- |||||||||| arsenic trioxide / Generic mfg.
GROUND GLASS OPACITIES IN A PATIENT RECEIVING TREATMENT WITH ALL-TRANS RETINOIC ACID AND ARSENIC TRIOXIDE (Convention Center Exhibit Hall: Rapid Area 3C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4208;
Her dexamethasone dose was doubled, in addition to cefepime and furosemide...Standard treatment includes IV dexamethasone 10 mg every 12 hours until resolution of symptoms for at least 3 days (1)... Prompt recognition and treatment of DS with dexamethasone is imperative to prevent progression to respiratory failure.
- |||||||||| Invanz (ertapenem) / Merck (MSD)
VENOUS AIR EMBOLISM: A CASE REPORT (Convention Center Exhibit Hall: Rapid Area 2B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4182;
The patient improved with the above-mentioned therapy and was discharged to complete 14 days of IV ertapenem... A high degree of clinical suspicion is required for timely diagnosis and management of air embolism to decrease morbidity and mortality.
- |||||||||| ivermectin oral / Generic mfg., furosemide / Generic mfg.
DISSEMINATED STRONGYLOIDIASIS IN A PATIENT WITH ACUTE LYMPHOCYTIC LEUKEMIA (Convention Center Exhibit Hall: Rapid Area 1C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3579;
Recognition of possible strongyloidiasis in immunocompromised patients with eosinophilia and other signs such as diarrhea and rash is important. As DS has a high mortality rate but can be treated effectively when recognized promptly.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Actemra IV (tocilizumab) / Roche, JW Pharma
REACTIVATION MILIARY TB IN THE SETTING OF POSTINFECTIOUS COVID-19 LUNGS (Convention Center Exhibit Hall: Rapid Area 3C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3319;
He was treated for COVID pneumonia for ten days in the hospital with Decadron, Lasix, and tocilizumab. Patients with latent TB are likely at a high risk of reactivation post recovering from COVID-19 infection, due to immunosuppression and lung parenchymal damage
- |||||||||| furosemide / Generic mfg.
COCAINE: A LINE TO ACUTE PANCREATITIS (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3097;
Cocaine-induced acute pancreatitis is not a common phenomenon, and there are only a handful of reported cases of cocaine-induced pancreatitis. Due to cocaine's potent vasoconstrictive and prothrombotic properties, clinicians should consider this an etiology in some cases of idiopathic acute pancreatitis.
- |||||||||| dasatinib / Generic mfg.
RECURRENT DASATINIB-INDUCED CHYLOTHORAX (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3053;
Further follow-up for patients with a history of Dasatinib-Induced chylothorax is needed, even after discounting Dasatinib, to see if there are at increased risk for chylothorax. For recurrent chylothorax, an alternative tyrosine kinase inhibitor should be used.
- |||||||||| furosemide / Generic mfg.
Journal: Response Guided Slow Infusion of Albumin, Vasoconstrictors and Furosemide Improves Ascites Mobilization and Survival in Acute on Chronic Liver Failure: A Proof-of-Concept Study. (Pubmed Central) - Sep 11, 2022
In the mechanistic cohort, 72% of patients survived with significant improvement in gut permeability, endotoxemia, serum cytokines, neutrophil dysfunction, and hemodynamic alterations. Ascitic fluid mobilization by response-guided SAFI ± T/NAdr therapy improves survival by improving splanchnic and systemic hemodynamics, decreasing gut congestion, gut permeability, and endotoxemia, improving neutrophil functions, and reducing pro-inflammatory cytokines in circulation.
- |||||||||| furosemide / Generic mfg.
Preclinical, Journal: Anti-ascites effect of total saponins of Phytolaccae Radix on mice with ascites and mechanism (Pubmed Central) - Sep 10, 2022
Thus, studying the effects of furosemide and AF-16 on the electrophysiological behavior of cerebellar granules, we suggest that GABA receptors, containing the α subunit, may be specifically involved in the increase of the peak current by AF, and different receptor subtype distribution may be responsible for differences in this increase on the cell. This study investigated the anti-ascites effect of the total saponins of Phytolaccae Radix(PRTS) and the mechanism.H22 cell suspension was used(ip) to induce ascites in ICR male mice, and the model mice were randomized into model group, positive drug group(furosemide, 6 mg·kg~(-1)), total extract of Phytolaccae Radix(PRTE) group, and PRTS(1.29 g·kg~(-1)).Another 10 male mice were selected as the blank group.Mice in the blank group and model group were given(ig) normal saline containing 0.5% CMC-Na, and those in the positive drug group, PRTE group, and PRTS group received(ig) corresponding doses of drugs, once a day, for 8 consecutive days.The ascites volume, urine volume, and fecal water content in mice with ascites, serum levels of antidiure-tic hormone(ADH), renin in renin-angiotensin-aldosterone system(RAAS), angiotensin Ⅱ(AngⅡ), and aldosterone(ALD), expression of aquaporin(AQP)1-AQP4 in kidney, expression of AQP1, AQP3 in colon, and expression of phosphatidylinositol 3-kinase/protein kinase B(PI3 K/Akt) pathway-related proteins were detected to explore the anti-ascites mechanism of PRTS.The results showed that the PRTS can increase the urine volume and fecal water content and decrease the ascites volume of ascites mice.Moreover, PRTS significantly reduced the expression of AQP1-AQP4 in kidney and AQP1, AQP3 in colon, serum levels of renin, AngⅡ, ALD, and ADH, and the expression of p-PI3 K and p-Akt in the kidney of ascites mice.PRTS exerts anti-ascites effect by promoting urination and defecation.The mechanism is that it inhibits the activities of RAAS and ADH and suppresses the phosphorylation of PI3 K/Akt signaling pathway, thereby restricting the expression of AQPs in the kidney and colon.
