- |||||||||| Tenormin (atenolol) / AstraZeneca
Journal: Treatment optimization of beta-blockers in chronic heart failure therapy. (Pubmed Central) - Dec 30, 2020
Among the patients who received beta blockers, 34.2% were taking guideline recommended beta blockers while 65.8% were taking atenolol, which is not guideline recommended beta blocker...Prior hospitalization [Adjusted Odds ratio (AOR) 0.38, 95% confidence interval (CI) 0.19-0.76], dose of furosemide > 40 mg (AOR 0.39, 95% CI 0.20-0.76), ischemic heart disease (AOR 3.27, 95% CI 1.66-6.45), atrial fibrillation (AOR 4.41, 95% CI 1.38-14.13) were significantly associated with the utilization of beta-blockers...Clinicians should attempt to use evidence based beta blockers at guideline recommended target doses that have been shown to have morbidity and mortality benefit in chronic heart failure. Moreover, more effort needs to be done to minimize the potentially modifiable risk factors for underutilization of beta blocker in chronic heart failure therapy.
- |||||||||| Jynarque (tolvaptan) / Otsuka
Clinical, Journal: Relationship between Soluble (pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure. (Pubmed Central) - Dec 30, 2020
There was a significant positive correlation with a high correlation coefficient (CC) between PRA and PRC (p < 0.0001, CC = 0.76), and a negative correlation with weak CC between BNP and s(P)RR (p = 0.01, CC = -0.45). In conclusion, s(P)RR was always high and had no correlations with disease state and PRA/PRC in severe HF patients.
- |||||||||| furosemide / Generic mfg.
Journal: Evaluation of Diuretic Activity and Phytochemical Contents of Aqueous Extract of the Shoot Apex of Podocarpus falcactus. (Pubmed Central) - Dec 29, 2020
Male rats were treated with distilled water, the standard drug (furosemide 10 mg/kg), and three different doses (100, 200, and 400 mg/kg) of the aqueous extract...The aqueous extract exhibited significant diuretic activity due to its phytochemical content, which could be used as a starting point for further studies. The aqueous extract showed significant diuretic activity and confirmed the folkloric use of Podocarpus falcactus.
- |||||||||| [VIRTUAL] Transition of Oral Loop Diuretics Prior to Discharge from Acute Heart Failure Exacerbation Hospitalization () - Dec 26, 2020 - Abstract #ASHP2020ASHP_5073;
The primary objective of this study is to determine if transition from intravenous to oral furosemide > 24 hours prior to discharge reduces 30-day readmission rates This retrospective cohort study has received IRB approval and will be completed using patient medical records extracted from CERNER...The secondary aims of this study are to evaluate how many patients had an increase in their loop diuretic dose and to determine if increasing the home dose of loop diuretic on discharge had an impact on 30-day readmission. Patient readmission causes, including if readmissions were for an adverse effect potentially caused by the increased loop diuretic dose will also be evaluated.
- |||||||||| spironolactone / Generic mfg.
[VIRTUAL] Spironolactone use in cirrhotic patients with ascites: a retrospective review () - Dec 26, 2020 - Abstract #ASHP2020ASHP_5049;
Patients less than 18 years of age and those with concurrent diagnosis of gastrointestinal bleed during admission will be excluded. The efficacy and current facility utilization of spironolactone will be evaluated by assessing the length of stay for patients admitted on spironolactone and the time to readmission for patients discharged on spironolactone.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Outcomes in patients receiving loop diuretic IV push vs continuous infusion () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4948;
Purpose: Loop diuretics such as furosemide and bumetanide are labeled for use in managing fluid overload in acute decompensated heart failure (ADHF) patients...Patients admitted to an ICU, on dialysis or serum creatinine 3 mg/dL or greater, treated for alternate indications, or who received inotropes or vasodilators will be excluded. Endpoints include change in weight, length of stay, incidence of AKI, incidence of electrolyte abnormalities and the financial cost difference between IVP and CI.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Multi-segment diuretic therapy to overcome diuretic resistance () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3424;
Challenge with MSDT therapy can rapidly identify patients responsive to decongestive medical therapies from those requiring advanced renal replacement therapies. Patients achieving adequate decongestion from MSDT can benefit from symptomatic relief and avoidance of new RRT for hypervolemia.
- |||||||||| furosemide / Generic mfg., paroxetine / Generic mfg.
