furosemide / Generic mfg. 
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  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Permanent childhood hearing impairment in infants admitted to the neonatal intensive care unit: nested case-control study. (Pubmed Central) -  Jun 24, 2021   
    • In infants across all gestational age "any ventilation episodes", presence of seizures, and severe congenital anomalies were associated with a statistically significant increase in prevalence of hearing loss. Higher prevalence of hearing loss was noted in preterm infants (<32 weeks) who received furosemide treatment and lower prevalence was noted with antenatal use of magnesium sulphate.
  • ||||||||||  torasemide / Generic mfg., furosemide / Generic mfg.
    Journal:  LOOP DIURETICS IN HEART FAILURE: EVIDENCE-BASED CHOICE. (Pubmed Central) -  Jun 23, 2021   
    The safety profile of torasemide is more favorable, as it is associated with a reduced risk of hypokalemia compared to furosemide. The abovementioned facts favor the use of torasemide in patients with symptomatic НF, as well as the transition from furosemide to torasemide in patients with edema caused by НF, which remain uncontrolled despite receiving optimal doses of furosemide.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Kinetics of Ringer's Solution In Extracellular Dehydration and Hemorrhage. (Pubmed Central) -  Jun 22, 2021   
    Furosemide-induced dehydration and blood withdrawal in normotensive volunteers had modest effects on the Ringer's acetate kinetics. Urinary excretion was inhibited more by hemorrhage than by dehydration.
  • ||||||||||  Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
    Clinical, Journal:  Sacubitril/valsartan in patients listed for heart transplantation: effect on physical frailty. (Pubmed Central) -  Jun 22, 2021   
    Our study showed a rapid improvement in PF in HT waiting list patients treated with sacubitril/valsartan. The improvement in all PF domains was paralleled by VO and 6MWT increase and together with an NT-pro-BNP reduction constant over the follow-up.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Vasopressin receptor subtypes and renal sodium transport. (Pubmed Central) -  Jun 22, 2021   
    Stimulation of V1a-receptors inhibits renal sodium reabsorption and induces natriuresis, comparable to the effect of the diuretic furosemide, in the thick ascending limb of the loop of Henle...In this review, we discuss the role of vasopressin and its interaction with V-receptor subtypes in natriuresis and for stabilizing the physicochemical parameters of the internal environment and water-salt homeostasis in humans. A better understanding of these systems and their regulation is necessary to facilitate identification of additional system components and mechanisms, clarify their contribution during various normal and pathological functional states, and suggest novel strategies for the development of therapeutic interventions.
  • ||||||||||  tolvaptan / Generic mfg.
    Clinical, Journal:  Renoprotective effect of tolvaptan in patients with new-onset acute heart failure. (Pubmed Central) -  Jun 22, 2021   
    Further studies are needed to determine if UO and FST could be a non-invasive tool to evaluate interstitial fibrosis. A lower incidence of WRF was observed in patients with new-onset AHF who were treated with the tolvaptan add-on therapy, specifically those with left ventricular systolic dysfunction and renal impairment on admission.
  • ||||||||||  furosemide / Generic mfg., paracetamol / Generic mfg., warfarin / Generic mfg.
    Clinical, Journal:  Factors contributing to reported medication administration incidents in patients' homes - A text mining analysis. (Pubmed Central) -  Jun 22, 2021   
    The obtained results show a particle size reduction when compared to the pristine material, as well as an increase of the dissolution rate of 4.5-fold. These findings about MA incidents that have occurred in patients' homes and have been reported by home care professionals demonstrate the need for medication safety improvement in home care.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Predictive Identification of Co-formers in Co-amorphous Systems. (Pubmed Central) -  Jun 22, 2021   
    To test the predictive power of this model, 29 potential co-formers were used to form either co-amorphous or crystalline two-component materials with mebendazole. Of these 29 two-component systems, the co-amorphous nature of a total of 26 materials was correctly predicted by the model, giving a predictive hit rate of 90 %.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Furosemide as a Probe Molecule for the Treatment of Neuroinflammation in Alzheimer's Disease. (Pubmed Central) -  Jun 22, 2021   
    Our mechanism of action studies further demonstrate that furosemide reduces LPS-induced upregulation of endoplasmic reticulum (ER) stress marker genes, including Grp78, Atf4, Chop, tXbp1, and sXbp1. These data support the observation that furosemide is a known drug with the capacity to downregulate the proinflammatory microglial M1 phenotype and upregulate the anti-inflammatory M2 phenotype, a potentially powerful and beneficial pharmacologic effect for inflammatory diseases such as AD.