- |||||||||| hydralazine hydrochloride / Generic mfg., furosemide / Generic mfg.
Pseudomelanosis Duodeni in a Patient With Renal Transplant and Immunosuppression: A New Association ([IN-PERSON]) - Sep 8, 2022 - Abstract #CAP2022CAP_747;
Although the exact etiology, pathogenesis, and clinical significance remains unknown, it has been reportedly associated with the use of certain medications (including hydralazine, thiazide diuretics, furosemide, beta-blockers, and iron supplements), hypertension, chronic renal disease, gastrointestinal hemorrhage, and diabetes mellitus. Pathologists should be aware of this rare entity and its emerging associations to make an accurate diagnosis that would help new studies and better understanding of its diagnostic and prognostic significance.
- |||||||||| hydralazine hydrochloride / Generic mfg., furosemide / Generic mfg.
Pseudomelanosis Duodeni in a Patient With Renal Transplant and Immunosuppression: A New Association ([IN-PERSON]) - Sep 8, 2022 - Abstract #CAP2022CAP_424;
Although the exact etiology, pathogenesis, and clinical significance remains unknown, it has been reportedly associated with the use of certain medications (including hydralazine, thiazide diuretics, furosemide, beta-blockers, and iron supplements), hypertension, chronic renal disease, gastrointestinal hemorrhage, and diabetes mellitus. Pathologists should be aware of this rare entity and its emerging associations to make an accurate diagnosis that would help new studies and better understanding of its diagnostic and prognostic significance.
- |||||||||| Loop Diuretic-Induced Pancreatitis (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_3806;
Her medications included Prednisone, Plaquenil, and Eliquis...Bumetanide was held and later switched to ethacrynic acid with the resolution of symptoms...Nevertheless, our patient developed AP only with furosemide and bumetanide, indicating an added immune-mediated pathway involving sulfa metabolites likely contributing to AP, which also has been reported in the literature. Figure: CT abdomen from the time of initial ED presentation demonstrating edematous pancreas with minimal surrounding fat stranding and fluid in the region of the head and uncinate process, consistent with acute interstitial pancreatitis.
- |||||||||| Gastroenterological Manifestations in a Patient With Common Variable Immunodeficiency (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_3666;
Non-cirrhotic portal hypertension was managed with furosemide and spironolactone...Recognition of this complication allowed for symptom resolution within two days of starting lactulose therapy. NRH in CVID represents an autoimmune-like liver disease that might be driven by a local vasculopathy, and thus severe cases can warrant a trial of immunosuppression.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Fatal Drug-Induced Liver Injury in a Patient With Known Chronic Liver Disease Secondary to Ethanol and Hemochromatosis (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_1672;
This case report emphasizes the importance of identifying potential hepatotoxic agents such as AC in patients with already established chronic liver disease as they can precipitate life threatening complications such as DILI or DIC. Physicians should also be aware that susceptibility to drugs or chemical compounds can be altered in iron-overloaded livers such as this patient with known history of Hemochromatosis.
- |||||||||| Black Speckled Villi (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_1049;
His medications included iron supplementation, amlodipine, aspirin, atorvastatin, carvedilol, furosemide, and hydralazine...It is associated with chronic medical conditions including iron deficiency anemia, hypertension, diabetes, chronic kidney disease and common medications such as ferrous sulfate, hydralazine, propranolol, hydrochlorothiazide and furosemide...Figure: FIGURE 1. Pseudomelanosis duodeni.
