- |||||||||| ceftriaxone / Generic mfg., azithromycin / Generic mfg., furosemide / Generic mfg.
Devastating Extra-Pulmonary Manifestations of Legionella Pneumonia in a Young, Immunocompetent College Student (Walter E. Washington Convention Center, Room 206 (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3008;
IV fluids and Ceftriaxone/Azithromycin given...Given Lasix without improvement in oliguria.t...Comparing 16 prior cases- the average age was 49, CK peak of 59,000, and CRT of 7.5- our patient is younger, had severe muscular and renal injury, and did not have significant comorbidity. Our goals are to increase clinician awareness that extrapulmonary manifestations can affect young healthy populations, consider testing in severely ill patients, and describe the challenges of treating.
- |||||||||| furosemide / Generic mfg., bumetanide / Generic mfg.
Clinical, Journal: Diuretic treatment before and after transcatheter aortic valve implantation: A Danish nationwide study. (Pubmed Central) - Mar 24, 2023
Among patients undergoing TAVI, surviving one year, one fifth of patients had increased loop diuretic treatment, and a little over one fifth had reduced loop diuretic treatment 1-year post-procedure. In patients with increased diuretic treatment, the risk of death was higher compared to those with reduced/unchanged loop diuretic treatment.
- |||||||||| norfloxacin / Generic mfg., furosemide / Generic mfg., warfarin / Generic mfg.
Journal: Label-free biosensing of lignans for therapeutics using engineered model surfaces. (Pubmed Central) - Mar 20, 2023
The obtained binding values might suggest the potential medical application of DPT and APT without further optimization of their binding affinity to HSA. These results could be also adapted to other biomolecules and applications where sample consumption and the rapidity of the measurements are critical.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Henletor (torsemide) / Orchid, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
Clinical, Review, Journal: Heart Failure With Preserved Ejection Fraction: A Review. (Pubmed Central) - Mar 15, 2023
First-line pharmacologic therapy consists of sodium-glucose cotransporter type 2 inhibitors, such as dapagliflozin or empagliflozin, which reduced HF hospitalization or cardiovascular death by approximately 20% compared with placebo in randomized clinical trials...Diuretics (typically loop diuretics, such as furosemide or torsemide) should be prescribed to patients with overt congestion to improve symptoms...Approximately 3 million people in the US have HFpEF. First-line therapy consists of sodium-glucose cotransporter type 2 inhibitors, exercise, HF self-care, loop diuretics as needed to maintain euvolemia, and weight loss for patients with obesity and HFpEF.
- |||||||||| furosemide / Generic mfg.
Review, Journal: Co-Administration of Albumin and Furosemide in Acute Heart Failure with Diuretics Resistance. (Pubmed Central) - Mar 14, 2023
This review addresses the pathophysiological mechanisms of congestion in patients with acute heart failure and explores the theoretical basis that supports the co-administration of albumin and furosemide in this clinical context. It is intended to clarify the potential benefit of the combined approach in this specific population and identify possible gaps in the literature that could be the subject of future studies.
- |||||||||| furosemide / Generic mfg., bumetanide / Generic mfg.
Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex () - Mar 14, 2023 - Abstract #PAS2023PAS_4926;
Neuronal swelling was dependent on [Cl - ] o . We also found that: (1) enhancing KCC2 did not alter neuronal swelling but prevented Cl - increase, (2) blocking KCC2 aggravated Cl - increase during prolonged OGD and worsened neuronal swelling during reoxygenation, (3) blocking NKCC1 reduced neuronal swelling during early but not after prolonged OGD, while it aggravated Cl - increase during prolonged OGD, and (4) furosemide reduced both swelling and Cl - increase in prolonged and brief OGD.
- |||||||||| furosemide / Generic mfg.
Non-invasive Oscillometry to Measure the Effects of Furosemide on Lung Mechanics in Extremely Preterm Infants () - Mar 14, 2023 - Abstract #PAS2023PAS_4264;
We also found that: (1) enhancing KCC2 did not alter neuronal swelling but prevented Cl - increase, (2) blocking KCC2 aggravated Cl - increase during prolonged OGD and worsened neuronal swelling during reoxygenation, (3) blocking NKCC1 reduced neuronal swelling during early but not after prolonged OGD, while it aggravated Cl - increase during prolonged OGD, and (4) furosemide reduced both swelling and Cl - increase in prolonged and brief OGD. We tested 30 infants with a mean
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg., furosemide / Generic mfg.
Hearing Loss Prevalence and Clinical Factors in Neonates Admitted to the Neonatal Intensive Care Unit () - Mar 14, 2023 - Abstract #PAS2023PAS_2900;
41/189 (21.6%) of those who failed hearing screen had persistent hearing loss on Auditory Brainstem Response (ABR) testing 6 to 12 months after NICU discharge. Neonates who failed their hearing screen had significantly lower GA (p< 0.001) and birth weight (p< 0.01), had lower APGAR scores at 1 minute (p< 0.01) and 5 minutes (p< 0.01).
- |||||||||| furosemide / Generic mfg.
Journal: Diuretic dose trajectories in dilated cardiomyopathy: prognostic implications. (Pubmed Central) - Mar 13, 2023
At the bottom is reported on the left side of each panel (observation period) the trajectory of LD dose in the four groups (left panel) and in patients who have their LD suspended vs those who continue LD (right panel) in the first two years. On the right side of each panel is shown the incidence of primary outcomes during the subsequent follow-up in the subgroups (outcome assessment).
