furosemide / Generic mfg. 
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  • ||||||||||  furosemide / Generic mfg., spironolactone / Generic mfg.
    Clinical, Journal:  Risk Factors for Hepatic Hydrothorax in Cirrhosis Patients with Ascites - A Clinical Cohort Study. (Pubmed Central) -  Jun 30, 2022   
    In patients with cirrhosis and ascites, risk factors for hepatic hydrothorax were a recurrent need for paracentesis, a high bilirubin, diabetes and non-use of NSBBs. Among these patients with cirrhosis and ascites, development of hepatic hydrothorax increased mortality fourfold.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Furosemide prevents membrane KCC2 downregulation during convulsant stimulation in the hippocampus. (Pubmed Central) -  Jun 25, 2022   
    Further, we demonstrated that furosemide also suppressed cyclothiazide-induced epileptiform burst activity in cultured hippocampal neurons and lowered the mortality rate during acute seizure induction. Overall, furosemide prevents membrane KCC2 downregulation during acute seizure induction, restores KCC2-mediated GABA inhibition, and interrupts the progression from acute seizure to epileptogenesis.
  • ||||||||||  Riarify (beclometasone/formoterol/glycopyrrolate) / Chiesi
    Bromoderma in a patient with chronic obstructive pulmonary disease (Lomond) -  Jun 23, 2022 - Abstract #BAD2022BAD_123;    
    This case highlights the importance of considering inhaled medications in any case of a possible cutaneous drug reaction. To our knowledge this is the first reported case of glycopyrronium bromide inducing bromoderma.
  • ||||||||||  Noxafil (posaconazole) / Merck (MSD)
    Journal:  Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids. (Pubmed Central) -  Jun 22, 2022   
    These media have been applied in this study to examine the equilibrium solubility of twenty one exemplar drugs (naproxen, indomethacin, phenytoin, zafirlukast, piroxicam, ibuprofen, mefenamic acid, furosemide, aprepitant, carvedilol, tadalafil, dipyridamole, posaconazole, atazanavir, fenofibrate, felodipine, griseofulvin, probucol, paracetamol, acyclovir and carbamazepine) to determine if consistent solubility behaviour was present...The study indicates that the use of two appropriate bioequivalent fasted intestinal media from the nine will identify in vitro the maximum and minimum solubility boundaries for drugs and due to the media derivation this is probably applicable in vivo. These media could be applied during discovery and development activities to provide a solubility range, which would assist placement of the drug within the BCS/DCS and rationalise drug and formulation decisions.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Endolymphatic hydrops presumption tests for patients with vestibular migraine. (Pubmed Central) -  Jun 22, 2022   
    Fourteen patients with VM underwent caloric testing, video head impulse test (vHIT), cervical and ocular vestibular evoked myogenic potential (cVEMP and oVEMP), and EH presumption tests such as the Futaki's test and furosemide loading VEMP...Nine patients (64.3%) were positive for at least one EH presumption test. EH is not a rare finding in VM; however, the ratio is less than that in Meniere's disease.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Ceramide-1-Phosphate as a Potential Regulator of the Second Sodium Pump from Kidney Proximal Tubules by Triggering Distinct Protein Kinase Pathways in a Hierarchic Way. (Pubmed Central) -  Jun 22, 2022   
    Basolateral membranes of proximal tubule cells have the classic Na + K-ATPase and the ouabain-insensitive, K-insensitive, and furosemide-sensitive Na-ATPase, which participate in the active Na reabsorption...Conversely, we did not observe any effect on the Na + K-ATPase even at a broad C1P concentration range. The significant effect of ceramide-1-phosphate revealed a new potent physiological and pathophysiological modulator for the Na-ATPase, participating in the regulatory network involving glycero- and sphingolipids present in the basolateral membranes of kidney tubule cells.
  • ||||||||||  Biomarker, Trial completion date:  Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters (clinicaltrials.gov) -  Jun 20, 2022   
    P1,  N=32, Recruiting, 
    The significant effect of ceramide-1-phosphate revealed a new potent physiological and pathophysiological modulator for the Na-ATPase, participating in the regulatory network involving glycero- and sphingolipids present in the basolateral membranes of kidney tubule cells. Trial completion date: Jul 2023 --> Jun 2024
  • ||||||||||  furosemide / Generic mfg.
    Metolazone As An Adjunct To Loop Diuretics In Acute Heart Failure: A Systematic Review And Meta-analysis (Salon B, Lower Level) -  Jun 18, 2022 - Abstract #BCVS2022BCVS_244;    
    Conclusion Though some benefit in 24-hour urine output was noted on the addition of metolazone to furosemide, our analysis could not demonstrate the benefit of adding metolazone due to lack of adequate studies comparing similar groups in diuretic resistant AHF. Therefore, further RCTs are required in this subject to evaluate the benefit of adding metolazone in diuretic-resistant AHF patients.
  • ||||||||||  Anaesthetic management of a kidney transplantation in an adult with multiple drug allergy syndrome (Poster eBoard 1) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_1449;    
    Haemodynamic and oxygenation stability was attained throughout the surgery and diuresis occurred spontaneously after ureterovesical anastomosis and administration of furosemide 80mg...Prophylactic treatments with corticosteroids and H1 antagonists are still debated, albeit they seem to be beneficial. Implementation of preventive measures (allergens avoidance), vigilance for allergic reactions recognition and readiness to deal with them are the cornerstones that contribute to an optimal outcome, as in our case.
