furosemide / Generic mfg. 
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  • ||||||||||  furosemide / Generic mfg.
    Pyeloplasty Can Reverse the Effect of Growth Delay from Ureteropelvic Junction Obstruction in Infants () -  Dec 29, 2022 - Abstract #WSAUA2022WSAUA_244;    
    INTRODUCTION AND OBJECTIVE The decision to undergo pyeloplasty for congenital hydronephrosis due to ureteropelvic junction obstruction (UPJO) is typically based on severity of hydronephrosis or obstruction observed on Lasix nuclear renal scan...CONCLUSIONS Patients with congenital hydronephrosis due to UPJO that underwent pyeloplasty showed a significant increase in weight and height at 6-12 months post-operatively compared to those that deferred operative management. This suggests untreated UPJO might lead to growth delay in infants.
  • ||||||||||  furosemide / Generic mfg.
    PK/PD data, Journal:  Impact of Albumin Binding Function on Pharmacokinetics and Pharmacodynamics of Furosemide. (Pubmed Central) -  Dec 24, 2022   
    ABiC could serve as a marker for individual response to furosemide and could be used to generate patient-specific therapeutic regimens. In view of the relatively low number of patients in this study, the relationship between furosemide efficacy and albumin function should be investigated in larger studies in the future.
  • ||||||||||  furosemide / Generic mfg.
    Journal, Surgery:  'Are Routine Post-discharge Diuretics Necessary After Pediatric Cardiac Surgery?'. (Pubmed Central) -  Dec 24, 2022   
    The intervention was that "regular risk" patients received no diuretics and pre-specified "high risk" patients received 5 days of twice per day furosemide at discharge...This conclusion is limited as not enough subjects were enrolled to definitively show that this strategy is not inferior to the historical practice. There was a statistically significant increase in readmissions for pericardial effusions after implementation of this study protocol which can lead to serious complications and requires further study before conclusions can be drawn regarding optimal diuretic regimens.
  • ||||||||||  vancomycin / Generic mfg., furosemide / Generic mfg., gentamicin sulfate / Generic mfg.
    Journal:  Cumulative risk factors contributing to hearing loss in preterm infants. (Pubmed Central) -  Dec 24, 2022   
    There was a statistically significant increase in readmissions for pericardial effusions after implementation of this study protocol which can lead to serious complications and requires further study before conclusions can be drawn regarding optimal diuretic regimens. Although the relative contribution of underlying illness and medication cannot be identified by this study, cumulative use of ototoxic medication and the presence of physiologic risk factors independently increased the likelihood of hearing loss, warranting close monitoring of coincident therapy throughout neonatal critical care.
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, omecamtiv mecarbil (AMG 423) / Amgen, Servier, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
    Review, Journal:  Heart failure: an update from the last years and a look at the near future. (Pubmed Central) -  Dec 23, 2022   
    Ferric derisomaltose had an effect on the primary outcome of CV mortality or HF rehospitalizations in IRONMAN (rate ratio 0.82; 95% confidence interval 0.66-1.02; P = 0.070). Further options for the treatment of HF, including device therapies, cardiac contractility modulation, and percutaneous treatment of valvulopathies, are summarized in this article.
  • ||||||||||  tolvaptan / Generic mfg.
    Journal:  Effects of Low-Dose Tolvaptan for Fluid Management After Cardiovascular Surgery. (Pubmed Central) -  Dec 20, 2022   
    No significant differences were observed in the development of WRF and POAF between the 2 groups. Although low-dose tolvaptan administration did not shorten the time to achieving preoperative body weight, it did significantly increase urine volume without WRF and POAF.
  • ||||||||||  furosemide / Generic mfg.
    Lasix vs saline. (Twitter) -  Dec 18, 2022   
  • ||||||||||  ethacrynic acid / Generic mfg., furosemide / Generic mfg., bumetanide / Generic mfg.
    Journal:  Role of Monovalent Ions in the NKCC1 Inhibition Mechanism Revealed through Molecular Simulations. (Pubmed Central) -  Dec 12, 2022   
    Consistent with experimental evidence, all drugs take advantage of the K/Na ions, which plastically respond to their binding. This study not only provides atomic-level insights useful for drug discovery campaigns of more selective/potent NKCC1 inhibitors aimed to tackle diseases related to deregulated Cl homeostasis, but it also supplies a paradigmatic example of the key importance of dynamical effects when drug binding is mediated by monovalent ions.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Diuretic and anti-diarrheal potential of four fruit extracts of Capsicum annum L. (Pubmed Central) -  Dec 2, 2022   
    Urinary excretion of water and electrolytes (Na+ and K+) is significantly increased by the standard diuretic drug furosemide, which is comparable with the extract. The anti-diarrheal effects of 95% ethanolic extracts of Capsicum annum L. were examined by castor oil induced diarrhea and all varieties of Capsicum annum L. significantly inhibited the number of defecations.
