furosemide / Generic mfg. 
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 0 Diseases   79 Trials   79 Trials   6783 News 


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  • ||||||||||  gentamicin sulfate / Generic mfg.
    Journal:  Gentamicin induces calciuresis by blocking TRPV5. (Pubmed Central) -  May 14, 2022   
    Instead, gentamicin blocks distal Ca reabsorption by direct inhibition of the Ca channel TRPV5. These findings offer new insights into Ca wasting in patients treated with gentamicin.
  • ||||||||||  furosemide / Generic mfg., spironolactone / Generic mfg.
    The RELIEHF registry & clinical trial design (Relieving Increasing Oedema due to Heart Failure) (ePoster station 1) -  May 14, 2022 - Abstract #HEARTFAILURE2022HEART_FAILURE_1389;    
    Most patients with HF who were asked to participate in research were willing to do so and to participate in a randomised trial, although a substantial proportion were not eligible for this trial. Of those who were, the majority tolerated spironolactone at a dose of 100mg/day.
  • ||||||||||  furosemide / Generic mfg.
    Door-to-furosemide time and clinical outcomes in acute heart failure (ePoster station 1) -  May 14, 2022 - Abstract #HEARTFAILURE2022HEART_FAILURE_1339;    
    Patients presenting at the ED for AHF who had received IV furosemide in the first hour tended to have a better short-term prognosis, even after adjustment for key AHF prognosticators. This work adds to the existing evidence with real word data thar DTF time is an important and frequently overlooked aspect of AHF treatment.
  • ||||||||||  SAFETY AND EFFICACY OF HYPODERMOCLYSIS IN PATIENTS WITH HEMATOLOGICAL CANCERS () -  May 13, 2022 - Abstract #EHA2022EHA_2272;    
    Limitations of this study are its retrospective single-center design and the lack of evaluation of other patient-reported outcomes. Nevertheless, this data confirms the excellent safety of HDC for palliation of patients with both solid and HC.
  • ||||||||||  Tectin (tetrodotoxin) / WEX Pharma
    Journal:  Neural Contributions to the Cochlear Summating Potential: Spiking and Dendritic Components. (Pubmed Central) -  May 12, 2022   
    Round window electrocochleography to tones and clicks was performed before and after application of tetrodotoxin to prevent action potentials, and then again after kainic acid to prevent generation of an EPSP...These results show the sources of the SP include at least the four components studied, and that these have a mixture of polarities and magnitudes that vary across frequency and intensity. Thus, multiple possible interactions must be considered when interpreting the SP for clinical uses.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  A risk prediction model for contrast-induced nephropathy associated with gadolinium-based contrast agents. (Pubmed Central) -  May 12, 2022   
    Sex, SBP, absolute neutrophil count, albumin, fasting blood glucose levels, and furosemide use are significant predictors of contrast-induced nephropathy caused by gadolinium-based contrast agents. Therefore, the incidence of contrast-induced nephropathy may be estimated by the prediction model established in this study before the use of contrast agents.
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Introducing isotonic fluids into pediatric oncology. (Pubmed Central) -  May 11, 2022   
    Using isotonic fluids for hyper-hydration in pediatric oncology lead to a modest reduction of hospital-acquired hyponatremia without causing hypernatremia, but the effects on fluid balance need further investigation. The additional intake of bivalent cations and buffering anions in balanced fluids has measurable effects.
  • ||||||||||  Henletor (torsemide) / Orchid
    Diuretic Prescription Patterns in Haemodialysis Patients: International Variation Reported in the Dopps (Mini-Orals Hall) -  May 5, 2022 - Abstract #ERAEDTA2022ERA_EDTA_1719;    
    CONCLUSION We observed substantial international differences in diuretic prescription patterns to HD patients, with usage and doses much higher in some European countries than the US, where high-dose formulations are not available. The potential impact of diuretic prescription patterns on outcomes, including residual urine volume, volume-related complications and others should be investigated.
