- |||||||||| nefazodone / Generic mfg., furosemide / Generic mfg.
Journal: Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out Approach. (Pubmed Central) - Oct 6, 2021
For nefazodone, a mechanistic clearance for the gut and liver was added, for furosemide, an absorption window was introduced, and for aprepitant, the biorelevant solubility was refined using multiple solubility measurements. In all cases, these adjustments were supported by literature data and showcased a rational approach to assess the factors limiting absorption and exposure.
- |||||||||| amitriptyline / Generic mfg., duloxetine / Generic mfg.
Ancient drugs and current combined toxicity: a case report () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4525;
The knowledge of the prolonged duration of TCA overdose effects is essential to approach it properly. In addition, because multiple drug overdose is common in these patients the clinical management could be challenging and a joint evaluation by an emergentist and a toxicologist could be useful.
- |||||||||| amitriptyline / Generic mfg., duloxetine / Generic mfg.
Ancient drugs and current combined toxicity: a case report () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4524;
The knowledge of the prolonged duration of TCA overdose effects is essential to approach it properly. In addition, because multiple drug overdose is common in these patients the clinical management could be challenging and a joint evaluation by an emergentist and a toxicologist could be useful.
- |||||||||| amitriptyline / Generic mfg., duloxetine / Generic mfg.
Ancient drugs and current combined toxicity: a case report () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4523;
The knowledge of the prolonged duration of TCA overdose effects is essential to approach it properly. In addition, because multiple drug overdose is common in these patients the clinical management could be challenging and a joint evaluation by an emergentist and a toxicologist could be useful.
- |||||||||| amitriptyline / Generic mfg., duloxetine / Generic mfg.
Ancient drugs and current combined toxicity: a case report () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_4522;
The knowledge of the prolonged duration of TCA overdose effects is essential to approach it properly. In addition, because multiple drug overdose is common in these patients the clinical management could be challenging and a joint evaluation by an emergentist and a toxicologist could be useful.
- |||||||||| furosemide / Generic mfg., nitroglycerin / Generic mfg.
Acute pulmonary edema as the first clinical manifestation for aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_1841;
Acute pulmonary edema can be a form of presentation of aortic dissection, due to severe aortic regurgitation. Bedside echocardiography alongside a detailed clinical examination, may raise an early suspicion for aortic dissection, even in atypical presentation.
- |||||||||| furosemide / Generic mfg., nitroglycerin / Generic mfg.
Acute pulmonary edema as the first clinical manifestation for aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_1840;
Acute pulmonary edema can be a form of presentation of aortic dissection, due to severe aortic regurgitation. Bedside echocardiography alongside a detailed clinical examination, may raise an early suspicion for aortic dissection, even in atypical presentation.
- |||||||||| furosemide / Generic mfg., nitroglycerin / Generic mfg.
Acute pulmonary edema as the first clinical manifestation for aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_1839;
Acute pulmonary edema can be a form of presentation of aortic dissection, due to severe aortic regurgitation. Bedside echocardiography alongside a detailed clinical examination, may raise an early suspicion for aortic dissection, even in atypical presentation.
- |||||||||| furosemide / Generic mfg., nitroglycerin / Generic mfg.
Acute pulmonary edema as the first clinical manifestation for aortic dissection () - Oct 1, 2021 - Abstract #EUSEM2021EUSEM_1838;
Acute pulmonary edema can be a form of presentation of aortic dissection, due to severe aortic regurgitation. Bedside echocardiography alongside a detailed clinical examination, may raise an early suspicion for aortic dissection, even in atypical presentation.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
Journal: Pharmacological Management of Heart Failure: A Century of Expert Opinions in Cecil Textbook of Medicine. (Pubmed Central) - Oct 1, 2021
The pharmacological management of heart failure in the past century has progressed in fits and starts, with latent periods between significant advances lasting 8-40 years. In chronological order, the major advances were efficient diuresis, afterload reduction, and blunting the neurohormonal response to hemodynamic stress and cardiac remodeling.
- |||||||||| furosemide / Generic mfg.
Journal: Lateral Flow Immunochromatography Assay for Detection of Furosemide in Slimming Health Foods. (Pubmed Central) - Sep 29, 2021
The developed AuNPs-LFIA showed high consistency with liquid chromatography with tandem mass spectrometry (LC-MS/MS), and no false positive or false negative results were found in spiked slimming health foods, proving that the AuNPs-LFIA should be accurate and reliable. The AuNPs-LFIA reported here provides a serviceable analytical tool for the on-site detection and rapid initial screening of furosemide for the first time.
- |||||||||| furosemide / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: Pilot Study of Loop Diuretics Among Individuals Receiving Hemodialysis (clinicaltrials.gov) - Sep 29, 2021
P2, N=42, Completed,
Current findings could suggest positive insights due to the reduced amount of loop diuretics in patients with advanced HF. Recruiting --> Completed | Trial completion date: Oct 2021 --> Jun 2021 | Trial primary completion date: Oct 2021 --> Jun 2021
- |||||||||| furosemide / Generic mfg.
Preclinical, Journal: Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury. (Pubmed Central) - Sep 29, 2021
L-carnitine or furosemide was administered, and serial blood samples were collected and analyzed to assess the effects of hydronephrosis on the pharmacokinetic parameters...In conclusion, our results demonstrate that hydronephrotic kidneys are more susceptible to I-R-induced damage than healthy kidneys. Unilateral hydronephrosis does not affect the pharmacokinetics of substances secreted or absorbed in the renal tubules.
