- |||||||||| furosemide / Generic mfg.
Review, Journal: Role of the Furosemide Stress Test in Renal Injury Prognosis. (Pubmed Central) - Feb 2, 2021
Dosage, timing, and clinical outcomes of the FST proposed thus far have been significantly different, which further accentuates the need for standardization in the application of the test in order to facilitate the comparison of results between series. This review will summarize published research regarding the usefulness of the FST in different settings, providing the reader some insights about the possible implications of FST in clinical decision-making in patients with kidney disease and the challenges that research will have to address in the near future before widely applying the FST.
- |||||||||| 60 y/o man with A fib, HTN, T2DM - Post STEMI - EF 35% - NYHA III DAPT, BB, ARNI, Aldactone, Statin, SGLT2, NOAC, Colchicine, AADT, Vascepa, Lasix That is 8-10 meds just for CV indications My "cold shoulder" is based on a vast majority of this being preventable. (Twitter) - Jan 30, 2021
- |||||||||| prednisone / Generic mfg., furosemide / Generic mfg., spironolactone / Generic mfg.
[VIRTUAL] Linear Iga Bullous Dermatosis in a Patient with Disseminated Mycobacterium Chimaera Infection () - Jan 30, 2021 - Abstract #CDAI2020CDA-I_96;
We propose the underlying infection induced immunologic dysregulation that predisposed to the advent of drug-induced LABD. Alternatively, the LABD may represent an autoimmune manifestation of the underlying infection itself. Learning Objective 1.To review a case of linear IgA bullous dermatosis in a patient with disseminated Mycobacterium chimaera infection.2.To discuss potential causes of linear IgA bullous dermatosis.3.To consider the role of drug exposure and an altered immunologic milieu in the setting of atypical infection as potential causes of linear IgA bullous dermatosis in this case. Takeaway Message 1.Linear IgA bullous dermatosis is a rare autoimmune bullous disease and has been associated with underlying infection, malignancy, autoimmunity or drug exposure.2.Mycobacterium chimaera is a rare infection that may manifest in select patients that underwent open heart surgery and were exposed to contaminated heater-cooler units.3.Patients with disseminated atypical infections may be predisposed to drug reactions and autoimmune manifestations, such as linear IgA bullous dermatosis as highlighted in our case.
- |||||||||| furosemide / Generic mfg.
Retrospective data, Journal: Identification of Predictors of Abnormal Calcium, Magnesium and Phosphorus Blood Levels in the Emergency Department: A Retrospective Cohort Study. (Pubmed Central) - Jan 28, 2021
Among patients for whom calcium, magnesium and phosphorus were tested in the Emergency Department, the most significant risk factors (OR>2) for electrolytic abnormality were as follows: hypocalcemia - respiratory distress, diuretics (excluding loop and thiazide), anti-neoplastic medication, long QTc, chronic kidney disease (CKD); hypercalcemia - bone pain, vitamin D, hallucinations; hypomagnesemia - diabetes, corticosteroids; hypermagnesemia - poor extremity perfusion, CKD, furosemide; hypophosphatemia - seizure; hyperphosphatemia - phosphate-binders, CKD, peripheral vascular atherosclerotic disease...Predictors of intervention on an electrolyte abnormality include poor peripheral perfusion, nausea and chronic obstructive pulmonary disease (COPD). Emergency physicians can potentially reduce the unnecessary testing of calcium, magnesium and phosphorus blood levels by targeting patients with high-acuity conditions or chronic comorbidities such as CKD, diabetes and COPD.
- |||||||||| Jynarque (tolvaptan) / Otsuka, Samsca (tolvaptan) / Otsuka, pecavaptan (BAY1753011) / Bayer
Clinical, Review, Journal: Vasopressin antagonism in heart failure: a review of the hemodynamic studies and major clinical trials. (Pubmed Central) - Jan 27, 2021
Compared with furosemide in another study, the renal and neurohormonal effects of TV were favorable...A new orally effective balanced V1/V2 antagonist (pecavaptan) is currently undergoing phase II study as both adjunctive and alternative therapy during and after hospitalization for acute HF. The purpose of this review is to summarize what we have learned from the clinical experience with TV and CV, and to suggest implications of these findings for future work with newer agents.