  • ||||||||||  furosemide / Generic mfg.
    Anesthetic management of an ex-vivo surgical repair of a renal artery aneurysm with renal auto-transplantation (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_571;    
    Although scant evidence in the literature, our center has vast experience using an osmotic agent (mannitol) and diuretics (furosemide) to promote diuresis and decrease the incidence of acute tubular necrosis (ATN) after kidney transplantation. Also, the choice of drugs without renal metabolism is of the utmost importance during anesthesia and postoperative analgesia.
  • ||||||||||  furosemide / Generic mfg.
    Pheochromocytoma presenting as Takotsubo syndrome during cesarean section (Virtual Platform - Poster section) -  Jun 17, 2022 - Abstract #Euroanaesthesia2022Euroanaesthesia_514;    
    The patient received furosemide and oxygen...Our case meets with the international diagnostic criteria [2]. In asymptomatic pheochromocytoma, an increase in catecholamines may be precipitated by anesthesia or drug administration [3].
  • ||||||||||  furosemide / Generic mfg., bumetanide / Generic mfg.
    Diuretic use before and after transcatheter aortic valve implantation: a nationwide study (Research Gateway 7) -  Jun 15, 2022 - Abstract #ESC2022ESC_415;    
    Among patients undergoing TAVI not treated with high-dose diuretics at time of intervention, approximately 1 out of 4 patients had intensification of diuretic treatment one year after intervention. Ischemic heart disease and chronic renal failure were associated with intensification.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech, Spikevax (elasomeran) / Moderna, Takeda
    Acute febrile neutrophilic dermatosis after SARS-CoV-2-Vaccination (e-Poster Hall) -  Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_202;    
    Her medical history was not relevant for any dermatological or systemic diseases, and she was exclusively on paracetamol because of fever and joint pain...In addition, several drugs, including diazepam, diclofenac, furosemide, and granulocyte-colony stimulating factor may induce AFND...In addition, colchicine, dapsone, and potassium iodide could be used as second-line therapy...reported a case of AFND after the first dose of mRNA-1273 vaccine from Moderna...described the acute onset of painful, dark erythematous plaques in a 51-year-old woman affected by COVID-19 nine days after stopping corticosteroids. To our best knowledge, only a few cases of AFND after Comirnat
  • ||||||||||  furosemide / Generic mfg., bumetanide / Generic mfg.
    Journal:  Ferric iron loaded porphyrinic zirconium MOFs on corncob for the enhancement of diuretics extraction. (Pubmed Central) -  Jun 9, 2022   
    With a sensitivity between 0.6 and 1.0 μg/L and a recovery between 83.2% and 119.2%, it is used for the analysis of trace amounts of Fur and Bum in weight loss products and environmental water. The functionalized corncob has potential application for the adsorption of diuretics, and the metal ions implantation in MOFs provides a promising strategy for enhancing extraction capacity.
  • ||||||||||  furosemide / Generic mfg.
    Enrollment open:  Testing of an Electronic Patch During Mild Dehydration (clinicaltrials.gov) -  Jun 7, 2022   
    P=N/A,  N=40, Recruiting, 
    As the system can help the management of patients with HF, further validations in larger samples and development for clinical applications are warranted. Not yet recruiting --> Recruiting
  • ||||||||||  furosemide / Generic mfg.
    Clinical, Journal:  Hepatic and Non-Hepatic Hydrothorax in Pediatric Ascites. (Pubmed Central) -  Jun 4, 2022   
    Not yet recruiting --> Recruiting With pediatric ascites, there are  certain risk factors that are associated with having hydrothorax, and ascites etiology may be associated with morbidity.
  • ||||||||||  acetazolamide / Generic mfg., furosemide / Generic mfg.
    Journal:  Congenital hydrocephalus in a trisomy 9p gained child: a case report. (Pubmed Central) -  Jun 4, 2022   
    Furosemide and amlodipine both led to nonspecific activation of both classical and alternative RAAS pathways in cats. High cerebrospinal fluid volume load and coexisting heart disease in children with trisomy 9p may call for endoscopic choroid plexus coagulation and pharmacological therapy to diminish the daily cerebrospinal fluid production to volumes that allow proper ventriculoperitoneal shunting.
  • ||||||||||  furosemide / Generic mfg., amiloride hydrochloride / Generic mfg.
    Enrollment change, Trial termination:  Safety and Efficacy of Furosemide 40mg + Amiloride Hydrochloride 10mg to Reduct Edema (clinicaltrials.gov) -  Jun 3, 2022   
    P3,  N=27, Terminated, 
    High cerebrospinal fluid volume load and coexisting heart disease in children with trisomy 9p may call for endoscopic choroid plexus coagulation and pharmacological therapy to diminish the daily cerebrospinal fluid production to volumes that allow proper ventriculoperitoneal shunting. N=60 --> 27 | Suspended --> Terminated; EF decided suspended the study because the investigational product was changed.
  • ||||||||||  Henletor (torsemide) / Orchid
    Enrollment change, Trial completion date, Trial primary completion date:  TRANSFORM-HF Ancillary Mechanistic Study (clinicaltrials.gov) -  Jun 1, 2022   
    P=N/A,  N=250, Enrolling by invitation, 
    N=60 --> 27 | Suspended --> Terminated; EF decided suspended the study because the investigational product was changed. N=750 --> 250 | Trial completion date: Jul 2022 --> Dec 2023 | Trial primary completion date: Jul 2022 --> Sep 2023