[VIRTUAL] Management of a patient with a complicated amlodipine overdose () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3393;
Her home medications included paroxetine 20 mg and amlodipine 10 mg...This was treated with furosemide and continuous renal replacement therapy...Approximately 72 hours after arrival, the patient was transferred to a higher level of care for potential initiation of extracorporeal membrane oxygenation (ECMO). Although her outcome is unknown, this case report serves to document our findings in regard to the use of high dose insulin therapy, Intralipid, and methylene blue as these outcomes are largely underreported.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Furosemide de-resuscitation in critically ill septic shock patients () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3308;
Multiple furosemide doses per day resulted in a lower total fluid balance and had an increased occurrence to be initiated within three days. However, these findings should be interpreted in context, since power was not met.
- |||||||||| [VIRTUAL] Safe Use of Loop Diuretics in the Management of ADHF in the setting of WRF () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2937;
The data on the use of loop diuretics in the management of ADHF and the association of WRF with its use is limited; however, in this clinical research review, the available information does not support a strong link of loop diuretics and WRF. Clinicians should monitor the use of loop diuretics in this setting, and more research is useful for clinicians to apply evidence-based medicine to patient care.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Lithium toxicity in a patient on furosemide daily for recently diagnosed heart failure: a case report () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2826;
Providers should be vigilant when managing patients on lithium therapy and monitor for signs and symptoms of toxicity at each encounter. Pharmacists are able to provide comprehensive medication review and troubleshoot for interacting medications and can work with providers to identify patients who may be at an increased risk of lithium toxicity before complications develop.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] TIMing Evaluation of the Initiation of Thiazide-type diuretics (TIME-IT) for sequential nephron blockade () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2406;
Patients will have been administered sequential nephron blockade with chlorothiazide or metolazone and bumetanide or furosemide utilizing one of two distinct timing strategies: administration of thiazide-type diuretic ≥ 25 minutes or < 25 minutes prior to intravenous loop diuretic...The primary outcome is to compare 6-hour total urine output between groups. Secondary outcomes are to compare 6-hour total urine output in patients receiving solely metolazone or chlorothiazide, 6-hour hourly urine output, hypokalemia, hypomagnesemia, hyponatremia, hypotension, and AKI between groups.
- |||||||||| Lopressor (metoprolol tartrate) / Novartis
[VIRTUAL] Spontaneous coronary artery dissection in a patient with membranous nephropathy () - Dec 26, 2020 - Abstract #ASHP2020ASHP_1670;
Her home medication list included mycophenolate mofetil 500 mg twice daily, prednisone 40 mg daily, furosemide 40 mg daily as needed for swelling, bumetanide 2 mg twice daily, losartan 25 mg daily, and a one-a-day multivitamin...After two days of observation and clinical improvement, she was discharged on her home medications, as well as metoprolol succinate 25 mg once daily, clopidogrel 75 mg once daily and aspirin 81 mg once daily...As we examine the patient’s medical history, as well as the timeline while admitted at the hospital, we investigate how membranous nephropathy may have been a potential risk factor that contributed to the spontaneous coronary artery dissection. It is essential for future healthcare professionals to be aware of this possible correlation, especially since mortality is high and causes continue to be not well understood.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Effects of early diuresis on outcomes in septic patients with chronic heart failure () - Dec 26, 2020 - Abstract #ASHP2020ASHP_1296;
In this study, early diuresis in septic patients with CHF was not associated with significant effects on mortality, electrolyte imbalances, or length of stay, but is associated with a lower mean fluid balance, increased incidence of mechanical ventilation, and fewer mechanical ventilator free days. The clinical significance of these results will need to be confirmed in a larger and longer follow-up study to ensure the study is adequately powered to detect significance across all patient outcome variables.
- |||||||||| cisplatin / Generic mfg.
[VIRTUAL] Cisplatin and Renal Dysfunction; Where electrolytes begin and forced diuresis ends () - Dec 26, 2020 - Abstract #ASHP2020ASHP_1215;
Mannitol may have utility in some circumstances and is preferred over furosemide due to the potential synergistic ototoxicity seen with both cisplatin and loop diuretics. In light of these results, our future aim is to perform a prospective study in patients receiving varying doses of cisplatin and hydration protocols to determine the most effective method for preventing cisplatin related nephrotoxicity.
- |||||||||| dexamethasone / Generic mfg., allopurinol / Generic mfg.
