furosemide / Generic mfg. 
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  • ||||||||||  Suglat (ipragliflozin) / EMD Serono, Kotobuki, Astellas
    Preclinical, Journal:  SGLT2 inhibitor and loop diuretic induce different vasopressin and fluid homeostatic responses in non-diabetic rats. (Pubmed Central) -  Aug 26, 2022   
    In conclusion, the osmotic diuresis of the SGLT2 inhibitor increased serum sodium concentration and the vasopressin-related stimulation of fluid intake and renal water retention maintained fluid balance, whereas the loop diuretic did not engage the compensatory vasopressin system. The data suggest differences in vasopressin and fluid homeostatic responses between SGLT2 inhibitors and loop diuretics.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Biopharmaceutics studies applied to goyazensolide: a drug candidate from Lychnophora species. (Pubmed Central) -  Aug 24, 2022   
    KS monitoring should accompany MRI-oximetry, for new insights into renal pathophysiology and swift translation into human studies. Biopharmaceutics characteristics of goyazensolide are similar to drugs available on the market and attest to the feasibility of starting the process of developing a formulation containing this substance.
  • ||||||||||  furosemide / Generic mfg.
    Trial completion date, Trial primary completion date:  FaST-1: Furosemide as Supportive Therapy for COVID-19 Respiratory Failure (clinicaltrials.gov) -  Aug 18, 2022   
    P2/3,  N=640, Recruiting, 
    Active, not recruiting --> Completed Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Jan 2022 --> Dec 2022
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Hollow mesoporous silica nanoparticles-loaded ion-crosslinked bilayer films with excellent mechanical properties and high bioavailability for buccal delivery. (Pubmed Central) -  Aug 18, 2022   
    In this study, we prepared hollow mesoporous silica nanoparticles-loaded ion-crosslinked bilayer films (CCS-PVA-TPP-FSM@HMSNs) using carboxymethyl chitosan (CCS) and polyvinyl alcohol (PVA) for buccal delivery of furosemide (FSM)...In pharmacokinetic study with golden hamster models, the relative bioavailability was increased by 191.54%, and the absolute bioavailability was 82.20%. In summary, this study provides evidence that this innovative CCS-PVA-TPP-FSM@HMSNs films could be a promising and industrialized buccal drug delivery system.
  • ||||||||||  acetazolamide / Generic mfg., topiramate / Generic mfg., furosemide / Generic mfg.
    Journal:  Dural venous sinus stenting in idiopathic intracranial hypertension: a national database study of 541 patients. (Pubmed Central) -  Aug 17, 2022   
    VSS is an effective and safe procedure resulting in significant improvement of headaches, visual impairment, dizziness, and tinnitus; acetazolamide and topiramate usage were lower after VSS in patients with IIH. The paucity of pre- and post-VSS CSF shunt and ONSF procedure data does not provide enough evidence to establish significance.
  • ||||||||||  furosemide / Generic mfg., tacrolimus XR / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    SIROLIMUS-ASSOCIATED DIFFUSE ALVEOLAR HEMORRHAGE CAMOUFLAGED BY HEART FAILURE (Convention Center Exhibit Hall: Poster Area) -  Aug 16, 2022 - Abstract #CHEST2022CHEST_2653;    
    In many cases the diagnosis can be masked by other disease processes (as in our patient). Hence, a high clinical suspicion is required for early diagnosis and treatment to reduce morbidity and mortality associated with this potentially fatal complication.
  • ||||||||||  furosemide / Generic mfg., desmopressin / Generic mfg., escitalopram / Generic mfg.
    WATER INTOXICATION: A CASE OF HYPONATREMIA AND ACUTE RENAL FAILURE (Convention Center Exhibit Hall: Poster Area) -  Aug 16, 2022 - Abstract #CHEST2022CHEST_2567;    
    Rhabdomyolysis markers should be closely monitored in patients with severe hyponatremia to avoid kidney damage, electrolyte abnormalities, and subsequent death. Collaborative management with Nephrology is warranted.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    POST-COVID-19 EOSINOPHILIC PNEUMONIA (Convention Center Exhibit Hall: Poster Area) -  Aug 16, 2022 - Abstract #CHEST2022CHEST_1862;    
    CASE PRESENTATION: Case 1: A 73-year-old gentleman with underlying asymptomatic rheumatoid arthritis (RA), was admitted with COVID pneumonia for which he received tocilizumab, remdesivir, and 12 days of dexamethasone...Despite receiving Furosemide, Vancomycin, and Ceftazidime, he required high-flow nasal cannula oxygenation (HFNC)...Intravenous Levofloxacin and Vancomycin resulted in no clinical improvement...Both patients were started on Prednisone with a prolonged taper... Pulmonary eosinophilic pneumonia is a complication of post-COVID-ILD and can be successfully managed with steroids.
  • ||||||||||  The Blue Grown Up In Your Operating Room (Hall C) -  Aug 15, 2022 - Abstract #ASA2022ASA_4890;    
    Continuous spinal anesthesia was planned, but the patchy block needed conversion to general anesthesia. Post intubation inotropic and vasopressor support and ICU recovery were needed.
  • ||||||||||  Journal:  Antihypertensive medicine use differs between Ghana and Nigeria. (Pubmed Central) -  Aug 13, 2022   
    The differences between Ghana and Nigeria may result from a combination of medical, contextual and policy evidence and reflect factors related to clinical guidance (e.g. standard treatment guidelines), accessibility to prescribers and the role of community pharmacies, and structure of the health system and universal health coverage including funding for medicines. We show the feasibility of using novel data sources to gain insights on medicines use in the community.
  • ||||||||||  digoxin / Generic mfg.
    Journal:  Corneal Endothelial Dysfunction as a Manifestation of Digoxin Toxicity. (Pubmed Central) -  Aug 12, 2022   
    We encountered 1 case of corneal edema secondary to corneal endothelial dysfunction in a patient with digoxin toxicity. Special care should be taken to elicit a complete history because ocular signs can be manifestations of systemic alterations with vital importance for patients.
  • ||||||||||  Lexiscan (regadenoson) / GE Healthcare, Astellas, Gilead
    Heart Failure With Preserved Ejection Fraction Secondary to Coronary Endothelial Dysfunction and Microvascular Disease (Zone 1, Science and Technology Hall, Level 3; Poster Board no. 1025) -  Aug 11, 2022 - Abstract #AHA2022AHA_5206;    
    Angiography showed normal coronary arteries while coronary reactivity testing was diagnostic of severe epicardial and microvascular endothelial dysfunction (60% mid/distal LAD constriction and 19% decreased blood flow in response to intracoronary (IC) acetylcholine), and endothelial-independent microvascular dysfunction (coronary flow reserve 2.4 in response to IC adenosine), diagnostic of HFpEF due to coronary endothelial and microvascular disease (Figure D). The patient
  • ||||||||||  furosemide / Generic mfg.
    Preclinical, Journal:  A novel contrast-induced acute kidney injury mouse model based on low-osmolar contrast medium. (Pubmed Central) -  Aug 9, 2022   
    We found that this mouse model possessed a significant reduction in renal function, severe renal tissue damage, and increased renal tubular cells apoptosis, indicating that LOCM is a feasible inducer for CI-AKI mice model. Taken together, we found that uninephrectomy (UPHT) combined with 24 h water deprivation and furosemide administration 20 min before LOCM (iohexol, 10 ml/kg) application is a feasible pretreatment to establish a novel CI-AKI mouse model.