- |||||||||| furosemide / Generic mfg.
Enrollment closed, Enrollment change: FaST-1: Furosemide as Supportive Therapy for COVID-19 Respiratory Failure (clinicaltrials.gov) - Mar 2, 2023
P2/3, N=32, Active, not recruiting,
ISMN, calcitriol, clopidogrel, a few subtypes of insulin, anti-hypertensive and cholesterol-lowering medications were found to be associated with incident CSDR. Recruiting --> Active, not recruiting | N=640 --> 32
- |||||||||| acetazolamide / Generic mfg.
Eligibility for acetazolamide in real-world acute heart failure patients (Moderated ePosters 1) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_1720;
The attempt to create a congestive score for decompensated HF patients seems to fail for adequate volume assessment in real-world patients. The almost universal use of SLGT2 inhibitors limits the reproducibility of the ADVOR trial.
- |||||||||| furosemide / Generic mfg.
Kidney disease in chronic heart failure: insights from the Spanish Cardiorenal registry (ePosters Station 8) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_971;
The independent variables associated with lower eGFR were age, female sex, arterial hypertension, chronic obstructive pulmonary disease, previous CKD, basal diastolic blood pressure, left ventricular ejection fraction, CA125 levels, and basal furosemide dose (figure 1). In this contemporary cohort of patients with HF, the prevalence of kidney impairment was 70% These patients showed some characteristics of more advanced disease and signs of congestion.
- |||||||||| furosemide / Generic mfg.
Ambulatory intravenous loop diuretics for worsening heart failure (ePosters Station 2) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_905;
Ambulatory 4-hour IV loop diuretics sessions induced a diuresis of approximately 900 mL with a substantial sodium content, without causing significant complications. Background use of renin-angiotensin blockers and addition of thiazide during the session increased diuresis and natriuresis, and could potentially be implemented to maximize the efficacy of ambulatory IV diuretic therapy.
- |||||||||| Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Safety and clinical effects of sodium-glucose cotransporter-2 inhibitors in transthyretin amyloid cardiomyopathy (Moderated ePosters 3) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_877;
Purpose: We are conducting a single-arm, prospective, 12-week pilot trial of the SGLT2 inhibitor empagliflozin 10 mg oral daily in patients with ATTR-CM to evaluate safety and tolerability as assessed by serious adverse events (SAEs), and clinical effects including changes in diuretic requirement, kidney function, and weight...Median (IQR) daily loop diuretic dose in mg of furosemide equivalence decreased from 40 (20 to 80) to 35 (20 to 40) mg from baseline to 12 weeks, respectively (p = 0.5)... To date, 10 subjects (average age 82.1
- |||||||||| furosemide / Generic mfg.
Hypertonic saline in the management of refractory congestion in decompensated heart failure (Moderated ePosters 1) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_780;
Furosemide was part of outpatient therapy in 86%, with median dose of 80 mg/day, 12% received hydrochlorothiazide and 49% received mineralocorticoid receptor antagonists... In a cohort of patients who received hypertonic saline as an additional decongestion strategy for advanced decompensated acute heart failure we found increased diuretic efficiency without electrolyte disturbance or significant deterioration in renal function.
- |||||||||| Reasanz (serelaxin) / Novartis
Presentation, clinical course and outcomes of women and men hospitalized with acute heart failure: insights from RELAX-AHF 2 trial (Moderated ePosters 1) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_697;
Purpose We sought to characterize the clinical phenotype, patient journey, and outcome of men and women with AHF enrolled in a large contemporary, multinational AHF trial, RELAX-AHF 2, the second seRELAXin in Acute Heart Failure trial...During hospital stay, women received lower doses of loop diuretics (120 vs 160 mg furosemide equivalent total intravenous cumulative diuretic dose through day 5, and 243 versus 280 mg furosemide equivalent total oral cumulative diuretic dose through day 5, both p 0.1) as compared to men...However, early incident WRF was more frequent in women and was associated with worse clinical outcomes, that were not observed in men or in women with no WRF through day 5. More studies are warranted to investigate sex differences in renal outcomes in AHF.
- |||||||||| furosemide / Generic mfg.
Predictive value of urinary spot sodium in acutely decompensated heart failure: results from the TAILOR-AHF observational study (Moderated ePosters 1) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_583;
UrNa was divided by pre-administered furosemide (or equivalent) dose resulting in the UrNa/Furo-Ratio...Delta-creatinine during admission and clinical outcome at 90-days after discharge (re-hospitalization and all-cause mortality) were not significantly associated with UrNa; although the latter may be underpowered. Our results strengthen the hypothesis that spot UrNa can be useful to guide decongestive therapy in ADHF patients.
- |||||||||| furosemide / Generic mfg.
Adjustments in furosemide dose in patients with heart faillure receiving SGLT2is-does HbA1c matter? (ePosters Station 13) - Feb 28, 2023 - Abstract #HEARTFAILURE2023HEART_FAILURE_541;
Conclusions : We recorded statistically significant difference in the need for reduction of the received furosemide dose between patients with those with elevated HbA1c >8mg/dl being prescribed with lower dose of furosemide, irrespectively of sex, ejection fraction, specific SGLT2i and GFR. Further studies are needed in order to identify whether HbA1c levels could be used as a guidance in order to better monitor and adjust the dose of furosemide in patients with heart failure receiving SGLT2is.
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