- |||||||||| furosemide / Generic mfg.
Trial completion date, Trial primary completion date: Salt-Sensitivity and Immunity Cell Activation (clinicaltrials.gov) - Sep 27, 2021
P1/2, N=20, Recruiting,
Unilateral hydronephrosis does not affect the pharmacokinetics of substances secreted or absorbed in the renal tubules. Trial completion date: Sep 2021 --> Sep 2025 | Trial primary completion date: Sep 2021 --> Sep 2025
- |||||||||| furosemide / Generic mfg.
Negative Pressure Pulmonary Edema In Pacu (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4553;
Patient transferred to SICU. Administered IV Lasix and extubated to CPAP, then HFNC and room air.
- |||||||||| furosemide / Generic mfg.
Hypercalcemic Pancreatitis In Pregnancy (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3999;
Due to preeclampsia, patient sustained pulmonary edema requiring supplemental O2, lasix and bed elevation...Transferred to ICU for optimization of hypercalcemia. Patient scheduled for parathyroidectomy after Ca improved <10mg/dL.
- |||||||||| furosemide / Generic mfg.
Diuresis Vs. Liver Transplant, A Case Of Prolonged Pre-operative Hospitalization Due To Fluid Overload (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_3653;
She was unable to discharge on PO diuretics during her waitlist, however following liver transplantation, she was transitioned to oral Furosemide and discharged on post-operative day 13. The exact cause as to why her volume status changed drastically following transplantation is unknown, but a hypothesis includes normalization her albumin and protein stores.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Initial Diuretic Dosing and Length of Stay in Patients Hospitalized for Congestive Heart Failure (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_6442;
In a cohort of patients admitted for heart failure, more than 1 in 3 patients received an initial dose of intravenous loop diuretics that was equivalent to or below their home diuretic dose and this was associated with a longer length of hospital stay. These findings may represent a quality improvement opportunity in the care of patients hospitalized for heart failure.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Worsening Renal Function in Acute Heart Failure in the Context of Diuretic Response (OnDemand) - Sep 24, 2021 - Abstract #AHA2021AHA_6050;
In patients with a poor diuretic response (≤0.35 kg weight loss/40 mg furosemide equivalent as identified by STEPP), WRF was associated with a higher risk of (CV) death or cardiovascular/renal hospitalisation (P<0.001 in both cohorts), but this was not the case for patients with a good diuretic response (P=0.900 for both cohorts).ConclusionIn two large cohorts of patients with AHF, WRF in the first 4 days was not associated with worse outcomes when patients had a good diuretic response. The occurrence of WRF in patients with AHF should therefore be considered in the context of diuretic response.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Regulation Of ENaC In Antigen-presenting Cells Determines The Relationship Between Isolevuglandins And Salt Sensitivity Of Blood Pressure (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_1152;
It is not known if this variability relates to individual salt sensitivity of blood pressure and whether it is produced by different individual regulation of function of the channel.We measured systolic blood pressure (SBP), isoLG-containing dendritic cells (DC), CD14+16-, CD14-16+ and CD14+16+ monocytes (flow cytometry and a specific antibody), plasma aldosterone (Aldo), and plasma and urine epoxyeicosatrienoic acids (PEETs and UEETs, the sum of the 8-9, 11-12 and 14-15 isoforms by HPLC) in 9 hypertensive subjects who were off therapy for 2 weeks, before (B) and after in-patient 24 hr salt loading (HI, 460 mmol Na+) and salt depletion (LO, 10 mmol Na+/24 plus furosemide 40 mg x 3).Age was 51±2, with 33% female, BMI 34.5±3.8 kg/m2 and screening SBP 139±5 mmHg mmHg...However, in bivariate analyses both ∆SBP and ∆UEET were significant regressors for ∆isoLGs in the four cell types, explaining 55 to 89% of their variability. There were no correlations between PEETs or Aldo and isoLGs in any cell type.We conclude: (1) ENaC of APCs is not regulated by Aldo or systemic PEETs, and (2) Within the framework of our hypothesis, the bivariate analyses suggest that (a) Renal EETs inhibit APC ENaC as they do renal ENaC, thus regulating isoLG generation by Na+, (b) the effect may reflect exposure of APCs to Na+ in the renal medulla (relationships with UEETs but not PEETs) and (c) the resulting renal EET-regulated change in isoLGs by changes in Na+ balance is associated with the degree of salt sensitivity of blood pressure in humans.
- |||||||||| furosemide / Generic mfg.
[VIRTUAL] Assessing the Applicability of Three Heart Failure Randomised Controlled Trials by Calibration to Scottish Registry (ePosters) - Sep 24, 2021 - Abstract #AHA2021AHA_599;
Compared to register patients, trial participants had lower furosemide doses and were younger (mean (standard deviation) age 73 (12) years vs 62 (11), 64 (11) and 69 (10) years) with higher eGFR (59 (23) vs 67 (21), 62 (21) and 68 (18) ml/min/1.73m2 for register vs COMET, DIG and TOPCAT respectively). Calibration may be used to estimate the applicability of trial findings to populations typically encountered in clinical settings, with only small reductions in the precision of the effect estimates, and without breaking randomisation.
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