  • ||||||||||  furosemide / Generic mfg.
    Preclinical, Journal:  How predictive is body weight on fluid intake in rats? It depends on sex. (Pubmed Central) -  Jun 22, 2021   
    We found that intake stimulated by either water deprivation or furosemide correlated with body weight in male rats...This effect, however, is likely the result of a relationship between body weight and food intake because when food was absent or reduced, the correlation between body weight and intake disappeared. These results demonstrate that multiple factors need to be considered when determining the best way to compare fluid intake between males and females and provides insight to help explain the discrepancies in the literature regarding sex differences in fluid intake.
  • ||||||||||  sildenafil / Generic mfg., furosemide / Generic mfg.
    Journal:  3D printed furosemide and sildenafil tablets: innovative production and quality control. (Pubmed Central) -  Jun 22, 2021   
    While they complied, not all of these quality tests for tablets might be suitable for 3D printed tablets due to the layering of the tablets and the small batch production. To assess adequate layer adhesion adjusted friability (EP 2.9.7) and resistance to crushing (EP 2.9.8) tests are proposed.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic. (Pubmed Central) -  Jun 22, 2021   
    In addition, a short half-life would confer a high peak-to-trough ratio which could evoke an excessive peak diuretic effect, a common liability associated with loop diuretics such as furosemide. This report describes the discovery of a new ROMK inhibitor 22e (MK-8153), with a longer projected human half-life (∼14 h), which should lead to a reduced peak-to-trough ratio, potentially extrapolating to more extended and better tolerated diuretic effects.
  • ||||||||||  High-Risk Transvenous Lead Extractions (Mezzanine 16AB) -  Jun 20, 2021 - Abstract #ASA2021ASA_2868;    
    Her outpatient medications were metformin, amlodipine, aspirin and furosemide...General anesthesia is maintained with sevoflurane/oxygen mixture...What is "ghost"? and what is the significance of its presence for the patient?
  • ||||||||||  labetalol / Generic mfg.
    30-Year-Old Woman in Third Trimester of Pregnancy with Suspected Covid Infection Presenting with Chest Pain and Aortic Emergency (Mezzanine 16AB) -  Jun 20, 2021 - Abstract #ASA2021ASA_2604;    
    She was being treated for pregnancy-induced hypertension during her current pregnancy with oral labetalol 1200mg/day...Pharmacologic support with multiple boluses of epinephrine 1mg, vasopressin 10 units and sodium bicarbonate 50meq were initiated followed by epinephrine and norepinephrine infusions at 0.2 to 0.5mcg.kg.min titrated to MAPs > 50 mm Hg...Tranexamic acid bolus and infusion was given to reduce CPB-associated fibrinolysis...She remained oliguric on CPB and did not respond to a bolus of iv Lasix 80mg...What are the reasons for failure to wean off CPB in this patient ?8.What would be the next step in the management of this unstable patient? Would ECMO placement influence outcome?9 What are the ethical and logistic challenges to instituting ECMO service during the Covid pandemic ?
  • ||||||||||  High-Risk Transvenous Lead Extractions (Mezzanine 16AB) -  Jun 20, 2021 - Abstract #ASA2021ASA_2300;    
    Her outpatient medications were metformin, amlodipine, aspirin and furosemide...General anesthesia is maintained with sevoflurane/oxygen mixture...What is "ghost"? and what is the significance of its presence for the patient?
  • ||||||||||  labetalol / Generic mfg.