- |||||||||| hydrochlorothiazide / Generic mfg., furosemide / Generic mfg.
Clinical, Journal: Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study. (Pubmed Central) - Jan 26, 2021
To evaluate the effects of diuretics on CKD-MBD, we have performed a prospective randomized trial comparing hydrochlorothiazide with furosemide in a stage 3CKD population followed for 1 year. Furosemide increased bone remodeling and parathormone levels, whereas hydrochlorothiazide attenuated parathyroid hormone rise and decreased bone turnover markers.
- |||||||||| furosemide / Generic mfg.
Clinical, Journal: Intravenous furosemide vs nebulized furosemide in patients with pulmonary edema: A randomized controlled trial. (Pubmed Central) - Jan 26, 2021
According to our results, we can say that nebulized furosemide is not superior to intravenous furosemide in reducing dyspnea and crackles in patients with acute pulmonary edema, but significantly improved respiratory rate and arterial blood oxygen and has less hemodynamic changes than the intravenous furosemide. The results of this study showed the beneficial effects of nebulized furosemide in the treatment of pulmonary edema, which can be prescribed as a treatment in addition to standard treatment and significantly lead in better control of pulmonary edema in the short term.
- |||||||||| furosemide / Generic mfg.
Journal: Prophylactic Peritoneal Drainage is Associated with Improved Fluid Output after Congenital Heart Surgery. (Pubmed Central) - Jan 23, 2021
Over POD 1-5, PPD use accounted for 48.8 mL/kg increased fluid output (95% CI [2.2, 95.4], p = 0.043) and 3.41 mg/kg less furosemide administered (95% CI [1.69, 5.14], p < 0.001)...Although PPD placement did not affect end-outcomes, it was used in higher acuity patients. PPD placement is associated with improved fluid output despite lower diuretic administration and may be a useful postoperative fluid management adjunct in some complex CHS patients.
- |||||||||| Jynarque (tolvaptan) / Otsuka
Clinical, Journal: Early Administration of Tolvaptan Can Improve Survival in Patients with Cirrhotic Ascites. (Pubmed Central) - Jan 22, 2021
The prognosis was significantly better in the tolvaptan group with low-dose furosemide than in the conventional therapy group (p < 0.001). (4) Tolvaptan can improve survival in patients with cirrhotic ascites, especially when tolvaptan is started before high-dose furosemide administration.
- |||||||||| telmisartan / Generic mfg.
Journal: Cardiovascular medications and regulation of COVID-19 receptors expression. (Pubmed Central) - Jan 16, 2021
Treatment of primary human hepatocytes with captopril, but not enalapril, significantly increased ACE2 expression...Telmisartan, a second class RAAS inhibitors, did not affect ACE2 levels...Some of these medications increased TMPRSS2, while others, like furosemide, significantly reduced COVID-19 receptors...Treatment of common co-morbidities often require chronic use of multiple medications, which may result in an additive increase in the expression of ACE2 and TMPRSS2. Our data suggest that more research is needed to determine the effect of different medications, as well as medication combinations, on COVID-19 receptors.
- |||||||||| Henletor (torsemide) / Orchid
Clinical, Journal: Loop Diuretics: Clinical Application Information for Nephrology Nurses and Practitioners. (Pubmed Central) - Jan 15, 2021
Loop diuretics are routinely used for many clinical indications, and nephrology practitioners are well informed in the management of their use in daily practice. This article highlights key information on the most commonly used loop diuretics (e.g., furosemide and torsemide) and provides important clinical features related to pharmacokinetics properties, dosing consideration, route of administration, side effects, and other considerations for practitioners.
- |||||||||| probenecid / Generic mfg., furosemide / Generic mfg.
