furosemide / Generic mfg. 
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  • ||||||||||  furosemide / Generic mfg.
    Journal:  Can furosemide mask the use of performance-enhancing drugs? (Pubmed Central) -  Aug 25, 2021   
    Based on the pharmacology and the available literature, we conclude that the masking effect of furosemide is limited. Furosemide is a doping agent that is mainly relevant for sports with weight categories.
  • ||||||||||  furosemide / Generic mfg.
    Trial primary completion date:  PURE: Peritoneal Ultrafiltration in Cardio Renal Syndrome. (clinicaltrials.gov) -  Aug 18, 2021   
    P1/2,  N=84, Not yet recruiting, 
    Lower than standard dose of S/V significantly reduces NT-proBNP and diuretic requirement without change in potassium or creatinine, which provides hope that patients who cannot tolerate standard doses of S/V due to hypotension may be able to receive the benefits of S/V therapy. Trial primary completion date: Apr 2022 --> Sep 2022
  • ||||||||||  Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
    Journal:  Short-Term Effects of Sacubitril/valsartan on Echocardiographic Parameters in Dogs With Symptomatic Myxomatous Mitral Valve Disease. (Pubmed Central) -  Aug 14, 2021   
    No changes were observed between groups for NTproBNP, blood pressure, ECG parameters, and urinary aldosterone per creatinine ratio. The current study suggested that the short-term effects of SV can reverse myocardial remodeling, as inferred from several echocardiographic indices (i.e., the reduction in LA/Ao, LVIDDN, EDVI and ESVI) in dogs with MMVD stage C. These findings would support the use of SV in clinically symptomatic heart failure in dogs.
  • ||||||||||  furosemide / Generic mfg.
    Preclinical, Journal:  Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide. (Pubmed Central) -  Aug 13, 2021   
    Liquisolid tablets showed 2-folds increase in drug release as compared to the generic tablets after 60 min in HCl 0.1 N using USP apparatus-II. Furosemide loaded SNEDDS tablets have great prospects for further in vivo studies, and the theoretical model is useful for calculating the adequate amounts of adsorbents required to solidify these systems.
  • ||||||||||  cisplatin / Generic mfg., furosemide / Generic mfg.
    Preclinical, Journal:  The furosemide stress test and computational modeling identify renal damage sites associated with predisposition to acute kidney injury in rats. (Pubmed Central) -  Aug 11, 2021   
    Computational modeling of epithelial transport of solutes and water along the nephrons applied to experimental data suggested that proximal tubule transport was only minimally reduced, the sodium-chloride symporter (NCC) was upregulated by 50%, and the renal outer medullary potassium channel (ROMK) was downregulated by 85% in predisposed animals. In conclusion, serial coupling of the FST and computational modeling may be used to detect and localize subclinical tubular alterations.
  • ||||||||||  furosemide / Generic mfg.
    Trial completion:  IRIHS-REA: Impact of Rational Control of Fluid Balance in the Intensive Care Unit (clinicaltrials.gov) -  Aug 10, 2021   
    P3,  N=171, Completed, 
    In conclusion, serial coupling of the FST and computational modeling may be used to detect and localize subclinical tubular alterations. Recruiting --> Completed
  • ||||||||||  Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
    There Is Quality Of Life Beyond The Ejection Fraction: Optimized Treatment Of Heart Failure With Ejection Fraction 8% - A Case Report (Exhibit Hall: ePoster Hub) -  Aug 9, 2021 - Abstract #HFSA2021HFSA_293;    
    In the case described, the excellent clinical response to the optimized therapy allowed a very satisfactory evolution in an 36-month follow-up, despite the very low maintenance of LVEF. The combination of resynchronization therapy + Sacubitril / Valsartan is an excellent alternative for patients with very low ejection fraction and limited functional class (III and IV).
  • ||||||||||  spironolactone / Generic mfg.
    Tachycardiomyopathy Due To Hyperthyroidism: Case Report (Exhibit Hall: ePoster Hub) -  Aug 9, 2021 - Abstract #HFSA2021HFSA_105;    
    This occurs by increasing blood volume, reducing systemic vascular resistance and reducing circulation time, triggering LV hypertrophy, and reducing myocardial contractile reserve. The hyperthyroidism with decompensated HF is a medical emergency with up to 30% mortality.
  • ||||||||||  Covid-19 Associated Lymphocytic Myocarditis With Genetic Predisposition (Exhibit Hall: ePoster Hub) -  Aug 9, 2021 - Abstract #HFSA2021HFSA_89;    
    Our case suggests that lymphocytic myocarditis could be a rare manifestation of coronavirus disease whose risk factors may include hereditary cardiomyopathies. It has potential to become a chronic condition with a challenging symptomatic management.
  • ||||||||||  digoxin / Generic mfg., furosemide / Generic mfg.
    Clinical, Journal:  Intralesional combined digoxin and furosemide in plantar warts: Does it work? (Pubmed Central) -  Aug 8, 2021   
    The loop diuretic dose reduction approach was not associated with a reduced event rate of over-diuresis compared to the home dose continuation approach. Intralesional injection of combined digoxin and furosemide is safe and effective treatment option in multiple plantar warts.
  • ||||||||||  probenecid / Generic mfg., rifampicin / Generic mfg., furosemide / Generic mfg.
    PK/PD data, Journal:  Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions. (Pubmed Central) -  Aug 6, 2021   
    With the increasing availability of different administrative health data sources, the strengths and weaknesses of methods used to analyse these data for the purpose of regulatory PV should be evaluated. Whole-body PBPK models of probenecid and furosemide were built and evaluated, providing useful tools to support the investigation of transporter mediated DDIs.
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] Time to spontaneous resolution in infant stone disease () -  Aug 5, 2021 - Abstract #AUA2021AUA_2798;    
    This may be due to intrinsic physiologic and environmental factors related to initial stone formation itself. A meta-analysis may be required to further confirm the relationship between these factors and the rate of stone resolution in children.
  • ||||||||||  furosemide / Generic mfg.
    [VIRTUAL] The head and neck surgeon's role in the management of hypercalcemic crises due to primary hyperparathyroidism () -  Aug 3, 2021 - Abstract #AHNS2021AHNS_445;    
    All patients were volume-resuscitated with saline and additional agents including furosemide, calcitonin, and bisphosphonates...A plan to avoid large volumes of 0.9% normal saline and to encourage the use of calcium-free balanced crystalloids and isotonic sodium bicarbonate solutions for volume resuscitation and saline diuresis should be discussed early. With the increased incidence of parathyroid carcinoma in this patient subset, the surgeon must also have a heightened suspicion for parathyroid carcinoma