon Pharmaceutical
    Journal:  DRUG-RELATED PROBLEMS IN CARDIAC NEONATES UNDER INTENSIVE CARE. (Pubmed Central) -  Nov 19, 2020   
    Targeted imaging may be helpful, as some specific, although not pathognomonic, features exist which may aid in the diagnosis. The study showed that DRP are very frequent in patients with cardiac diseases hospitalized in the NICU, predominating problems related to the effectiveness and safety of the drug treatment.
  • ||||||||||  eplerenone / Generic mfg.
    Clinical, Journal:  Reduced Diuretic Dose in Patients Treated With Eplerenone: Data From the EPHESUS Trial. (Pubmed Central) -  Nov 18, 2020   
    Eplerenone treatment led to a loop diuretic dose reduction during follow-up without evidence of treatment effect modification by loop diuretics. These findings suggest that eplerenone reduces congestive signs and symptoms, which enables clinicians to reduce loop diuretic doses.