furosemide / Generic mfg. 
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  • ||||||||||  piperacillin sodium/tazobactam sodium / Generic mfg., vancomycin / Generic mfg., furosemide / Generic mfg.
    More Than Just a Hill of Beans: Clinical Controversies Related to Acute Kidney Injury in the ICU ([VIRTUAL]) -  Dec 2, 2021 - Abstract #ASHP2021ASHP_4622;    
    Learning Objectives: Evaluate the level of evidence associated with acute kidney injury and concomitant vancomycin administration with piperacillin/tazobactam in critically ill patients.Summarize the clinical usefulness of furosemide stress testing in acute kidney injury.Recommend an evidence-based strategy on the role of continuous infusion vancomycin in critically ill patients. Target Audience: Pharmacist Level of Content:Advanced Activity Type: Application-based
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Assessment of glomerular and tubular function to guide fluid management in a pre-eclamptic critical patient with oliguria and volume overload: case report. (Pubmed Central) -  Dec 1, 2021   
    Oliguria in the setting of critically ill patients is usually treated by admini-stering fluids and furosemide [1]...This case report aims to highlight the utility of the assessment of the glomerular and tubular functions to identify an ineffective diuretic strategy and to select a successful one, which prevented the use of invasive RRT. A 33-year-old female patient suffering from preeclampsia (gestational age was 35 + 6 weeks) was admitted to our Post-surgical Intensive Care Unit (PICU) after an urgent caesarean section performed under spinal anaesthesia, without further incidents.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Comparison of high resolution mrm and sequential window acquisition of all theoretical fragment-ion acquisition modes for the quantitation of 48 wastewater-borne pollutants in lettuce. (Pubmed Central) -  Nov 29, 2021   
    During extraction, the use of formic acid was adopted to further improve the results of some problematic compounds (e.g., fenofibrate, furosemide, metronidazole, oxcarbazepine, sulfanilamide)...Both methods provided similar recoveries between 80 and 120% in lettuce leaves, although sulfanilamide, ciprofloxacin, and sulfamethazine presenting values of 26.8, 27.8, and 28.4% in MRM and 25, 33.9, and 35% in SWATH, respectively...Application of the present method to lettuce crops growth in controlled conditions showed the presence of 14 out 48 studied compounds with similar concentrations in both acquisition modes ranging from 3.3 and 1.3 ng g   for climbazole (for MRM and SWATH, respectively) to 33.2 and 17.7 ng g   for sulfamethazine. Drug residues such as carbamazepine (6.0 and 8.5 ng g  ), and its metabolite carbamazepine epoxide (18.1 and 16.5 ng g  ), frequently found in wastewater effluents, were also detected.
  • ||||||||||  furosemide / Generic mfg.
    PK/PD data, Journal:  Pharmacokinetics and bioavailability of furosemide in sheep. (Pubmed Central) -  Nov 29, 2021   
    The IM injection of furosemide may be the alternative routes in addition to IV. However, further research is required to determine the effect of dose and route of administration on the clinical efficacy of furosemide in sheep.
  • ||||||||||  Cytovene (ganciclovir) / Roche
    Clinical, Journal:  Impact of the use of nephrotoxic drugs in critically ill pediatric patients. (Pubmed Central) -  Nov 29, 2021   
    However, further research is required to determine the effect of dose and route of administration on the clinical efficacy of furosemide in sheep. It is necessary for intensivist physicians to have knowledge of the main nephrotoxic drugs to predict, reduce or avoid damage to their patients.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Continuous positive airway pressure therapy in the management of hypercapnic cardiogenic pulmonary edema. (Pubmed Central) -  Nov 29, 2021   
    All patients received medical therapy with furosemide and nitrates and helmet CPAP therapy...Serial ABG tests showed clear reduction in CO2 levels with improvement of pH and progressive lactate reduction. CPAP therapy can be effective in the treatment of hypercapnic CPE as long as the patients have no signs of chronic hypercapnia on ABG and as long as the diagnosis of heart failure is supported by bedside lung-heart ultrasound examination.
  • ||||||||||  hydralazine hydrochloride / Generic mfg., furosemide / Generic mfg.
