furosemide / Generic mfg. 
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  • ||||||||||  furosemide / Generic mfg., amiloride hydrochloride / Generic mfg.
    Journal:  Vascular Control of Kidney Epithelial Transporters. (Pubmed Central) -  Aug 1, 2021   
    Here, we show that levels of Na-K-2Cl cotransporter isoform 2 (NKCC2) and Na/H exchanger isoform 3 (NHE3) are reduced at baseline in SMKO mice, accompanied by attenuated natriuretic and diuretic responses to furosemide...This was accompanied by a reduced natriuretic response to amiloride...Thus, enhanced urinary sodium excretion observed after cell-specific deletion of AT receptors from smooth muscle cells is associated with altered sodium transporter abundance across epithelia in multiple nephron segments. These findings suggest a system of vascular-epithelial cross-talk in the kidney, modulating expression of sodium transporters and contributing to regulation of pressure-natriuresis.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Very High Dose Furosemide Continuous Infusions: A Case Series. (Pubmed Central) -  Jul 31, 2021   
    Very high-dose furosemide continuous infusions provide a significant increase in diuresis without worsening renal function, disturbing electrolytes, or increasing the risk of ototoxicity. Further studies are necessary to examine the efficacy and safety of this novel strategy.
  • ||||||||||  Clinical, Journal:  Drug-drug interactions in neonatal intensive care: A prospective cohort study. (Pubmed Central) -  Jul 31, 2021   
    Neonates in intensive care have a high exposure to DDIs and the occurrence of major DDIs is related specifically to the prescription of fentanyl. The number of prescribed drugs, gestational age, cesarean delivery and low APGAR score in the first minute were identified as risk factors for DDIs in NICU.
  • ||||||||||  Clinical, Journal, Adverse events:  PREVENTABLE ADVERSE DRUG EVENTS: DESCRIPTIVE EPIDEMIOLOGY. (Pubmed Central) -  Jul 30, 2021   
    Our study suggests that patients with mental health conditions and diabetes require close monitoring. Efforts to address the identified contributing factors are needed.
  • ||||||||||  furosemide / Generic mfg.
    Retrospective data, Journal:  Clinical relevance of serum electrolytes in dogs and cats with acute heart failure: A retrospective study. (Pubmed Central) -  Jul 28, 2021   
    The combination of S+BNZ is effective, safe, and superior to benazepril alone, when used with furosemide for the management of mild, moderate or severe CHF caused by MMVD in dogs. The observed association between serum chloride concentrations and diuretic doses suggests that hypochloremia could serve as a marker of disease severity and therapeutic response in dogs with acute CHF.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Review, Journal:  Current Concepts of Pediatric Acute Kidney Injury-Are We Ready to Translate Them into Everyday Practice? (Pubmed Central) -  Jul 27, 2021   
    The aim of this review is also to show the state-of-the-art in methods assessing risk and prognosis by discussing the potential role of risk stratification strategies, taking into account both glomerular function and clinical settings conditioned by fluid overload, urine output, or drug nephrotoxicity. The last task is to suggest careful assessment of eGFR as a surrogate marker of renal functional reserve and implementation of point-of-care testing, available in the case of biomarkers like NGAL and [IGFBP-7] × [TIMP-2] product, into everyday practice in patients at risk of AKI due to planned invasive procedures or treatment.
  • ||||||||||  indomethacin / Generic mfg., furosemide / Generic mfg.
    Journal:  Bartter-Gitelman syndromes (Pubmed Central) -  Jul 24, 2021   
    Indomethacin is efficient to reduce water and electrolyte loss in Bartter. In Gitelman, potassium-sparing diuretics may be helping for severe hypokaliemia but they will reinforce hypovolemia.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Hydration Marker Diagnostic Accuracy to Identify Mild Intracellular and Extracellular Dehydration. (Pubmed Central) -  Jul 21, 2021   
    Thus, in 15 young healthy men, the authors determined the diagnostic accuracy of 15 hydration markers after three randomized 48-hr trials; euhydration (water 36 ml·kg-1·day-1), ID caused by exercise and 48 hr of fluid restriction (water 2 ml·kg-1·day-1), and ED caused by a 4-hr diuretic-induced diuresis begun at 44 hr (Furosemide 0.65 mg/kg)...In conclusion, using a common dehydration threshold ≥4, the thirst 0-9 scale identified mild intracellular and extracellular dehydration with adequate diagnostic accuracy. In young healthy adults' thirst 0-9 scale is a valid and practical dehydration-screening tool.
  • ||||||||||  spironolactone / Generic mfg.
    Clinical, Journal:  A case of a complete atrioventricular canal defect in a ferret. (Pubmed Central) -  Jul 14, 2021   
    The dose of 500 mg/kg showed a promising diuretic and antiurolithiatic activity. To the authors knowledge, this is the first time an atrioventricular canal defect has been described in a pet ferret.
  • ||||||||||  Journal:  Drugs for chronic heart failure. (Pubmed Central) -  Jul 14, 2021   
    To the authors knowledge, this is the first time an atrioventricular canal defect has been described in a pet ferret. No abstract available
  • ||||||||||  furosemide / Generic mfg.
    Preclinical, Journal:  Successful in vitro fertilization in women with Fontan physiology. (Pubmed Central) -  Jul 7, 2021   
    To prevent the risks of pDDIs, work is required to raise awareness, and clinical pharmacists should be involved in reviewing medications at discharge. A multidisciplinary team-based approach can result in successful oocyte retrieval and IVF in women with complex congenital heart disease and Fontan physiology.