PK/PD data, Journal: Involvement of Organic Anion Transporters in the Pharmacokinetics and Drug Interaction of Rosmarinic Acid. (Pubmed Central) - Jan 14, 2021
Rosmarinic acid inhibited the transport activities of OAT1, OAT3, organic anion transporting polypeptide (OATP)1B1, and OATP1B3 with IC values of 60.6 μM, 1.52 μM, 74.8 μM, and 91.3 μM, respectively, and the inhibitory effect of rosmarinic acid on OAT3 transport activity caused an in vivo pharmacokinetic interaction with furosemide by inhibiting its renal excretion and by increasing its plasma concentration. In conclusion, OAT1 and OAT3 are the major transporters that may regulate the pharmacokinetic properties of rosmarinic acid and may cause herb-drug interactions with rosmarinic acid, although their clinical relevance awaits further evaluation.
- |||||||||| furosemide / Generic mfg., nitroglycerin / Generic mfg.
Trial completion date, Trial primary completion date: N-FURIOUS: Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial (clinicaltrials.gov) - Jan 13, 2021
P2, N=70, Recruiting,
However, R2*_Slope and Δ(R2*_Slope) showed the largest sensitivity in distinguishing CKD from controls. Trial completion date: Dec 2020 --> Dec 2021 | Trial primary completion date: Dec 2020 --> Dec 2021
- |||||||||| digoxin / Generic mfg., furosemide / Generic mfg.
Clinical, Journal: No effect of topical digoxin and furosemide gel for patients with external anogenital warts. (Pubmed Central) - Jan 8, 2021
As DNA viruses such as HPV rely on cellular K+ influx and Ionic contra-viral therapy (ICVT) comprised of digoxin and furosemide inhibits the K+ influx, ICVT might be a potential new treatment for AGW. Recently, a phase 2 randomized-controlled trial showed a reduction in size and viral load of HPV-induced cutaneous warts after 6 weeks of treatment with topical ICVT.
- |||||||||| furosemide / Generic mfg.
PK/PD data, Journal: Contribution of Uptake and Efflux Transporters to Oral Pharmacokinetics of Furosemide. (Pubmed Central) - Jan 7, 2021
Our in vitro data and PBPK model suggest that the absorption of furosemide is permeability-limited, and OATP2B1 and MRP4 are important for its permeability across intestinal membrane. Further, as furosemide has been proposed as a probe substrate of renal organic anion transporters (OATs) for assessing clinical drug-drug interactions (DDIs) during drug development, the confounding effects of intestinal transporters identified in this study on furosemide PK should be considered in the clinical transporter DDI studies.
- |||||||||| furosemide / Generic mfg.
Enrollment open, Trial initiation date: Furosemide vs. Placebo for Severe Antepartum Hypertension (clinicaltrials.gov) - Jan 7, 2021
P3, N=70, Recruiting,
Further, as furosemide has been proposed as a probe substrate of renal organic anion transporters (OATs) for assessing clinical drug-drug interactions (DDIs) during drug development, the confounding effects of intestinal transporters identified in this study on furosemide PK should be considered in the clinical transporter DDI studies. Not yet recruiting --> Recruiting | Initiation date: Nov 2020 --> Jan 2020
- |||||||||| furosemide / Generic mfg.
Preclinical, Journal: In Vivo Diuretic Activity of Hydromethanolic Extract and Solvent Fractions of the Root Bark of Clerodendrum myricoides Hochst. (Lamiaceae). (Pubmed Central) - Jan 1, 2021
The normal control groups received either water or 2% tween 80, the standard group received furosemide (10 mg/kg), and the test groups were administered the hydromethanolic extract and solvent fractions at the doses of 100, 200, and 400 mg/kg by the oral route...The crude hydromethanolic extract also failed to produce any sign of toxicity up to 2000 mg/kg. From this study, the hydromethanolic extract and ethyl acetate fraction of the root bark of C. myricoides produced a prominent diuretic effect in rats.
- |||||||||| furosemide / Generic mfg.
Journal: Micromechanical Punching: A Versatile Method for Non-Spherical Microparticle Fabrication. (Pubmed Central) - Jan 1, 2021
As an illustration of application of MMP in drug delivery, flat, microdisk-shaped Furosemide embedded poly(lactic-co-glycolic acid) microparticles are fabricated and Furosemide release is observed. Thus, it is shown in the paper that Micromechanical punching has potential to make micro/nanofabrication more accessible to the research and industrial communities active in applications that require engineered particles.
|