Journal: Effect of common medications on the expression of SARS-CoV-2 entry receptors in kidney tissue. (Pubmed Central) - Dec 23, 2020
The prolonged exposure to combinations of these medications could regulate the expression of ACE2 and TMPRSS2 in a way that may affect kidney susceptibility to SARS-CoV-2 infection. Data presented here suggest that we should be vigilant about the potential effects of commonly used medications on kidney tissue expression of ACE2 and TMPRSS2.
- |||||||||| Tenormin (atenolol) / AstraZeneca
Clinical, Journal: Exogenous intoxication by non-prescribed use of vitamin D, a case report. (Pubmed Central) - Dec 23, 2020
This case report shows that even the self-administration of a product designed to bring health benefits can become a risky behavior. These vitamin and mineral supplements are supposed to bring patient empowerment and reduce government spending in health-care, but indeed represent a significant public health concern due to possible overdose and drug interactions.
- |||||||||| furosemide / Generic mfg.
Journal: Prescription-based prediction of baseline mortality risk among older men. (Pubmed Central) - Dec 22, 2020
A majority of older men had a history of prescribed medications and many drug classes were associated with mortality rate, including drug classes not directly indicated for a specific comorbidity represented in commonly used comorbidity measures. Prescription history can improve baseline risk assessment but some associations might be context-sensitive.
- |||||||||| furosemide / Generic mfg., nitroglycerin / Generic mfg.
Trial primary completion date: N-FURIOUS: Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial (clinicaltrials.gov) - Dec 22, 2020
P2, N=70, Recruiting,
Prescription history can improve baseline risk assessment but some associations might be context-sensitive. Trial primary completion date: Sep 2020 --> Dec 2020
- |||||||||| mycophenolate mofetil / Generic mfg., furosemide / Generic mfg.
Clinical, Journal: Case 279: Central-Variant Posterior Reversible Encephalopathy Syndrome. (Pubmed Central) - Dec 20, 2020
HistoryA 25-year-old woman with recently diagnosed systemic lupus erythematosus and class IV lupus nephritis confirmed with biopsy and treated with mycophenolate mofetil presented with a 2-day history of progressively worsening edema of her face and lower extremities...She was admitted to the hospital and treated with methylprednisolone, furosemide, and C1 esterase inhibitor...The following day (hospital day 11), unenhanced MRI of the brain was performed along with MR angiography of the brain. Biopsy of the temporal artery was normal, without evidence of inflammation.
- |||||||||| furosemide / Generic mfg.
Journal: Per-6-Thiolated Cyclodextrins: A Novel Type of Permeation Enhancing Excipients for BCS Class IV Drugs. (Pubmed Central) - Dec 18, 2020
The per-6-thiolated was characterized for thiol content, -SH stability, cytotoxicity, and solubility-improving properties by using the model BCS Class IV drug furosemide (FUR)...Moreover, in-vivo studies showed a 4.9-fold improved oral bioavailability of FUR due to incorporation in per-6-thiolated α-CD. These results indicate that per-6-thiolated α-CD would be a promising auxiliary agent for mucosal delivery of in particular BCS Class IV drugs.
- |||||||||| furosemide / Generic mfg.
Journal: Renal lymphatic vessel dynamics. (Pubmed Central) - Dec 18, 2020
Ethacrynic acid, another loop diuretic, had no effect on vessel tone. These data represent a significant step forward in our understanding of the mechanisms underlying renal lymphatic vessel function and highlight potential off target effects of furosemide that may exacerbate fluid accumulation in edema-forming conditions.
- |||||||||| furosemide / Generic mfg.
Enrollment change: AKI: Protocol to Assess the Severity of Acute Kidney Injury (clinicaltrials.gov) - Dec 17, 2020
P=N/A, N=77, Completed,
These data represent a significant step forward in our understanding of the mechanisms underlying renal lymphatic vessel function and highlight potential off target effects of furosemide that may exacerbate fluid accumulation in edema-forming conditions. N=44 --> 77
- |||||||||| furosemide / Generic mfg.
Clinical, Journal: Adult Patients with Respiratory Distress: Current Evidence-based Recommendations for Prehospital Care. (Pubmed Central) - Dec 16, 2020
Prehospital treatment of adult patients with respiratory distress varies widely across California. We present evidence-based recommendations for the prehospital treatment of undifferentiated adult patients with respiratory distress that will assist with standardizing management and may be useful for EMS medical directors when creating and revising protocols.
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