  • ||||||||||  furosemide / Generic mfg.
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Postpartum Management of Gestational Hypertensive Disorders Using Furosemide (clinicaltrials.gov) -  Dec 1, 2022   
    P4,  N=15, Terminated, 
    The anti-diarrheal effects of 95% ethanolic extracts of Capsicum annum L. were examined by castor oil induced diarrhea and all varieties of Capsicum annum L. significantly inhibited the number of defecations. N=140 --> 15 | Trial completion date: Dec 2024 --> Jun 2022 | Enrolling by invitation --> Terminated | Trial primary completion date: Dec 2024 --> Jun 2022; Challenges with enrollment; primary investigator left the institution
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Intravenous Physical Compatibility of Heparin Sodium and Furosemide. (Pubmed Central) -  Nov 30, 2022   
    Our observations found demonstrative changes in physical compatibility in the admixtures of heparin sodium and furosemide at a ratio of 4:1. The findings suggest that a combination of the solutions in this study be avoided until further research is completed.
  • ||||||||||  furosemide / Generic mfg., bumetanide / Generic mfg.
    Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1599;    
    Blocking NKCC1 decreases neuronal swelling early during OGD. Yet, furosemide is more effective in preventing neuronal swelling than only blocking NKCC1 during prolonged hypoxia, suggesting additional non-CCC water pathways at this age.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  mTOR Signaling in BDNF-Treated Guinea Pigs after Ototoxic Deafening. (Pubmed Central) -  Nov 27, 2022   
    Animals were ototoxically deafened by systemic administration of kanamycin and furosemide, and one week later, the right cochleas were treated with gelatin sponge soaked in rhBDNF, while the left cochleas were used as negative controls...Conversely, Western blot analysis showed no significant differences in the protein levels between groups, probably due to dilution of proteins in the neighboring tissues of the organ of Corti. Altogether, our data indicate that mTOR signaling proteins are expressed by the organ of Corti (with a major role for supporting cells) and that the modulation of mTOR may be a protective mechanism triggered by BDNF in the degenerating organ of Corti.
  • ||||||||||  Journal:  A study of the quality of cardiovascular and diabetes medicines in Malang District, Indonesia, using exposure-based sampling. (Pubmed Central) -  Nov 26, 2022   
    While we cannot conclude that the prevalence of poor-quality medicines in Malang district is zero, our sampling method, which reflects likely exposure to specific brands and outlets, suggests that the risk to patients is very low; certainly nothing like the rates found in recent reviews of surveys in LMICs. Our study demonstrates the feasibility of sampling medicines based on likely exposure to specific products and underlines the dangers of extrapolating results across countries.
  • ||||||||||  hydrochlorothiazide / Generic mfg., furosemide / Generic mfg.
    Journal:  Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial. (Pubmed Central) -  Nov 25, 2022   
    Our study demonstrates the feasibility of sampling medicines based on likely exposure to specific products and underlines the dangers of extrapolating results across countries. The addition of HCTZ to loop diuretic therapy improved diuretic response in patients with AHF.
  • ||||||||||  furosemide / Generic mfg.
    Trial completion date, Trial primary completion date:  FLUSH-NS: Furosemide Alone or Unexpectedly With Solution of Hypertonic Saline in Nephrotic Syndrome (clinicaltrials.gov) -  Nov 23, 2022   
    P=N/A,  N=30, Recruiting, 
    The addition of HCTZ to loop diuretic therapy improved diuretic response in patients with AHF. Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Dec 2021 --> Jan 2023
  • ||||||||||  furosemide / Generic mfg.
    Journal:  Toward quantification of loop diuretic responsiveness for congestive heart failure. (Pubmed Central) -  Nov 22, 2022   
    Diuretics, such as furosemide, are routinely administered to dogs with congestive heart failure (CHF)...Specifically, we review body water homeostasis and congestion in light of the increasingly recognized role of interstitial Na, propose definitions for diuretic responsiveness and resistance in veterinary subjects, review relevant findings of recent studies, explain how the particular cause of resistance can guide treatment, and identify current knowledge gaps. We believe that a quantitative approach to loop diuretic usage primarily involving natriuresis will advance our understanding and care of dogs with CHF.
  • ||||||||||  furosemide / Generic mfg.
    Journal:  A case report of furosemide extravasation in the hand: a rare cause of compartment syndrome. (Pubmed Central) -  Nov 22, 2022   
    To the best of our knowledge, there have been no cases reported in the literature of furosemide-induced extravasation injury with subsequent compartment syndrome that has required surgical intervention. Presented herein is the case of a 70-year-old female patient who was administered intravenous furosemide from the dorsum of the left hand and whose extravasation injury progressed to compartment syndrome requiring an emergency fasciotomy.