  • ||||||||||  trandolapril / Generic mfg., furosemide / Generic mfg.
    Water Restriction and Age Increase the Risk of Triple Whammy-Induced Acute Kidney Injury (Mini-Orals Hall) -  May 5, 2022 - Abstract #ERAEDTA2022ERA_EDTA_1093;    
    There were no histological alterations in any of the experimental groups. CONCLUSION Water restriction is an important risk factor in the development of AKI in TW therapy, and although age differences do not have a relevant effect on their own, the combination of age and water restriction increases the risk.
  • ||||||||||  cyclophosphamide / Generic mfg., acyclovir / Generic mfg., furosemide / Generic mfg.
    De Novo Double Glomerulopathy (Membranous Nephropathy, Mn and Collapsing Focal Segmental Glomerulosclerosis, CFSGS) Associated to Positive Myeloperoxidase-O (MPO) Antibody Following Pfizer-Biontech MRNA Vaccination Covid 19 (Mini-Orals Hall) -  May 5, 2022 - Abstract #ERAEDTA2022ERA_EDTA_1050;    
    The family physician added furosemide to her therapy for generalized edema with no diuretic effect...RESULTS We started the Ponticelli regimen (alternate months steroids and cyclophosphamide)...A left ocular, frontal and parietal herpes zoster induced a short discontinuation of therapy and responded well to Acyclovir; then we concluded the fourth month of therapy...One month later, blood tests showed: creatinine 1 mg/dL, serum albumin 4 g/dL, proteinuria 0.7 g/die, MPO 2 UA/mL and PLA2R Ab absent. CONCLUSION To our knowledge, this is the first case of nephrotic sindrome secondary to a de novo MN and FSGS, associated with positive MPO antibody, following Pfizer–BioNTech mRNA vaccination COVID 19; the patient responded well to immunosoppression going in remission and regaining renal function.
  • ||||||||||  furosemide / Generic mfg.
    THE B1 H+-ATPASE (ATP6V1B1) SUBUNIT IS REQUIRED FOR NON-TYPE A INTERCALATED CELL FUNCTION DURING ALKALOSIS (Hall S02) -  May 5, 2022 - Abstract #ERAEDTA2022ERA_EDTA_672;    
    METHOD Acid-base metabolism of Atp6v1b1 mice was studied during an alkali load (0.28 M NaHCO 3 in drinking water and 2 mg deoxycorticosterone i.p for 4 days) or during a chronic furosemide treatment (20 mg i.p. injection daily for 9 days)...CONCLUSION Thus, this study demonstrates for the first time that i) the B1 H + -ATPase subunit is critical for normal non-type A ICs function and protects against alkalosis. ii) Moreover, the B1 subunit is required for the assembly of complete and functional basolateral vacuolar H + -ATPases complexes in intercalated cells.
  • ||||||||||  furosemide / Generic mfg.
    Trial completion, Trial completion date:  Furosemide vs. Placebo for Severe Antepartum Hypertension (clinicaltrials.gov) -  May 3, 2022   
    P3,  N=65, Completed, 
    ii) Moreover, the B1 subunit is required for the assembly of complete and functional basolateral vacuolar H + -ATPases complexes in intercalated cells. Recruiting --> Completed | Trial completion date: Dec 2022 --> Apr 2022
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Journal:  A cirrhotic patient in an internal medicine ward. (Pubmed Central) -  Apr 30, 2022   
    Therapy comprises of restriction of sodium intake, diuretic therapy with combination of spironolactone and furosemide, alternatively large-volume paracentesis...Treatment includes correcting of predisposing conditions, administering of non-absorbable disaccharides or rifaximin...Specific type of infection in cirrhosis is spontaneous bacterial peritonitis, which has to be always excluded with diagnostic paracentesis. The mainstay of successful therapy of infections is timely and vigorous broad spectrum antibiotic therapy which can significantly improve otherwise unfavourable outcome of these patients.