    Review, Journal:  Duodenal Pseudomelanosis: A Literature Review. (Pubmed Central) -  Nov 29, 2021   
    In this review, we aimed to clearly define its endoscopic and microscopic presentation; its epidemiology, associated comorbidities, and drugs; the most useful special histochemical techniques used to classify the nature of the pigmentation; and the most relevant differential diagnoses. In addition, by considering our findings, we also formulated a number of hypotheses about its pathogenesis.
  • ||||||||||  furosemide / Generic mfg.
    When Delivery Doesn’t Solve It All: A Case Report to Highlight the Postoperative Management of HELLP Syndrome ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_1030;    
    With growing knowledge into protective ventilation principles, mechanical Methods have been increasingly applied to parturients with respiratory complications. Furosemide has been proposed as the most effective diuretic for the management of postpartum preeclampsia Learning points:Even though delivery is proposed as the final therapeutic action in a deteriorating HELLP syndrome, postpartum vigilance of severe maternal complications must not be overlooked in the first two weeks and a steady multidisciplinary approach should be implemented, if needed.
  • ||||||||||  dexamethasone / Generic mfg.
    Anaesthesia Management of a Patient with Pneumonectomy Undergoing Robotic Bilateral Adrenalectomy: A Case Report ([VIRTUAL]) -  Nov 25, 2021 - Abstract #Euroanaesthesia2021Euroanaesthesia_985;    
    Robotic bilateral adrenalectomy operation can be performed smoothly in a patient with pneumonectomy, with lung-protective ventilation strategies, neuroprotective steroid administration, and fluid restriction. We recommend that bilateral adrenalectomy surgeries be performed by starting the operation with the surgery on the same side by positioning the intact
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  OUTpatient intravenous LASix Trial in reducing hospitalization for acute decompensated heart failure (OUTLAST). (Pubmed Central) -  Nov 21, 2021   
    This narrative review describes the rational and pharmacological basis of anticholinergic burden tools and provides insight about their predictive value for adverse outcomes. The use of a standardized protocol of outpatient IV furosemide infusion for a one-month period following hospitalization for ADHF was found to be safe and efficacious in reducing 30-day re-hospitalization.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Development of a furosemide-containing expandable system for gastric retention. (Pubmed Central) -  Nov 21, 2021   
    The present study highlighted the value of novel test methods during the development of gastroretentive formulations. Yet, a system with reproducible gastroretentive properties especially under fasted conditions has to be designed.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  The furosemide stress test: current use and future potential. (Pubmed Central) -  Nov 16, 2021   
    The stress test can also predict cessation of continuous renal replacement therapy in patients with established AKI. On the basis of the evidence presented in this review, we propose future potential studies of furosemide in AKI.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Tlr2/4 Double Knockout Attenuates the Degeneration of Primary Auditory Neurons: Potential Mechanisms From Transcriptomic Perspectives. (Pubmed Central) -  Nov 16, 2021   
    In a PAND model involving administration of kanamycin combined with furosemide to destroy cochlear hair cells, Tlr 2/4 double knockout (DKO) mice had auditory preservation advantages, which were mainly manifested at 4-16 kHz...The SGN transcriptome of DKO and WT mice indicated that there was an inverted gene set enrichment relationship between their different transcriptomes and the SGN degeneration transcriptome, which is consistent with the morphology results. Core module analysis suggested that DKO mice may modulate SGN degeneration by activating two clusters, and the involved molecules include EGF, STAT3, CALB2, LOX, SNAP25, CAV2, SDC4, MYL1, NCS1, PVALB, TPM4, and TMOD4.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma, Valcyte (valganciclovir) / Roche, Mitsubishi Tanabe, Kineret (anakinra) / SOBI
    Trial completion date, Trial primary completion date:  Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants (clinicaltrials.gov) -  Nov 8, 2021   
    P=N/A,  N=1600, Recruiting, 
    The furosemide‑to‑UNa ratio can be a surrogate marker for diuretic resistance and has a prognostic impact in chronic HF. Trial completion date: Sep 2021 --> Sep 2024 | Trial primary completion date: Sep 2021 --> Sep 2024
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD)
    Clinical, Journal:  Pembrolizumab-induced focal segmental glomerulosclerosis: A case report. (Pubmed Central) -  Nov 7, 2021   
    Therefore, patients should undergo evaluation for renal function and urinalysis at baseline and after treatment. If patients treated with PD-1 inhibitors present with renal injury and/or unexplained proteinuria >1 g/day, we would recommend a kidney biopsy to determine the underlying cause and establish an appropriate therapeutic plan.