- |||||||||| Imjudo (tremelimumab) / AstraZeneca, Pfizer, Humira (adalimumab) / Eisai, AbbVie
A Case of Spontaneous Resolution of Malignant Peritoneal Mesothelioma (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_557;
Case Description/ A case of 44 y/o female with a history of severe psoriasis (on Humira) and NASH, coccidioidomycosis in 2018 (on ketoconazole) presented with jaundice and abdominal distention in September 2020...She was medically managed with furosemide and spironolactone...She had multiple psoriatic flares which were managed with prednisone...2015. "Tremelimumab for the treatment of malignant mesothelioma."15:12, 1819-1829 15:12
- |||||||||| acetazolamide / Generic mfg., furosemide / Generic mfg.
A Case of Recurrent Ascites Secondary to Ventriculoperitoneal Shunt in a Patient With Idiopathic Intracranial Hypertension (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_550;
Surgical intervention is usually indicated in cases that prove refractory to conservative measures (such as weight loss and acetazolamide) or in cases of progressive papilledema and visual deficit...She started noticing re-accumulation of fluid that did not improve with prescribed furosemide...While pathophysiology behind IIH is hypothesized to be due to inability of CSF to be reabsorbed by arachnoid granulations and extracranial lymphatics, there is no satisfactory explanation in the literature regarding the pathophysiology of CSF ascites due to VPS. It is suspected that our patient’s infected VPS caused device malfunction leading to ascites.
- |||||||||| indapamide / Generic mfg., furosemide / Generic mfg.
Assessment of Diuretic Drug Consumption in Ukraine (Virtual) - Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_2392;
furosemide was the leader in consumption among diuretics in Ukraine. The DID of furosemide for 2019-2021 was 4.79-5.24 DID, due to its low cost, frequency of use, availability, relative safety and effectiveness.
- |||||||||| furosemide / Generic mfg.
Journal, IO biomarker: Update on the diagnosis and management of SIADH and Diabetes insipidus (Pubmed Central) - Aug 30, 2022
The RIB therapy limits the risk of overcorrection and requires less often re-lowering treatment than continuous infusion therapy.Fluid restriction has long been considered as first-line treatment of chronic hyponatremia due to SIADH. Additional treatment with Furosemid and/or oral NaCl tablets does not improve efficacy but reduces tolerance to therapy.Copeptin-based dynamic tests show higher diagnostic accuracy in the differential diagnosis of patients with hypotonic polyuria polydipsia syndrome than the indirect water deprivation test.
- |||||||||| furosemide / Generic mfg.
Trial completion: Inhaled Furosemide for Transient Tachypnea of Newborn (clinicaltrials.gov) - Aug 30, 2022
P=N/A, N=64, Completed,
Additional treatment with Furosemid and/or oral NaCl tablets does not improve efficacy but reduces tolerance to therapy.Copeptin-based dynamic tests show higher diagnostic accuracy in the differential diagnosis of patients with hypotonic polyuria polydipsia syndrome than the indirect water deprivation test. Unknown status --> Completed
- |||||||||| furosemide / Generic mfg.
Retrospective data, Journal: Comparison of Different Furosemide Regimens in the Treatment of Acute Heart Failure: A Meta-Analysis. (Pubmed Central) - Aug 30, 2022
There was no significant difference in terms of length of hospital stay (MD = -0.71, 95% CI (-2.74~1.31), P = 0.49) and all-cause mortality (RR = 1.59, 95% CI (0.92~2.75), P = 0.10). Compared with intermittent administration, continuous infusion of furosemide had a significant effect on the 24-hour urine volume and total weight loss in patients with AHF.
- |||||||||| furosemide / Generic mfg.
Trial completion date, Trial primary completion date: Furosemide Use to Fill the Bladder of Pediatric Females Awaiting Pelvic Ultrasound (clinicaltrials.gov) - Aug 29, 2022
P1, N=100, Recruiting,
Compared with intermittent administration, continuous infusion of furosemide had a significant effect on the 24-hour urine volume and total weight loss in patients with AHF. Trial completion date: Apr 2022 --> Apr 2023 | Trial primary completion date: Apr 2022 --> Apr 2023
- |||||||||| furosemide / Generic mfg.
Journal: Study Evaluating the Use of RenalGuard to Protect Patients at High Risk of AKI. (Pubmed Central) - Aug 28, 2022
Trial completion date: Apr 2022 --> Apr 2023 | Trial primary completion date: Apr 2022 --> Apr 2023 In high-risk patients undergoing complex cardiovascular interventions in experienced centers, furosemide-induced high urine output with matched hydration using the RenalGuard system did not reduce the risk of CIN and adverse outcomes at 12 months compared with conventional intravenous hydration.
- |||||||||| Bystolic (nebivolol) / Menarini, AbbVie
Journal: VASCULITIS AND RENOVASCULAR HYPERTENSION - A CASE REPORT. (Pubmed Central) - Aug 27, 2022
Renovascular hypertension is responsible for less than 1% of all cases of hypertension and, when present, it is usually caused by atherosclerotic disease or fibromuscular dysplasia. However, in more infrequent cases, an inflammatory systemic disease may be present and must be considered.
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