  • ||||||||||  furosemide / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  ORKID: Outpatient Recovery From Acute Kidney Injury Requiring Dialysis (clinicaltrials.gov) -  Apr 27, 2022   
    P4,  N=1, Terminated, 
    Recruiting --> Active, not recruiting N=15 --> 1 | Trial completion date: Oct 2022 --> Apr 2022 | Recruiting --> Terminated | Trial primary completion date: Oct 2022 --> Apr 2022; Inadequate recruitment
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Non alcoholic palm nectar from Cocos nucifera as a promising nutraceutical preparation. (Pubmed Central) -  Apr 26, 2022   
    Diuretic activity of samples was determined by Lipschitz method, and the results revealed that NPNC exhibited significant diuretic activity, comparable with furosemide...The focus of this study is to reveal the potential medicinal properties of NPNC and its products; honey (NPNCH) and sugar (NPNCS). If the nutritional and medicinal values of the selected preparations from natural sources can be proved with scientific evidence, its ability to beat commercially available carbonated beverages and energy drinks with negative health consequences may get widespread acceptance.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  A praeeclampsia két arca. (Pubmed Central) -  Apr 26, 2022   
    Orv Hetil. 2022; 163(17): 663-669.
  • ||||||||||  thyroxine / Generic mfg.
    Journal:  Initial treatment of myxedema coma using oral levothyroxine: a case report from Tanzania. (Pubmed Central) -  Apr 26, 2022   
    Although diagnostic and scoring criteria based on clinical, laboratory, and imaging features have been proposed, no consensus has been reached. This article shows an alternative treatment option for myxedema coma using oral levothyroxine, which led to a favorable outcome.
  • ||||||||||  Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
    Journal:  Usefulness of Dapagliflozin for Nephrotic Syndrome Secondary to Diabetic Kidney Disease. (Pubmed Central) -  Apr 26, 2022   
    These agents were then replaced with dapagliflozin, which resulted in a positive diuretic effect and subsequent improvement of hypoalbuminemia and renal dysfunction. This case report demonstrates the utility of dapagliflozin for nephrotic syndrome to achieve a positive diuretic effect and improve hypoalbuminemia without deteriorating the renal function.
  • ||||||||||  Premiplex (mecasermin rinfabate) / Takeda
    Journal:  Development of Protein-Specific Analytical Methodologies to Evaluate Compatibility of Recombinant Human (rh)IGF-1/rhIGFBP-3 with Intravenous Medications Co-Administered to Neonates. (Pubmed Central) -  Apr 21, 2022   
    The protein complex of recombinant human insulin-like growth factor-1 and insulin‑like growth factor binding protein‑3 (rhIGF-1/rhIGFBP-3; mecasermin rinfabate), is an investigational product for the prevention of complications of prematurity...Methods developed for the rhIGF-1/rhIGFBP-3 admixtures, optimized in studies with furosemide, caffeine citrate and ampicillin, demonstrated good reproducibility, linearity, and limit of detection/quantitation...Furosemide was found to be physically incompatible with rhIGF-1/rhIGFBP-3. Our findings support the use of these methodologies for detection of protein modifications under various clinical administration conditions, and additionally supplement physical compatibility data studies of ultra-low concentrations of rhIGF-1/rhIGFBP-3 post co-administration to preterm infants with other medications (manuscript in-preparation).
  • ||||||||||  Sylvant (siltuximab) / Jazz
    TAFRO SYNDROME: A RARE VARIANT OF MULTICENTRIC CASTLEMAN DISEASE IN A 15-YEAR-OLD FEMALE () -  Apr 20, 2022 - Abstract #ASPHO2022ASPHO_424;    
    The index of suspicion for MCD should remain high for patients for whom rheumatologic processes are suspected. While this disease has significant lymph node involvement, it should be noted that this patients lymphadenopathy only became apparent with imaging; her unusual presentation made it so her physical exam did not immediately reflect lymph node abnormalities.