    30-Year-Old Woman in Third Trimester of Pregnancy with Suspected Covid Infection Presenting with Chest Pain and Aortic Emergency (Mezzanine 16AB) -  Jun 20, 2021 - Abstract #ASA2021ASA_1792;    
    She was being treated for pregnancy-induced hypertension during her current pregnancy with oral labetalol 1200mg/day...Pharmacologic support with multiple boluses of epinephrine 1mg, vasopressin 10 units and sodium bicarbonate 50meq were initiated followed by epinephrine and norepinephrine infusions at 0.2 to 0.5mcg.kg.min titrated to MAPs > 50 mm Hg...Tranexamic acid bolus and infusion was given to reduce CPB-associated fibrinolysis...She remained oliguric on CPB and did not respond to a bolus of iv Lasix 80mg...What are the reasons for failure to wean off CPB in this patient ?8.What would be the next step in the management of this unstable patient? Would ECMO placement influence outcome?9 What are the ethical and logistic challenges to instituting ECMO service during the Covid pandemic ?
  • ||||||||||  midazolam hydrochloride / Generic mfg., lisinopril / Generic mfg.
    It's Just A Cataract: How A Simple Thing Can Go Bad (Mezzanine 16AB) -  Jun 20, 2021 - Abstract #ASA2021ASA_322;    
    His medications include: lisinopril, 10 mg QD, atorvastatin, 20 mg QD, furosemide, 40 mg QD, ASA, 81 mg QD, tamsulosin, 0.4 mg QD, allopurinol, 100 mg QD, and ibuprofen, 800 mg as needed...He has not taken any of his medications, and was told to stop his aspirin 10 days prior to surgery...The patient is given midazolam, 1 mg IV and propofol, 50 mg IV...During this time, the patient begins to complain about back pain, and you administer fentanyl, 50 ug IV...How do you respond? If the patient presented for surgery at this time and stated he had been off of his ASA and clopidogrel for 10 days, how would you respond?
  • ||||||||||  pecavaptan (BAY1753011) / Bayer
    Trial completion:  AVANTI: A Trial to Study BAY1753011 in Patients With Congestive Heart Failure (clinicaltrials.gov) -  Jun 16, 2021   
    P2,  N=482, Completed, 
    If the patient presented for surgery at this time and stated he had been off of his ASA and clopidogrel for 10 days, how would you respond? Active, not recruiting --> Completed
  • ||||||||||  Teysuno (gimeracil/oteracil/tegafur) / Nordic Group, Otsuka
    Clinical, Journal:  A Rare Case of Reversible Cardiac Dysfunction Associated with Tegafur/Gimeracil/Oteracil (S-1) Therapy. (Pubmed Central) -  Jun 11, 2021   
    Furosemide, human atrial natriuretic peptide, dobutamine, enalapril, spironolactone, and bisoprolol were administered. Thirteen days after being diagnosed with heart failure, his symptoms disappeared, his echocardiogram showed that the left ventricular ejection fraction had increased to 65%, and the cardiothoracic ratio improved to 47% according to his chest X-rays.S-1-related myocardial dysfunction may be reversible, as it can improve after approximately 2 weeks.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Brain-Relaxing Effect of Different Diuretic Regimens in Supratentorial Tumor Surgery: A Comparative Study Guided by Optic Nerve Sheath Diameter. (Pubmed Central) -  Jun 8, 2021   
    In this study, we compare the ordinary dose of mannitol with the low dose combined with furosemide and detect the effect on ICP by ONSD...After diuresis, Group M showed significant reduction in heart rate and mean arterial blood pressure, serum sodium, potassium, and lactate (P = 0.02, P = 0.02, P = 0.001, P = 0.001, P = 0.001, P = 0.001 respectively), with increased urine output (UOP) and fluids replacement (P = 0.00, P = 0.01, respectively). Compared to high dose, adding loop diuretics to low-dose mannitol during supratentorial brain tumor surgeries resulted in comparable BRSs with a lower incidence of hemodynamic and metabolic disturbances.